| protein | description | function | other |
| CTRL | ['Chymotrypsin-like protease CTRL-1 precursor (EC 3.4.21.-).', 'chymotrypsin-like protease CTRL-1', 'Chymotrypsin-like'] | [] | is_root=0 expression=None fitness=no |
| ENTK | ['Enteropeptidase precursor (EC 3.4.21.9) (Enterokinase) [Contains: Enteropeptidase non-catalytic heavy chain', 'enterokinase', 'enteropeptidase', 'Enteropeptidase catalytic light chain].', 'unnamed protein product'] | ['Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.'] | is_root=0 expression=None fitness=no |
| VCAM1 | ['Vascular cell adhesion protein 1 precursor (V-CAM 1).', 'vascular cell adhesion molecule-1 truncated form T-VCAM-1', 'Vascular cell adhesion molecule 1', 'Adult male testis cDNA, RIKEN full-length enriched library, clone:4933416C16 product:vascular cell adhesion molecule 1, full insert sequence.', 'Vascular cell adhesion molecule 1.', 'precursor peptide', 'Vascular cell adhesion protein 1 precursor (V-CAM 1) (CD106 antigen) (INCAM-100).', 'Adult male spinal cord cDNA, RIKEN full-length enriched library, clone:A330077N24 product:vascular cell adhesion molecule 1, full insert sequence.', '2 days pregnant adult female ovary cDNA, RIKEN full-length enriched library, clone:E330027O05 product:vascular cell adhesion molecule 1, full insert sequence.', 'Vascular cell adhesion molecule-1 6D variant lacking D7 precursor.', 'vascular cell adhesion molecule phosphatidylinositol-form precursor', 'vascular cell adhesion molecule-1', 'vascular cell adhesion molecule-1 7D variant', 'VCAM-1', 'Vcam1', 'unnamed protein product', 'vascular cell adhesion molecule-1 6D variant lacking D7', 'vascular cell adhesion molecule 1', 'Vascular cell adhesion molecule-1 7D variant precursor.', 'Vascular cell adhesion molecule 1, isoform a precursor', 'Vascular cell adhesion molecule 1 (Vcam1 protein).'] | ['Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation (By similarity).', 'Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.'] | is_root=1 expression=None fitness=no |
| MMP1 | ['Matrix metalloproteinase 1.', 'collagenase', 'collagenase-1 precursor', 'Interstitial collagenase precursor (EC 3.4.24.7) (Matrix metalloproteinase-1) (MMP-1).', 'preprocollagenase', 'Matix metalloproteinase I collagenase propeptide (Fragment).', 'Metacestode specific membrane protein 1.', 'CG4859-PA, isoform A', 'CG4859-PA, isoform A.', 'gametolysin', 'metacestode specific membrane protein 1', 'RE62222p', 'matrix metalloproteinase 1 precursor', 'Gametolysin (EC 3.4.24.38).', 'Interstitial collagenase (EC 3.4.24.7) (Matrix metalloproteinase-1) (MMP-1) (Fibroblast collagenase) (Myocardial collagenase) (Fragment).', 'S-methylmethionine permease 1.', 'matix metalloproteinase I collagenase propeptide', 'matrix metalloproteinase 1', 'MMP1 protein', 'RE19818p', 'MMP1 protein (Fragment).', 'unnamed protein product', 'CG4859-PB, isoform B.', 'CG4859-PB, isoform B', '27 kDa interstitial collagenase].', 'type I interstitial collagenase', 'Interstitial collagenase precursor (EC 3.4.24.7) (Matrix metalloproteinase-1) (MMP-1) [Contains: 18 kDa interstitial collagenase].', 'Interstitial collagenase precursor (EC 3.4.24.7) (Matrix metalloproteinase-1) (MMP-1) (Fibroblast collagenase) [Contains: 22 kDa interstitial collagenase', 'RE62222p (RE19818p).', 'ORF L0555', 'Matrix metalloproteinase 1, preproprotein', 'matrix metalloproteinase 1 (interstitial collagenase)', 'Interstitial collagenase precursor (EC 3.4.24.7) (Matrix metalloproteinase-1) (MMP-1) (Fibroblast collagenase).'] | ['Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X.', 'Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. May play a role in the deterioration of the heart wall extracellular matrix proteins during the onset of dilated cardiomyopathy.', 'High-affinity S-methylmethionine (SMM) permease, required for utilization of S-methylmethionine as a sulfur source.'] | is_root=1 expression=None fitness=no |
| C1QTNF3 | ['CDNA PSEC0232 fis, clone HEMBA1006549, moderately similar to Complement-c1q tumor necrosis factor-related protein 3.', 'putative secretory protein CORS26', 'CTRP3', 'complement-c1q tumor necrosis factor-related protein', 'unnamed protein product', 'Complement C1q tumor necrosis factor-related protein 3 precursor (Secretory protein CORS26).'] | [] | is_root=0 expression=None fitness=no |
| CTSG | ['Cathepsin G precursor (EC 3.4.21.20) (CG).', 'CTSG', 'preprocathepsin G', 'Cathepsin G, preproprotein', 'CTSG protein.', 'cathepsin G'] | [] | is_root=0 expression=None fitness=no |
| C1R | ['Hypothetical protein DKFZp686O02154.', 'Complement C1r subcomponent precursor (EC 3.4.21.41) (Complement component 1, r subcomponent) [Contains: Complement C1r subcomponent heavy chain', 'hypothetical protein', 'Complement C1r subcomponent light chain].', 'human complement C1r'] | ['C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.'] | is_root=0 expression=None fitness=no |
| C1S | ['Complement component 1, s subcomponent', 'complement subcomponent C1s precursor', 'Complement C1s subcomponent light chain].', 'complement component C1s', 'complement protein C1s precursor', 'Complement C1s subcomponent precursor (EC 3.4.21.42) (C1 esterase) [Contains: Complement C1s subcomponent heavy chain'] | ['C1s B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.'] | is_root=0 expression=None fitness=no |
| HS4505861 | ['plasminogen activator, tissue', 'Tissue-type plasminogen activator chain B].', 'tissue plasminogen actovator', 'Tissue-type plasminogen activator precursor (EC 3.4.21.68) (tPA) (t- PA) (t-plasminogen activator) (Alteplase) (Reteplase) [Contains: Tissue-type plasminogen activator chain A', 'plasminogen activator', 'tissue plasminogen activator (t-PA)', 'Plasminogen activator, tissue type, isoform 1 preproprotein', 'tissue plasminogen activator', 'unnamed protein product', 'tissue-type plasminogen activator'] | ['Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events.'] | is_root=0 expression=None fitness=no |
| ABCC8 | ['Sulfonylurea receptor 1.'] | ['Putative subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K+ channels and insulin release.'] | is_root=0 expression=None fitness=no |
| KIAA0067 | ['Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET).', 'SET domain, bifurcated 1.', 'SET domain, bifurcated 1'] | ['Histone methyltransferase. Methylates Lys-9 of histone H3. H3 Lys-9 methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Targeted to histone by TRIM28/TIF1B and contributes to silencing of euchromatic genes by KRAB zinc-finger proteins.'] | is_root=0 expression=None fitness=no |
| RB2 | ['Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (PRB2) (P130) (RBR-2).'] | ['May have a function in cell cycle regulation. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E.'] | is_root=0 expression=None fitness=no |
| ANGPTL4 | ['hepatic angiopoietin-related protein', 'Angiopoietin-related protein 4 precursor (Angiopoietin-like 4) (Hepatic fibrinogen/angiopoietin-related protein) (HFARP).', '13 days embryo male testis cDNA, RIKEN full-length enriched library, clone:6030477G01 product:angiopoietin-like 4, full insert sequence.', 'Angiopoietin-related protein 4 precursor (Angiopoietin-like 4) (Hepatic fibrinogen/angiopoietin-related protein) (HFARP) (Fasting- induced adipose factor) (Secreted protein Bk89) (425O18-1).', 'angiopoietin-like protein PP1158', 'Adult male tongue cDNA, RIKEN full-length enriched library, clone:2310005A11 product:angiopoietin-like 4, full insert sequence. (Fragment).', 'NG27', 'fibrinogen/angiopoietin-related protein', 'Angiopoietin-like protein 4', 'angiopoietin-like protein 4', 'Fibrinogen/angiopoietin-related protein', 'unnamed protein product', 'NG27 protein', 'angiopoietin-like protein', 'Fibrinogen/angiopoietin-related protein (Fragment).', 'Angiopoietin-like 4 protein', 'Angiopoietin-like protein 4.'] | ['Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorgenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity (By similarity).', 'Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorgenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity.'] | is_root=1 expression=None fitness=no |
| KLK3 | ['prostate specific antigen (PSA)', 'Glandular kallikrein-3, submandibular (EC 3.4.21.35) (Tissue kallikrein) (S1 kallikrein) (RGK-3) (RSGK-50) (Fragment).', 'prostate specific antigen', 'prostate-specific antigen', 'kallikrein precursor', 'Plasma kallikrein light chain].', 'kallikrein 3, (prostate specific antigen)', 'Plasma kallikrein precursor (EC 3.4.21.34) (Plasma prekallikrein) (Kininogenin) (Fletcher factor) [Contains: Plasma kallikrein heavy chain', 'Prostate-specific antigen precursor (EC 3.4.21.77) (PSA) (Kallikrein- 3) (Semenogelase) (Gamma-seminoprotein) (Seminin) (P-30 antigen).', 'unnamed protein product', 'prostate specific antigen precursor', 'Prostate specific antigen, isoform 1 preproprotein', 'Prostate specific antigen precursor.', 'kallikrein B, plasma (Fletcher factor) 1', 'plasma kallikrein', 'plasma kallikrein precursor', 'plasma prekallikrein'] | ['Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.', 'The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.', 'Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.'] | is_root=0 expression=None fitness=no |
| F10 | ['Coagulation factor X.', 'Coagulation factor X precursor (EC 3.4.21.6) (Stuart factor) (Stuart- Prower factor) [Contains: Factor X light chain', 'Factor X heavy chain', 'Coagulation factor X, precursor', 'coagulation factor X', 'Activated factor Xa heavy chain].'] | ['Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.', 'Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting (By similarity).'] | is_root=0 expression=None fitness=no |
| GABRP | ['Gamma-aminobutyric-acid receptor pi subunit precursor (GABA(A) receptor).', 'GABA-A receptor pi subunit', 'Gamma-aminobutyric acid (GABA) A receptor, pi'] | ['GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.'] | is_root=0 expression=None fitness=no |
| AMS1 | ['Methionine adenosyltransferase I, alpha', 'methionine adenosyltransferase', 'S-adenosylmethionine synthetase isoform type-1 (EC 2.5.1.6) (Methionine adenosyltransferase 1) (AdoMet synthetase 1) (Methionine adenosyltransferase I/III) (MAT-I/III).', 'methionine adenosyltransferase I, alpha', 'unnamed protein product'] | ['Catalyzes the formation of S-adenosylmethionine from methionine and ATP.'] | is_root=0 expression=None fitness=no |
| F11 | ['Coagulation factor XI precursor (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) (FXI) [Contains: Coagulation factor XIa heavy chain', 'unknown', 'Coagulation factor XIa light chain].', 'coagulation factor XI (plasma thromboplastin antecedent)', 'preprofactor XI', 'Hypothetical protein F11.'] | ['Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.'] | is_root=0 expression=None fitness=no |
| RARRES3 | ['Retinoic acid receptor responder protein 3 (Tazarotene-induced gene 3 protein) (RAR-responsive protein TIG3) (Retinoid-inducible gene 1 protein).', 'retinoid inducible gene 1', 'H-REV107 protein-related protein', 'Retinoic acid receptor responder (tazarotene induced) 3'] | ['May be a growth regulator that mediates some of the growth suppressive effects of retinoids.'] | is_root=1 expression=None fitness=no |
| F12 | ['Coagulation factor XII precursor (EC 3.4.21.38) (Hageman factor) (HAF) [Contains: Coagulation factor XIIa heavy chain', 'Coagulation factor XIIa light chain].', 'coagulation factor XII', 'Beta-factor XIIa part 1', 'Beta-factor XIIa part 2', 'coagulation factor XII (Hageman factor)'] | ['Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin.'] | is_root=0 expression=None fitness=no |
| FKBP60 | ['FK506-binding protein 9 precursor (EC 5.2.1.8) (Peptidyl-prolyl cis- trans isomerase) (PPIase) (Rotamase).', 'Unknown (protein for MGC:126772)'] | ['PPIases accelerate the folding of proteins during protein synthesis.'] | is_root=0 expression=None fitness=no |
| KYNU | ['Kynureninase (EC 3.7.1.3) (L-kynurenine hydrolase).', 'unknown', 'Kynureninase (L-kynurenine hydrolase), isoform b', 'KYNU', 'Kynu protein.', 'KYNU protein.', 'Kynureninase (EC 3.7.1.3).', 'Kynureninase (L-kynurenine hydrolase)', 'Kynureninase (L-kynurenine hydrolase), isoform b.', 'Kynureninase.', 'Kynu protein', 'kynureninase', '0 day neonate thymus cDNA, RIKEN full-length enriched library, clone:A430107L22 product:kynureninase (L-kynurenine hydrolase), full insert sequence.', 'unnamed protein product', 'L-kynurenine hydrolase', 'Kynureninase (Fragment).', 'Hypothetical protein KYNU (Fragment).'] | ['Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic (AA) and 3- hydroxyanthranilic acids (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity (By similarity).', 'Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic (AA) and 3- hydroxyanthranilic acids (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.'] | is_root=1 expression=None fitness=no |
| HS10863879 | ['Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter).', 'sodium-dependent multivitamin transporter', 'sodium-dependent multi-vitamin transporter'] | ['Transports pantothenate, biotin and lipoate in the presence of sodium.'] | is_root=0 expression=None fitness=no |
| FSCN1 | ['Fascin homolog 1, actin-bundling protein.', 'Fascin (Singed-like protein) (55 kDa actin bundling protein) (p55).', 'Fscn1 protein (Fragment).', 'Fscn1 protein', 'FSCN1 protein (Fragment).', 'Fascin (Singed-like protein).', 'Hypothetical protein LOC507342', 'unnamed protein product', 'FSCN1 protein', 'Fscn1 protein (15 days pregnant adult female placenta cDNA, RIKEN full-length enriched library, clone:I530027N03 product:fascin homolog 1, actin bundling protein (Strongylocentrotus) purpuratus, full insert sequence).'] | ['Organizes filamentous actin into bundles with a minimum of 4.1'] | is_root=1 expression=None fitness=no |
| ID1 | ['Inhibitor of DNA binding 1, isoform a', 'transcription regulator helix-loop-helix protein', 'Id1 protein (Inhibitor of DNA binding/differentiation 1A).', 'Idb1', 'Id1 protein', 'Id1B', 'ID1.', 'ID1', 'DNA-binding protein inhibitor ID-1 (Inhibitor of DNA binding 1).', 'inhibitor of DNA binding/differentiation 1A', 'Inhibitor of DNA binding 1', 'Helix-loop-helix protein.', 'Zinc finger protein ID1.', 'zinc finger protein ID1', 'inhibitor of DNA binding 1, dominant negative helix-loop-helix protein', 'helix-loop-helix protein Id-1', 'Id protein', 'Inhibitor of DNA binding 1 (Idb1 protein).', 'helix-loop-helix protein'] | ['ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding.'] | is_root=1 expression=None fitness=no |
| CAV | ['Caveolin-1.'] | ['May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).'] | is_root=0 expression=None fitness=no |
| CXCR4 | ['Chemokine (C-X-C motif) receptor 4 (CXCR4).', 'Chemokine (C-X-C motif) receptor 4, isoform b', 'CXC chemokine receptor 4 (Fragment).', 'G protein-coupled receptor', 'CXCR4 chemokine receptor', 'CXC chemokine receptor 4', 'fusin (LESTR)', 'Chemokine receptor 4 (Fragment).', 'chemokine receptor 4', 'Chemokine receptor CXCR4 (CXC chemokine receptor).', 'Unknown (protein for MGC:82907)', 'C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (SDF-1 receptor) (Stromal cell-derived factor 1 receptor) (Fusin) (LESTR).', 'Chemokine receptor (Fragment).', 'HM89', 'unknown', 'C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (Stromal cell- derived factor 1 receptor) (SDF-1 receptor) (Fusin) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (LCR1) (FB22) (NPYRL) (HM89) (CD184 antigen).', 'Cxcr4B', 'CXC chemokine receptor 4.', 'chemokine receptor-4', 'CXCR4', 'G-protein coupled receptor; CXCR4', 'Chemokine (C-X-C motif) receptor 4.', 'neuropeptide Y receptor', 'CXCR-4 homolog', 'Chemokine receptor CXCR4 (Fragment).', 'fusin', 'C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (SDF-1 receptor) (Stromal cell-derived factor 1 receptor) (Fusin) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Fragment).', 'murine CXCR-4', 'Hypothetical protein CXCR4.', 'seven transmembrane segment receptor', 'unnamed protein product', 'Chemokine receptor 4 (Hypothetical protein).', 'C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (SDF-1 receptor) (Stromal cell-derived factor 1 receptor) (Fusin) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (LCR1).', 'G-protein coupled receptor.', 'C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (Stromal cell- derived factor 1 receptor) (SDF-1 receptor) (Fusin) (Leukocyte-derived seven transmembrane domain receptor) (LESTR).', 'Chemokine (C-X-C motif) receptor 4', 'Chemokine receptor CXCR4.', 'chemokine receptor CXCR4', 'NPYRL', 'fusin homolog', 'CXCR4 gene product', 'C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (Stromal cell- derived factor 1 receptor) (SDF-1 receptor) (Fusin) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Pre-B-cell-derived chemokine receptor) (PB-CKR).', 'C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (SDF-1 receptor) (Stromal cell-derived factor 1 receptor) (Fusin).', 'chemokine receptor', 'Chemokine receptor CXCR4 (Cxcr4B).', 'neuropeptide Y receptor type 3', 'CXC chemokine receptor', 'chemokine (C-X-C motif) receptor 4'] | ['Receptor for the C-X-C chemokine SDF-1. Transduces a signal by increasing the intracellular calcium ions level.', 'Receptor for the C-X-C chemokine SDF-1. Transduces a signal by increasing the intracellular calcium ions level. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodelling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a primary receptor for some HIV-2 isolates and as a coreceptor with CD4 for HIV-1 X4 viruses (lymphocyte-tropic HIV-1 viruses, also called syncytium-inducing (SI) strains). Promotes Env-mediated fusion of the virus.', 'Receptor for the C-X-C chemokine SDF-1. Transduces a signal by increasing the intracellular calcium ions level. Involved in B-cell lymphopoiesis, bone-marrow myelopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodelling processes in endothelial cells. Involved in cerebellar neuronal layer formation, preventing premature migration of proliferating granule cells from the external granule layer inwards. In the CNS, could mediate hippocampal-neuron survival.', 'Receptor for the C-X-C chemokine SDF-1. Transduces a signal by increasing the intracellular calcium ions level. Involved in B-cell lymphopoiesis, bone-marrow myelopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodelling processes in endothelial cells. Involved in cerebellar neuronal layer formation, preventing premature migration of proliferating granule cells from the external granule layer inwards. In the CNS, could mediate hippocampal-neuron survival (By similarity).'] | is_root=1 expression=None fitness=no |
| LTBP1 | ['TGF-beta masking protein large subunit', 'Hypothetical protein LTBP1 (Fragment).', 'Latent transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).', 'latent transforming growth factor beta binding protein 1L', 'Latent transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).', 'unknown', 'Latent transforming growth factor beta binding protein-1S precursor (Fragment).', 'Latent transforming growth factor beta-binding protein 1 precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF- beta-1-BP-1) (Transforming growth factor beta-1-masking protein, large subunit).', 'Ltbp1 protein.', 'Latent transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor-beta-1 binding protein 1) (TGF-beta1-BP-1).', '2 days pregnant adult female oviduct cDNA, RIKEN full-length enriched library, clone:E230007P04 product:latent transforming growth factor beta binding protein 1, full insert sequence.', 'Ltbp1 protein', 'latent transforming growth factor beta binding protein 1S', 'unnamed protein product', 'latent transforming growth factor beta binding protein-1S precursor', 'transforming growth factor-beta 1 binding protein precursor'] | ['May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM).'] | is_root=1 expression=None fitness=no |
| CXCL1 | ['gro protein', 'melanoma growth stimulatory activity preprotein', 'Cxcl1 protein', 'secretory protein KC precursor', 'KC protein', 'Growth regulated alpha protein precursor (CXCL1) (Platelet-derived growth factor-inducible protein KC) (Secretory protein N51) [Contains: KC(5-72) (KC-T) (Hematopoietic synergistic factor) (HSF)].', 'Growth regulated protein alpha precursor (CXCL1) (Melanoma growth stimulatory activity) (MGSA) (Neutrophil-activating protein 3) (NAP-3) (GRO-alpha(1-73)) [Contains: GRO-alpha(4-73)', 'chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)', 'Cxcl1 protein (Fragment).', 'Growth regulated alpha protein precursor (CXCL1) (Cytokine-induced neutrophil chemoattractant) (CINC-1) (Platelet-derived growth factor- inducible protein KC).', 'GRO-alpha(5-73)', 'chemokine KC', 'GRO- alpha(6-73)].', 'gro', 'growth regulated protein GRO precursor', 'Growth regulated alpha protein precursor (CXCL1).', 'Chemokine (C-X-C motif) ligand 1', 'GRO', 'unnamed protein product', 'gro protein coding region'] | ['Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation (By similarity). Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. KC(5-72) shows a highly enhanced hematopoietic activity.', 'Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation.', 'Has chemotactic activity for neutrophils.', 'Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.'] | is_root=1 expression=None fitness=no |
| DGKD | ['Diacylglycerol kinase, delta (EC 2.7.1.107) (Diglyceride kinase) (DGK- delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).', 'diacylglycerol kinase delta2'] | ['May function as signaling molecule. Isoform 2 may be involved in cell growth and tumorigenesis.'] | is_root=0 expression=None fitness=no |
| F7 | ['coagulation factor VII (serum prothrombin conversion accelerator)', 'Factor VII heavy chain].', 'FVII coagulation protein', 'Coagulation factor VII (Serum prothrombin conversion accelerator) (FVII coagulation protein).', 'coagulation factor VII', 'factor VII', 'Coagulation factor VII precursor (EC 3.4.21.21) (Serum prothrombin conversion accelerator) (SPCA) (Proconvertin) (Eptacog alfa) [Contains: Factor VII light chain'] | ['Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting (By similarity).', 'Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.'] | is_root=0 expression=None fitness=no |
| TNC | ['CG13648-PA', 'unnamed protein product', 'Tenascin (Fragment).', 'Tenascin', 'precursor tenascin protein', 'Tenascin precursor (TN) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Miotendinous antigen) (Glioma-associated-extracellular matrix antigen) (GP 150-225) (Tenascin-C) (TN-C) (P230).', 'Tenascin precursor (TN) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Miotendinous antigen) (Glioma-associated-extracellular matrix antigen) (GP 150-225) (Tenascin-C) (TN-C).', 'fibronectin type III', 'Tenascin-C.', 'Tenascin-c-like protein (Fragment).', 'tenascin precursor', 'Tenascin C (Hexabrachion).', 'tenascin', 'Tenascin C (Hexabrachion) (Tenascin precursor).', '0 day neonate thymus cDNA, RIKEN full-length enriched library, clone:A430071G16 product:tenascin C, full insert sequence. (Fragment).', 'Tenascin precursor (TN) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Miotendinous antigen) (Glioma-associated-extracellular matrix antigen) (GP 150-225).', 'CG13648-PA.', 'human tenascin-C', 'Tenascin-C (Fragment).', 'tenascin-C', 'Fibronectin type III (Fragment).', 'Precursor tenascin protein precursor.', 'tenascin-c-like protein', 'Troponin C.', 'tenascin C (hexabrachion)', '230 kd tenascin precursor', 'troponin C'] | ['Plays a role during early brain development particularly in growth cone guidance. Involved in neurite outgrowth from cortical neurons grown on the monolayer of astrocytes.', 'SAM (substrate-adhesion molecule) that appears to inhibit cell migration. May play a role in supporting the growth of epithelial tumors. Ligand for integrins alpha-8/beta-1, alpha- 9/beta-1, alpha-v/beta-3 and alpha-v/beta-6.', 'SAM (substrate-adhesion molecule) that appears to inhibit cell migration. May play a role in supporting the growth of epithelial tumors. Is a ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.'] | is_root=1 expression=None fitness=no |
| FGR | ['Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog', 'p55-c-fgr protein', 'FGR protein', 'Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.1.112) (P55-FGR) (C-FGR).', 'unnamed protein product'] | [] | is_root=0 expression=None fitness=no |
| HS10863935 | ['Reticulon-1 (Neuroendocrine-specific protein).', 'Reticulon 1, isoform A', 'nueroendocrine-specific protein A', 'RTN1 protein.'] | ['May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.'] | is_root=0 expression=None fitness=no |
| HS4758052 | ['cellular retinoic acid-binding protein; CRABP I'] | [] | is_root=0 expression=None fitness=no |
| F9 | ['factor IX', 'factor IX (Christmas factor) precursor', 'Coagulation factor IX precursor (EC 3.4.21.22) (Christmas factor) (Plasma thromboplastin component) (PTC) [Contains: Coagulation factor IXa light chain', 'coagulation factor IX precursor', 'coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B)', 'F9 protein', 'Coagulation factor IXa heavy chain].', 'Coagulation factor IX (Plasma thromboplastic component, Christmas disease, hemophilia B) (F9 protein).'] | ['Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting (By similarity).', 'Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.'] | is_root=0 expression=None fitness=no |
| HS4557849 | ['bumetanide-sensitive Na-K-2Cl cotransporter', 'Solute carrier family 12 member 1 (Bumetanide-sensitive sodium- (potassium)-chloride cotransporter 2) (Kidney-specific Na-K-Cl symporter).'] | ['Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.'] | is_root=0 expression=None fitness=no |
| CP | ['preceruloplasmin (EC 1.16.3.1)', 'Ceruloplasmin precursor (EC 1.16.3.1) (Ferroxidase).', 'Ceruloplasmin (Ferroxidase).'] | ['Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein found in plasma. Four possible functions are ferroxidase activity, amine oxidase activity, copper transport and homeostasis, and superoxide dismutase activity.'] | is_root=0 expression=None fitness=no |
| EPHB6 | ['Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).', 'EPHB6', 'Eph-family protein'] | ['Kinase-defective receptor for members of the ephrin-B family.'] | is_root=0 expression=None fitness=no |
| CYP40 | ['40 kDa peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) (PPIase) (Rotamase) (Cyclophilin-40) (CYP-40) (Cyclophilin-related protein).'] | ['PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.'] | is_root=0 expression=None fitness=no |
| ACR | ['Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain', 'Acrosin heavy chain].'] | ['Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.'] | is_root=0 expression=None fitness=no |
| HS6912550 | ['HGMP07J', 'Olfactory receptor, family 10, subfamily J, member 1', 'Olfactory receptor 10J1 (Olfactory receptor-like protein HGMP07J) (Olfactory receptor OR1-26).'] | ['Putative odorant receptor.'] | is_root=0 expression=None fitness=no |
| CYSLT2 | ['cysteinyl leukotriene receptor 2', 'G-protein coupled receptor protein (Cysteinyl leukotriene receptor 2).', 'cysteinyl leukotriene CysLT2 receptor', 'Cysteinyl leukotriene receptor 2', 'cysteinyl leukotriene receptor CYSLT2', 'unnamed protein product', 'G-protein coupled receptor protein', 'cysteinyl leukotriene receptor type 2', 'Cysteinyl leukotriene receptor 2 (CysLTR2) (HG57) (HPN321) (hGPCR21).', 'putative G-protein coupled receptor'] | ['Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.'] | is_root=0 expression=None fitness=no |
| PTGS2 | ['Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II) (Glucocorticoid- regulated inflammatory cyclooxygenase) (Gripghs) (T', 'Cyclooxygenase 2 (Fragment).', 'mitogen inducible cyclooxygenase', 'Prostaglandin-endoperoxide synthase 2, precursor', 'Cyclooxygenase-2 (EC 1.14.99.1) (Fragment).', 'Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II).', 'prostaglandin synthase 2', 'Ptgs2 protein', 'prostaglandin synthase', 'Lung RCB-0558 LLC cDNA, RIKEN full-length enriched library, clone:G730027G19 product:prostaglandin-endoperoxide synthase 2, full insert sequence.', 'prostaglandin endoperoxide synthase-2', 'TIS10 encoded protein', 'Prostaglandin-endoperoxide synthase 2', 'prostaglandin G/H synthase-2', 'Prostaglandin G/H synthase 2 (Prostaglandin-endoperoxide synthase 2).', 'prostaglandin H synthase-2', 'cyclooxygenase-2', 'prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)', 'Prostaglandin-endoperoxide synthase 2.', 'Ptgs2 protein.', 'Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II) (Mitogen-inducible PGHS).', 'Adult male hippocampus cDNA, RIKEN full-length enriched library, clone:C630011G21 product:prostaglandin-endoperoxide synthase 2, full insert sequence (Mammary gland RCB-0526 Jyg-MC(A) cDNA, RIKEN full- length enriched library, clone:G830017L07 product:pro', 'unnamed protein product', 'prostaglandin G/H synthase 2', 'glucocorticoid-regulated inflammatory prostaglandin synthase', 'cyclooxygenase 2'] | ['May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.', 'May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.'] | is_root=1 expression=None fitness=no |
| UNIACC:Q92526 | ['Chaperonin containing TCP1, subunit 6B'] | [] | is_root=0 expression=None fitness=no |
| UNIACC:Q13873 | ['BMPR-II precursor', 'unnamed protein product'] | [] | is_root=0 expression=None fitness=no |
| ACAC | ['Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)].', 'acetyl-CoA carboxylase'] | ['Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. This protein carries three functions'] | is_root=0 expression=None fitness=no |
| MAN1A1 | ['Man9-mannosidase', 'MAN1A1 protein.', 'Adult male thymus cDNA, RIKEN full-length enriched library, clone:5832424A03 product:mannosidase 1, alpha, full insert sequence (NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630107L17 product:mannosidase 1, alpha,', 'Mannosidase 1, alpha', 'MAN1A1 protein', 'mannosidase alpha class 1A member 1', 'Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Fragment).', 'Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase).', 'mannosyl-oligosaccharide alpha-1,2-mannosidase', 'unnamed protein product', 'MAN1A1', 'Mannosidase alpha class 1A member 1 (Fragment).'] | ['Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).'] | is_root=1 expression=None fitness=no |
| IL1RL2 | ['Interleukin-1 receptor-like 2 precursor (IL-1Rrp2) (Interleukin-1 receptor-related protein 2) (IL1R-rp2).', 'IL-1Rrp2'] | ['Receptor for interleukin 1 family member 9 (IL1F9). Binding to the agonist leads to the activation of NF-kappa-B.'] | is_root=0 expression=None fitness=no |
| HS9951915 | ['S-adenosylhomocysteine hydrolase', 'AHCY'] | [] | is_root=0 expression=None fitness=no |
| HS21361478 | ['SEPTIN6 type II', 'Septin 6, isoform B', 'septin 6'] | [] | is_root=0 expression=None fitness=no |
| CRABP1 | ['Cellular retinoic acid-binding protein 1 (Cellular retinoic acid- binding protein I) (CRABP-I) (Retinoic acid-binding protein I, cellular).'] | ['Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.'] | is_root=0 expression=None fitness=no |
| LY6E | ['Lymphocyte antigen Ly-6E precursor (Retinoic acid-induced gene E protein) (RIG-E) (Thymic shared antigen 1) (TSA-1) (Stem cell antigen 2) (SCA-2).', 'Ly6e', '9804', 'Lymphocyte antigen 6 complex, locus E (Ly6e protein).', 'RIG-E', 'Ly6e protein (Fragment).', 'Ly6e protein', 'Sca-2 precursor', 'Lymphocyte antigen 6 complex, locus E', 'thymic shared antigen-1/stem cell antigen-2', 'thymic shared antigen-1', '13 days embryo head cDNA, RIKEN full-length enriched library, clone:3110052M08 product:lymphocyte antigen 6 complex, locus E, full insert sequence.', 'Lymphocyte antigen Ly-6E precursor (Thymic shared antigen 1) (TSA-1) (Stem cell antigen 2).', 'Lymphocyte antigen Ly-6E precursor (Stem cell antigen 2) (SCA-2).', 'unnamed protein product', 'RIG-E precursor', 'stem cell antigen 2'] | ['Involved in T-cell development.'] | is_root=1 expression=None fitness=no |
| NNT | ['NAD(P) transhydrogenase, mitochondrial precursor (EC 1.6.1.2) (Pyridine nucleotide transhydrogenase) (Nicotinamide nucleotide transhydrogenase).', 'Nicotinamide nucleotide transhydrogenase.', 'Nicotinamide nucleotide transhydrogenase'] | ['The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.'] | is_root=0 expression=None fitness=no |
| ANGEL1 | ['Angel homolog 1.', 'KIAA0759', 'hypothetical protein'] | [] | is_root=0 expression=None fitness=no |
| HS4826932 | ['cyclophilin-40', 'cyclophilin 40', 'Peptidylprolyl isomerase D', 'peptidylprolyl isomerase D (cyclophilin D)'] | [] | is_root=0 expression=None fitness=no |
| FPR2 | ['lipoxin A4 receptor', 'Formyl peptide receptor-like 1', 'FMLP-related receptor I (FMLP-R-I) (Lipoxin A4 receptor) (LXA4 receptor) (Formyl peptide receptor-like 1) (RFP) (HM63).', 'formyl peptide receptor', 'FMLP-related receptor', 'formyl peptide receptor-like 1', 'RFP=formyl peptide receptor homolog [human, bone marrow, Peptide, 351 aa]', 'Lipoxin A4 receptor'] | ['Low affinity receptor to N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).'] | is_root=0 expression=None fitness=no |
| ESP1 | ['testisin', 'PRSS21', 'Testisin, isoform 1', 'Testisin precursor (EC 3.4.21.-) (Eosinophil serine protease 1) (ESP- 1).', 'eosinophil serine protease'] | ['Could regulate proteolytic events associated with testicular germ cell maturation.'] | is_root=0 expression=None fitness=no |
| HS15451856 | ['Caveolin 1', 'Cell growth-inhibiting protein 32.', 'caveolin 1, caveolae protein, 22kDa', 'caveolin-1'] | [] | is_root=0 expression=None fitness=no |
| CACH4 | ['Voltage-dependent P/Q-type calcium channel alpha-1A subunit (Voltage- gated calcium channel alpha subunit Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).'] | ['Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the high-voltage activated (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin- IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).'] | is_root=0 expression=None fitness=no |
| CACH6 | ['voltage-activated calcium channel alpha-1 subunit', 'Voltage-dependent R-type calcium channel alpha-1E subunit (Voltage- gated calcium channel alpha subunit Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).', 'voltage-operated calcium channel, alpha-1 subunit', 'Voltage-dependent R-type calcium channel alpha-1E subunit (Voltage- gated calcium channel alpha subunit Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (RBE-II) (RBE2) (Brain calcium channel II) (BII).'] | ['Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the high-voltage activated (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega- conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega- Aga-IVA). Calcium channels contaning alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.'] | is_root=0 expression=None fitness=no |
| HPN | ['Serine protease hepsin (EC 3.4.21.-) (Transmembrane protease, serine 1) [Contains: Serine protease hepsin non-catalytic chain', 'hepsin (serine protease) precursor', 'Hepsin (transmembrane protease, serine 1)', 'Serine protease hepsin catalytic chain].', 'unnamed protein product', 'hepsin', 'Serine protease hepsin (EC 3.4.21.-) [Contains: Serine protease hepsin non-catalytic chain'] | ['Plays an essential role in cell growth and maintenance of cell morphology.'] | is_root=0 expression=None fitness=no |
| AGT | ['angiotensinogen (serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 8)', 'angiotensinogen', 'preangiotensinogen', 'Angiotensinogen precursor [Contains: Angiotensin-1 (Angiotensin I) (Ang I)', 'angiotensinogen precursor', 'Angiotensinogen', 'Angiotensin-2 (Angiotensin II) (Ang II)', 'Angiotensin-3 (Angiotensin III) (Ang III) (Des-Asp[1]-angiotensin II)].', 'Angiotensinogen (Serine (Or cysteine) proteinase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 8).'] | ['In response to lowered blood pressure, the enzyme renin cleaves angiotensin-1, from angiotensinogen. ACE (angiotensin converting enzyme) then removes a dipeptide to yield the physiologically active peptide angiotensin-2, the most potent pressor substance known, which helps regulate volume and mineral balance of body fluids.', 'Angiotensin-3 stimulates aldosterone release.'] | is_root=0 expression=None fitness=no |
| CACNA1G | ['T calcium channel alpha1G subunit', 'Voltage-dependent T-type calcium channel alpha-1G subunit (Voltage- gated calcium channel alpha subunit Cav3.1) (Cav3.1c) (NBR13).'] | ['Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the low-voltage activated (LVA) group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.'] | is_root=0 expression=None fitness=no |
| HOHO1 | ['Potassium channel, subfamily K, member 1.', 'Potassium channel, subfamily K, member 1', 'two P domain potassium channel subunit', 'TWIK-1', 'potassium channel, subfamily K, member 1', 'potassium channel KCNO1', 'Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1) (Potassium channel KCNO1).'] | ['Weakly inward rectifying potassium channel.'] | is_root=0 expression=None fitness=no |
| CACNA1H | ['low-voltage-activated calcium channel alpha13.2 subunit', 'Voltage-dependent T-type calcium channel alpha-1I subunit (Voltage- gated calcium channel alpha subunit Cav3.3) (Ca(v)3.3).', 'Voltage-dependent T-type calcium channel alpha-1H subunit (Voltage- gated calcium channel alpha subunit Cav3.2).', 'T calcium channel alpha1I subunit, delta36B splice variant', 'Voltage-dependent T-type calcium channel alpha-1H subunit (Voltage- gated calcium channel alpha subunit Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).'] | ['Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the low-voltage activated (LVA) group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.', 'Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Isoform alpha-1I gives rise to T-type calcium currents. T-type calcium channels belong to the low-voltage activated (LVA) group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H (By similarity).'] | is_root=0 expression=None fitness=no |
| AIM1 | ['AIM1', 'Absent in melanoma 1 protein.'] | ['May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton.'] | is_root=0 expression=None fitness=no |
| HS4507157 | ['gp250 precursor', 'mosaic protein LR11', 'Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).'] | ['Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction.'] | is_root=0 expression=None fitness=no |
| CORIN | ['Atrial natriuteric peptide-converting enzyme (EC 3.4.21.-) (pro-ANP- converting enzyme) (Corin) (Heart-specific serine proteinase ATC2) (Transmembrane protease, serine 10).', 'Corin', 'Corin.', 'corin', 'unnamed protein product'] | ['Converts Pro-ANP to ANP. Cleaves Pro-ANP specifically between Arg-123 and Ser-124.'] | is_root=0 expression=None fitness=no |
| CDH17 | ['Cadherin-17 precursor (Liver-intestine-cadherin) (LI-cadherin).', 'cadherin', 'intestinal peptide-associated transporter HPT-1', 'Cadherin-17 precursor (Liver-intestine-cadherin) (LI-cadherin) (Intestinal peptide-associated transporter HPT-1).'] | ['Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.', 'Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine.'] | is_root=0 expression=None fitness=no |
| EREG | ['epiregulin', 'Epiregulin.', 'Epiregulin', 'Epiregulin (Fragment).', 'EREG protein (Fragment).', 'EREG', 'epiregulin precursor', 'Epiregulin precursor.'] | ['May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis.'] | is_root=1 expression=None fitness=no |
| KRTHB1 | ['Type II hair-specific keratin (Type II basic hair keratin) (Fragment).', 'type II hair keratin 1', 'Keratin, type II cuticular Hb1 (Hair keratin, type II Hb1) (ghHKb1) (ghHb1) (MLN 137).', 'type II basic hair keratin', 'Type II hair keratin 1 (Fragment).', 'type II hair-specific keratin', 'keratin'] | [] | is_root=1 expression=None fitness=no |
| CDH23 | ['cadherin related 23', 'Cadherin-23 precursor (Otocadherin).', 'cadherin 23'] | ['Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin 23 may function as hair bundle organizer perhaps by cross-linking the stereocilia (By similarity).'] | is_root=0 expression=None fitness=no |
| AIM | ['DNA (cytosine-5)-methyltransferase 1 (EC 2.1.1.37) (Dnmt1) (DNA methyltransferase HsaI) (DNA MTase HsaI) (MCMT) (M.HsaI).', 'DNA (cytosine-5-)-methyltransferase', 'DNA (cytosine-5)-methyltransferase 1 (EC 2.1.1.37) (Dnmt1) (DNA methyltransferase I) (DNA MTase RnoIP) (MCMT) (M.RnoIP).'] | ['Methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development. Mediates transcriptional repression by direct binding to HDAC2.', 'Methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development (By similarity). Mediates transcriptional repression by direct binding to HDAC2 (By similarity).'] | is_root=0 expression=None fitness=no |
| RMSA1 | ['Very very hypothetical protein RMSA-1.', 'chromosomal protein'] | [] | is_root=0 expression=None fitness=no |
| DNASE2 | ['Deoxyribonuclease II alpha precursor (EC 3.1.22.1) (DNase II alpha) (Acid DNase) (Lysosomal DNase II) (R31240_2).', 'deoxyribonuclease II, lysosomal', 'deoxyribonuclease II precursor', 'deoxyribonuclease II alpha', 'deoxyribonuclease II', 'Deoxyribonuclease II, lysosomal'] | ['Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.'] | is_root=0 expression=None fitness=no |
| CDH1 | ['E-cadherin', 'Epithelial-cadherin precursor (E-cadherin) (Uvomorulin) (Cadherin-1) (CAM 120/80) (CD324 antigen).', 'cadherin 1, type 1, E-cadherin (epithelial)'] | ['Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. E-cadherin has a potent invasive suppressor role. It is also a ligand for integrin alpha- E/beta-7.'] | is_root=0 expression=None fitness=no |
| AKAP100 | ['A-kinase anchor protein 6 (Protein kinase A-anchoring protein 6) (PRKA6) (A-kinase anchor protein 100 kDa) (AKAP 100) (mAKAP).', 'A-kinase anchor protein'] | ['Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.'] | is_root=0 expression=None fitness=no |
| AKAP350 | ['Hyperion protein', 'A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Hyperion protein) (Yotiao protein) (Centrosome- and Go'] | ['Binds to type II regulatory subunits of protein kinase A. Scaffolding protein that assembles several protein kinases and phosphatases on centrosome and Golgi apparatus where physiological events can be regulated by phosphorylation state of protein substrates. Isoform 4/Yotiao is associated with the N-methyl-D- aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses explaining that its role may be to organize postsynaptic specializations.'] | is_root=0 expression=None fitness=no |
| DNAH11 | ['axonemal beta heavy chain dynein type 11', 'Ciliary dynein heavy chain 11 (Axonemal beta dynein heavy chain 11).'] | ['Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.'] | is_root=0 expression=None fitness=no |
| CDHF9 | ['Cadherin EGF LAG seven-pass G-type receptor 1 precursor (Flamingo homolog 2) (hFmi2).', 'protocadherin Flamingo 2', 'OTTHUMP00000028852', 'unnamed protein product'] | ['Receptor that may have an important role in cell/cell signaling during nervous system formation.'] | is_root=0 expression=None fitness=no |
| CDHF10 | ['Cadherin, EGF LAG seven-pass G-type receptor 2 (Flamingo homolog, Drosophila).', 'cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)', 'Cadherin EGF LAG seven-pass G-type receptor 2 precursor (Epidermal growth factor-like 2) (Multiple epidermal growth factor-like domains 3) (Flamingo 1).', 'unnamed protein product', 'FLAMINGO 1', 'seven transmembrane helix receptor'] | ['Receptor that may have an important role in cell/cell signaling during nervous system formation.'] | is_root=0 expression=None fitness=no |
| DNAH17L | ['Ciliary dynein heavy chain 9 (Axonemal beta dynein heavy chain 9).', 'ciliary dynein heavy chain 9'] | ['Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.'] | is_root=0 expression=None fitness=no |
| CLGI | ['TIMP', 'prefibroblast collagenase inhibitor', 'TIMP1', 'tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor)', 'TIMP1 protein (Tissue inhibitor of metalloproteinase 1) (Erythroid potentiating activity, collagenase inhibitor).', 'Metalloproteinase inhibitor 1 precursor (TIMP-1) (Erythroid potentiating activity) (EPA) (Tissue inhibitor of metalloproteinases) (Fibroblast collagenase inhibitor) (Collagenase inhibitor).', 'unnamed protein product', 'metalloproteinase inhibitor', 'Tissue inhibitor of metalloproteinase 1, precursor', 'collagenase inhibitor'] | ['Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.'] | is_root=0 expression=None fitness=no |
| HS9966903 | ['mannosidase, alpha, class 1C, member 1', 'Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IC) (Alpha-1,2-mannosidase IC) (Mannosidase alpha class 1C member 1) (HMIC).', '1,2-alpha-mannosidase IC'] | ['Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc.'] | is_root=0 expression=None fitness=no |
| AKAP8L | ['A kinase (PRKA) anchor protein 8-like', 'A-kinase anchor protein-like protein 8 (Neighbor of A-kinase anchoring protein 95) (Homologous to AKAP95 protein) (HA95) (Helicase A-binding protein 95) (HAP95).', 'LA95 protein'] | ['Could play a role in constitutive transport element (CTE)-mediated gene expression. Does not seem to be implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and chromatin condensation. May regulate the initiation phase of DNA replication when associated with TMPO-beta.'] | is_root=0 expression=None fitness=no |
| HS10863871 | ['skeletal muscle ryanodine receptor', 'Ryanodine receptor 1 (Skeletal muscle-type ryanodine receptor) (RyR1) (RYR-1) (Skeletal muscle calcium release channel).'] | ['Communication between transverse-tubules and sarcoplasmic reticulum. Contraction of skeletal muscle is triggered by release of calcium ions from SR following depolarization of T-tubules.'] | is_root=0 expression=None fitness=no |
| FRK | ['Fyn-related kinase.', 'SRC-like tyrosine kinase', 'Fyn-related kinase', 'fyn-related kinase', 'Tyrosine-protein kinase FRK (EC 2.7.1.112) (Nuclear tyrosine protein kinase RAK).'] | [] | is_root=0 expression=None fitness=no |
| MTMR5 | ['SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).'] | ['Probable pseudophosphatase. Lacks several amino acids in the catalytic pocket which renders it catalytically inactive as a phosphatase. The pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts.'] | is_root=0 expression=None fitness=no |
| KIAA1741 | ['182 kDa tankyrase 1-binding protein.'] | [] | is_root=0 expression=None fitness=no |
| TRPS1 | ['zinc finger protein GC79', 'Zinc finger transcription factor Trps1 (Zinc finger protein GC79) (Tricho-rhino-phalangeal syndrome type I protein).'] | ['Transcriptional repressor. May act to restrict expression of GATA-regulated genes at selected sites and stages in vertebrate development. Might be involved in prostate cancer apoptosis.'] | is_root=0 expression=None fitness=no |
| MYO15 | ['Myosin-15 (Myosin XV) (Unconventional myosin-15).', 'unconventional myosin-15'] | ['Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). May play a role in the formation or maintenance of the actin-rich structures of the inner ear sensory hair cells.'] | is_root=0 expression=None fitness=no |
| MYO1B | ['MYO1B protein', 'Myosin Ib (Myosin I alpha) (MMI-alpha) (MMIa) (MYH-1c).'] | ['Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport (By similarity).'] | is_root=0 expression=None fitness=no |
| NEDD9 | ['enhancer of filmentation 1', 'Neural precursor cell expressed, developmentally down-regulated gene 9', 'Neural cell expressed, developmentally down-regulated 9 (Fragment).', 'Neural cell expressed, developmentally down-regulated 9, isoform 2.', 'Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).', 'NEDD9 protein (Neural cell expressed, developmentally down-regulated 9).', 'Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9).', 'Neural precursor cell expressed, developmentally down-regulated 9, isoform 1', 'Neural precursor cell expressed, developmentally down-regulated 9, isoform 2', 'Neural cell expressed, developmentally down-regulated 9.', 'unnamed protein product', 'Crk-associated substrate related protein Cas-L', 'NEDD9 protein', 'neural precursor cell expressed, developmentally down-regulated 9'] | ['Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form.', 'Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form (By similarity).'] | is_root=1 expression=None fitness=no |
| HGFAC | ['Hepatocyte growth factor activator long chain].', 'Hepatocyte growth factor activator.', 'Hepatocyte growth factor activator precursor (EC 3.4.21.-) (HGF activator) (HGFA) [Contains: Hepatocyte growth factor activator short chain', 'HGF activator precursor', 'hepatocyte growth factor activator'] | ['Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form.'] | is_root=0 expression=None fitness=no |
| HGFL | ['hepatocyte growth factor-like protein', 'Hepatocyte growth factor-like protein beta chain].', 'Hepatocyte growth factor-like protein precursor (Macrophage stimulatory protein) (MSP) (Macrophage-stimulating protein) [Contains: Hepatocyte growth factor-like protein alpha chain'] | ['Probably has no proteolytic activity, since crucial AA characteristic of serine proteases catalytic sites are not conserved.'] | is_root=0 expression=None fitness=no |
| HGF | ['Hepatocyte growth factor beta chain].', 'hepatocyte growth factor (hepapoietin A; scatter factor)', 'hepatocyte growth factor', 'Hepatocyte growth factor precursor (Scatter factor) (SF) (Hepatopoeitin A) [Contains: Hepatocyte growth factor alpha chain', 'unnamed protein product'] | ['HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. It has no detectable protease activity.'] | is_root=0 expression=None fitness=no |
| UNIACC:P58840 | ['Hypothetical acrosin-like protease (EC 3.4.21.-) (Fragment).', 'bA395L14.13 (novel protein similar to acrosin (ACR))'] | [] | is_root=0 expression=None fitness=no |
| HS13654237 | ['DNA-dependent protein kinase catalytic subunit (EC 2.7.1.37) (DNA- PKcs) (DNPK1) (p460).', 'DNA-dependent protein kinase catalytic subunit', 'protein kinase, DNA-activated, catalytic polypeptide', 'DNA-dependent protein kinase catalytic subunit (EC 2.7.1.37) (DNA- PKcs) (P460).', 'DNA-PKcs'] | ['Serine/threonine-protein kinase involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease DCLRE1C. The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Involved in modulation of transcription (By similarity).', 'Serine/threonine-protein kinase involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease DCLRE1C. The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Involved in modulation of transcription.'] | is_root=0 expression=None fitness=no |
| CRK | ['Proto-oncogene C-crk (P38) (Adapter molecule crk).', 'CRK-II'] | ['The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4.'] | is_root=0 expression=None fitness=no |
| MYH12 | ['Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).', 'myosin heavy chain 12'] | ['Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. May also be required for some polarization process involved in dendrite formation.'] | is_root=0 expression=None fitness=no |
| COL1A1 | ['Collagen alpha-1(I) chain precursor.'] | ['Type I collagen is a member of group I collagen (fibrillar forming collagen).'] | is_root=0 expression=None fitness=no |
| C2 | ['Complement C2 precursor (EC 3.4.21.43) (C3/C5 convertase) [Contains: Complement C2b fragment', 'complement component 2', 'complement component C2', 'Complement C2a fragment].', 'Complement component 2 (OTTHUMP00000062690).', 'Complement component 2, precursor', 'OTTHUMP00000062690'] | ['Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments'] | is_root=0 expression=None fitness=no |
| COL3A1 | ['type III preprocollagen alpha 1 chain', 'Type III preprocollagen alpha 1 chain.', 'prepro-alpha-1 type 3 collagen', 'Collagen alpha-1(III) chain precursor.'] | ['Collagen type III occurs in most soft connective tissues along with type I collagen.'] | is_root=0 expression=None fitness=no |
| ADCY4 | ['adenylyl cyclase type IV', 'Adenylate cyclase type IV (EC 4.6.1.1) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).', 'Adenylate cyclase 4', 'adenylyl cyclase type 4', 'adenylate cyclase type IV', 'unnamed protein product'] | ['This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.', 'This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (By similarity).'] | is_root=0 expression=None fitness=no |
| COL4A2 | ['Collagen alpha-2(IV) chain precursor.'] | ["Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen."] | is_root=0 expression=None fitness=no |
| COL4A4 | ['Collagen alpha-4(IV) chain precursor.', 'type IV collagen alpha 4 chain', 'collagen alpha 4 type IV', 'Collagen alpha 4 type IV.'] | ["Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen."] | is_root=0 expression=None fitness=no |
| HS5803199 | ['Kallikrein 11, isoform 1 preproprotein', 'keratinocyte trypsin-like serine protease', 'Homo sapiens kallikrein 11', 'KLK11', 'trypsin-like serine protease', 'Kallikrein-11 precursor (EC 3.4.21.-) (Hippostasin) (Trypsin-like protease).', 'Hippostasin'] | ['Possible multifunctional protease. Efficiently cleaves bz-Phe-Arg-4-methylcoumaryl-7-amide, a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin.'] | is_root=0 expression=None fitness=no |
| COL4A6 | ['Collagen alpha-6(IV) chain precursor.'] | ["Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen."] | is_root=0 expression=None fitness=no |
| C7 | ['Complement component C7 precursor.', 'Complement component 7, precursor'] | ['C7 is a constituent of the membrane attack complex. C7 binds to C5b forming the C5b-7 complex, where it serves as a membrane anchor.'] | is_root=0 expression=None fitness=no |
| HS4506141 | ['novel serine protease, PRSS11', 'Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).', 'HTRA serine protease', 'serin protease with IGF-binding motif'] | ['Protease that regulate the availability of IGFs by cleaving IGF-binding proteins.'] | is_root=0 expression=None fitness=no |
| ADTB3A | ['Adaptor-related protein complex 3, beta 1 subunit', 'AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).', 'beta-3A-adaptin subunit of the AP-3 complex'] | ['Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles.'] | is_root=0 expression=None fitness=no |
| HS7019477 | ['HtrA serine peptidase 2, isoform 1 preproprotein', 'Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).', 'serine protease', 'serine protease Htra2'] | ['Serine protease that shows proteolytic activity against a nonspecific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Isoform 2 seems to be proteolytically inactive.'] | is_root=0 expression=None fitness=no |
| HS22048625 | ['Probable serine protease HTRA4 precursor (EC 3.4.21.-).', 'unnamed protein product'] | [] | is_root=0 expression=None fitness=no |
| HS14251207 | ['Putative helicase Mov10l1 (EC 3.6.1.-) (Moloney leukemia virus 10-like protein 1) (MOV10-like 1).', 'dJ402G11.8', 'MOV10-like 1', 'OTTHUMP00000028556'] | ['Putative RNA helicase. Isoform 1 may play a role in male germ cell development.'] | is_root=0 expression=None fitness=no |
| DF | ['Complement factor D precursor (EC 3.4.21.46) (C3 convertase activator) (Properdin factor D) (Adipsin).'] | ['Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.'] | is_root=0 expression=None fitness=no |
| CTD-2522E6.1-001 | ['ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing)', 'Ubiquitin-activating enzyme E1 (A1S9 protein).', 'Ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing).', 'ubiquitin-activating enzyme E1', 'Ubiquitin-activating enzyme E1'] | ['Activates ubiquitin by first adenylating with ATP its carboxy-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thiolester and free AMP.'] | is_root=0 expression=None fitness=no |
| HS15559207 | ['elastase 2 precursor', 'Elastase 2A, preproprotein', 'Elastase-2A precursor (EC 3.4.21.71).', 'elastase 2A (ELA2A)', 'pancreatic elastase IIA zymogen'] | ['Acts upon elastin.'] | is_root=0 expression=None fitness=no |
| UNIACC:P08218 | ['Elastase-2B precursor (EC 3.4.21.71).', 'pancreatic elastase IIB zymogen'] | ['Acts upon elastin.'] | is_root=0 expression=None fitness=no |
| HS4505881 | ['Angiostatin', 'Plasminogen precursor (EC 3.4.21.7) [Contains: Plasmin heavy chain A', 'Plasminogen.', 'Plasmin heavy chain A, short form', 'Activation peptide', 'unnamed protein product', 'plasminogen', 'Plasmin light chain B].'] | ['Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation; in ovulation it weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. It cleaves fibrin, fibronectin, thrombospondin, laminin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4.', 'Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.'] | is_root=0 expression=None fitness=no |
| ELA2 | ['elastase II precursor', 'neutrophil elastase', 'elastase 2, neutrophil', 'serine protease', 'elastase/medullasin precursor (EC 3.4.21.37)', 'Elastase-2 precursor (EC 3.4.21.71).', 'unnamed protein product', 'Elastase 2, neutrophil', 'Leukocyte elastase precursor (EC 3.4.21.37) (Neutrophil elastase) (PMN elastase) (Bone marrow serine protease) (Medullasin).', 'Elastase 2, neutrophil.'] | ['Medullasin modifies the functions of natural killer cells, monocytes and granulocytes.', 'Acts upon elastin.'] | is_root=0 expression=None fitness=no |
| ELA3 | ['Elastase-3A precursor (EC 3.4.21.70) (Elastase IIIA) (Protease E).', 'Elastase 3A, pancreatic, preproprotein', 'pancreatic protease E precursor'] | ['Efficient protease with alanine specificity but only little elastolytic activity.'] | is_root=0 expression=None fitness=no |
| ITGAD | ['Integrin alpha-D precursor (Leukointegrin alpha D) (CD11d) (ADB2).', 'leukointegrin alpha d chain'] | ['Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood- borne pathogens, particulate matter, and senescent erythrocytes from the blood.'] | is_root=0 expression=None fitness=no |
| HS4506143 | ['Neurotrypsin precursor (EC 3.4.21.-) (Motopsin) (Leydin).', 'neurotrypsin', 'unnamed protein product'] | ['Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations (By similarity).'] | is_root=0 expression=None fitness=no |
| IFNAR | ['Interferon-alpha receptor 1 variant (Fragment).', 'interferon alpha/beta receptor', 'interferon-alpha receptor 1 precursor variant', 'Interferon-alpha/beta receptor alpha chain precursor (IFN-alpha-REC).'] | ['Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta- subunits themselves.'] | is_root=0 expression=None fitness=no |
| AZU1 | ['Azurocidin 1, preproprotein.', 'Azurocidin precursor (Cationic antimicrobial protein CAP37) (Heparin- binding protein) (HBP).', 'Azurocidin 1, preproprotein', 'azurocidin'] | ['This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram- negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation.'] | is_root=0 expression=None fitness=no |
| POLE | ['DNA polymerase epsilon catalytic subunit', 'DNA polymerase epsilon, catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A).', 'DNA polymerase epsilon, catalytic polypeptide'] | ['Participates in DNA repair and in chromosomal DNA replication.'] | is_root=0 expression=None fitness=no |
| APBA1 | ['Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).'] | ['Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta- amyloid precursor protein (APP) and hence formation of beta-APP.'] | is_root=0 expression=None fitness=no |
| HS5174559 | ['melanoma associated antigen P97', 'Melanotransferrin precursor (Melanoma-associated antigen p97) (CD228 antigen).', 'melanotransferrin'] | ['Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.'] | is_root=0 expression=None fitness=no |
| HTRA3 | ['pregnancy-related serine protease HTRA3', 'HtrA serine peptidase 3', 'serine protease HTRA3', 'Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).'] | ['Probable serine protease.'] | is_root=0 expression=None fitness=no |
| CXCR1 | ['interleukin 8 receptor, alpha', 'interleukin-8 receptor type A', 'unknown', 'IL8RA', 'interleukin-8 receptor type 1, IL8R1 [human, neutrophils, Peptide, 350 aa]', 'interleukin 8 receptor alpha', 'IL-8 receptor', 'High affinity interleukin-8 receptor', 'Hypothetical protein IL8RA.', 'High affinity interleukin-8 receptor A (IL-8R A) (IL-8 receptor type 1) (CXCR-1) (CD181 antigen) (CDw128a antigen).'] | ['Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.'] | is_root=0 expression=None fitness=no |
| MAP3K1 | ['MAP kinase kinase kinase 1', 'Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.1.37) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).', 'Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.1.37) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (Fragment).', 'MEK kinase 1'] | ['Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.'] | is_root=0 expression=None fitness=no |
| MUC5 | ['Mucin-5B precursor (Mucin 5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).'] | ['Salivary mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva.'] | is_root=0 expression=None fitness=no |
| HAT | ['airway trypsin-like protease', 'Transmembrane protease, serine 11D catalytic chain].', 'Transmembrane protease, serine 11D precursor (EC 3.4.21.-) (Airway trypsin-like protease) [Contains: Transmembrane protease, serine 11D non-catalytic chain', 'unnamed protein product'] | ['May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.'] | is_root=0 expression=None fitness=no |
| DESC1 | ['serine protease', 'Transmembrane protease, serine 11E catalytic chain].', 'Transmembrane protease, serine 11E precursor (EC 3.4.21.-) (Serine protease DESC1) [Contains: Transmembrane protease, serine 11E non- catalytic chain'] | ['Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position (By similarity).'] | is_root=0 expression=None fitness=no |
| HS11415040 | ['Suppressor of tumorigenicity 14 (EC 3.4.21.-) (Matriptase) (Membrane- type serine protease 1) (MT-SP1) (Prostamin) (Serine protease TADG-15) (Tumor associated differentially-expressed gene 15 protein).', 'membrane-type serine protease 1', 'Matriptase', 'matriptase'] | ['Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.'] | is_root=0 expression=None fitness=no |
| INSP3R1 | ['Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (IP3R).'] | ['Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate.'] | is_root=0 expression=None fitness=no |
| HS5453978 | ['cGMP-dependent protein kinase 2 (EC 2.7.1.37) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).', 'Type II cGMP-dependent protein kinase'] | [] | is_root=0 expression=None fitness=no |
| EMAP2 | ['echinoderm microtubule-associated protein-like EMAP2', 'Echinoderm microtubule-associated protein-like 2 (EMAP-2) (HuEMAP-2).'] | ['May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity).'] | is_root=0 expression=None fitness=no |
| CANP3 | ['Calpain-3 (EC 3.4.22.-) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3).', 'Calpain-3 (EC 3.4.22.-) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3) (nCL-1).', 'calpain', 'calpain 3, (p94)', 'p94 protein'] | ['Calcium-regulated non-lysosomal thiol-protease.'] | is_root=0 expression=None fitness=no |
| HS9256612 | ['Protocadherin beta 2, precursor', 'Protocadherin beta 2,.', 'protocadherin beta 2', 'protocadherin-beta2', 'Protocadherin beta 2 precursor (PCDH-beta2).'] | ['Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.'] | is_root=0 expression=None fitness=no |
| HS4826950 | ['kallikrein 7 long variant protein', 'Glandular kallikrein-7, submandibular/renal precursor (EC 3.4.21.35) (Tissue kallikrein) (RGK-7) (RSKG-7) (Kallikrein-related protein K1) (Esterase B) (Proteinase A).', 'stratum corneum chymotryptic enzyme', 'Kallikrein-7 precursor (EC 3.4.21.-) (hK7) (Stratum corneum chymotryptic enzyme) (hSCCE).', 'unnamed protein product', 'kallikrein'] | ['May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at 6-Leu-|-Cys-7, 16-Tyr-|-Leu-17, 25- Phe-|-Tyr-26, and 26-Tyr-|-Thr-27. Could play a role in the activation of precursors to inflammatory cytokines.', 'Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Predominant kallikrein protein in the kidney.'] | is_root=0 expression=None fitness=no |
| ZNF124 | ['ZNF124 protein', 'Zinc finger protein 124 (HZF-16).'] | ['May be involved in transcriptional regulation.'] | is_root=0 expression=None fitness=no |
| ADAMTS11 | ['aggrecanase-2', 'ADAM metallopeptidase with thrombospondin type 1 motif, 5, preproprotein.', 'ADAM metallopeptidase with thrombospondin type 1 motif, 5, preproprotein', 'ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (ADAM-TS 11).'] | ['Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.'] | is_root=0 expression=None fitness=no |
| KLK1 | ['Nerve growth factor gamma chain precursor (EC 3.4.21.35) (Gamma-NGF) (Tissue kallikrein) (True tissue kallikrein) (True kallikrein) (PS kallikrein) (RGK-1) (rK-1) (Pancreatic kallikrein) [Contains: Nerve growth factor gamma chain 1', 'Nerve growth factor gamma chain 2].', 'Kallikrein-1 precursor (EC 3.4.21.35) (Tissue kallikrein) (Kidney/pancreas/salivary gland kallikrein).', 'kallikrein'] | ['Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.'] | is_root=0 expression=None fitness=no |
| HBRR | ['Ryanodine receptor 3 (Brain-type ryanodine receptor) (RyR3) (RYR-3) (Brain ryanodine receptor-calcium release channel).', 'ryanodine receptor 3'] | ['Communication between transverse-tubules and sarcoplasmic reticulum. Contraction of skeletal muscle is triggered by release of calcium ions from SR following depolarization of T-tubules (By similarity).'] | is_root=0 expression=None fitness=no |
| BMPR2 | ['type II serine/threonine kinase receptor', 'type II receptor for bone morphogenetic protein-4', 'Bone morphogenetic protein receptor type II precursor (EC 2.7.1.37) (BMP type II receptor) (BMPR-II).', 'Bone morphogenetic protein receptor type II, precursor'] | ['On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.'] | is_root=0 expression=None fitness=no |
| BF | ['complement factor B', 'Complement factor B precursor (EC 3.4.21.47) (C3/C5 convertase) (Properdin factor B) (Glycine-rich beta glycoprotein) (GBG) (PBF2) [Contains: Complement factor B Ba fragment', 'Complement factor B Bb fragment].', 'B-factor, properdin.', 'B-factor, properdin'] | ['Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments'] | is_root=0 expression=None fitness=no |
| JAG2 | ['jagged2 precursor', 'Jagged-2 precursor (Jagged2) (HJ2).', 'Jagged-2 (Jagged2) (Fragment).', 'Jagged2'] | ['Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).', 'Putative Notch ligand involved in the mediation of Notch signaling. May have a role in neurogenesis in the peripheral nervous system, limb development and in the adult brain.'] | is_root=0 expression=None fitness=no |
| CDHF8 | ['Protocadherin Fat 2 precursor (hFat2) (Multiple epidermal growth factor-like domains 1).', 'protocadherin Fat 2'] | [] | is_root=0 expression=None fitness=no |
| AHC | ['nuclear hormone receptor/negative regulator of retinoic acid receptor-mediated transcription', 'Nuclear receptor 0B1 (Nuclear receptor DAX-1) (DSS-AHC critical region on the X chromosome protein 1).', 'Nuclear receptor subfamily 0, group B, member 1'] | ['Receptor that may be a component of a cascade required for development of steroidogenic tissues. Acts as a dominant negative regulator of transcription mediated by the retinoic acid receptor.'] | is_root=0 expression=None fitness=no |
| CTLA3 | ['Granzyme A precursor (EC 3.4.21.78) (Cytotoxic T-lymphocyte proteinase 1) (Hanukkah factor) (H factor) (HF) (Granzyme-1) (CTL tryptase) (Fragmentin-1).', 'Hanukah factor serine protease precursor', 'GZMA', 'Granzyme A, precursor', 'GZMA protein.'] | ['This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Lys or Arg. May be involved in apoptosis.'] | is_root=0 expression=None fitness=no |
| C10ORF116 | ['Adipose most abundant gene transcript 2.', 'Adipose specific 2.', 'unknown product specific to adipose tissue', 'Adipose specific 2', 'adipose specific 2'] | [] | is_root=1 expression=None fitness=no |
| CGL1 | ['serine protease-like protein precursor', 'cytotoxic T-lymphocyte-associated serine esterase 1', 'Granzyme B precursor (EC 3.4.21.79) (T-cell serine protease 1-3E) (Cytotoxic T-lymphocyte proteinase 2) (Lymphocyte protease) (SECT) (Granzyme-2) (Cathepsin G-like 1) (CTSGL1) (CTLA-1) (Fragmentin-2) (Human lymphocyte protein) (HLP) (C11).'] | ['This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.'] | is_root=0 expression=None fitness=no |
| DLD | ['Dihydrolipoyl dehydrogenase, mitochondrial precursor (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein).', 'lipoamide dehydrogenase precursor old gene name LAD '] | ['Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes.'] | is_root=0 expression=None fitness=no |
| CGL2 | ['Granzyme H', 'serine protease', 'cytotoxin serine protease-C precursor', 'Granzyme H precursor (EC 3.4.21.-) (Cytotoxic T-lymphocyte proteinase) (Cathepsin G-like 2) (CTSGL2) (CCP-X) (Cytotoxic serine protease C) (CSP-C).', 'cytotoxic T-lymphocyte-associated serine esterase 1', 'cytotoxic serine proteinase'] | ['This enzyme is probably necessary for target cell lysis in cell-mediated immune responses.'] | is_root=0 expression=None fitness=no |
| GZMK | ['Granzyme K precursor (EC 3.4.21.-) (Granzyme-3) (NK-tryptase-2) (NK- TRYP-2) (Fragmentin-3).', 'Protease, serine, 2, preproprotein', 'Trypsin-2 precursor (EC 3.4.21.4) (Trypsin II) (Anionic trypsinogen).', 'Granzyme K, precursor', 'Trypsinogen E (Protease, serine, 2, preproprotein) (Anionic trypsinogen).', 'trypsinogen E', 'anionic trypsinogen', 'HNK-Tryptase-2', 'pre-granzyme 3', 'trypsinogen'] | [] | is_root=0 expression=None fitness=no |
| ALOX5 | ['5-lipoxygenase', 'arachidonate 5-lipoxygenase', 'lipoxygenase', 'Arachidonate 5-lipoxygenase (EC 1.13.11.34) (5-lipoxygenase) (5-LO).', 'unnamed protein product', 'Arachidonate 5-lipoxygenase.'] | [] | is_root=0 expression=None fitness=no |
| GZMM | ['metase', 'Granzyme M, precursor', 'Granzyme M precursor (EC 3.4.21.-) (Met-ase) (Natural killer cell granular protease) (HU-Met-1) (Met-1 serine protease).'] | ['Cleaves peptide substrates after methionine, leucine, and norleucine.'] | is_root=0 expression=None fitness=no |
| KCC2 | ['electroneutral potassium-chloride cotransporter KCC2', 'Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (Erythroid K-Cl cotransporter 2) (Neuronal K-Cl cotransporter) (hKCC2).', 'unnamed protein product'] | ['Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons.'] | is_root=0 expression=None fitness=no |
| FBN2 | ['Fibrillin-2 precursor.', 'fibrillin-2'] | ['Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2- containing microfibrils regulate the early process of elastic fiber assembly.'] | is_root=0 expression=None fitness=no |
| HS5031885 | ['Apolipoprotein(a) precursor (EC 3.4.21.-) (Apo(a)) (Lp(a)).', 'unnamed protein product'] | ['Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.'] | is_root=0 expression=None fitness=no |
| HS14602459 | ['Transmembrane protease, serine 2 precursor (EC 3.4.21.-) [Contains: Transmembrane protease, serine 2 non-catalytic chain', 'Transmembrane protease, serine 2 catalytic chain].', 'transmembrane serine protease 2'] | [] | is_root=0 expression=None fitness=no |
| ECHOS1 | ['Transmembrane protease, serine 3 (EC 3.4.21.-) (Serine protease TADG- 12) (Tumor associated differentially-expressed gene 12 protein).', 'Transmembrane protease, serine 3, isoform 1', 'serine protease', 'transmembrane serine protease 3', 'unnamed protein product', 'Transmembrane protease, serine 4, isoform 1', 'Transmembrane protease, serine 4 (EC 3.4.21.-) (Membrane-type serine protease 2) (MT-SP2).'] | ['Probable protease. Seems to be capable of activating ENaC (By similarity).', 'Probable protease. Seems to be capable of activating ENaC.'] | is_root=0 expression=None fitness=no |
| IF | ['Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain', 'Complement factor I light chain].'] | ['Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively.'] | is_root=0 expression=None fitness=no |
| HS13540535 | ['spinesin', 'Transmembrane protease, serine 5 (EC 3.4.21.-) (Spinesin).'] | [] | is_root=0 expression=None fitness=no |
| FBN | ['Fibrillin-1 precursor.', 'fibrillin', 'fibrillin [human, Marfan syndrome patient, Peptide Mutant, 2871 aa]'] | ['Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1- containing microfibrils provide long-term force bearing structural support.'] | is_root=0 expression=None fitness=no |
| CMA1 | ['Chymase precursor (EC 3.4.21.39) (Mast cell protease I).', 'mast cell chymase', 'chymase', 'Chymase 1, mast cell, preproprotein'] | ['Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.'] | is_root=0 expression=None fitness=no |
| BPAG1 | ['Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).'] | ['Cytoskeletal linker protein. Anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. The proteins may self-aggregate to form filaments or a two-dimensional mesh (By similarity).'] | is_root=0 expression=None fitness=no |
| HSPC087 | ['Zinc finger protein 294.'] | [] | is_root=0 expression=None fitness=no |
| HS4506115 | ['Protein C (inactivator of coagulation factors Va and VIIIa)', 'Activation peptide].', 'unknown', 'Hypothetical protein PROC.', 'unnamed protein product', 'protein C', 'Protein C', 'protein C precursor', 'Vitamin K-dependent protein C heavy chain', 'Vitamin K-dependent protein C precursor (EC 3.4.21.69) (Autoprothrombin IIA) (Anticoagulant protein C) (Blood coagulation factor XIV) [Contains: Vitamin K-dependent protein C light chain'] | ['Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids.'] | is_root=0 expression=None fitness=no |
| HS10190742 | ['Ubiquitin carboxyl-terminal hydrolase 29 (EC 3.1.2.15) (Ubiquitin thiolesterase 29) (Ubiquitin-specific processing protease 29) (Deubiquitinating enzyme 29).', 'ubiquitin-specific processing protease'] | [] | is_root=0 expression=None fitness=no |
| HS4506145 | ['preprotrypsinogen IV (AA -15 to 232)', 'Trypsin-1 precursor (EC 3.4.21.4) (Trypsin I) (Cationic trypsinogen).', 'trypsinogen A', 'Trypsin IV precursor (EC 3.4.21.4) (Pretrypsinogen IV).', 'Trypsinogen A.', 'trypsinogen', 'Trypsin-3 precursor (EC 3.4.21.4) (Trypsin III) (Brain trypsinogen) (Mesotrypsinogen) (Trypsin IV).'] | [] | is_root=0 expression=None fitness=no |
| KIAA0301 | ['MDN1, midasin homolog (Yeast).', 'Midasin (MIDAS-containing protein).', 'midasin', 'MDN1, midasin homolog (yeast)'] | ['May function as a nuclear chaperone and be involved in the assembly/disassembly of macromolecular complexes in the nucleus.'] | is_root=0 expression=None fitness=no |
| ELA1 | ['Elastase 1, pancreatic', 'Elastase-1 precursor (EC 3.4.21.36).'] | ['Acts upon elastin.'] | is_root=0 expression=None fitness=no |
| ADAM28 | ['metalloprotease disintegrin cysteine-rich protein, transmembrane form MDC-Lm', 'ADAM 28 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 28) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein-L) (MDC-L) (eMDC II) (ADAM23).'] | ['May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.'] | is_root=0 expression=None fitness=no |
| ABC3 | ['ATP-binding cassette, sub-family A (ABC1), member 3', 'lamellar body membrane specific ATP-binding cassette protein', 'ATP-binding cassette sub-family A member 3 (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (ABC-C transporter).', 'ABC-C transporter'] | ['Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol.'] | is_root=0 expression=None fitness=no |
| TPS1 | ['Tryptase beta-1 precursor (EC 3.4.21.59) (Tryptase-1) (Tryptase I).', 'tryptase-I', 'Tryptase alpha-1 precursor (EC 3.4.21.59) (Tryptase-1).', 'mast cell tryptase beta I'] | ['Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.'] | is_root=0 expression=None fitness=no |
| CCT6A | ['Chaperonin containing TCP1, subunit 6A, isoform a', 'heat shock protein', 'Chaperonin containing TCP1, subunit 6A, isoform a.', 'T-complex protein 1 subunit zeta (TCP-1-zeta) (CCT-zeta) (CCT-zeta-1) (Tcp20) (HTR3) (Acute morphine dependence-related protein 2).', 'chaperonin-like protein'] | ['Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.'] | is_root=0 expression=None fitness=no |
| AC002059.2-001 | ['OTTHUMP00000028903', 'OTTHUMP00000028903.', 'RNA binding protein', 'unnamed protein product', 'EWS', 'Ewing sarcoma breakpoint region 1, isoform EWS', 'RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein).'] | ['Might normally function as a repressor. EWS-fusion- proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.'] | is_root=0 expression=None fitness=no |
| HS7661932 | ['Protein KIAA0133.', 'unnamed protein product'] | [] | is_root=0 expression=None fitness=no |
| TPS2 | ['Tryptase beta-2 precursor (EC 3.4.21.59) (Tryptase-2) (Tryptase II).', 'Tryptase beta 2, precursor', 'beta-tryptase', 'Tryptase beta 2,.'] | ['Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.'] | is_root=0 expression=None fitness=no |
| TPSD1 | ['Tryptase delta precursor (EC 3.4.21.59) (Delta tryptase) (Mast cell mMCP-7-like) (Tryptase-3) (HmMCP-3-like tryptase III).', 'hmMCP-3-like tryptase III'] | ['Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type (By similarity).'] | is_root=0 expression=None fitness=no |
| TMT | ['transmembrane tryptase', 'Tryptase gamma heavy chain].', 'Tryptase gamma precursor (EC 3.4.21.-) (Transmembrane tryptase) [Contains: Tryptase gamma light chain'] | [] | is_root=0 expression=None fitness=no |
| EIF4B | ['Eukaryotic translation initiation factor 4B (eIF-4B).', 'initation factor 4B'] | ["Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'- terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F."] | is_root=0 expression=None fitness=no |
| CLCR | ['Chymotrypsin C, preproprotein', 'chymotrypsin C (caldecrin)', 'Caldecrin precursor (EC 3.4.21.2) (Chymotrypsin C).'] | ['Has chymotrypsin-type protease activity and hypocalcemic activity.'] | is_root=0 expression=None fitness=no |
| ELA3B | ['Elastase-3B precursor (EC 3.4.21.70) (Elastase IIIB) (Protease E).', 'ELA3B protein'] | ['Efficient protease with alanine specificity but only little elastolytic activity.'] | is_root=0 expression=None fitness=no |
| HPR | ['Haptoglobin-related protein precursor.', 'haptoglobin-related protein'] | [] | is_root=0 expression=None fitness=no |
| HP | ['haptoglobin alpha(2FS)-beta precursor', 'Haptoglobin precursor [Contains: Haptoglobin alpha chain', 'haptoglobin', 'Haptoglobin beta chain].', 'Haptoglobin.'] | ['Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes.'] | is_root=0 expression=None fitness=no |
| BRCA2 | ['Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein).', 'unnamed protein product'] | ['Involved in double-strand break repair and/or homologous recombination. May participate in S phase checkpoint activation.'] | is_root=0 expression=None fitness=no |
| ADCY2 | ['Adenylate cyclase type II (EC 4.6.1.1) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2).', 'adenylyl cyclase type II'] | ['This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.'] | is_root=0 expression=None fitness=no |
| DMD | ['Dystrophin.'] | ['May play a role in anchoring the cytoskeleton to the plasma membrane.'] | is_root=0 expression=None fitness=no |
| PLAU | ['Urokinase-type plasminogen activator chain B].', 'Urokinase-type plasminogen activator precursor (EC 3.4.21.73) (uPA) (U-plasminogen activator) [Contains: Urokinase-type plasminogen activator long chain A', 'urikinase-type plasminogen activator', 'Urokinase-type plasminogen activator short chain A', 'urokinase-plasminogen activator'] | ['Potent plasminogen activator and is clinically used for therapy of thrombolytic disorders.'] | is_root=0 expression=None fitness=no |
| PIK3CG | ['idem', 'Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase p110) (PI3K) (PI3Kgamma).', 'unnamed protein product'] | ['3-phosphorylates the cellular phosphoinositide PtdIns- 4,5-biphosphate (PtdIns(4,5)P2).'] | is_root=0 expression=None fitness=no |
| ANKRD3 | ['Serine/threonine-protein kinase RIPK4 (EC 2.7.1.37) (Receptor- interacting serine/threonine-protein kinase 4) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).', 'ANKRD3'] | [] | is_root=0 expression=None fitness=no |
| EDD | ['progestin induced protein', 'Ubiquitin--protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).'] | ['E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). This protein may be involved in maturation and/or post-transcriptional regulation of mRNA. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) for the DNA damage response. Plays an essential role in extraembryonic development.'] | is_root=0 expression=None fitness=no |
| ZNF41 | ['Zinc finger protein 41.'] | ['May be involved in transcriptional regulation.'] | is_root=0 expression=None fitness=no |
| EPS8 | ['epidermal growth factor receptor kinase substrate', 'Epidermal growth factor receptor kinase substrate 8.'] | ['Upon binding to EGF receptor enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets.'] | is_root=0 expression=None fitness=no |
| ZNF186 | ['Zinc finger protein 73 (Zinc finger protein 186) (hZNF2).', 'kruppel-type zinc finger protein'] | ['May be involved in transcriptional regulation.'] | is_root=0 expression=None fitness=no |
| CSPG2 | ['Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M) (Glial hyaluronate-binding protein) (GHAP).', 'chondroitin sulfate proteoglycan versican V0 splice-variant precursor peptide'] | ['May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.'] | is_root=0 expression=None fitness=no |
| HSPG2 | ['Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).'] | ['This protein is an integral component of basement membranes. It is responsible for the fixed negative electrostatic charge and is involved in the charge-selective ultrafiltration properties. It serves as an attachment substrate for cells.'] | is_root=0 expression=None fitness=no |
| HS4506811 | ['Sodium channel protein type VII alpha subunit (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).', 'Na+ channel'] | ['Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.'] | is_root=0 expression=None fitness=no |
| NID2 | ['Nidogen-2 precursor (NID-2) (Osteonidogen).', 'nidogen-2'] | ['Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions.'] | is_root=0 expression=None fitness=no |
| DFFRX | ['ubiquitin specific protease 9, X-linked (fat facets-like, Drosophila)', 'Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thiolesterase FAF-X) (Ubiquitin specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein related, X-linked) (Ubiquitin-specific protease 9, X chro'] | ['May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin.'] | is_root=0 expression=None fitness=no |
| DFFRY | ['DFFRY', 'Probable ubiquitin carboxyl-terminal hydrolase FAF-Y (EC 3.1.2.15) (Ubiquitin thiolesterase FAF-Y) (Ubiquitin specific-processing protease FAF-Y) (Deubiquitinating enzyme FAF-Y) (Fat facets protein related, Y-linked) (Ubiquitin-specific protease 9, Y chro'] | ['May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin.'] | is_root=0 expression=None fitness=no |
| COL11A1 | ['Collagen alpha-1(XI) chain precursor.'] | ['May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.'] | is_root=0 expression=None fitness=no |
| LAMA2 | ['laminin M chain (merosin)', 'Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).', 'unnamed protein product'] | ['Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.'] | is_root=0 expression=None fitness=no |
| AHCY | ['Adenosylhomocysteinase (EC 3.3.1.1) (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase).'] | ['Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.'] | is_root=0 expression=None fitness=no |
| BSSP4 | ['Protease, serine, 22', 'brain-specific serine protease-4', 'Brain-specific serine protease 4 precursor (EC 3.4.21.-) (BSSP-4) (Serine protease 22) (Tryptase epsilon).', 'serine protease PRSS22'] | ['Preferentially cleaves the synthetic substrate H-D-Leu- Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA.'] | is_root=0 expression=None fitness=no |
| HS16936520 | ['Wnt-10a protein precursor.', 'WNT10a precursor', 'Hypothetical protein WNT10A.', 'unknown', 'Wingless-type MMTV integration site family, member 10A, precursor', 'unnamed protein product', 'WNT10A'] | ['Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters.'] | is_root=0 expression=None fitness=no |
| ALDH6A1 | ['methylmalonate-semialdehyde dehydrogenase', 'Aldehyde dehydrogenase 6A1, precursor', 'methylmalonate semialdehyde dehydrogenase', 'Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial precursor (EC 1.2.1.27) (MMSDH) (Malonate-semialdehyde dehydrogenase [acylating]) (EC 1.2.1.18).'] | ['Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.'] | is_root=0 expression=None fitness=no |
| RPS23 | ['40S ribosomal protein S23.'] | [] | is_root=0 expression=None fitness=no |
| BAI2 | ['Brain-specific angiogenesis inhibitor 2 precursor.', 'BAI 2'] | ['Might be involved in angiogenesis inhibition.'] | is_root=0 expression=None fitness=no |
| HS13994276 | ['pancreasin', 'marapsin', 'MPN', 'Protease serine 27 precursor (EC 3.4.21.-) (Marapsin) (Pancreasin) (Channel-activating protease 2) (CAPH2).', 'Marapsin', 'serine protease 27'] | [] | is_root=0 expression=None fitness=no |
| CRARF | ['Complement-activating component of Ra-reactive factor precursor (EC 3.4.21.-) (Ra-reactive factor serine protease p100) (RaRF) (Mannan-binding lectin serine protease 1) (Mannose-binding protein associated serine protease) (MASP-1) [Contains: Complement-ac', 'Complement-activating component of Ra-reactive factor light chain].'] | ['Component of the bactericidal ra-reactive factor rarf which specifically binds to RA and R2 polysaccharides expressed by certain enterobacteria. It triggers the activation of complement cascade by activating the C4 and C2 components. It activates the C4 component by cleaving the alpha-chain of C4.'] | is_root=0 expression=None fitness=no |
| MASP2 | ['MASP-2 protein', 'Mannan-binding lectin serine protease 2 B chain].', 'MASP-2; mannan-binding lectin-associated serine protease-2', 'Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain'] | ['Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.'] | is_root=0 expression=None fitness=no |
| AMHR | ['anti-mullerian hormone type II receptor precursor', 'MIS type II receptor', 'Anti-Muellerian hormone type II receptor precursor (EC 2.7.1.37) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).', 'anti-mullerian hormone type II receptor'] | ['On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.'] | is_root=0 expression=None fitness=no |
| LA16C-314G4.2-001 | ['Protein disulfide-isomerase A2 precursor (EC 5.3.4.1) (PDIp).', 'Protein disulfide isomerase, pancreatic.', 'protein disulfide isomerase PDIP precursor', 'protein disulfide isomerase, pancreatic'] | [] | is_root=0 expression=None fitness=no |
| HS10863943 | ['ubiquitous TPR motif, X isoform', 'Ubiquitously transcribed X chromosome tetratricopeptide repeat protein (Ubiquitously transcribed TPR protein on the X chromosome).'] | [] | is_root=0 expression=None fitness=no |
| UNIACC:O95302 | ['FK506-binding protein'] | [] | is_root=0 expression=None fitness=no |
| HS6005844 | ['Prostatic glandular kallikrein-8 precursor (EC 3.4.21.35) (Tissue kallikrein) (P1 kallikrein) (RGK-8).', 'neuropsin', 'serine protease ovasin', 'Neuropsin precursor (EC 3.4.21.-) (NP) (Kallikrein-8) (Brain serine protease 1).', 'neuropsin type1', 'kallikrein', 'KLK8', 'Neuropsin precursor (EC 3.4.21.-) (NP) (Kallikrein-8) (Ovasin) (Serine protease TADG-14) (Tumor-associated differentially expressed gene 14 protein).', 'serine protease TADG14'] | ['Suggested to be involved in kindling epileptogenesis and hippocampal plasticity. Has a strong proteolytic activity against fibronectin (By similarity).', 'Suggested to be involved in kindling epileptogenesis and hippocampal plasticity.', 'Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.'] | is_root=0 expression=None fitness=no |
| HS4506153 | ['Prostasin heavy chain].', 'prostasin precursor', 'prostasin', 'Prostasin, preproprotein', 'Prostasin precursor (EC 3.4.21.-) [Contains: Prostasin light chain', 'unnamed protein product'] | ['Possesses a trypsin-like cleavage specificity.', 'Possesses a trypsin-like cleavage specificity (By similarity).'] | is_root=0 expression=None fitness=no |
| DSG1 | ['desmoglein 1', 'desmoglein type 1', 'Desmoglein-1 precursor (Desmosomal glycoprotein 1) (DG1) (DGI) (Pemphigus foliaceus antigen).'] | ['Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.'] | is_root=0 expression=None fitness=no |
| DSG3 | ['Desmoglein-3 precursor (130 kDa pemphigus vulgaris antigen) (PVA).', 'pemphigus vulgaris antigen'] | ['Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.'] | is_root=0 expression=None fitness=no |
| PLK2 | ['Serine/threonine-protein kinase PLK2 (EC 2.7.1.37) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).', 'serum-inducible kinase', 'Polo-like kinase 2'] | ['May play a role in the division of at least some cell types, such as fibroblasts, and could function in embryogenesis, wound healing or neoplasia (By similarity).'] | is_root=0 expression=None fitness=no |
| KLK10 | ['Kallikrein-10 precursor (EC 3.4.21.-) (Protease serine-like 1) (Normal epithelial cell-specific 1).', 'KLK10 protein (Kallikrein 10 splice variant 3) (Fragment).', 'KLK10', 'T-kininogenase heavy chain] (Fragment).', 'serine protease-like protease', 'kallikrein 10 splice variant 3', 'kallikrein 10', 'Glandular kallikrein-10 precursor (EC 3.4.21.35) (Tissue kallikrein) (T-kininogenase) (K10) (Proteinase B) (Endopeptidase K) [Contains: T- kininogenase light chain', 'Kallikrein 10, precursor'] | ['Has a tumor-suppressor role for NES1 in breast and prostate cancer.', 'Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. This protein may be involved in the regulation of renal function.'] | is_root=0 expression=None fitness=no |
| KLK12 | ['Glandular kallikrein-12, submandibular/renal precursor (EC 3.4.21.35) (Tissue kallikrein) (RSKG-3).', 'kallikrein precursor RSKG3', 'KLK12', 'Kallikrein-12 precursor (EC 3.4.21.-) (Kallikrein-like protein 5) (KLK-L5).', 'kallikrein-like 5', 'kallikrein-like protein 5'] | ['Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.'] | is_root=0 expression=None fitness=no |
| HS11496281 | ['Kallikrein-13 precursor (EC 3.4.21.-) (Kallikrein-like protein 4) (KLK-L4).', 'kallikrein 13', 'kallikrein-like protein 4 KLK-L4', 'Kallikrein 13, precursor'] | [] | is_root=0 expression=None fitness=no |
| HS11545747 | ['Kallikrein-14 precursor (EC 3.4.21.-) (Kallikrein-like protein 6) (KLK-L6).', 'kallikrein-like protein 6', 'kallikrein 14', 'Homo sapiens kallikrein-like protein 6'] | [] | is_root=0 expression=None fitness=no |
| HS20302143 | ['Kallikrein-15 precursor (EC 3.4.21.-) (ACO protease).', 'Kallikrein 15, isoform 4 preproprotein', 'KLK15'] | ['Protease whose physiological substrate is not yet known.'] | is_root=0 expression=None fitness=no |
| CTBP | ['C-terminal binding protein 1 (EC 1.1.1.-) (CtBP1).', 'unknown', 'C-terminal binding protein', 'C-terminal binding protein 1, isoform 1', 'phosphoprotein CtBP', 'Hypothetical protein CTBP1.'] | ['Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex (By similarity). Co- repressor targeting diverse transcription regulators. Has dehydrogenase activity.'] | is_root=0 expression=None fitness=no |
| CTBP2 | ['C-terminal binding protein 2 (CtBP2).', 'C-terminal binding protein 2', 'C-terminal binding protein 2, isoform 1', 'Hypothetical protein DKFZp762O119 (C-terminal binding protein 2).', 'CTBP2 protein', 'hypothetical protein'] | ['Corepressor targeting diverse transcription regulators (By similarity).'] | is_root=0 expression=None fitness=no |
| HS4885489 | ['V-mos Moloney murine sarcoma viral oncogene homolog.', 'MOS protein', 'c-mos transforming protein', 'V-mos Moloney murine sarcoma viral oncogene homolog', 'Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.1.37) (c- mos) (Oocyte maturation factor mos).'] | [] | is_root=0 expression=None fitness=no |
| HS5031829 | ['prostrate kallikrein 2', 'glandular kallikrein-1', 'kallikrein 2, prostatic', 'Kallikrein 2, prostatic, isoform 1', 'glandular kallikrein', 'Kallikrein-2 precursor (EC 3.4.21.35) (Tissue kallikrein-2) (Glandular kallikrein-1) (hGK-1).', 'glandular kallikrein precursor'] | ['Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.'] | is_root=0 expression=None fitness=no |
| EMSP1 | ['Kallikrein 4, preproprotein', 'Kallikrein 4, preproprotein.', 'Kallikrein-4 precursor (EC 3.4.21.-) (Prostase) (Kallikrein-like protein 1) (KLK-L1) (Enamel matrix serine proteinase 1).', 'serine protease 17; enamel matrix serine proteinase 1; EMSP1; prostase; KLK4; KLK-L1', 'kallikrein 4 splice variant', 'prostase', 'kallikrein-like protein 1 KLK-L1'] | [] | is_root=0 expression=None fitness=no |
| HS6912644 | ['stratum corneum tryptic enzyme', 'Kallikrein-5 precursor (EC 3.4.21.-) (Stratum corneum tryptic enzyme) (Kallikrein-like protein 2) (KLK-L2).', 'Kallikrein 5, preproprotein', 'kallikrein-like protein 2 KLK-L2', 'kallikrein 5 splice variant 2', 'kallikrein 5 splice variant 1', 'KLK5', 'Kallikrein 5 splice variant 2 (Kallikrein 5 splice variant 1).', 'kallikrein 5'] | ['May be involved in desquamation.'] | is_root=0 expression=None fitness=no |
| HS4506155 | ['Kallikrein-6 precursor (EC 3.4.21.-) (Protease M) (Neurosin) (Zyme) (SP59).', 'kallikrein 6 precursor', 'serine protease', 'Kallikrein 6, isoform A preproprotein', 'neurosin', 'protease M', 'Kallikrein 6.', 'kallikrein 6 (neurosin, zyme)', 'kallikrein-like serine protease; zyme; protease M; neurosin'] | [] | is_root=0 expression=None fitness=no |
| MBN | ['Proteinase 3 (serine proteinase, neutrophil, Wegener granulomatosis autoantigen)', 'Myeloblastin precursor (EC 3.4.21.76) (Leukocyte proteinase 3) (PR-3) (PR3) (AGP7) (Wegener s autoantigen) (P29) (C-ANCA antigen) (Neutrophil proteinase 4) (NP-4).', 'Proteinase 3 (Serine proteinase, neutrophil, Wegener granulomatosis autoantigen).'] | ['Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.'] | is_root=0 expression=None fitness=no |
| KIAA0128 | ['Septin-6.'] | ['Involved in cytokinesis (Potential).'] | is_root=0 expression=None fitness=no |
| KLK9 | ['kallikrein-like 3', 'kallikrein-like protein 3', 'kallikrein 9', 'Kallikrein-9 precursor (EC 3.4.21.-) (Kallikrein-like protein 3) (KLK- L3).', 'Kallikrein 9.'] | [] | is_root=0 expression=None fitness=no |
| F2 | ['Thrombin light chain', 'coagulation factor II (thrombin)', 'prothrombin', 'prothrombin precursor', 'Thrombin heavy chain].', 'Prothrombin precursor (EC 3.4.21.5) (Coagulation factor II) [Contains: Activation peptide fragment 1', 'Activation peptide fragment 2'] | ['Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C.'] | is_root=0 expression=None fitness=no |
| COL12A1 | ['Collagen alpha-1(XII) chain precursor.', 'collagen type XII alpha-1'] | ['Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity).'] | is_root=0 expression=None fitness=no |
| HS4506453 | ['Retinol binding protein 3, interstitial.', 'interstitial retinol-binding protein 3', 'IRBP precursor', 'Interphotoreceptor retinoid-binding protein precursor (IRBP) (Interstitial retinol-binding protein).', 'retinol binding protein 3, interstitial'] | ['IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.'] | is_root=0 expression=None fitness=no |
| FCYT | ['Polycystic kidney and hepatic disease 1 (Autosomal recessive).', 'polycystic kidney and hepatic disease 1 (autosomal recessive)', 'polycystic kidney and hepatic disease 1', 'Polycystic kidney and hepatic disease 1 precursor (Fibrocystin) (Polyductin) (Tigmin).'] | ['May be a receptor protein that acts in collecting-duct and biliary differentiation.'] | is_root=0 expression=None fitness=no |
| CXCR2 | ['interleukin-8 receptor type B', 'interleukin-8 receptor, IL-8 receptor=low affinity isoform [human, leukocytes, Peptide, 360 aa]', 'unknown', 'Hypothetical protein IL8RB.', 'interleukin 8 receptor, beta', 'High affinity interleukin-8 receptor B (IL-8R B) (CXCR-2) (GRO/MGSA receptor) (IL-8 receptor type 2) (CD182 antigen) (CDw128b antigen).', 'interleukin 8 receptor B', 'low-affinity interleukin 8 receptor, IL8RB [human, Peptide, 360 aa]', 'Interleukin 8 receptor beta', 'interleukin 8 receptor beta'] | ['Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to GRO/MGSA and NAP-2 also with a high affinity.'] | is_root=0 expression=None fitness=no |
| ACTR8 | ['Actin-related protein 8.', 'unnamed protein product'] | [] | is_root=0 expression=None fitness=no |
| EXTL | ['Exostosin-like 1 (EC 2.4.1.224) (Glucuronosyl-N-acetylglucosaminyl- proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Exostosin-L) (Multiple exostosis-like protein).', 'exostoses-like protein 1', 'multiple exostosis-like protein', 'multiple exostoses-like 1'] | ['Probable glycosyltransferase (By similarity).'] | is_root=0 expression=None fitness=no |
| IKAP | ['IkappaB kinase complex-associated protein (IKK complex-associated protein) (p150).'] | ['May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK).'] | is_root=0 expression=None fitness=no |
| HS4501849 | ['ABC3'] | [] | is_root=0 expression=None fitness=no |
| GAPD2 | ['Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (EC 1.2.1.12) (Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2) (GAPDH-2).', 'Glyceraldehyde-3-phosphate dehydrogenase', 'Glyceraldehyde-3-phosphate dehydrogenase, spermatogenic'] | ['May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity).'] | is_root=0 expression=None fitness=no |
| ENPP3 | ['phosphodiesterase I/nucleotide pyrophosphatase beta', 'Ectonucleotide pyrophosphatase/phosphodiesterase 3 (E-NPP 3) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (Phosphodiesterase I beta) (PD-Ibeta) (CD203c antigen) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1)', 'Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].'] | ['Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD (By similarity).'] | is_root=0 expression=None fitness=no |
| IGHEP1 | ['inter-alpha-trypsin inhibitor heavy chain H1', 'Inter-alpha-trypsin inhibitor heavy chain H1 precursor (ITI heavy chain H1) (Inter-alpha-inhibitor heavy chain 1) (Inter-alpha-trypsin inhibitor complex component III) (Serum-derived hyaluronan-associated protein) (SHAP).', 'Inter-alpha (Globulin) inhibitor H1.', 'Inter-alpha (globulin) inhibitor H1'] | ['Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells.', 'May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.'] | is_root=0 expression=None fitness=no |
| CCT6B | ['T-complex protein 1 subunit zeta-2 (TCP-1-zeta-2) (CCT-zeta-2) (TCP- 1-zeta-like) (CCT-zeta-like) (Testis-specific Tcp20) (Testis-specific protein TSA303).'] | ['Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).'] | is_root=0 expression=None fitness=no |
| FES | ['Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.1.112) (C-Fes).', 'c-fes'] | [] | is_root=0 expression=None fitness=no |
| CTRB | ['Chymotrypsin B chain C].', 'chymotrypsinogen B1', 'preprochymotrypsinogen (EC 3.4.21.1)', 'Chymotrypsin B chain B', 'Chymotrypsinogen B1', 'chymotrypsin B', 'Chymotrypsinogen B precursor (EC 3.4.21.1) [Contains: Chymotrypsin B chain A'] | [] | is_root=0 expression=None fitness=no |
| CPPI | ['Dipeptidyl-peptidase 1 light chain (Dipeptidyl-peptidase I light chain)].', 'cathepsin C', 'prepro dipeptidyl peptidase I', 'Dipeptidyl-peptidase 1 heavy chain (Dipeptidyl-peptidase I heavy chain)', 'Dipeptidyl-peptidase 1 precursor (EC 3.4.14.1) (Dipeptidyl-peptidase I) (DPP-I) (DPPI) (Cathepsin C) (Cathepsin J) (Dipeptidyl transferase) [Contains: Dipeptidyl-peptidase 1 exclusion domain chain (Dipeptidyl- peptidase I exclusion domain chain)'] | ['Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuramindase and factor XIII.'] | is_root=0 expression=None fitness=no |
| HS4505779 | ['phosphorylase kinase', 'Phosphorylase b kinase alpha regulatory chain, skeletal muscle isoform (Phosphorylase kinase alpha M subunit).'] | ['Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.'] | is_root=0 expression=None fitness=no |
| DARC | ['Duffy blood group', 'Duffy antigen/chemokine receptor (Fy glycoprotein) (GpFy) (Glycoprotein D) (Plasmodium vivax receptor) (CD234 antigen).', 'Duffy blood group.'] | ['Non-specific receptor for many chemokines such as IL-8, GRO, RANTES, MCP-1 and TARC. It is also the receptor for the human malaria parasites Plasmodium vivax and Plasmodium knowlesi.'] | is_root=0 expression=None fitness=no |