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Information on SUBCLASS 0.1.4
Subclass Accession number: 862
Subclass: 0.1.4 PSSM
Type: EH beta-alpha
DB: ArchDB40

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
EC : 3.4 (>75 %)  3.4.21 (>75 %)  
GO : GO:0004175 (>75 %)  GO:0004252 (>75 %)  GO:0008233 (>75 %)  GO:0008236 (>75 %)  
SCOP : 50493 (>75 %)  50494 (>75 %)  50514 (>75 %)  
 Number of loops: 21

Average sequence ID (%) : 31.7 +/- 28.1
Average RMSD (Å) : 0.405 +/- 0.213

Consensus geometry
d (Å): 11 delta (°): 0-45 theta (°): 45-90 rho (°): 135-180
Consensus Sequence: pphX
(φψ)-conformation: bbaa
Pattern: [nsty][hknqrsw][aclv][agknrst][adnqrs][fhilvy][aiklmv][deknps][aflw][ily][dgknqr]
Conservation:0.074-0.2180.544-0.894-0.9860.167-0.797-0.1192.3550.845-0.970
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1a7s_*_2011a7s   -204214TRVALFRDWIDEEGGGGHHHHHxxaaaaaaaaa
1azz_A_2261azz   A229239TRVTYFLDWIQEESGGGHHHHHxxaaaaaaaaa
1bio_*_2261bio   -229239TRVASYAAWIDEEGGGGHHHHHxxaaaaaaaaa
1cgh_A_2261cgh   A229239TRVSSFLPWIREEGGGGHHHHHxxaaaaaaaaa
1dle_A_2251dle   A229239INLFQVLPWLKEEGGGGHHHHHxxaaaaaaaaa
1e5x_A_2571e5x   A258268YLANSLNSLRLEEGGGSHHHHHxxaaaaaaaaa
1elv_A_6471elv   A651661TRVKNYVDWIMEEGGGGHHHHHxxaaaaaaaaa
1eq9_A_2261eq9   A229239TRVSSFVSWINEEGGGGHHHHHxxaaaaaaaaa
1fjs_A_2261fjs   A229239TKVTAFLKWIDEEGGGGHHHHHxxaaaaaaaaa
1gdn_A_2261gdn   A229239ASVGALRSFIDEETTTTHHHHHxxaaaaaaaaa
1gj7_B_2261gj7   B229239TRVSHFLPWIREEGGGSHHHHHxxaaaaaaaaa
1gvk_B_2261gvk   B229239TRVSAYISWINEEGGGSHHHHHxxaaaaaaaaa
1gvz_A_2281gvz   A229239TKVMPHKKWIKEESGGGHHHHHxxaaaaaaaaa
1gwu_A_1741gwu   A175185NQCRFIMDRLYEEGGGGHHHHHbxaaaaaaaaa
1h8d_H_2261h8d   H229239THVFRLKKWIQEETGGGHHHHHxxaaaaaaaaa
1kli_H_2261kli   H229239TRVSQYIEWLQEEGGGGHHHHHxxaaaaaaaaa
1m9u_A_2261m9u   A229239TRVSAYLGWIGEEGGGTHHHHHxxaaaaaaaaa
1nzj_A_761nzj   A7686LWQSQRHDAYREEGGG-HHHHHxbaaaaaaaaa
1p57_B_2261p57   B229239TKVSDFREWIFEEGGGGHHHHHxxaaaaaaaaa
1s83_A_2261s83   A229239TKVCNYVNWIQEEGGG-HHHHHxxaaaaaaaaa
2hlc_A_2262hlc   A229239SRVTSYMDWIQEEGGGGHHHHHxxaaaaaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1a7s_*_2011a7s   *     EOHETHANOL D - 201
1a7s_*_2011a7s   *     EOHETHANOL F - 202
1a7s_*_2011a7s   *     EOHETHANOL R - 205
1a7s_*_2011a7s   *     EOHETHANOL L - 208
1a7s_*_2011a7s   *     NAGN-ACETYL-D-GLUCOSAMINE D - 211
1bio_*_2261bio   *     GOLGLYCEROL R - 230
1cgh_A_2261cgh   A     PPHPHENYLALANINE PHOSPHINIC ACID E - 226
1cgh_A_2261cgh   A     PPHPHENYLALANINE PHOSPHINIC ACID V - 227
1e5x_A_2571e5x   A     MSESELENOMETHIONINE L - 259
1e5x_A_2571e5x   A     MSESELENOMETHIONINE A - 260
1e5x_A_2571e5x   A     MSESELENOMETHIONINE R - 267
1e5x_A_2571e5x   A     MSOSELENOMETHIONINE SELENOXIDE E - 269
1e5x_A_2571e5x   A     MSESELENOMETHIONINE Q - 271
1elv_A_6471elv   A     NES2-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-ETHANESULFONIC ACID K - 654
1elv_A_6471elv   A     NES2-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-ETHANESULFONIC ACID N - 655
1elv_A_6471elv   A     NES2-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-ETHANESULFONIC ACID Y - 656
1elv_A_6471elv   A     NES2-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-ETHANESULFONIC ACID V - 657
1elv_A_6471elv   A     NES2-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-ETHANESULFONIC ACID D - 658
1elv_A_6471elv   A     NES2-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-ETHANESULFONIC ACID W - 659
1elv_A_6471elv   A     NES2-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-ETHANESULFONIC ACID I - 660
1eq9_A_2261eq9   A     PMSBENZYLSULFINIC ACID D - 226
1eq9_A_2261eq9   A     PMSBENZYLSULFINIC ACID V - 227
1fjs_A_2261fjs   A     Z34N-[2-[5-[AMINO(IMINO)METHYL]-2-HYDROXYPHENOXY]-3,5-DIFLUORO-6-[3-(4,5-DIHYDRO-1-METHYL-1H-IMIDAZOL-2-YL) PHENOXY]PYRIDIN-4-YL]-N-METHYLGLYCINE G - 226
1fjs_A_2261fjs   A     Z34N-[2-[5-[AMINO(IMINO)METHYL]-2-HYDROXYPHENOXY]-3,5-DIFLUORO-6-[3-(4,5-DIHYDRO-1-METHYL-1H-IMIDAZOL-2-YL) PHENOXY]PYRIDIN-4-YL]-N-METHYLGLYCINE I - 227
1fjs_A_2261fjs   A     Z34N-[2-[5-[AMINO(IMINO)METHYL]-2-HYDROXYPHENOXY]-3,5-DIFLUORO-6-[3-(4,5-DIHYDRO-1-METHYL-1H-IMIDAZOL-2-YL) PHENOXY]PYRIDIN-4-YL]-N-METHYLGLYCINE Y - 228
1fjs_A_2261fjs   A     GOLGLYCEROL K - 230
1fjs_A_2261fjs   A     GOLGLYCEROL T - 232
1fjs_A_2261fjs   A     GOLGLYCEROL L - 235
1fjs_A_2261fjs   A     GOLGLYCEROL K - 236
1fjs_A_2261fjs   A     GOLGLYCEROL W - 237
1fjs_A_2261fjs   A     GOLGLYCEROL D - 239
1fjs_A_2261fjs   A     GOLGLYCEROL S - 241
1gdn_A_2261gdn   A     GOLGLYCEROL S - 230
1gdn_A_2261gdn   A     GOLGLYCEROL G - 232
1gdn_A_2261gdn   A     GOLGLYCEROL A - 233
1gj7_B_2261gj7   B     1326-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE G - 226
1gj7_B_2261gj7   B     1326-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE V - 227
1gj7_B_2261gj7   B     1326-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE Y - 228
1gvz_A_2281gvz   A     GOLGLYCEROL P - 233
1gvz_A_2281gvz   A     GOLGLYCEROL H - 234
1gvz_A_2281gvz   A     GOLGLYCEROL K - 235
1gvz_A_2281gvz   A     GOLGLYCEROL I - 238
1gvz_A_2281gvz   A     ACTACETATE ION I - 238
1gvz_A_2281gvz   A     ACTACETATE ION K - 239
1gvz_A_2281gvz   A     ACTACETATE ION I - 242
1gvz_A_2281gvz   A     ACTACETATE ION E - 243
1gwu_A_1741gwu   A     HEMPROTOPORPHYRIN IX CONTAINING FE K - 174
1gwu_A_1741gwu   A     CACALCIUM ION K - 174
1gwu_A_1741gwu   A     HEMPROTOPORPHYRIN IX CONTAINING FE N - 175
1gwu_A_1741gwu   A     CACALCIUM ION N - 175
1gwu_A_1741gwu   A     HEMPROTOPORPHYRIN IX CONTAINING FE Q - 176
1gwu_A_1741gwu   A     CACALCIUM ION Q - 176
1gwu_A_1741gwu   A     HEMPROTOPORPHYRIN IX CONTAINING FE F - 179
1gwu_A_1741gwu   A     CACALCIUM ION F - 179
1kli_H_2261kli   H     BENBENZAMIDINE G - 226
1kli_H_2261kli   H     BENBENZAMIDINE V - 227
1kli_H_2261kli   H     BENBENZAMIDINE Y - 228
1p57_B_2261p57   B     CR42-{5-[AMINO(IMINIO)METHYL]-1H-BENZIMIDAZOL-2-YL} BENZENOLATE G - 226
1p57_B_2261p57   B     CR42-{5-[AMINO(IMINIO)METHYL]-1H-BENZIMIDAZOL-2-YL} BENZENOLATE V - 227
1p57_B_2261p57   B     CR42-{5-[AMINO(IMINIO)METHYL]-1H-BENZIMIDAZOL-2-YL} BENZENOLATE Y - 228
1s83_A_2261s83   A     4HA4-HYDROXYBUTAN-1-AMINIUM G - 226
1s83_A_2261s83   A     4HA4-HYDROXYBUTAN-1-AMINIUM V - 227
1s83_A_2261s83   A     4HA4-HYDROXYBUTAN-1-AMINIUM Y - 228
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1gvk_B_2261gvk   B SOBSO4 BINDING SITE FOR CHAIN BR - 230
1gvk_B_2261gvk   B SOBSO4 BINDING SITE FOR CHAIN BS - 232
1gvk_B_2261gvk   B SOBSO4 BINDING SITE FOR CHAIN BA - 233
1gvz_A_2281gvz   A AC1GOL BINDING SITE FOR CHAIN AH - 234
1gvz_A_2281gvz   A AC1GOL BINDING SITE FOR CHAIN AW - 237
1gvz_A_2281gvz   A AC4ACT BINDING SITE FOR CHAIN AK - 239

Clusters included in this Subclass
CLUSTER: EH.4.14
CLUSTER: EH.4.30
CLUSTER: EH.5.2