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Information on SUBCLASS 1.2.1
Subclass Accession number: 8823
Subclass: 1.2.1 PSSM
Type: HH alpha-alpha
DB: ArchDB-EC

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB
Number of loops: 56

Average sequence ID (%) : 11.4 +/- 14.1
Average RMSD (Å) : 0.502 +/- 0.191

Consensus geometry
d (Å): 5 delta (°): 45-90 theta (°): 90-135 rho (°): 90-135
Consensus Sequence: XpXXX
(φψ)-conformation: aabaa
Pattern: xx[acfgilvy]x[adegknqrst][cdhnswy][dehknpqrt]xxxx
Conservation:-0.090-1.5630.297-1.0331.3010.4561.825-1.0350.082-0.2860.046
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1ab4_*_4681ab4   -489499LRILGSADRLMHHHHH-HHHHHaaaaaxaaaaa
1aq0_A_591aq0   A6070SNLAASPAAAAHHHHH-HHHHHaaaaabaaaaa
1b6r_A_731b6r   A7484FPIIADRLTQKHHHHHSHHHHHaaaaaxaaaaa
1ble_*_361ble   -3646DDIAQDEMRKTHHHHH-HHHHHaaaaabaaaaa
1bxn_A_4391bxn   A449459DAARWCGPLRAHHHHH-HHHHHaaaaabaaaaa
1c8k_A_7281c8k   A730740EYYDRIPELRQHHHHH-HHHHHaaaaabaaaaa
1c8k_A_7731c8k   A788798SALYKNPREWTHHHHTSHHHHHaaaaabaaaaa
1e1o_A_1691e1o   A171181LDLIANDKSRQHHHHH-HHHHHaaaaabaaaaa
1e4e_A_1241e4e   A127137SAICMDKSLTYHHHHHSHHHHHaaaaaxaaaaa
1em8_B_1081em8   B109119TDLRANPTARAHHHHH-HHHHHaaaaabaaaaa
1ezv_A_1331ezv   A149159DFEDNDHPNRVHHHHH-HHHHHaaaaaxaaaaa
1fp2_A_1501fp2   A152162DFLDKNPEYNTHHHHH-HHHHHaaaaabaaaaa
1g19_A_3031g19   A308318NFLVENADVADHHHHH-HHHHHaaaaabaaaaa
1g2q_A_311g2q   A3141LPIFRNPGLFQHHHHHSHHHHHaaaaabaaaaa
1g99_A_3301g99   A331341GIGENSASIRKHHHHH-HHHHHaaaaaxaaaaa
1gik_A_1741gik   A174184SEAARFKYIENHHHHHBHHHHHaaaaabaaaaa
1gk8_A_4371gk8   A447457SACKWSPELAAHHHHH-HHHHHaaaaabaaaaa
1gwu_A_2591gwu   A264274RSFANSTQTFFHHHHH-HHHHHaaaaabaaaaa
1hbn_A_3671hbn   A383393EQYEEYPALLEHHHHH-HHHHHaaaaabaaaaa
1i2t_A_10411i2t   A10451055LLLLASEDSLRHHHHH-HHHHHaaaaabaaaaa
1ig0_A_1261ig0   A135145SLHFNSPEFRSHHHHH-HHHHHaaaaabaaaaa
1iow_*_881iow   -91101SALSMDKLRSKHHHHH-HHHHHaaaaaxaaaaa
1izo_A_2471izo   A256266LALHEHPKYKEHHHHHSTHHHHaaaaabaaaaa
1j0h_A_4841j0h   A495505ALRKQYRSLRRHHHHH-HHHHHaaaaabaaaaa
1jdr_A_2421jdr   A249259KEYANDQDKFFHHHHT-HHHHHaaaaabaaaaa
1jg7_A_3031jg7   A311321NELKHSDVLRKHHHHH-HHHHHaaaaabaaaaa
1ji1_A_5331ji1   A543553TIRNQYPALRTHHHHH-HHHHHaaaaabaaaaa
1ji2_A_4811ji2   A492502RLRHRLASLTRHHHHH-HHHHHaaaaabaaaaa
1jqn_A_7471jqn   A752762AMCRDWPFFSTHHHHH-HHHHHaaaaabaaaaa
1khc_A_2961khc   A297307ATFNKLVSYRKHHHHH-HHHHHaaaaabaaaaa
1kjq_A_1051kjq   A108118TKLTMNREGIRHHHHHSHHHHHaaaaabaaaaa
1l3s_A_7291l3s   A738748RYFESFPGVKRHHHHH-HHHHHaaaaabaaaaa
1l5r_A_7291l5r   A730740EYYEALPELKLHHHHH-HHHHHaaaaaxaaaaa
1l5w_A_6931l5w   A695705KWRKKDKVLDAHHHHH-HHHHHaaaaabaaaaa
1l5w_A_7401l5w   A755765DVLYRDQEAWTHHHHHSHHHHHaaaaaxaaaaa
1lns_A_5761lns   A580590KKYSKDFNVFKHHHHH-HHHHHaaaaabaaaaa
1m2t_A_1641m2t   A164174SEAARFNPILWHHHHHBHHHHHaaaaabaaaaa
1mrj_*_1591mrj   -159169SEAARYKFIEQHHHHHBHHHHHaaaaabaaaaa
1nln_A_1641nln   A177187FLERHSPYFRSHHHHH-HHHHHaaaaabaaaaa
1nup_A_1721nup   A174184GYIAESPILRMHHHHH-HHHHHaaaaabaaaaa
1oe8_A_1831oe8   A191201NLLASSPRLAKHHHHH-HHHHHaaaaabaaaaa
1pa2_A_2571pa2   A262272TSFASNQTLFFHHHHH-HHHHHaaaaabaaaaa
1pjr_*_1941pjr   -201211QLFDRVPDVLHHHHHH-HHHHHaaaaabaaaaa
1pmi_*_1551pmi   -160170KTLATVPELNEHHHHH-HHHHHaaaaabaaaaa
1q5d_A_2571q5d   A268278LNLLRSPEALEHHHHH-HHHHHaaaaabaaaaa
1qho_A_3871qho   A397407GLRRNNAAIQYHHHHH-HHHHHaaaaabaaaaa
1qi7_A_1751qi7   A175185AEVARFRYIQNHHHHHBHHHHHaaaaabaaaaa
1qmq_A_2511qmq   A262272EFLAKSPEHRQHHHHH-HHHHHaaaaabaaaaa
1qo8_A_4181qo8   A419429QLYKKAKMVRGHHHHH-HHHHHaaaaabaaaaa
1qop_B_221qop   B3343VSAQKDPEFQAHHHHT-HHHHHaaaaaxaaaaa
1r31_A_2411r31   A253263AFAAVDPYRAAHHHHH-HHHHHaaaaabaaaaa
1tsy_*_1141tsy   -127137DRVLHDDAFAAHHHHH-HHHHHaaaaaxaaaaa
1uok_*_4601uok   -469479ELRKNNEIVVYHHHHH-HHHHHaaaaabaaaaa
1vgv_A_3291vgv   A337347TRLLKDENEYQHHHHH-HHHHHaaaaaxaaaaa
2ahj_A_532ahj   A6171ARAWTDPEFRQHHHHH-HHHHHaaaaabaaaaa
2kfn_A_7842kfn   A790800LYFERYPGVLEHHHHH-HHHHHaaaaabaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1e1o_A_1691e1o   A     GOLGLYCEROL L - 190
1e1o_A_1691e1o   A     GOLGLYCEROL R - 194
1e4e_A_1241e4e   A     ADPADENOSINE-5'-DIPHOSPHATE K - 133
1e4e_A_1241e4e   A     MGMAGNESIUM ION K - 133
1e4e_A_1241e4e   A     ADPADENOSINE-5'-DIPHOSPHATE Y - 137
1fp2_A_1501fp2   A     HMO4'-HYDROXY-7-METHOXYISOFLAVONE F - 150
1fp2_A_1501fp2   A     SAHS-ADENOSYL-L-HOMOCYSTEINE W - 151
1fp2_A_1501fp2   A     HMO4'-HYDROXY-7-METHOXYISOFLAVONE W - 151
1fp2_A_1501fp2   A     SAHS-ADENOSYL-L-HOMOCYSTEINE F - 164
1fp2_A_1501fp2   A     HMO4'-HYDROXY-7-METHOXYISOFLAVONE F - 164
1fp2_A_1501fp2   A     SAHS-ADENOSYL-L-HOMOCYSTEINE M - 168
1fp2_A_1501fp2   A     HMO4'-HYDROXY-7-METHOXYISOFLAVONE M - 168
1fp2_A_1501fp2   A     SAHS-ADENOSYL-L-HOMOCYSTEINE A - 169
1g99_A_3301g99   A     ADPADENOSINE-5'-DIPHOSPHATE A - 330
1g99_A_3301g99   A     ADPADENOSINE-5'-DIPHOSPHATE G - 331
1g99_A_3301g99   A     ADPADENOSINE-5'-DIPHOSPHATE I - 332
1g99_A_3301g99   A     ADPADENOSINE-5'-DIPHOSPHATE N - 335
1g99_A_3301g99   A     ADPADENOSINE-5'-DIPHOSPHATE S - 336
1g99_A_3301g99   A     ADPADENOSINE-5'-DIPHOSPHATE A - 337
1g99_A_3301g99   A     ADPADENOSINE-5'-DIPHOSPHATE I - 339
1gwu_A_2591gwu   A     HEMPROTOPORPHYRIN IX CONTAINING FE F - 277
1gwu_A_2591gwu   A     CACALCIUM ION F - 277
1gwu_A_2591gwu   A     HEMPROTOPORPHYRIN IX CONTAINING FE M - 281
1gwu_A_2591gwu   A     CACALCIUM ION M - 281
1gwu_A_2591gwu   A     HEMPROTOPORPHYRIN IX CONTAINING FE M - 284
1gwu_A_2591gwu   A     CACALCIUM ION M - 284
1hbn_A_3671hbn   A     GOLGLYCEROL Y - 380
1hbn_A_3671hbn   A     MGN2-METHYL-GLUTAMINE Y - 385
1hbn_A_3671hbn   A     MGMAGNESIUM ION Y - 385
1hbn_A_3671hbn   A     MGN2-METHYL-GLUTAMINE D - 394
1hbn_A_3671hbn   A     MGMAGNESIUM ION D - 394
1ig0_A_1261ig0   A     VIB3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY -ETHYL)-4-METHYL-THIAZOL-3-IUM D - 126
1ig0_A_1261ig0   A     VIB3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY -ETHYL)-4-METHYL-THIAZOL-3-IUM K - 129
1iow_*_881iow   *     ADPADENOSINE-5'-DIPHOSPHATE K - 97
1iow_*_881iow   *     PHY1(S)-AMINOETHYL-(2-CARBOXYPROPYL)PHOSPHORYL-PHOSPHINIC ACID K - 97
1iow_*_881iow   *     MGMAGNESIUM ION K - 97
1izo_A_2471izo   A     HEMPROTOPORPHYRIN IX CONTAINING FE I - 247
1izo_A_2471izo   A     HEMPROTOPORPHYRIN IX CONTAINING FE S - 248
1izo_A_2471izo   A     HEMPROTOPORPHYRIN IX CONTAINING FE F - 250
1jdr_A_2421jdr   A     HEMPROTOPORPHYRIN IX CONTAINING FE F - 262
1jdr_A_2421jdr   A     HEMPROTOPORPHYRIN IX CONTAINING FE F - 266
1jdr_A_2421jdr   A     HEMPROTOPORPHYRIN IX CONTAINING FE L - 269
1jqn_A_7471jqn   A     ASPASPARTIC ACID M - 769
1jqn_A_7471jqn   A     ASPASPARTIC ACID K - 773
1khc_A_2961khc   A     UNXUNKNOWN ATOM OR ION L - 296
1khc_A_2961khc   A     UNXUNKNOWN ATOM OR ION A - 297
1khc_A_2961khc   A     UNXUNKNOWN ATOM OR ION N - 300
1khc_A_2961khc   A     UNXUNKNOWN ATOM OR ION K - 307
1khc_A_2961khc   A     UNXUNKNOWN ATOM OR ION H - 311
1khc_A_2961khc   A     UNXUNKNOWN ATOM OR ION E - 314
1khc_A_2961khc   A     UNXUNKNOWN ATOM OR ION K - 315
1khc_A_2961khc   A     UNXUNKNOWN ATOM OR ION A - 316
1khc_A_2961khc   A     UNXUNKNOWN ATOM OR ION V - 318
1khc_A_2961khc   A     UNXUNKNOWN ATOM OR ION R - 319
1kjq_A_1051kjq   A     MGMAGNESIUM ION R - 114
1kjq_A_1051kjq   A     ADPADENOSINE-5'-DIPHOSPHATE R - 114
1kjq_A_1051kjq   A     ADPADENOSINE-5'-DIPHOSPHATE R - 118
1l3s_A_7291l3s   A     SUCSUCROSE M - 750
1l3s_A_7291l3s   A     SUCSUCROSE E - 751
1l3s_A_7291l3s   A     SUCSUCROSE V - 754
1l3s_A_7291l3s   A     SUCSUCROSE Q - 755
1l3s_A_7291l3s   A     SUCSUCROSE K - 758
1m2t_A_1641m2t   A     ADEADENINE S - 164
1m2t_A_1641m2t   A     ADEADENINE E - 165
1m2t_A_1641m2t   A     ADEADENINE R - 168
1m2t_A_1641m2t   A     GOLGLYCEROL N - 170
1m2t_A_1641m2t   A     GOLGLYCEROL P - 171
1m2t_A_1641m2t   A     GOLGLYCEROL I - 172
1m2t_A_1641m2t   A     GOLGLYCEROL W - 174
1m2t_A_1641m2t   A     GOLGLYCEROL R - 175
1m2t_A_1641m2t   A     GOLGLYCEROL A - 176
1m2t_A_1641m2t   A     GOLGLYCEROL R - 177
1m2t_A_1641m2t   A     GOLGLYCEROL Q - 178
1m2t_A_1641m2t   A     GOLGLYCEROL Y - 179
1m2t_A_1641m2t   A     GOLGLYCEROL N - 181
1mrj_*_1591mrj   *     ADNADENOSINE S - 159
1mrj_*_1591mrj   *     ADNADENOSINE E - 160
1mrj_*_1591mrj   *     ADNADENOSINE R - 163
1pa2_A_2571pa2   A     CACALCIUM ION F - 275
1pa2_A_2571pa2   A     HEMPROTOPORPHYRIN IX CONTAINING FE F - 275
1pa2_A_2571pa2   A     CACALCIUM ION M - 279
1pa2_A_2571pa2   A     HEMPROTOPORPHYRIN IX CONTAINING FE M - 279
1pa2_A_2571pa2   A     CACALCIUM ION M - 282
1pa2_A_2571pa2   A     HEMPROTOPORPHYRIN IX CONTAINING FE M - 282
1q5d_A_2571q5d   A     EPB7,11-DIHYDROXY-8,8,10,12,16-PENTAMETHYL-3-[1-METHYL-2-(2-METHYL-THIAZOL-4-YL)VINYL]-4,17-DIOXABICYCLO[14.1.0]HEPTADECANE-5,9-DIONE D - 257
1q5d_A_2571q5d   A     HEMPROTOPORPHYRIN IX CONTAINING FE T - 258
1q5d_A_2571q5d   A     EPB7,11-DIHYDROXY-8,8,10,12,16-PENTAMETHYL-3-[1-METHYL-2-(2-METHYL-THIAZOL-4-YL)VINYL]-4,17-DIOXABICYCLO[14.1.0]HEPTADECANE-5,9-DIONE T - 258
1q5d_A_2571q5d   A     HEMPROTOPORPHYRIN IX CONTAINING FE T - 259
1q5d_A_2571q5d   A     HEMPROTOPORPHYRIN IX CONTAINING FE I - 260
1q5d_A_2571q5d   A     HEMPROTOPORPHYRIN IX CONTAINING FE L - 262
1qmq_A_2511qmq   A     HEMPROTOPORPHYRIN IX CONTAINING FE T - 252
1qmq_A_2511qmq   A     LRBLAMBDA-BIS(2,2'-BIPYRIDINE)-(5-METHYL-2-2'-BIPYRIDINE) -C9-ADAMANTANE RUTHENIUM (II) T - 252
1qmq_A_2511qmq   A     DRBDELTA-BIS(2,2'-BIPYRIDINE)-(5-METHYL-2-2'-BIPYRIDINE)-C9-ADAMANTANE RUTHENIUM (II) T - 252
1qmq_A_2511qmq   A     HEMPROTOPORPHYRIN IX CONTAINING FE V - 253
1qmq_A_2511qmq   A     HEMPROTOPORPHYRIN IX CONTAINING FE F - 256
1qmq_A_2511qmq   A     ACTACETATE ION F - 263
1qmq_A_2511qmq   A     ACTACETATE ION K - 266
1qmq_A_2511qmq   A     ACTACETATE ION S - 267
1qmq_A_2511qmq   A     ACTACETATE ION P - 268
1qmq_A_2511qmq   A     ACTACETATE ION E - 269
1qmq_A_2511qmq   A     ACTACETATE ION H - 270
1qmq_A_2511qmq   A     ACTACETATE ION R - 271
1qmq_A_2511qmq   A     ACTACETATE ION Q - 272
1qmq_A_2511qmq   A     ACTACETATE ION I - 275
1qo8_A_4181qo8   A     HEMPROTOPORPHYRIN IX CONTAINING FE Y - 430
1r31_A_2411r31   A     MEV(R)-MEVALONATE R - 261
1r31_A_2411r31   A     MEV(R)-MEVALONATE T - 264
1r31_A_2411r31   A     MEV(R)-MEVALONATE H - 265
1r31_A_2411r31   A     MEV(R)-MEVALONATE N - 266
1r31_A_2411r31   A     MEV(R)-MEVALONATE K - 267
1r31_A_2411r31   A     MEV(R)-MEVALONATE G - 268
1r31_A_2411r31   A     COACOENZYME A N - 271
1r31_A_2411r31   A     MEV(R)-MEVALONATE N - 271
1vgv_A_3291vgv   A     MSESELENOMETHIONINE I - 332
1vgv_A_3291vgv   A     MSESELENOMETHIONINE L - 339
1vgv_A_3291vgv   A     MSESELENOMETHIONINE N - 344
1vgv_A_3291vgv   A     MSESELENOMETHIONINE E - 345
1vgv_A_3291vgv   A     MSESELENOMETHIONINE Y - 346
1vgv_A_3291vgv   A     MSESELENOMETHIONINE Q - 347
2kfn_A_7842kfn   A     MGMAGNESIUM ION Y - 791
2kfn_A_7842kfn   A     MGMAGNESIUM ION Y - 795
2kfn_A_7842kfn   A     MGMAGNESIUM ION V - 798
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1e4e_A_1241e4e   A AC3ADP BINDING SITE FOR CHAIN AK - 133
1iow_*_881iow   * ADPADP BINDING SITE.K - 97

Clusters included in this Subclass
CLUSTER: HH.0.2
CLUSTER: HH.1.2
CLUSTER: HH.2.3