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Information on SUBCLASS 12.2.2
Subclass Accession number: 8762
Subclass: 12.2.2 PSSM
Type: HE alpha-beta
DB: ArchDB-EC

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
EC : 3.4 (>75 %)  3.4.23 (>75 %)  
SCOP : 50629 (>75 %)  50630 (>75 %)  50646 (>75 %)  
 Number of loops: 3

Average sequence ID (%) : 32.1 +/- 16.2
Average RMSD (Å) : 0.200 +/- 0.000

Consensus geometry
d (Å): 19 delta (°): 45-90 theta (°): 135-180 rho (°): 135-180
Consensus Sequence: XXHpXhcXpcSSpYXp
(φψ)-conformation: aabpbpbaaabaapbp
Pattern: [ILT][A][C][TVW]x[H][HKN]x[FY][DN][APS][DES][DK][S][S][ST][Y]x[HKS][NT][GS][ET][EST][FLV][DST][IL][HRT]
Conservation:-0.7020.4912.825-0.858-1.1172.358-0.391-0.8580.8370.335-0.702-0.391-0.1540.4910.4910.0221.891-0.961-0.7020.053-0.011-0.349-0.650-0.650-0.5980.055-0.754
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1lya_A_511lya   A5177IACWIHHKYNSDKSSTYVKNGTSFDIHHHHHTS--B-GGG-TT-EEEEEEEEEEaaaaabxbxbaaabaaxbxagpxbbbb
1qrp_E_481qrp   E4874LACTNHNRFNPEDSSTYQSTSETVSITHHHHTS--B-GGG-TT-EEEEEEEEEEaaaaabxbxbaaabaaxbxbabbbbbb
1rne_*_481rne   -4874TACVYHKLFDASDSSSYKHNGTELTLRHHHHSS--B-GGG-SS-EEEEEEEEEEaaaaabxbxxaaabaapbxavxxbbbx
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1lya_A_511lya   A     NAGN-ACETYL-D-GLUCOSAMINE K - 69
1lya_A_511lya   A     NAGN-ACETYL-D-GLUCOSAMINE N - 70
1lya_A_511lya   A     NAGN-ACETYL-D-GLUCOSAMINE G - 71
1lya_A_511lya   A     NAGN-ACETYL-D-GLUCOSAMINE T - 72
1lya_A_511lya   A     NAGN-ACETYL-D-GLUCOSAMINE S - 73
1qrp_E_481qrp   E     HFAALPHA-HYDROXY-BETA-PHENYL-PROPIONIC ACID T - 74
1rne_*_481rne   *     NAGN-ACETYL-D-GLUCOSAMINE K - 65
1rne_*_481rne   *     NAGN-ACETYL-D-GLUCOSAMINE H - 66
1rne_*_481rne   *     NAGN-ACETYL-D-GLUCOSAMINE N - 67
1rne_*_481rne   *     NAGN-ACETYL-D-GLUCOSAMINE G - 68
1rne_*_481rne   *     NAGN-ACETYL-D-GLUCOSAMINE T - 69
1rne_*_481rne   *     C60[[[3-(2-METHYL-PROPANE-2-SULFONYL)-1-BENZENYL]-2-PROPYL]-CARBONYL-HISTIDYL]-AMINO-[CYCLOHEXYLMETHYL]-[2-HYDROXY-4-ISOPROPYL]-PENTAN-5-OIC ACID BUTYLAMIDE T - 72
1rne_*_481rne   *     C60[[[3-(2-METHYL-PROPANE-2-SULFONYL)-1-BENZENYL]-2-PROPYL]-CARBONYL-HISTIDYL]-AMINO-[CYCLOHEXYLMETHYL]-[2-HYDROXY-4-ISOPROPYL]-PENTAN-5-OIC ACID BUTYLAMIDE L - 73
1rne_*_481rne   *     C60[[[3-(2-METHYL-PROPANE-2-SULFONYL)-1-BENZENYL]-2-PROPYL]-CARBONYL-HISTIDYL]-AMINO-[CYCLOHEXYLMETHYL]-[2-HYDROXY-4-ISOPROPYL]-PENTAN-5-OIC ACID BUTYLAMIDE R - 74

Clusters included in this Subclass
CLUSTER: HE.12.21