root 1 name | root 1 molecular functions | root 1 biological processes | root 1 cellular components | root 2 name | root 2 molecular functions | root 2 biological processes | root 2 cellular components | root 3 name | root 3 molecular functions | root 3 biological processes | root 3 cellular components | linkers names | linkers molecular functions | linkers biological processes | linkers cellular components |
TNC |
calcium ion binding -- integrin binding -- fibronectin binding -- protein binding -- kinase regulator activity -- molecular function unknown -- |
protein metabolism -- neuromuscular junction development -- ciliary or flagellar motility -- protein complex assembly -- mesoderm development -- axonal fasciculation -- negative regulation of axon extension -- wing disc morphogenesis -- cell adhesion -- negative regulation of cell adhesion -- neural crest cell migration -- |
flagellum (sensu Bacteria) -- extracellular space -- basement membrane -- extracellular matrix (sensu Metazoa) -- cellular component unknown -- |
LTBP1 |
growth factor binding -- calcium ion binding -- transforming growth factor beta receptor activity -- |
transforming growth factor beta receptor signaling pathway -- biological process unknown -- |
extracellular space -- extracellular matrix (sensu Metazoa) -- |
VCAM1 |
sugar binding -- protein binding -- integrin binding -- |
cell adhesion -- cell-cell adhesion -- |
extracellular space -- plasma membrane -- integral to membrane -- membrane -- |
F2 -- ENTK -- HS20302143 -- HS5803199 -- |
1: calcium ion binding -- 4: serine-type endopeptidase activity -- 1: chymotrypsin activity -- 1: receptor binding -- 2: peptidase activity -- 1: serine-type peptidase activity -- 1: kinase activity -- 1: enteropeptidase activity -- 2: hydrolase activity -- 1: trypsin activity -- 1: ATP binding -- 1: thrombin activity -- 1: scavenger receptor activity -- |
1: development -- 1: wound healing -- 1: apoptosis -- 4: proteolysis -- 1: fibrinolysis -- 1: pathogenesis -- 1: STAT protein nuclear translocation -- 1: caspase activation -- 1: regulation of blood coagulation -- 1: response to wounding -- 1: blood coagulation -- 1: regulation of progression through cell cycle -- 1: acute-phase response -- 1: tyrosine phosphorylation of STAT protein -- 1: platelet activation -- |
1: extracellular space -- 1: soluble fraction -- 1: brush border -- 3: extracellular region -- 2: integral to membrane -- 2: membrane -- |
VCAM1 |
sugar binding -- protein binding -- integrin binding -- |
cell adhesion -- cell-cell adhesion -- |
extracellular space -- plasma membrane -- integral to membrane -- membrane -- |
TNC |
calcium ion binding -- integrin binding -- fibronectin binding -- protein binding -- kinase regulator activity -- molecular function unknown -- |
protein metabolism -- neuromuscular junction development -- ciliary or flagellar motility -- protein complex assembly -- mesoderm development -- axonal fasciculation -- negative regulation of axon extension -- wing disc morphogenesis -- cell adhesion -- negative regulation of cell adhesion -- neural crest cell migration -- |
flagellum (sensu Bacteria) -- extracellular space -- basement membrane -- extracellular matrix (sensu Metazoa) -- cellular component unknown -- |
HS4506145 -- GZMK -- |
1: calcium ion binding -- 1: serine-type endopeptidase activity -- 1: chymotrypsin activity -- 1: serine-type peptidase activity -- 2: peptidase activity -- 1: hydrolase activity -- 2: trypsin activity -- |
2: proteolysis -- 1: digestion -- |
1: extracellular region -- 1: extracellular space -- 1: cytoplasm -- |
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TNC |
calcium ion binding -- integrin binding -- fibronectin binding -- protein binding -- kinase regulator activity -- molecular function unknown -- |
protein metabolism -- neuromuscular junction development -- ciliary or flagellar motility -- protein complex assembly -- mesoderm development -- axonal fasciculation -- negative regulation of axon extension -- wing disc morphogenesis -- cell adhesion -- negative regulation of cell adhesion -- neural crest cell migration -- |
flagellum (sensu Bacteria) -- extracellular space -- basement membrane -- extracellular matrix (sensu Metazoa) -- cellular component unknown -- |
LTBP1 |
growth factor binding -- calcium ion binding -- transforming growth factor beta receptor activity -- |
transforming growth factor beta receptor signaling pathway -- biological process unknown -- |
extracellular space -- extracellular matrix (sensu Metazoa) -- |
HS5031885 -- HS14602459 -- HS13994276 -- TMT -- CTRL -- KLK12 -- HS4506141 -- KLK10 -- HS4506143 -- HGF -- ELA2 -- HS4826950 -- HS6912644 -- HGFL -- MBN -- HS11415040 -- FCYT -- CTRB -- C2 -- MTMR5 -- HS11545747 -- HP -- HS10863871 -- CGL2 -- HS4506115 -- HPR -- HS11496281 -- KLK1 -- HS4506155 -- KLK3 -- HPN -- ESP1 -- F12 -- KLK9 -- F11 -- HS4505881 -- IF -- ECHOS1 -- CRARF -- ACR -- HS5031829 -- HS13540535 -- MASP2 -- AZU1 -- HS6005844 -- HS4505861 -- UNIACC:P08218 -- HGFAC -- HS15559207 -- C1S -- EMSP1 -- |
2: inositol or phosphatidylinositol phosphatase activity -- 1: nucleotide binding -- 1: complement component C1s activity -- 1: transcription corepressor activity -- 1: cysteine-type peptidase activity -- 1: plasma kallikrein activity -- 20: hydrolase activity -- 1: RNA binding -- 1: hepatocyte growth factor receptor binding -- 1: endonuclease activity -- 1: plasminogen activator activity -- 2: sugar porter activity -- 3: sugar binding -- 1: methyltransferase activity -- 16: trypsin activity -- 1: transporter activity -- 1: nuclease activity -- 1: protein-lysine 6-oxidase activity -- 5: receptor activity -- 3: growth factor activity -- 1: plasmin activity -- 1: molecular function unknown -- 1: RNA helicase activity -- 6: scavenger receptor activity -- 41: serine-type endopeptidase activity -- 1: protein self binding -- 1: S-adenosylmethionine-dependent methyltransferase activity -- 1: acrosin activity -- 1: NAD binding -- 1: electron transporter activity -- 1: protein tyrosine/serine/threonine phosphatase activity -- 36: peptidase activity -- 5: protein binding -- 2: DNA binding -- 1: sugar efflux transporter activity -- 5: metal ion binding -- 1: lipid transporter activity -- 2: copper ion binding -- 1: sodium channel regulator activity -- 1: endopeptidase inhibitor activity -- 1: cysteine-type endopeptidase activity -- 1: transcription regulator activity -- 1: ATP binding -- 1: cell adhesion molecule binding -- 1: di-, tri-valent inorganic cation transporter activity -- 1: glycerate dehydrogenase activity -- 1: calcium-release channel activity -- 2: pancreatic elastase II activity -- 1: unfolded protein binding -- 5: tissue kallikrein activity -- 9: calcium ion binding -- 1: structural constituent of cell wall -- 1: insulin-like growth factor binding -- 1: coagulation factor IXa activity -- 2: receptor signaling protein activity -- 1: oxidoreductase activity -- 2: structural molecule activity -- 1: classical-complement-pathway C3/C5 convertase activity -- 1: nucleotidyltransferase activity -- 1: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- 1: subtilase activity -- 1: phosphoprotein phosphatase activity -- 1: toxin binding -- 2: hemoglobin binding -- 1: transcription factor activity -- 2: zinc ion binding -- 1: nickel ion binding -- 1: protein C (activated) activity -- 1: transferase activity, transferring groups other than amino-acyl groups -- 2: coagulation factor XIa activity -- 1: cyclopropane-fatty-acyl-phospholipid synthase activity -- 16: chymotrypsin activity -- 1: lipid binding -- 5: serine-type peptidase activity -- 1: macrophage elastase activity -- 3: transferase activity -- 1: coagulation factor XIIa activity -- 1: acyltransferase activity -- 1: ryanodine-sensitive calcium-release channel activity -- 1: hydroxypyruvate reductase activity -- 1: complement factor I activity -- 1: catalytic activity -- 2: heparin binding -- 1: naringenin-chalcone synthase activity -- 1: manganese ion transporter activity -- |
1: maintenance of protein localization -- 1: lipoprotein metabolism -- 1: wing morphogenesis -- 1: polysaccharide transport -- 1: establishment of mitotic spindle localization -- 1: amyloid precursor protein metabolism -- 1: sodium ion homeostasis -- 1: regulation of transcription from RNA polymerase II promoter -- 1: lipid catabolism -- 1: acute-phase response -- 1: negative regulation of cell proliferation -- 1: negative regulation of progression through cell cycle -- 1: lipid biosynthesis -- 1: protein kinase C activation -- 5: complement activation -- 1: defense response to Gram-negative bacteria -- 1: positive regulation of mitotic metaphase/anaphase transition -- 1: cytokinesis -- 1: hepatocyte growth factor receptor signaling pathway -- 2: apoptosis -- 1: calcium ion transport -- 1: positive regulation of vasoconstriction -- 1: L-serine biosynthesis -- 1: sporulation -- 1: DNA-protein covalent cross-linking -- 1: tracheal epithelial cell migration (sensu Insecta) -- 1: negative regulation of apoptosis -- 1: negative regulation of angiogenesis -- 2: cellular morphogenesis -- 1: regulation of progression through cell cycle -- 1: hemolysis of host red blood cells -- 1: cation transport -- 1: sensory perception of sound -- 3: regulation of transcription, DNA-dependent -- 1: mitotic sister chromatid segregation -- 1: induction of positive chemotaxis -- 4: transport -- 1: lipopolysaccharide biosynthesis -- 5: innate immune response -- 1: macrophage chemotaxis -- 1: Wnt receptor signaling pathway -- 1: protein folding -- 1: pathogenesis -- 2: collagen catabolism -- 1: negative regulation of enzyme activity -- 1: salivary gland development -- 1: protein modification -- 1: fertilization (sensu Metazoa) -- 1: organ morphogenesis -- 1: myofibril assembly -- 1: cell-cell adhesion -- 1: cell-matrix adhesion -- 2: biosynthesis -- 2: negative regulation of blood coagulation -- 1: biological process unknown -- 3: fibrinolysis -- 1: phosphoenolpyruvate-dependent sugar phosphotransferase system -- 1: lignin biosynthesis -- 5: immune response -- 2: cell motility -- 1: defense response -- 1: inflammatory response -- 1: activation of MAPK activity -- 1: apposition of dorsal and ventral wing surfaces -- 1: cell proliferation -- 1: glial cell differentiation -- 1: tissue development -- 1: regulation of cell differentiation -- 2: digestion -- 1: lipid metabolism -- 1: cell fate determination -- 1: meiotic spindle organization and biogenesis -- 1: mitosis -- 1: response to wounding -- 1: tissue regeneration -- 47: proteolysis -- 1: midgut development -- 1: protein targeting to mitochondrion -- 1: cellular extravasation -- 1: anti-inflammatory response -- 1: regulation of cell shape -- 1: axon guidance -- 1: protein import into mitochondrial inner membrane -- 3: transcription -- 1: microglial cell activation -- 1: extracellular carbohydrate transport -- 1: meiosis I -- 1: metabolism -- 1: regulation of growth -- 1: chromosome segregation -- 1: anti-apoptosis -- 1: negative regulation of transcription -- 1: positive regulation of cell adhesion -- 1: skeletal development -- 2: positive regulation of cell proliferation -- 1: circulation -- 1: penetration of zona pellucida -- 1: positive regulation of MHC class II biosynthesis -- 1: electron transport -- 2: lipid transport -- 8: blood coagulation -- 1: phospholipid dephosphorylation -- 1: antimicrobial humoral response (sensu Vertebrata) -- 1: manganese ion transport -- 1: DNA replication -- 2: protein amino acid dephosphorylation -- 1: regulation of vascular permeability -- 1: sensory perception -- 1: monocyte activation -- 1: protein autoprocessing -- 1: positive regulation of interleukin-1 beta biosynthesis -- 1: negative regulation of sister chromatid cohesion -- 1: myelination -- 1: cell migration -- 5: complement activation, classical pathway -- 1: regulation of exit from mitosis -- 2: cytolysis -- 1: iron ion homeostasis -- 2: cell adhesion -- 1: embryo implantation -- 1: positive regulation of phagocytosis -- 1: positive regulation of tumor necrosis factor-alpha biosynthesis -- 1: development -- 1: positive regulation of fractalkine biosynthesis -- 1: homologous chromosome segregation -- 1: hormone metabolism -- 1: muscle attachment -- 1: muscle contraction -- 1: cell cycle -- 1: regulation of progression through mitotic cell cycle -- 2: heterophilic cell adhesion -- 1: acrosome reaction -- 1: flavonoid biosynthesis -- 1: tracheal outgrowth (sensu Insecta) -- 1: nervous system development -- 1: organismal physiological process -- 1: chemotaxis -- 1: glial cell migration -- 1: central nervous system development -- 2: epidermis development -- 1: calcium ion homeostasis -- 1: regulation of cell growth -- |
1: azurophil granule -- 1: contractile fiber -- 3: cytoplasm -- 1: cell wall -- 1: mitochondrion -- 1: extracellular matrix (sensu Metazoa) -- 1: spindle -- 1: integrin complex -- 3: plasma membrane -- 2: periplasmic space -- 23: extracellular space -- 21: extracellular region -- 1: smooth endoplasmic reticulum -- 1: intracellular -- 13: membrane -- 5: integral to plasma membrane -- 1: endoplasmic reticulum membrane -- 2: organelle inner membrane -- 1: viral capsid -- 3: cellular component unknown -- 1: capsule (sensu Bacteria) -- 2: nucleus -- 1: centrosome -- 1: vacuole (sensu Fungi) -- 1: acrosome -- 1: membrane fraction -- 1: mitochondrial intermembrane space protein transporter complex -- 1: complement component C2 complex -- 10: integral to membrane -- 1: actin cytoskeleton -- |
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LTBP1 |
growth factor binding -- calcium ion binding -- transforming growth factor beta receptor activity -- |
transforming growth factor beta receptor signaling pathway -- biological process unknown -- |
extracellular space -- extracellular matrix (sensu Metazoa) -- |
MMP1 |
calcium ion binding -- interstitial collagenase activity -- S-methylmethionine transporter activity -- hydrolase activity -- metalloendopeptidase activity -- structural molecule activity -- zinc ion binding -- peptidase activity -- metal ion binding -- metallopeptidase activity -- |
salivary gland cell autophagic cell death -- dorsal trunk growth -- S-methylmethionine transport -- tracheal system development (sensu Insecta) -- anti-apoptosis -- collagen catabolism -- peptidoglycan metabolism -- autophagic cell death -- proteolysis -- larval development (sensu Insecta) -- |
extracellular space -- plasma membrane -- extracellular matrix (sensu Metazoa) -- |
CTD-2522E6.1-001 -- |
1: ubiquitin-like activating enzyme activity -- 1: nucleotide binding -- 1: ATP binding -- 1: ligase activity -- 1: ubiquitin activating enzyme activity -- |
1: DNA replication -- 1: ubiquitin cycle -- |