Diapositiva PPT

Target

sequence

Database Search

Templates

Sequence Homologs

SVR*

SCR*

Sequence Multiple

Alignment

Structural Multiple

Alignment

Target-Templates

Alignment

HMM profile

SVR

SCR

ab initio

Loops

Database

Rigid

Body

Distance

Restraints

Scaffold

Side-chain

modelling

threading

evaluation

NO

Check

Secondary Structure

Propose

modifications

Minimisation

3D Model

experimental

evaluation

FOLD

ASSIGNMENT

TEMPLATES

SELECTION

EVALUATE

MODEL BUILDING

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