The iLoops Server uses protein structural features (protein loops as classified in ArchDB and/or domains as classified in SCOP) to determine whether any pair of proteins interact or not. To do that, it uses data from both known protein interactions and putative non-interacting proteins (co-localized, non-redundant, non-interacting random protein pairs non-similar to PPIs), assigning positive and negative scores to the structural features.
The main result page displays a summary of the predictions for the given protein pairs with available detailed data for each prediction. It also allows the download of all the predictions as a compressed XML file.
A detailed explanation on how to execute the server and interpret the results is found in Help:Server usage section. More information about iLoops can be found in Help:About iLoops section, Help:FAQ section and on: Planas-Iglesias, J. et al. Understanding protein-protein interactions using local structural features, Journal of Molecular Biology (2013).
The iLoops Server is limited to 25 protein pairs. If you want to analyze more protein pairs, please contact us: sbi+iLoops 'at' upf 'dot' edu.
iLoops: a protein-protein interaction prediction server based on structural features
Joan Planas-Iglesias; Manuel A. Marin-Lopez; Jaume Bonet; Javier Garcia-Garcia; Baldo Oliva
Bioinformatics 2013; doi: 10.1093/bioinformatics/btt401