The following information has been received by the server: ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ ________________________________________________________________________________ reference predict_h10291 (May 22, 2002 09:30:12) reference pred_h10291 (May 22, 2002 09:30:02) PPhdr from: monica.jorda01@campus.upf.es PPhdr resp: MAIL PPhdr orig: HTML PPhdr want: ASCII PPhdr password(###) prediction of: - default prediction of: - PHDsec PHDacc PHDhtm ProSite SEG ProDom return msf format ret store # default: single protein sequence description=alceu MTAMMKAAVFVEPGRIELADKPIPDIGPNDALVRITTTTICGTDVHILKGEYPVAKGLTV GHEPVGIIEKLGSAVTGYREGQRVIAGAICPNFNSYAAQDGVASQDGSYLMASGQCGCHG YKATAGWRFGNMIDGTQAEYVLVPDAQANLTPIPDGLTDEQVLMCPDIMSTGFKGAENAN IRIGHTVAVFAQGPIGLCATAGARLCGATTIIAIDGNDHRLEIARKMGADVVLNFRNCDV VDEVMKLTGGRGVDASIEALGTQATFEQSLRVLKPGGTLSSLGVYSSDLTIPLSAFAAGL GDHKINTALCPGGKERMRRLINVIESGRVDLGALVTHQYRLDDIVAAYDLFANQRDGVLK IAIKPH ________________________________________________________________________________ Result of PROSITE search (Amos Bairoch): ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ please quote: A Bairoch, P Bucher & K Hofmann: The PROSITE database, its status in 1997. Nucl. Acids Res., 1997, 25, 217-221. ________________________________________________________________________________ -------------------------------------------------------- Pattern-ID: PKC_PHOSPHO_SITE PS00005 PDOC00005 Pattern-DE: Protein kinase C phosphorylation site Pattern: [ST].[RK] 269 SLR 326 SGR Pattern-ID: CK2_PHOSPHO_SITE PS00006 PDOC00006 Pattern-DE: Casein kinase II phosphorylation site Pattern: [ST].{2}[DE] 136 TQAE Pattern-ID: MYRISTYL PS00008 PDOC00008 Pattern-DE: N-myristoylation site Pattern: G[^EDRKHPFYW].{2}[STAGCN][^P] 57 GLTVGH 72 GSAVTG 114 GQCGCH 175 GAENAN 196 GLCATA 202 GARLCG 252 GVDASI 261 GTQATF 276 GGTLSS 283 GVYSSD 332 GALVTH Pattern-ID: ADH_ZINC PS00059 PDOC00058 Pattern-DE: Zinc-containing alcohol dehydrogenases signature Pattern: GHE.{2}G.{5}[GA].{2}[IVSAC] 61 GHEPVGIIEKLGSAV ________________________________________________________________________________ Result of ProDom domain search (Sonnhammer; Corpet, Gouzy, Kahn): ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ - please quote: ELL Sonnhammer & D Kahn, Prot. Sci., 1994, 3, 482-492 ________________________________________________________________________________ --- ------------------------------------------------------------ --- Results from running BLAST against PRODOM domains --- --- PLEASE quote: --- F Corpet, J Gouzy, D Kahn (1998). The ProDom database --- of protein domain families. Nucleic Ac Res 26:323-326. --- --- BEGIN of BLASTP output BLASTP 1.4.7 [16-Oct-94] [Build 12:52:03 Oct 30 1994] Reference: Altschul, Stephen F., Warren Gish, Webb Miller, Eugene W. Myers, and David J. Lipman (1990). Basic local alignment search tool. J. Mol. Biol. 215:403-10. Query= prot (#) ppOld, default: single protein sequence description=alceu /home/phd/server/work/predict_h10291 (366 letters) Database: prodom_00_1 174,952 sequences; 19,895,393 total letters. Searching..................................................done Smallest Sum High Probability Sequences producing High-scoring Segment Pairs: Score P(N) N PD087928 p2000.1 (1) ADH_ALCEU // ALCOHOL DEHYDROGENASE ... 541 2.2e-71 1 PD201096 p2000.1 (1) ADH_ALCEU // ALCOHOL DEHYDROGENASE ... 419 9.5e-53 1 PD085468 p2000.1 (1) FADH_PSEPU // GLUTATHIONE-INDEPENDE... 155 2.0e-14 1 PD016155 p2000.1 (3) FADH(1) O06012(1) YBDR(1) // OXIDO... 91 2.7e-07 2 PD010884 p2000.1 (5) ADH(3) ADH1(1) P77990(1) // DEHYDR... 84 0.00034 1 >PD087928 p2000.1 (1) ADH_ALCEU // ALCOHOL DEHYDROGENASE EC 1.1.1.1 OXIDOREDUCTASE ZINC NAD Length = 102 Score = 541 (250.5 bits), Expect = 2.2e-71, P = 2.2e-71 Identities = 102/102 (100%), Positives = 102/102 (100%) Query: 63 EPVGIIEKLGSAVTGYREGQRVIAGAICPNFNSYAAQDGVASQDGSYLMASGQCGCHGYK 122 EPVGIIEKLGSAVTGYREGQRVIAGAICPNFNSYAAQDGVASQDGSYLMASGQCGCHGYK Sbjct: 1 EPVGIIEKLGSAVTGYREGQRVIAGAICPNFNSYAAQDGVASQDGSYLMASGQCGCHGYK 60 Query: 123 ATAGWRFGNMIDGTQAEYVLVPDAQANLTPIPDGLTDEQVLM 164 ATAGWRFGNMIDGTQAEYVLVPDAQANLTPIPDGLTDEQVLM Sbjct: 61 ATAGWRFGNMIDGTQAEYVLVPDAQANLTPIPDGLTDEQVLM 102 >PD201096 p2000.1 (1) ADH_ALCEU // ALCOHOL DEHYDROGENASE EC 1.1.1.1 OXIDOREDUCTASE ZINC NAD Length = 82 Score = 419 (194.0 bits), Expect = 9.5e-53, P = 9.5e-53 Identities = 82/82 (100%), Positives = 82/82 (100%) Query: 285 YSSDLTIPLSAFAAGLGDHKINTALCPGGKERMRRLINVIESGRVDLGALVTHQYRLDDI 344 YSSDLTIPLSAFAAGLGDHKINTALCPGGKERMRRLINVIESGRVDLGALVTHQYRLDDI Sbjct: 1 YSSDLTIPLSAFAAGLGDHKINTALCPGGKERMRRLINVIESGRVDLGALVTHQYRLDDI 60 Query: 345 VAAYDLFANQRDGVLKIAIKPH 366 VAAYDLFANQRDGVLKIAIKPH Sbjct: 61 VAAYDLFANQRDGVLKIAIKPH 82 >PD085468 p2000.1 (1) FADH_PSEPU // GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE EC 1.2.1.46 FDH FALDH OXIDOREDUCTASE ZINC NAD Length = 130 Score = 155 (71.8 bits), Expect = 2.0e-14, P = 2.0e-14 Identities = 36/98 (36%), Positives = 54/98 (55%) Query: 167 DIMSTGFKGAENANIRIGHTVAVFAQGPIGLCATAGARLCGATTIIAIDGNDHRLEIARK 226 DI+ TG+ GA A + G TV V GP+GL A A ARL GA +I D N RL A+ Sbjct: 16 DILPTGYHGAVTAGVGPGSTVYVAGAGPVGLAAAASARLLGAAVVIVGDLNPARLAHAKA 75 Query: 227 MGADVVLNFRNCDVVDEVMKLTGGRGVDASIEALGTQA 264 G ++ + + +++ L G VD +++A+G +A Sbjct: 76 QGFEIADLSLDTPLHEQIAALLGEPEVDCAVDAVGFEA 113 >PD016155 p2000.1 (3) FADH(1) O06012(1) YBDR(1) // OXIDOREDUCTASE ZINC DEHYDROGENASE NAD ALCOHOL GLUTATHIONE-DEPENDENT FORMALDEHYDE FDH FALDH NADP Length = 121 Score = 91 (42.1 bits), Expect = 2.7e-07, Sum P(2) = 2.7e-07 Identities = 17/46 (36%), Positives = 27/46 (58%) Query: 320 LINVIESGRVDLGALVTHQYRLDDIVAAYDLFANQRDGVLKIAIKP 365 L+ IE G++D +VTH LD+ Y F ++ DG +K+ +KP Sbjct: 76 LLEKIEEGQIDPSFVVTHSLPLDEGPQGYKTFRDKEDGCIKVVLKP 121 Score = 45 (20.8 bits), Expect = 2.7e-07, Sum P(2) = 2.7e-07 Identities = 9/25 (36%), Positives = 14/25 (56%) Query: 261 GTQATFEQSLRVLKPGGTLSSLGVY 285 GT +++ + GGT+S GVY Sbjct: 19 GTGKALREAIMCCRKGGTVSIPGVY 43 >PD010884 p2000.1 (5) ADH(3) ADH1(1) P77990(1) // DEHYDROGENASE ALCOHOL OXIDOREDUCTASE ZINC NADP-DEPENDENT NADP 3D-STRUCTURE SECONDARY-ALCOHOL NADP+ ALDEHYDE Length = 74 Score = 84 (38.9 bits), Expect = 0.00034, P = 0.00034 Identities = 15/44 (34%), Positives = 27/44 (61%) Query: 296 FAAGLGDHKINTALCPGGKERMRRLINVIESGRVDLGALVTHQY 339 + G+ I+ LCPGG+ RM +L ++I ++D L+TH++ Sbjct: 3 WGCGMAHKTIHGGLCPGGRLRMEKLADLIMYKKLDPSKLITHRF 46 Parameters: E=0.001 B=500 V=500 -ctxfactor=1.00 Query ----- As Used ----- ----- Computed ---- Frame MatID Matrix name Lambda K H Lambda K H +0 0 BLOSUM62 0.321 0.139 0.406 same same same Query Frame MatID Length Eff.Length E S W T X E2 S2 +0 0 366 366 0.0010 88 3 11 22 0.19 34 Statistics: Query Expected Observed HSPs HSPs Frame MatID High Score High Score Reportable Reported +0 0 64 (29.6 bits) 541 (250.5 bits) 6 6 Query Neighborhd Word Excluded Failed Successful Overlaps Frame MatID Words Hits Hits Extensions Extensions Excluded +0 0 7010 13576177 2681054 10882667 12455 3 Database: prodom_00_1 Release date: unknown Posted date: 5:56 PM EDT Jun 21, 2000 # of letters in database: 19,895,393 # of sequences in database: 174,952 # of database sequences satisfying E: 5 No. of states in DFA: 559 (55 KB) Total size of DFA: 128 KB (128 KB) Time to generate neighborhood: 0.01u 0.00s 0.01t Real: 00:00:00 Time to search database: 17.74u 0.05s 17.79t Real: 00:00:18 Total cpu time: 17.77u 0.07s 17.84t Real: 00:00:18 --- END of BLASTP output --- ------------------------------------------------------------ --- --- Again: these results were obtained based on the domain data- --- base collected by Daniel Kahn and his coworkers in Toulouse. --- --- PLEASE quote: --- F Corpet, J Gouzy, D Kahn (1998). The ProDom database --- of protein domain families. Nucleic Ac Res 26:323-326. --- --- The general WWW page is on: ---- --------------------------------------- --- http://www.toulouse.inra.fr/prodom.html ---- --------------------------------------- --- --- For WWW graphic interfaces to PRODOM, in particular for your --- protein family, follow the following links (each line is ONE --- single link for your protein!!): --- http://www.toulouse.inra.fr/prodom/cgi-bin/ReqProdomII.pl?id_dom1=PD087928 ==> multiple alignment, consensus, PDB and PROSITE links of domain PD087928 http://www.toulouse.inra.fr/prodom/cgi-bin/ReqProdomII.pl?id_dom2=PD087928 ==> graphical output of all proteins having domain PD087928 http://www.toulouse.inra.fr/prodom/cgi-bin/ReqProdomII.pl?id_dom1=PD201096 ==> multiple alignment, consensus, PDB and PROSITE links of domain PD201096 http://www.toulouse.inra.fr/prodom/cgi-bin/ReqProdomII.pl?id_dom2=PD201096 ==> graphical output of all proteins having domain PD201096 http://www.toulouse.inra.fr/prodom/cgi-bin/ReqProdomII.pl?id_dom1=PD085468 ==> multiple alignment, consensus, PDB and PROSITE links of domain PD085468 http://www.toulouse.inra.fr/prodom/cgi-bin/ReqProdomII.pl?id_dom2=PD085468 ==> graphical output of all proteins having domain PD085468 http://www.toulouse.inra.fr/prodom/cgi-bin/ReqProdomII.pl?id_dom1=PD016155 ==> multiple alignment, consensus, PDB and PROSITE links of domain PD016155 http://www.toulouse.inra.fr/prodom/cgi-bin/ReqProdomII.pl?id_dom2=PD016155 ==> graphical output of all proteins having domain PD016155 http://www.toulouse.inra.fr/prodom/cgi-bin/ReqProdomII.pl?id_dom1=PD010884 ==> multiple alignment, consensus, PDB and PROSITE links of domain PD010884 http://www.toulouse.inra.fr/prodom/cgi-bin/ReqProdomII.pl?id_dom2=PD010884 ==> graphical output of all proteins having domain PD010884 --- --- NOTE: if you want to use the link, make sure the entire line --- is pasted as URL into your browser! --- --- END of PRODOM --- ------------------------------------------------------------ ________________________________________________________________________________ -------------------------------------------------------------------------------- --- --- --- Note: Your protein has a homolologue of known structure in PDB! --- --- ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ --- --- --- --- PHD prediction are inferior to a prediction by homology, which --- --- is possible if protein with known tertiary structure exists in --- --- PDB. For the sequence you sent, there is a known homologue in --- --- in PDB. We append the alignment of your sequence to some seq- --- --- uences, among them the PDB entry. --- --- --- --- Predicting 3D structure for your sequence is a straightforward --- --- task by using, e.g., SWISS-MODEL (for the address see: --- --- http://cubic.bioc.columbia.edu/~rost/wwwServices.html --- --- --- --- Should you have sent a known structure to evaluate the PHD pre- --- --- diction, please mind that the performance of PHD is expected to --- --- be superior for proteins used for training the networks. The --- --- list of proteins used for training is: --- --- --- --- 256b_A, 2aat , 8abp , 6acn , 1acx , 8adh , 3ait , 1ak3_A, --- --- 2alp , 9api_A, 9api_B, 8atc_A, 8atc_B, 1azu , 3b5c , 1bbp_A, --- --- 1bds , 3blm , 1bmv_1, 1bmv_2, 4bp2 , 2cab , 7cat_A, 1cbh, --- --- 1cc5 , 2ccy_A, 1cd4 , 1cdt_A, 3cla , 3cln , 4cms , 4cpa_I, --- --- 6cpa , 6cpp , 4cpv , 1crn , 1cse_I, 6cts , 2cyp , 5cyt_R, --- --- 3dfr , 6dfr , 3ebx , 1eca , 5er2_E, 1etu , 1fc2_C, 1fc2_D, --- --- 1fdl_H, 1fdx , 1fkf , 2fnr , 2fxb , 1fxi_A, 4fxn , 3gap_A, --- --- 2gbp , 2gcr , 1gd1_O, 2gls_A, 2gn5 , 1gox , 1gp1_A, 4gr1, --- --- 1hds_B, 1hip , 6hir , 2hla_A, 3hla_B, 3hmg_A, 3hmg_B, 2hmz_A, --- --- 5hvp_A, 2i1b , 3icb , 7icd , 1il8_A, 9ins_B, 1l58 , 1lap, --- --- 2lbp , 5ldh , 2lh4 , 2lhb , 1lrd_3, 2ltn_A, 2ltn_B, 5lyz, --- --- 1mcp_L, 4mdh_A, 2mev_1, 2mev_3, 2mev_4, 2mhu , 1mrt , 2or1_L, --- --- 1ovo_A, 2pab_A, 1paz , 9pap , 2pcy , 4pfk , 3pgm , 2phh, --- --- 2pka_A, 2pka_B, 1pmb_A, 1ppt , 1prc_C, 1prc_H, 1prc_L, 1prc_M, --- --- 1pyp , 1r09_2, 1rbp , 1rhd , 4rhv_1, 4rhv_3, 4rhv_4, 1rnh, --- --- 3rnt , 7rsa , 2rsp_A, 2rus_A, 4rxn , 1s01 , 4sbv_A, 1sdh_A, --- --- 4sgb_I, 1sgt , 1sh1 , 2sns , 2sod_B, 2stv , 2taa_A, 2tbv_A, --- --- 2tgp_I, 1tgs_I, 3tim_A, 6tmn_E, 2tmv_P, 1tnf_A, 4ts1_A, 2tsc_A, --- --- 1ubq , 2utg_A, 9wga_A, 2wrp_R, 1wsy_A, 1wsy_B, 4xia_A --- --- --- --- For personal messages or questions to the PHD authors, --- --- send email to predict_help@columbia.edu --- --- --- --- Burkhard Rost --- --- CUBIC, Columbia Univ, New York, USA --- --- --- -------------------------------------------------------------------------------- --- ------------------------------------------------------------ --- 3D homologue: the known structure that appeared to have sig- --- 3D homologue: nificant sequence identity to your protein is: --- 3D homologue: 1KEV, 1YKF, 1SDG, 1DEH, 1TEH, 1QOR, 1CDO, . --- 3D homologue: Note: we do NOT check whether the similarity --- 3D homologue: is in the region for which structure has --- 3D homologue: been determined. Thus, please verify! --- ------------------------------------------------------------ The alignment that has been used as input to the network is: ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ ________________________________________________________________________________ --- --- Version of database searched for alignment: --- SWISS-PROT release 39.0 (5/00) with 85 249 proteins --- --- ------------------------------------------------------------ --- MAXHOM multiple sequence alignment --- ------------------------------------------------------------ --- --- MAXHOM ALIGNMENT HEADER: ABBREVIATIONS FOR SUMMARY --- ID : identifier of aligned (homologous) protein --- STRID : PDB identifier (only for known structures) --- IDE : percentage of pairwise sequence identity --- WSIM : percentage of weighted similarity --- LALI : number of residues aligned --- NGAP : number of insertions and deletions (indels) --- LGAP : number of residues in all indels --- LSEQ2 : length of aligned sequence --- ACCNUM : SwissProt accession number --- OMIM : OMIM (Online Mendelian Inheritance in Man) ID --- NAME : one-line description of aligned protein --- --- MAXHOM ALIGNMENT HEADER: SUMMARY ID STRID IDE WSIM LALI NGAP LGAP LSEQ2 ACCNUM OMIM NAME adh_alceu 100 100 366 0 0 366 P14940 ALCOHOL DEHYDROGENASE (EC adh_clobe 1KEV 37 46 345 4 18 351 P25984 NADP-DEPENDENT ALCOHOL DE adh_thebr 1YKF 37 47 345 4 18 352 P14941 NADP-DEPENDENT ALCOHOL DE adh1_enthi 36 46 348 4 18 360 P35630 NADP-DEPENDENT ALCOHOL DE adh_mycpn 34 45 345 4 18 351 P75214 PROBABLE NADP-DEPENDENT A fadh_metmr 33 36 360 7 37 424 P47734 (FALDH). dhso_bacsu 32 37 339 7 36 352 Q06004 (GLUCITOL DEHYDROGENASE). ybdr_ecoli 32 34 352 10 45 412 P77316 INTERGENIC REGION. dhso_yeast 31 33 335 8 33 357 P35497 SORBITOL DEHYDROGENASE (E adh3_emeni 31 22 307 14 59 352 P07754 ALCOHOL DEHYDROGENASE III tdh_xancp 31 32 334 8 32 340 O34268 THREONINE 3-DEHYDROGENASE tdh_ecoli 30 33 327 8 37 341 P07913 THREONINE 3-DEHYDROGENASE fadh_amyme 30 33 326 3 25 360 P80094 FALDH). adhp_human 28 27 353 11 27 391 P08319 103740 ALCOHOL DEHYDROGENASE CLA dhso_human 28 32 333 8 31 356 Q00796 182500 SORBITOL DEHYDROGENASE (E dhso_bachd 28 31 336 10 30 343 Q9Z9U1 (GLUCITOL DEHYDROGENASE). dhso_bommo 28 28 323 10 52 348 Q02912 SORBITOL DEHYDROGENASE (E terd_psesp 28 26 283 8 46 319 P33010 PROBABLE ALCOHOL DEHYDROG fdeh_psepu 28 28 342 8 33 361 P09347 5-EXO-ALCOHOL DEHYDROGENA tdh_bacsu 28 31 334 6 29 347 O31776 THREONINE 3-DEHYDROGENASE adh3_paspi 28 30 336 8 33 369 P39450 DEPENDENT FORMALDEHYDE DE dhso_sheep 1SDG 28 31 329 8 38 354 P07846 SORBITOL DEHYDROGENASE (E tdh_rhime 28 31 334 8 35 344 Q52998 THREONINE 3-DEHYDROGENASE adh_sulsr 28 27 335 9 35 347 P50381 NAD-DEPENDENT ALCOHOL DEH adh5_yeast 28 23 314 10 55 351 P38113 ALCOHOL DEHYDROGENASE V ( adhx_rat 28 27 350 10 22 373 P12711 (FDH) (FALDH) (ALCOHOL DE adh1_bacst 28 27 333 9 27 337 P12311 ALCOHOL DEHYDROGENASE (EC fadh_psepu 28 28 351 9 48 398 P46154 (FDH) (FALDH). adha_rhime 28 27 328 10 35 340 O31186 ALCOHOL DEHYDROGENASE (EC adh2_yeast 28 23 314 10 55 347 P00331 ALCOHOL DEHYDROGENASE II adhx_mouse 28 27 350 10 22 373 P28474 (FDH) (FALDH) (ALCOHOL DE adh2_bacst 28 26 335 11 31 339 P42327 ALCOHOL DEHYDROGENASE (EC adh3_bacst 28 26 328 10 37 339 P42328 ALCOHOL DEHYDROGENASE (EC adh1_yeast 28 23 314 10 55 347 P00330 ALCOHOL DEHYDROGENASE I ( adh2_strca 28 28 347 9 18 379 P80468 ALCOHOL DEHYDROGENASE II adh3_syny3 28 31 347 7 11 369 P73138 DEPENDENT FORMALDEHYDE DE dhso_rat 28 30 329 8 39 399 P27867 SORBITOL DEHYDROGENASE (E xyl2_picst 28 28 333 8 36 363 P22144 D-XYLULOSE REDUCTASE (EC adhh_gadmo 28 28 344 9 20 375 P81600 DEPENDENT FORMALDEHYDE DE adhx_uroha 28 28 344 9 20 373 P80467 FORMALDEHYDE DEHYDROGENAS adhx_drome 28 27 345 9 16 378 P46415 DEHYDROGENASE) (EC 1.1.1. adhx_pea 28 27 338 10 33 378 P80572 FORMALDEHYDE DEHYDROGENAS adhl_gadmo 28 28 349 9 18 375 P81601 DEPENDENT FORMALDEHYDE DE adh_macmu 27 28 343 8 21 374 P28469 ALCOHOL DEHYDROGENASE ALP adhb_human 1DEH 27 28 343 9 21 374 P00325 103720 ALCOHOL DEHYDROGENASE BET adh1_allmi 27 28 334 8 39 374 P80222 ALCOHOL DEHYDROGENASE, MA adh3_ecoli 27 30 344 8 17 369 P25437 FORMALDEHYDE DEHYDROGENAS adhp_rabit 27 28 350 6 11 378 O46649 ALCOHOL DEHYDROGENASE CLA dhso_mouse 26 30 329 8 39 375 Q64442 (FRAGMENT). adha_human 26 28 348 7 11 374 P07327 103700 ALCOHOL DEHYDROGENASE ALP adhx_arath 26 27 346 8 13 379 Q96533 FORMALDEHYDE DEHYDROGENAS fah1_schpo 26 27 348 10 19 378 P78870 (EC 1.2.1.1) (FDH) (FALDH ydjl_ecoli 26 27 338 7 33 358 P77539 INTERGENIC REGION. adha_perma 26 27 342 10 23 374 P41680 ALCOHOL DEHYDROGENASE A C adhx_orysa 26 27 346 8 13 381 P93436 FORMALDEHYDE DEHYDROGENAS adh3_haein 26 28 347 7 11 378 P44557 DEPENDENT FORMALDEHYDE DE fadh_yeast 26 27 344 9 21 386 P32771 (FALDH) (ALCOHOL DEHYDROG adhx_myxgl 26 27 348 8 12 376 P80360 FORMALDEHYDE DEHYDROGENAS adha_uroha 26 28 348 8 12 375 P25405 ALCOHOL DEHYDROGENASE I-A adhx_caeel 26 27 341 8 23 384 Q17335 FORMALDEHYDE DEHYDROGENAS adha_rat 26 27 343 8 22 375 P06757 ALCOHOL DEHYDROGENASE A C adh_maldo 26 27 341 9 20 380 P48977 ALCOHOL DEHYDROGENASE (EC adhb_uroha 26 28 345 8 15 375 P25406 ALCOHOL DEHYDROGENASE I-B adhp_ecoli 25 28 310 5 51 336 P39451 ALCOHOL DEHYDROGENASE, PR adhx_maize 25 26 346 8 13 381 P93629 FORMALDEHYDE DEHYDROGENAS adh_gadca 1CDO 25 27 344 8 19 375 P26325 ALCOHOL DEHYDROGENASE (EC adh1_rabit 25 26 342 10 23 374 Q03505 ALCOHOL DEHYDROGENASE ALP adh7_rat 25 27 344 7 15 374 P41682 ALCOHOL DEHYDROGENASE CLA adh2_perma 25 26 345 9 17 375 P41681 ALCOHOL DEHYDROGENASE 2 ( --- --- MAXHOM ALIGNMENT: IN MSF FORMAT MSF of: /home/phd/server/work/predict_h10291.hsspFilter from: 1 to: 366 /home/phd/server/work/predict_h10291.msfRet MSF: 366 Type: P 22-May-02 09:32:3 Check: 9785 .. Name: predict_h1020 Len: 366 Check: 3158 Weight: 1.00 Name: adh_alceu Len: 366 Check: 3158 Weight: 1.00 Name: adh_clobe Len: 366 Check: 6294 Weight: 1.00 Name: adh_thebr Len: 366 Check: 2269 Weight: 1.00 Name: adh1_enthi Len: 366 Check: 1605 Weight: 1.00 Name: adh_mycpn Len: 366 Check: 8839 Weight: 1.00 Name: fadh_metmr Len: 366 Check: 828 Weight: 1.00 Name: dhso_bacsu Len: 366 Check: 2665 Weight: 1.00 Name: ybdr_ecoli Len: 366 Check: 5267 Weight: 1.00 Name: dhso_yeast Len: 366 Check: 1180 Weight: 1.00 Name: adh3_emeni Len: 366 Check: 5589 Weight: 1.00 Name: tdh_xancp Len: 366 Check: 6350 Weight: 1.00 Name: tdh_ecoli Len: 366 Check: 5296 Weight: 1.00 Name: fadh_amyme Len: 366 Check: 6850 Weight: 1.00 Name: adhp_human Len: 366 Check: 9963 Weight: 1.00 Name: dhso_human Len: 366 Check: 1912 Weight: 1.00 Name: dhso_bachd Len: 366 Check: 7422 Weight: 1.00 Name: dhso_bommo Len: 366 Check: 8149 Weight: 1.00 Name: terd_psesp Len: 366 Check: 4688 Weight: 1.00 Name: fdeh_psepu Len: 366 Check: 1562 Weight: 1.00 Name: tdh_bacsu Len: 366 Check: 6633 Weight: 1.00 Name: adh3_paspi Len: 366 Check: 2705 Weight: 1.00 Name: dhso_sheep Len: 366 Check: 4717 Weight: 1.00 Name: tdh_rhime Len: 366 Check: 7781 Weight: 1.00 Name: adh_sulsr Len: 366 Check: 5191 Weight: 1.00 Name: adh5_yeast Len: 366 Check: 6915 Weight: 1.00 Name: adhx_rat Len: 366 Check: 2110 Weight: 1.00 Name: adh1_bacst Len: 366 Check: 5244 Weight: 1.00 Name: fadh_psepu Len: 366 Check: 9931 Weight: 1.00 Name: adha_rhime Len: 366 Check: 5132 Weight: 1.00 Name: adh2_yeast Len: 366 Check: 2978 Weight: 1.00 Name: adhx_mouse Len: 366 Check: 3762 Weight: 1.00 Name: adh2_bacst Len: 366 Check: 2386 Weight: 1.00 Name: adh3_bacst Len: 366 Check: 3558 Weight: 1.00 Name: adh1_yeast Len: 366 Check: 5569 Weight: 1.00 Name: adh2_strca Len: 366 Check: 9501 Weight: 1.00 Name: adh3_syny3 Len: 366 Check: 4250 Weight: 1.00 Name: dhso_rat Len: 366 Check: 4493 Weight: 1.00 Name: xyl2_picst Len: 366 Check: 3821 Weight: 1.00 Name: adhh_gadmo Len: 366 Check: 2836 Weight: 1.00 Name: adhx_uroha Len: 366 Check: 607 Weight: 1.00 Name: adhx_drome Len: 366 Check: 8218 Weight: 1.00 Name: adhx_pea Len: 366 Check: 6800 Weight: 1.00 Name: adhl_gadmo Len: 366 Check: 1489 Weight: 1.00 Name: adh_macmu Len: 366 Check: 1778 Weight: 1.00 Name: adhb_human Len: 366 Check: 9921 Weight: 1.00 Name: adh1_allmi Len: 366 Check: 2934 Weight: 1.00 Name: adh3_ecoli Len: 366 Check: 902 Weight: 1.00 Name: adhp_rabit Len: 366 Check: 869 Weight: 1.00 Name: dhso_mouse Len: 366 Check: 6016 Weight: 1.00 Name: adha_human Len: 366 Check: 210 Weight: 1.00 Name: adhx_arath Len: 366 Check: 6763 Weight: 1.00 Name: fah1_schpo Len: 366 Check: 4587 Weight: 1.00 Name: ydjl_ecoli Len: 366 Check: 9544 Weight: 1.00 Name: adha_perma Len: 366 Check: 2215 Weight: 1.00 Name: adhx_orysa Len: 366 Check: 7221 Weight: 1.00 Name: adh3_haein Len: 366 Check: 4361 Weight: 1.00 Name: fadh_yeast Len: 366 Check: 8141 Weight: 1.00 Name: adhx_myxgl Len: 366 Check: 3388 Weight: 1.00 Name: adha_uroha Len: 366 Check: 2173 Weight: 1.00 Name: adhx_caeel Len: 366 Check: 6760 Weight: 1.00 Name: adha_rat Len: 366 Check: 8516 Weight: 1.00 Name: adh_maldo Len: 366 Check: 2031 Weight: 1.00 Name: adhb_uroha Len: 366 Check: 1383 Weight: 1.00 Name: adhp_ecoli Len: 366 Check: 92 Weight: 1.00 Name: adhx_maize Len: 366 Check: 5958 Weight: 1.00 Name: adh_gadca Len: 366 Check: 4762 Weight: 1.00 Name: adh1_rabit Len: 366 Check: 7482 Weight: 1.00 Name: adh7_rat Len: 366 Check: 3048 Weight: 1.00 Name: adh2_perma Len: 366 Check: 9059 Weight: 1.00 // 1 50 predict_h1020 MTAMMKAAVF VEPGRIELAD KPIPDIGPND ALVRITTTTI CGTDVHILKG adh_alceu MTAMMKAAVF VEPGRIELAD KPIPDIGPND ALVRITTTTI CGTDVHILKG adh_clobe ....MKGFAM LGINKLGWIE KERPVAGSYD AIVRPLAVSP CTSDIHTveG adh_thebr ....MKGFAM LSIGKVGWIE KEKPAPGPFD AIVRPLAVAP CTSDIHTveG adh1_enthi ....MKGLAM LGIGRIGWIE KKIPECGPLD ALVRPLALAP CTSDTHTvaG adh_mycpn ....MKAYAM LKIGATGWIE KPRPVCGPND AIIRPLAVAP CTSDVHTveG fadh_metmr .SVVMKALCW HGKYDVRVDT VPDPIidPTD AIVKITATAI CGSDLHLYDG dhso_bacsu VPQNMKAAVM HNTREIKIET LPVPDINHDE VLIKVMAVGI CGSDLHYyiG ybdr_ecoli ....MKALTY HGPHHVQVEN VPDPGvqADD IILRITATAI CGSDLHLYRG dhso_yeast ......AVVL EKVGDIAIEQ RPIPTidPHY VKLAIKATGI CGSDIHYyiG adh3_emeni ......AQVV EKAGTPPvkQ VPVPKPGPDE ILVKMRYSGV CHTDLHAMKG tdh_xancp ....MKALVK ResKGIWLEQ VPVPTPGPNE VLIKLEKTAI CGTDLHIywS tdh_ecoli ....MKALsl KAEEGIWMTD VPVPELGHND LLIKIRKTAI CGTDVHIywS fadh_amyme .......... .KGAPVELTD IVIPDPGPSE VTALIATCAV CHTDLTYREG adhp_human .....KAAIA WEAgpLCIEE VEVAPPKAHE VRIQIIATSL CHTDASVIDS dhso_human ......SLVV HGPGDLRLEN YPIPEPGPNE VLLRMHSVGI CGSDVHYwiG dhso_bachd ....MKALVK TqtGHFAVQE KPEPTPGKHQ VKIKVKYTGV CGSDIHTYEG dhso_bommo ......AAVL HGANDVRIEK IPVPEINDDE VLIKIDCVGI CGSDVKLycG terd_psesp .......... .......... .......... ..LFVSESCV CHTDLAIKDG fdeh_psepu .....RAAVM VEQNRVETWE VPIFDPAPGG ALVRVVLGGV CGSDVHIVSG tdh_bacsu MKALMKKDGA F...GAVLTE VPIPEIDKHE VLIKVKAASI CGTDVHIYNW adh3_paspi ......AVAF GPGLPLEIVE IDVAPPKKGE VLVKISHTGV CHTDAYTLSG dhso_sheep ......SLVV HGPGDLRLEN YPIPEPGPNE VLLKMHSVGI CGSDVHYwiG tdh_rhime MTNMMKALVK TKPegLWMER VPVPEIGPND VLIRVRKSAI CGTDVHIwwA adh_sulsr ....MRAVRL VEIgpLVLKD IDIPKPKGAQ VLIKVEAAGV CHSDVHMRQG adh5_yeast IPEKQKAIVF YedGKLEYKD VTVPEPKPNE ILVHVKYSGV CHSDLHAWHG adhx_rat .....KAAVA WEAgpLSIEE IEVAPPQAHE VRIKIIATAV CHTDAYTLSG adh1_bacst ....MKAAVV EqkKPLQVKE VEKPKISYGE VLVRIKACGV CHTDLHAAHG fadh_psepu .....RGVVY LGSGKVEVQK IDYPKmiEHG VILKVVSTNI CGSDQHMVRG adha_rhime ....MTAAVV REFgpLVIEE VPVPQPGPGQ VLIKYEATGV CHTDLHAAKG adh2_yeast IPETQKAIIF YenGKLEHKD IPVPKPKPNE LLINVKYSGV CHTDLHAWHG adhx_mouse .....KAAVA WEAgpLSIEE IEVAPPKAHE VRIKILATAV CHTDAYTLSG adh2_bacst ....MKAAVV NekKALEIKE VERPKLEEGE VLVKIEACGV CHTDLHAAHG adh3_bacst ....MKAAVV EqkEPLKIKE VEKPTISYGE VLVRIKACGV CHTDLHAAHG adh1_yeast IPETQKGVIF YehGKLEHKD IPVPKPKANE LLINVKYSGV CHTDLHAWHG adh2_strca .....KAAIA WEAgpLSVEE IEVSPPKDHE VRVKIVATGV CRTDEHAINP adh3_syny3 ......AVAF EVGKPLQIVE IDVAPPQQGE VLVKITHTGV CHTDAFTLSG dhso_rat ......SLVV HGPGDIRLEN YPIPELGPND VLLKMHSVGI CGSDVHYwiG xyl2_picst ......SLVL NKIDDISFET YDAPEiePTD VLVQVKKTGI CGSDIHFyiG adhh_gadmo .....KAAVA WEAgpLSLEE VEVAPPRAGE VRIKVVATGV CHTDAYTLSG adhx_uroha .....KAAVA WEAgpLSIEE IEVAPPKAHE VRVKIIATAV CHTDAYTLSG adhx_drome .....KAAVA WekKPLVIED IEVAPPKAHE VRIKITATGV CHTDAFTLSG adhx_pea .....KAAVA WEpkPLTIED VEVAPPQANE VRIQILFTAL CHTDAYTLGG adhl_gadmo .TIRCRAAVA WEAgpLSMEE VEVAPPQAGE VRIKIVATGI CHTDAYTLSG adh_macmu .....KAAVL WemKPFSIED VEVAPPKAYE VRIKMVTVGI CGTDDHVVSG adhb_human .....KAAVL WekKPFSIED VEVAPPKAYE VRIKMVAVGI CRTDDHVVSG adh1_allmi .....KAAIT WekKPFSIEE IEVAPPKAHE VRIKILATGI CRSDDHVTAG adh3_ecoli ......AVAF APGKPLEIVE IDVAPPKKGE VLIKVTHTGV CHTDAFTLSG adhp_rabit .....KAAIA WEAgpLSIEE VEVAPPKAHE VRVQINAAGL CRSDTHVINP dhso_mouse ......SLVV HGPGDIRLEN YPIPELGPND VLLKMHSVGI CGSDLHYwiG adha_human .....KAAVL WekKPFSIEE VEVAPPKAHE VRIKMVAVGI CGTDDHVVSG adhx_arath .....KAAVA YEpkPLVIED VQVAPPQAGE VRIKILYTAL CHTDAYTWSG fah1_schpo .TITCKAAvw GAKEPLSIED IQVAPPKAHE VRVKVDWSAV CHTDAYTLSG ydjl_ecoli ....MKALAR faFGGYKMID VPQPMCGPED VVIEIKAAAI CGADMKHYNV adha_perma .....KAAVL WEpkPFSIED IEVAPPKAHE VRIKMVATGV CRSDDHVVSR adhx_orysa .....KAAVA WEakPMTIED VQVAPPQAGE VRVKILFTAF CHTDHYTWSG adh3_haein ......AVAF APNQPLQIVE IDVEMPRKGE VLIRNTHTGV CHTDAFTLSG fadh_yeast ....IAAVAY DAKKPLSVEE ITVDAPKAHE VRIKIEYTAV CHTDAYTLSG adhx_myxgl .....KAAVA WekKPLSLEE IEVAPPKAHE VRMKVLATAV CHTDAYTLSG adha_uroha .....KAAIA WekKPLSIEQ IEVAPPKAHE VRIKILATGI CRSDDHVISG adhx_caeel ......AVAW SAKAPLSIET IQVAPPKAHE VRVKILYTAV CHTDAYTLDG adha_rat .....KAAVL WEpkPFTIED IEVAPPKAHE VRIKMVATGV CRSDDHAVSG adh_maldo ......AVAW EAGKPLVIEE VEVAPPQANE VRIKILFTSL CHTDVYFwkG adhb_uroha ......AVVW EPKKPFSIVE IEVAPPKAHE VRIKILASGI CRSDDHVLSG adhp_ecoli ....MKAAVV TKDHHVDVTY KTLRSLKHGE ALLKMECCGV CHTDLHVKNG adhx_maize .....KAAVA YEpkPLVIED VQVAPPQAGE VRVKILFTAL CHTDHYTWSG adh_gadca .....KAAVA WEakPLVIEE IEVDVPHANE IRIKIIATGV CHTDLYHleG adh1_rabit .....KAAVL WqnKPFSIEE VEVAPPKAHE VRIKMVATGI CRSDDHAVTG adh7_rat ......AVLW GTNQPFSIED IEVAPPKAKE VRVKILATGI CGTDDHVIKG adh2_perma .....KAAVL WKPgpLTMEE IDVAPPKGKE VRVKMVAAGI CGTDIKSlnK 51 100 predict_h1020 EYPVAKGLTV GHEPVGIIEK LGSAVTGYRE GQRVIAGAIC PNFNSYAAQD adh_alceu EYPVAKGLTV GHEPVGIIEK LGSAVTGYRE GQRVIAGAIC PNFNSYAAQD adh_clobe ALGDRKNMIL GHEAVGEVVE VGSEVKDFKP GDRVIVPCTT PDWRSLEVQA adh_thebr AIGERHNMIL GHEAVGEVVE VGSEVKDFKP GDRVVVPAIT PDWRTSEVQR adh1_enthi AIGDRHDMIL GHEAVGQIVK VGSLVKRLKV GDKVIVPAIT PDWGEEESQR adh_mycpn GIGERHNMVL GHEGCGVVDE VGSEVKSFKV GDRVLVAAIT PEWNSVNAQA fadh_metmr YMPTmsGDIL GHEPMGEVVE VGSEVTSLKT GDRVVVPFTI SCGHCFFCEK dhso_bacsu NYVVEKPFIL GHECAGEIAA VGSSVDQFKV GDRVAVEPGV TCGRCEACKE ybdr_ecoli KIpvKHGDIF GHEFMGEVVE TGKDVKNLQK GDRVVIPFVI AclQQYAACE dhso_yeast KYILKAPMVL GHESSGQVVE VGDAVTRVKV GDRVAIEPGV PSRYSDETKE adh3_emeni DWPLpmPLIG GHEGAGVVVA KGELVKdfKI GDRA...... .......... tdh_xancp QRTITPGLTI GHEFVGRVAE LGSAVTGYQV GQRVSAEGHI VCGHCRNCRG tdh_ecoli QKTIPVPMVV GHEYVGEVVG IGQEVKGFKI GDRVSGEGHI TCGHCRNCRG fadh_amyme GINDEFPFLL GHEAAGTVES VGEGVDSVQP GDYVVLNWRA VCGQCRACKR adhp_human KFelAFPVIV GHEAAGIVES IGPGVTNVKP GDKVIPlcLS PLTNLCGKIS dhso_human NFIVKKPMVL GHEASGTVEK VGSSVKHLKP GDRVAIEPGA PRENDEFCKM dhso_bachd HYPVAAPVTL GHEFSGEIVE LGEGVTGFNV GDRVTSETT. ...YSICGKC dhso_bommo ADVIDKPIVI GHEGAGTVVK VGDKVSSLRV GDRVAIEPTQ PCRSCELCKR terd_psesp VLPFPLPAVL GHEGSGIVEA VGPGVKHLKP GDAVVMtaSC GHCAScaQNY fdeh_psepu EAGAMppIIL GHEGIGRIEK LGTGVTTDYA GVPVKQgaLC HRCHSCTVLD tdh_bacsu DqrIKTPYVF GHEFSGIVEG VGENVSSVKV GEYVSAETHI VCGECVPCLT adh3_paspi DDPEgfPVVL GHEGAGVVVE VGEGVTSVKP GDHVIPLYTA ECGerETQGK dhso_sheep DFVVKKPMVL GHEASGTVVK VGSLVRHLQP GDRVAIQPGA PRQTDEFCKI tdh_rhime EKTIPVPMVV GHEFMGEVVE VGPAVSKHHV GERVSGEGHI VCGKCRNCRA adh_sulsr RFgvKLPVTL GHEIAGKIEE MGDEVVGYSK GDLVAVNPWQ GEGNCYYCRI adh5_yeast DWPFqfPLIG GHEGAGVVVK LGSNVKGWKV GDFAGIKWLN GTCMSCEYCE adhx_rat ADPEgfPVIL GHEGAGIVES VGEGVTKLKA GDTVIPLYic LNPKTNLCQK adh1_bacst DWPVklPLIP GHEGVGVIEE VGPGVTHLKV GDRVGI.... PWLYSACGHC fadh_psepu RTTAQVGLVL GHEITGEVIE KGRDVENLQI GDLVSVPF.. .NVACGRCRS adha_rhime DWPVrpPFIP GHEGVGYVAK LGAEVTRLKE GDRVGVPWLH TACGCcpCRT adh2_yeast DWPLplPLVG GHEGAGVVVG MGENVKGWKI GDYA...... .......... adhx_mouse RDPEgfPVIL GHEGAGIVES VGEGVTKLKA GDTVIPLYic LNPKTNLCQK adh2_bacst DWPIklPLIP GHEGVGIVVE VAKGVKSIKV GDRVGI.... PWLYSACGEC adh3_bacst DWPVklPLIP GHEGVGIVEE VGPGVTHLKV GDRVGI.... PWLYSACGHC adh1_yeast DWPLplPLVG GHEGAGVVVG MGENVKGWKI GDYA...... .......... adh2_strca SFKEgfPVIL GHEGAGIVES IGQGVSKFKP GDKVIPLYmc LNPKTNLCEK adh3_syny3 DDPEgfPVVL GHEGAGIVVE VGEGVTSVQL GDHVIPLYTA ECGKCLFCRS dhso_rat DFVVKKPMVL GHEAAGTVTK VGPMVKHLKP GDRVAIEPGV PREIDEFCKI xyl2_picst NFVLTKPMVL GHESAGTVVQ VGKGVTSLKV GDNVAIEPGI PSRFSDEYKS adhh_gadmo SDPeaFPVIL GHEGAGLVES VGEGVTKFKA GDTVIPLYvc KNPKTNLCQK adhx_uroha ADPEGspVIL GHEGAGIVES VGEGVTKFKP GDTVIPLYic LNPKTNLCQK adhx_drome ADPEgfPVVL GHEGAGIVES VGEGVTNFKA GDHVIALYIP QCNECKFCKS adhx_pea KDPEgfPCIL GHEAAGIVES VGEGVTDVKP GDHVIP.... ....SYQAEC adhl_gadmo SDPEgfPSVL GHEGAGIVES VGEGVTKFKS GDAVIPLYVP QCGECKFCKN adh_macmu TMVTPLPVIL GHEAAGIVES VGEGVTTVEP GDKVIPLALP QCgrNYCLKN adhb_human NLVTPLPVIL GHEAAGIVES VGEGVTTVKP GDKVIpcRVC KNPEsyCLKN adh1_allmi LLTMPLPMIL GHEAAGVVES TGEGVTSLKP GDKVIPLFV. .......... adh3_ecoli DDPEgfPVVL GHEGAGVVVE VGEGVTSVKP GDHVIPLYTA ECGECEFCRS adhp_rabit KFEGalPVIL GHEGAGIVES VGPGVTNVKP GDKVIPLYIP HCKKCKFCLS dhso_mouse DFVVKKPMVL GHEAAGTVTK VGELVKHLKP GDRVAIEPGV PREVDEYCKI adha_human TMVTPLPVIL GHEAAGIVES VGEGVTTVKP GDKVIPLAIP QCGKCRICKN adhx_arath KDPEgfPCIL GHEAAGIVES VGEGVTGVQA GDHVIPCYQA ECRECKFCKS fah1_schpo VDPeaFPIVL GHEGAGIVES IGEGVINVRP GDHVILLYTP ECKECKFCRS ydjl_ecoli DSGSDenSIR GHEFAGCIAQ VGEKVKDWKV GQRVVSDNSG HVCGVCPACE adha_perma SLASPLPAVL GHEGAGIVES VGEGVTSVKP GDKVIPLFth PEYNLCMKND adhx_orysa KDPEgfPCIL GHEAAGIVES VGEGVTEVQP GDHVIPCYQA ECRECKFCKS adh3_haein SDPEgfPVVL GHEGAGVVVA VGEGVLSVKP GDHVIPLYTA ECGECEFCRS fadh_yeast SDPEgfPCVL GHEGAGIVES VGDDVITVKP GDHVIALYTA ECGKCKFCTS adhx_myxgl VDPEGspVVL GHEGAGIVES VGEGVTKFKP GDSVIPLYIP QCGECKFCLN adha_uroha AFKMPLPMVL GHEAAGVVES VGEGVTCVKP GDKVIPLFvc GKCSSCRSTR adhx_caeel HDPEgfPVVL GHEGSGIVES VGEGVTGFAP GDHVVpcEYC KNPKTNLCQK adha_rat SLFTPLPAVL GHEGAGIVES IGEGVTCVKP GDKVIPLFsh PESNLCCQTK adh_maldo QNPL.FPRIY GHEAGGIVES VGEGVTDLKA GDHVLPvaHC KSEESNMCDL adhb_uroha ALKVNFPIIL GHEAAGVVES VGEGVTSMKP GDKVIPIFlc GECNSCRHPR adhp_ecoli DFGDKTGVIL GHEGIGVVAE VGPGVTSLKP GDRASVAWFY EGCGHCEYCN adhx_maize KDPEgfPCIL GHEAAGIVES VGEGVTDVQP GDHVIPCYQA ECKECKFCKS adh_gadca KHKDGFPVVL GHEGAGIVES VGPGVTEFQP GEKVIPLFic QSPKTNQCVK adh1_rabit SIAVPLPVIL GHEAAGIVES IGEGVTTVKP GDKVIpcRIC KHPEsfCLIN adh7_rat TMVSKFPVIV GHEAVGIVES VGEEVTTVRP GDKVIPLFLP QCRECNPCRN adh2_perma KLAPFCPIIM GHEGTGIVES VGEGVSTVKT GDKVIigECN TCLNSKNNIC 101 150 predict_h1020 GVASQDGSYL MASGQCGCHG YKATAGWRFG NMIDGTQAEY VLVPDAQANL adh_alceu GVASQDGSYL MASGQCGCHG YKATAGWRFG NMIDGTQAEY VLVPDAQANL adh_clobe GFQQHSNGML .......... ....AGWKFS NFKDGVFGEY FHVNDADMNL adh_thebr GYHQHSGGML .......... ....AGWKFS NVKDGVFGEF FHVNDADMNL adh1_enthi GYPMHSGGML .......... ....GGWKFS NFKDGVFSEV FHVNEADANL adh_mycpn GYPMHSGGML .......... ....GGWKFS NVKDGMFAEY FHVNDAEGNL fadh_metmr TLYssNPNAD MARKAMGHSP AGIFGYSHML GGFAGGQAEY LRVPYADVGP dhso_bacsu GRYnpDVQFL ATPP...... .......... ..VDGAFVQY IKMRQDFVFL ybdr_ecoli NTNAGKGAAL NKK.....QI PAPAALFGYS HlvPGGQAEY VRVPKGNVGP dhso_yeast GRYNLCPHMA FAATP..... .......... .PIDGTLVKY YLSPED..FL adh3_emeni GIKWLNGSCL SCEMCMQADE PLCPHASLSG YTVDGTFQQY TIGKAALASK tdh_xancp GRPHLCPNTV .......... .......GIG VNVNGAFAEY MVMPAS..NL tdh_ecoli GRTHLCRNTI GV........ .........G VNRPGCFAEY LVIPAF..NA fadh_amyme GRPQYCFSTF NATQKM.... .......... TLTDGTELTP ALGIGAFADK adhp_human NLKSPASDQQ LMEDKTSRFT CKGKPVYHFF G..TSTFSQY TVVSDI..NL dhso_human GRYNLSPSIF FCATPPD... .......... ...DGNLCRF YKHNAAFCYK dhso_bachd SYCTSGDYNL CSHRK..... .......GLG NQQDGSFAKY VIARQE..SL dhso_bommo GKYnrYCSSM GAPGN..... .......... .....LCRYY KHVADFCHKL terd_psesp SAQRADGPVL LSQGD..... .EVISGFFFG ......QSSF SSMAMAREHN fdeh_psepu ETPWDNSTFF EHAQKPNW.. .......... ....GSYADF ACLPNGMAFY tdh_bacsu GKS....... .......... HVCTNTAIIG VDTAGCFAEY VKVPAD..NI adh3_paspi GVMPDATSRF FVNGQP.... .......LYH YMGCSTFSEY TVVAEV..SL dhso_sheep GRYNLSPTIF FCATPPdcRF YKHNANFCYK .......... .......... tdh_rhime GRGHLCRNTL GV........ .........G VNRPGSFAEF VCLPEY..NV adh_sulsr GEE.....HL CDSPR..... .......WLG INFDGAYAEY VLNPHYKYMY adh5_yeast VGNESQCPYL DGT....... .........G FTHDGTFQEY ATADAVQAAH adhx_rat IRVTQGKGLM PD....GTSR FTCKGKPILH FMGTSTFSEY TVVADI..SV adh1_bacst DYCLSGQETL CERQQNA... .........G YSVDGGYAEY C..RAAADYV fadh_psepu CKEMHTGVCL TVNPARAGGA Y....GYVDM GDWTGGQAEY LLVPYADFNL adha_rhime GWETLCGSQQ NT........ .........G YSVDGTFAQY GLADPDFVGR adh2_yeast GIKWLNGSCM ACEYCELGNE SNCPHADLSG YTHDGSFQEY ATADAVQAAH adhx_mouse IRVTQGKGLM PD....GTSR FTCKGKSVFH FMGTSTFSEY TVVADI..SV adh2_bacst EYCLTGQETL CPHQLNG... .........G YSVDGGYAEY CKAPAD..YV adh3_bacst DYCLSGQETL CEHQKNA... .........G YSVDGGYAEY C..RAAADYV adh1_yeast GIKWLNGSCM ACEYCELGNE SNCPHADLSG YTHDGSFQQY ATADAVQAAH adh2_strca ISKIKTPISD QEVMSDGTSR FTCKGKPIYH FMGTSTFSEY TVVSES..SL adh3_syny3 GKTNLCVAVR ATQGKggTSR FSYNGQSLYH YMGCSTFSEY TVVAEV..SL dhso_rat GRYNLTPSIF FCATPPdcRF YKHSADFCYK .......... .......... xyl2_picst GH........ ..YNLCPHMA FAATPNSKEG EppPGTLCKY FKSPED..FL adhh_gadmo IRVTQGRGLM PDNTS....R FTCKGKQLFH FMGTSTFSEY TVVADI..SL adhx_uroha IRVTQGKGVM PD....GTSR FTCKGKQVLH FMGTSTFSEY TVVADI..SL adhx_drome GKTNLCQKIR LTQGAggTSR LSCKGQQLFH FMGTSTFAEY TVVADI..SL adhx_pea GECkaTGVGV MMADRKSRFS VKGKPIYHF. .MGTSTFSQY TVVHDV..SV adhl_gadmo PKTntQGKGL MPNGT...SR FSCNGQVLFH FMGSSTFSEY TVVAEI..SL adh_macmu DVSNPRGTLQ DGTSRFTCRG KP.....IHH FLGVSTFSQY TVVDEN..AV adhb_human DLGNPRGTLQ DGTRRFTCRG KP.....IHH FLGTSTFSQY TVVDENAVAK adh1_allmi ...PQCGECM PCLKSNGNLC IRNDLGSPSG LMADGTstEY TVVHETAVAR adh3_ecoli GKTntQGKGL MPDGT...TR FSYNGQPLYH YMGCSTFSEY TVVAEV..SL adhp_rabit PLTnkGKNPL IEQELMEDKT SRFTCKGKSI YHFFGISAFS QYTVVKDVNL dhso_mouse GRYNLTPTIF FCATPPdcRF YKHNADFCYK .......... .......... adha_human PESnnDVSNP QGTLQDGTSR FTCRRKPIHH FLGISTFSQY TVVDENAVAK adhx_arath GKTNLCGKVR SATgnDRKSR FSVNGKPIYH FMGTSTFSQY TVVHDV..SV fah1_schpo GKTntQGRGL MPDGT...SR FSCRDKTLLH YMGCSSFSQY TVVADI..SL ydjl_ecoli QGDFLCCTEK VNLGLD.... .........N NTWGGGFSKY CLVPGerHAL adha_perma LMQPR.GTLL DGTSRFTCRG ...KAIHNFI S..TSTFSQY TVVDEM..AV adhx_orysa GKTNLCGKVR AATGVGVmsR FSINGKPIYH FMGTSTFSQY TVVHDV..SV adh3_haein GKTNLCVSVR DTQGKGLmtR FSYQGQPIYH YMGCSTFSEY SVVAEV..SL fadh_yeast GKTntQGKGV MPDGTTRFHN AKGEDIYHF. .MGCSTFSEY TVVADV..SV adhx_myxgl PKTNLCQKIR VTQGKggTSR LTCRGKSLYH FMGASTFSEY AVVADI..SL adha_uroha GNLCTSNDLS AATGLmgTSR FTCKGKSLHH FISTSSFTEY TVVHEN..SV adhx_caeel IRISQGNGFM PD....GSSR FTCNGKQLFH FMGCSTFSEY TVVADI..SL adha_rat NLTQPKGALL DGTSRFSCRG KP.....IHH FISTSTFSQY TVVDDIAVAK adh_maldo LRINTDRGVM LSDGKSR.FS IKGKPIYHFV G..TSTFSEY TVVHVG..CL adhb_uroha GNVCKKSELG PFTGltSRFT YQGKPVYHFV R..TGTFTEY TVAPED..SV adhp_ecoli SGNETLCRSV KNA....... .........G YSVDGGMAEE CIVVADYAVK adhx_maize GKTNLCGKVR SATGVGVmsR FSVNGKPIYH FMGTSTFSQY TVVHDV..SV adh_gadca GWANESPDVM SPKE....TR FTCKGRKVLQ FLGTSTFSQY TVV..NQIAV adh1_rabit DLGKPKGMLL DGTSRFTCKG KP.....IHH FIGTSTFSQY TVVDEIAVAK adh7_rat PEGnlTGRGV LADGTTR.FT CKGKPVQHFM N..TSTFTEY TVLDES..SV adh2_perma KEVRLSGTHL TSEGN...SR ITCKGKTTYQ YITTGTFSEY IVIKEI..SV 151 200 predict_h1020 TPIPDGLTDE QVLMCPDIMS TGFKGAENAN IRIGHTVAVF AQGPIGLCAT adh_alceu TPIPDGLTDE QVLMCPDIMS TGFKGAENAN IRIGHTVAVF AQGPIGLCAT adh_clobe AILPKDMPLE NAVMITDMMT SGFHGAELAD IQMGSSVVVI GIGAVGLMGI adh_thebr AHLPKEIPLE AAVMIPDMMT TGFHGAELAD IELGATVAVL GIGPVGLMAV adh1_enthi ALLPRDIKPE DAVMLSDMVT TGFHGAELAN IKLGDTVCVI GIGPVGLMSV adh_mycpn ALMPEGMDLA DACMLSDMIP TGFHANELAD IQYGVALSFF CAGPVGLMAI fadh_metmr IKITSDLPDD KVLFLSDIFP TGYMAAENAQ IEPGDTVAVW GCGPVAQFVI dhso_bacsu ..IPDSLSYE EAAL.IEPFS VGIHAAARTK LQPGSTIAIM GMGPVGLMAV ybdr_ecoli FKVPPLLSDD KALFLSDILP TAWQAAKNAQ IQQGSSVAVY GAGPVGLLTI dhso_yeast VKLPEGVSYE E.GACVEPLS VGVHSNKLAG VRFGTKVVVF GAGPVGLLTG adh3_emeni ..IPDNVPLD AAAPILCAGI TVYKGLKESG ARPGQTVAIv aGGGLGSLAQ tdh_xancp WPIPDQIPSE LAAFFDPYGN AAHCALEFDV I..GEDVLIT GAGPIGIIAA tdh_ecoli FKIPDNISDD LAAI.....F DPFGNAVHTA LsvGEDVLVS GAGPIGIMAA fadh_amyme TLVHAGQCTK VdlLGCGVMA GLGAAVNTGA VSRGDSVAVI GCGAVGDAVI adhp_human AKIDDDANLE RVCLLGCGFS TGYGAanNAK VTPGSTCAVF GLGGVGLSAV dhso_human ..LPDNVTFE EGAL.IEPLS VGIHACRRGG VTLGHKVLVC GAGPIGMVTL dhso_bachd HHLPAGVDDR SAAMTEPLAC THHAIAK.TS INKGDLVVVT GPGPIGLLAA dhso_bommo ...PDNLTME EGAA.VQPLA IVIHACNRAK ITLGSKIVIL GAGPIGILCA terd_psesp LVKIDALVDD APIELLGPLG CGVQTGAGad VRAGRSFLVL GGGAVGLSAV fdeh_psepu .RLPDHAQPE ALAALGCALP TVLRGYDrgP VGLDDTVVVQ GAGPVGLAAV tdh_bacsu WRNPADMDPS IASIQEPLGN AVHTVLESQP A..GGTTAVI GCGPIGLMAV adh3_paspi AKINPQANAE QVCLLGCGVT TGIGAVHnaK VQEGDSVAVF GLGGIGLAVV dhso_sheep ..LPDNVTFE EGAL.IEPLS VGIHACRRAG VTLGNKVLVC GAGPIGLVNL tdh_rhime VSIPDDVPDE IAAI.....F DPFGNAVHTA LsvGEDVLVT GAGPIGIMGA adh_sulsr KLRRLNAVEA SPLTCSGI.. TTYRAVRKAS LdtKTLVVVG AGGGLGTMAV adh5_yeast IPPNVNLAEV APILCAGI.. TVYKALKRAN VIPGQWVTIs aCGGLGSLAI adhx_rat AKIDPSAPLD KVCLLGCGIS TGYGAAVnaK VEPGSTCAVF GLGGVGLAVI adh1_bacst VKIPDNLSFE EAAPIFCAGV TTYKALKVTG AKPGEWVAIY GIGGLGHVAV fadh_psepu LKLPDRDkiR DLTCLSDILP TGYHGAVTAG VGPGSTVYVA GAGPVGLAAA adha_rhime LPARLEFGPA APVLCAGV.. TVYKGLKETE VRPGEWVLVS GIGGLGHMAV adh2_yeast IPQGTDLAEV APILCAGI.. TVYKALKSAN LRAGHWAAIs aAGGLGSLAV adhx_mouse AKIDPSAPLD KVCLLGCGIS TGYGAAVnaK VEPGSTCAVF GLGGVGLAVI adh2_bacst AKIPDNLDPV EVAPILCAGV TTYKALKVSG ARPGEWVAIY GIGGLGHIAL adh3_bacst VKIPDNLSFE EAAPIFCAGV TTYKALKVTG AKPGEWVAIY GIGGLGHVAV adh1_yeast ..IPQGTDLA QVAPILCAGI TVYKALKSAN LMAGHWVAIs aAGGLGSLAV adh2_strca AKIDAAAPLD KVCLIGCGFS TGYGAAInaQ VEPGSTCAVF GLGGVGLSAV adh3_syny3 AKINPEANHE HVCLLGCGVT TGIGAVHnaK VQPGDSVAVF GLGGIGLAVV dhso_rat ..LPDSVTFE EGAL.IEPLS VGIYACRRGS VSLGNKVLVC GAGPIGIVTL xyl2_picst VKLPDHVSLE LGAL.VEPLS VGVHASKLGS VAFGDYVAVF GAGPVGLLAA adhh_gadmo ANVDPKAPLD KVCLLGCGIS TGYGAALnaK VEPGSTCAVF GLGAVGLAAI adhx_uroha TKINASAPLD KVCLLGCGVS TGYGAALnaK VEPGSTCAVF GLGGVGLAVI adhx_drome TKINEKAPLE KVCLLGCGIS TGYGAALnaK VEAGSTCAVW GLGAVGLAVG adhx_pea AKIHPDAPLD KVCLLGCGVP TGLGAVWnaK VEPGSIVAIF GLGTVGLAVA adhl_gadmo AKVHEKAPLD KVCLLGCAIS TGYGAALnaK VEAGSTCAVF GLGALGLAVI adh_macmu AKIDAASPME KVCLIGCGFS TGYGSAVkaK VTPGSTCAVF GLGGVGLSAV adhb_human IDAASPL..E KVCLIGCGFS TGYGSAVnaK VTPGSTCAVF GLGGVGLSAV adh1_allmi IDAAAPL..E KVCLIGCGFS TGYGAAvdAK VEPGSTCAVF GLGGVGLSTI adh3_ecoli AKINPEANHE HVCLLGCGVT TGIGAVHnaK VQPGDSVAVF GLGAIGLAVV adhp_rabit AKIDDDANLE RVCLIGCGFS TGYGAAInaK VTPGSTCAVF GLGGVGLSAI dhso_mouse ..LPDSVTFE EGAL.IEPLS VGIYACRRGS VSLGNKVLVC GAGPVGMVTL adha_human IDAASPL..E KVCLIGCGFS TGYGSAVnaK VTPGSTCAVF GLGGVGLSAI adhx_arath AKIDPTAPLD KVCLLGCGVP TGLGAVWnaK VEPGSNVAIF GLGTVGLAVA fah1_schpo VAISHSAPLR SICLLGCGVT TGFGAVtsAK VESGSTVAVV GCGCVGLAAM ydjl_ecoli WEIPDGVDYE DAAVLDPICN AYKSIAQQSK FLPGQDVVVI GTGPLGLFSV adha_perma AKIDGASPLE KVCLIGCGFS TGYGSAVkaK VTPGSTCAVF GLGGVGLSVI adhx_orysa AKINPQAPLD KVCLLGCGVS TGLGAVWnaK VEAGSIVAIF GLGTVGLAVA adh3_haein AKINPEANHE QVCLLGCGVT TGIGAVHnaK VQEGDSVAVF GLGAIGLAVV fadh_yeast VAIDPKAPLD AACLLGCGVT TGFGAALkaN VQKGDTVAVF GCGTVGLSVI adhx_myxgl CRVAPEAPPD RVCLLGCGVS TGYGAPLnaK VEPGSTCAIF GLGAVGLAAI adha_uroha VKIDAAAPLE KVCLIGCGFS TGYGAaeTAK VEPGSTCAVF GLGGVGLSAV adhx_caeel CKVNPEAPLE KVSLLGCGIS TGYGAVLNtk VEEGSTVAVW GLGAVGLAVI adha_rat IDAAAPL..D KVCLIGCGFS TGYGSAVqaK VTPGSTCAVF GLGGVGLSVV adh_maldo AKINPSAPLD KVCLLSCGIS TGLGATLnaK PKKGSTVAVF GLGAVGLAAA adhb_uroha VKIDASAPLE KVCLIGCGFS TGYGAAInaK VQPGSTCAVF GLGGVGLSAV adhp_ecoli ..VPDGLDSA AASSITCAGV TTYKAVKLSK IRPGQWIAIY GLGGLGNLAL adhx_maize AKINPQAPLD KVCLLGCGVP TGLGAVWnaK VESGSVVAVF GLGTVGLAVA adh_gadca AKIDPSAPLD TVCLLGCGVS TGFGAAVnaK VEPGSTCAVF GLGAVGLAAV adh1_rabit IDAAAPL..E KVCLIGCGFS TGYGSAVkaK VTPGSTCAVF GLGGVGLSVI adh7_rat AKIDAEAPPE KACLIGCGFS TGYGAAVkaK VSPGSTCAVF GLGGVGLSVV adh2_perma AKVDEDALLE KACIIGCGFA TGFGAAInaK VSPGSTCAVF GLGGVGLSVI 201 250 predict_h1020 AGARLCGATT IIAIDGNDHR LEIARKMGAD VVLNFRNCDV VDEVMKLTGG adh_alceu AGARLCGATT IIAIDGNDHR LEIARKMGAD VVLNFRNCDV VDEVMKLTGG adh_clobe AGAKLRGAGR IIGVGSRPIC VEAAKFYGAT DILNYKNGHI VDQVMKLTNG adh_thebr AGAKLRGAGR IIAVGSRPVC VDAAKYYGAT DIVNYKDGPI ESQIMNLTEG adh1_enthi AGANHLGAGR IFAVGSRKHC CDIALEYGAT DIINYKNGDI VEQILKATDG adh_mycpn AGAALKGAGR IIVVDSRPDI VEIAKAYGAT DYIDFKKVSV VDEILKWTNN fadh_metmr QSCWMLGAGR VIAIDRVPER LTMAQEHGKA EIIDFEEEDV YDRLMAMTNG dhso_bacsu AAAKAFGAGT IIVTDLEPLR LEAAKKMGAT HIINIREQDA LEEIKTITND ybdr_ecoli ACARLLGAEQ IFVVDHHPYR LHFAADRYGA IPINFDEddP AQSIIEQTAg dhso_yeast AVARAFGATD VIFVDVFDNK LQRAKDFGAT NTFNSSQfdL ADGVQKLLGG adh3_emeni QYAKAMGL.R TIAIDSGDEK KAMCEQLGAE VFIDFSKsdV VADVKAAtgG tdh_xancp GICKHIGARN VVVTDVNDFR LKLAADLGAT RVVNVSK.TS LKDVMADLHM tdh_ecoli AVAKHVGARN VVITDVNEYR LELARKMGIT RAVNVAKENL NDVMAELGMT fadh_amyme AGARLAGANK IIAVDRDAKK LEWATELGAT HTVNATETDV VEAVQALTGG adhp_human MGCKAAGASR IIGIDINSEK FVKAKALGAT DCLNPRdhKP IQEVIIELTK dhso_human LVAKAMGAAQ VVVTDLSATR LSKAKEIGAD LVLQISKESP QEIARKVEgg dhso_bachd QVAKSHGGTV IITGLSNDqr LKKAKEVGID YAIDTQEVDI KELVSELTDG dhso_bommo MSAKAMGASK IILTDVVQSR LDAALELGAD NVLLVRReeV VEKIVKLL.G terd_psesp MAAKLRGCSR IIVSEPSAAK REQALALGAT EVIDPLNENL VERVQQITEG fdeh_psepu LVAAASGAKD IIAIDHSPIR LDMARSLGAT ETISLADteR QRIVQERFGK tdh_bacsu AVAKAAGASQ VIAIDKNEYR LRLAKQMGAT CTVSIEKEDP LKIVSALTSG adh3_paspi QGARQAKAGR IFAIDTNPSK FELAKQFGAT DCINPNDYdp VQQVLVEMTK dhso_sheep LAAKAMGAAQ VVVTDLSASR LSKAKEVGAD FILEISNESP EEIAKKVEgg tdh_rhime MVAKRCGARK VVITDINPVR LDLARKLGID HVVDASKEKL ADVMRVIGMT adh_sulsr QIAKAVGGAT IIGVDVREEA VETAKRAGAD YVINASVQDP LAEIRRITEG adh5_yeast QYALAMGY.R VIGIDGGNAK RKLFEQLGGE IFIDFTEedI VGAIIKATNG adhx_rat MGCKVAGASR IIGIDINKDK FAKAKEFGAT ECINPQdsKS IQEVLIEMTD adh1_bacst QYAKAMGL.N VVAVDLGDEK LELAKQLGAD LVVNPKHDDA AQWIKEKVG. fadh_psepu ASARLLGAAV VIVGDLNPAR LAHAKAQGFE IADLSLDTPL HEQIAALLGE adha_rhime QYAKAMGM.H VAAADIFPDK LALAEKLGAD LVVDARAPDA VEEVQRRTG. adh2_yeast QYAKAMGY.R VLGIDGGPGK EELFTSLGGE VFIDFTKedI VSAVVKATNG adhx_mouse MGCKVAGASR IIGIDINKDK FAKAKEFGAS ECISPQdsKS IQEVLVEMTD adh2_bacst QYAKAMGL.N VVAVDISDEK SKLAKDLGAD IAINGLKEDP VKAIHDQVG. adh3_bacst QYAKAMGL.N VVAVDIGDEK LELAKELGAD LVVNPLKEDA AKFMKEKVG. adh1_yeast QYAKAMGY.R VLGIDGGEGK EELFRSIGGE VFIDFTKedI VGAVLKATDG adh2_strca MGCKAAGASK IFGIDINKDK FPLAKKLGAT DCLNPQDikP VQEIIAEMTN adh3_syny3 QGARQAKAGR IIAIDTNPAK FELAKQMGAT DCINPKDHdp IQQVIVEMTG dhso_rat LVAKAMGASQ VVVIDLSASR LAKAKEVGAD FTIQVAKETP HDIAKKVEsg xyl2_picst AVAKTFGAKG VIVVDIFDNK LKMAKDIGAA THTFNSKTGG SEELIKAFGG adhh_gadmo MGCKVAGATR IIGVDINPEK FGKAAEFGAT ECLNPKDhrP VQEVLVEMTD adhx_uroha MGCKVAGASR IIGIDLNKDK FAKAKEFGAT ECISPADfkP IQEVLIEMTD adhx_drome LGCKKAGAGK IYGIDINPDK FELAKKFGFT DFVNPKDvsI QNYLIDLTDG adhx_pea EGAKSAGASR IIGIDIDSNK YDTAKNFGVT EFINPKDhkP IQQVIIDLTD adhl_gadmo MGCQAAGASR IIAIDVNPDK FRIAKEFGAT DLVNPKDhkP VEQVLVEMTD adh_macmu MGCKAAGAAR IIAVDINKDK FAKAKELGAT ECINPQDykP IQEVLKEMTD adhb_human MGCKAAGAAR IIAVDINKDK FAKAKELGAT ECINPQDykP IQEVLKEMTD adh1_allmi MGCKAAGASR IIGIDINKDK FAKAKELGAT ECINPLDckP IQEVLSEMTG adh3_ecoli QGARQAKAGR IIAIDTNPKK FDLARRFGAT DCINPNDYdp IKDVLLDINK adhp_rabit MGCKTAGASR IIAIDINSDK FAKAKALGAT DCLNPRElkP VQDVIVEMTN dhso_mouse LVAKAMGAAQ VVVTDLSASR LTKAKEVGAD FTIQVGKETP QEIASKVEsg adha_human MGCKAAGAAR IIAVDINKDK FAKAKELGAT ECINPQDykP IQEVLKEMTD adhx_arath EGAKTAGASR IIGIDIDSKK YETAKKFGVN EFVNPKDHdp IQEVIVDLTD fah1_schpo QGAVAAGASR IIAIDINADK EVYAKKFGAT DFIDSSKvdL VQYVIDVTDG ydjl_ecoli QMARIMGAVN IVVVGLQEdr FPVAKELGAT AVVNGSTEDV VARCQQICGK adha_perma IGCKAAGAAR IIAVDINKDK FAKAKELGAT ECINPLDykP IQEVLQEMTD adhx_orysa EGAKSAGASR IIGIDIDSKK FDVAKNFGVT EFVNPKDHdp IQQVIVDLTD adh3_haein QGARQAKAGR IIAIDTNPAK FELAKQFGAT DCLNPNDYdp IKDVLLDINK fadh_yeast QGAKLRGASK IIAIDINNKK KQYCSQFGAT DFVNPKEdtI VEKLIEMTDG adhx_myxgl MGCRVAGASR IIAIDRNPDK FEKARIFGAt cVVPDASDKP ISQVLGEMTD adha_uroha MGCKAAGASR IIGVDINKDK FPKAKEMGAT ECVNPLDypI NEVLFDLTGG adhx_caeel MGAKAAGAKK IVGIDLIESK FESAKFFGAT ECINPKSVEl fQAWLVEQFD adha_rat IGCKTAGAAK IIAVDINKDK FAKAKELGAT DCINPQDykP IQEVLQEMTD adh_maldo EGARLSGASR IIGVDLHSDR FEEAKKFGVT EFVNPKAhkP VQEVIAELTN adhb_uroha MGCKAAGASR IIGIDINKEK FPKAKELGAT ECVNPLDypI NEVLFDMTDG adhp_ecoli QYAKNVFNAK VIAIDVNDEQ LKLATEMGAD LAINSHTEDA AKIVQEKTG. adhx_maize EGAKAAGASR VIGIDIDNKK FDVAKNFGVT EFVNPKEHdp IQQVLVDLTD adh_gadca MGCHSAGAKR IIAVDLNPDK FEKAKVFGAT DFVNPNDheP ISQVLSKMTN adh1_rabit MGCKAAGASR IIAVDINKDK FPKAKEVGAT ECINPQDykP IQEVIQEISD adh7_rat MGCKAAGASR IIGIDINKDK FQKALDVGAT ECINPRdtKP ISEVLSDMTG adh2_perma MGCKAAGAAR IIAVDTNKDK FAKAKTVGAT ECIDPQDfkP IQQVLFDMMN 251 300 predict_h1020 RGVDASIEAL GTQATFEQSL RVLKPGGTLS SLGVYSSDLT IPLSAFAAGL adh_alceu RGVDASIEAL GTQATFEQSL RVLKPGGTLS SLGVYSSDLT IPLSAFAAGL adh_clobe EGVDRVIMAG GGSETLSQAV SMVKPGGIIS NINYHGsaLL IPRVEWGCGM adh_thebr KGVDAAIIAG GNADIMATAV KIVKPGGTIA NVNYFGevLP VPRLEWGCGM adh1_enthi KGVDKVVIAG GDVHTFAQAV KMIKPGSDIG NVNYLGenID IPRSEWGVGM adh_mycpn EGVEKVLISG GGSTILETAI KVLRPGGKIG NVNYFGafLT IPRVEWGVGM fadh_metmr RGPDCCIDAV GCEavLREAI MCCRKGGTVS IPGVYVGLlq LPMgaMNKGL dhso_bacsu RGVDVAWETA GNPAALQSAL ASVRRGGKLA IVGLPSqpLN VPF......I ybdr_ecoli rGVDAVIDAV GFEaaLRQCI AAVRRGGIVS VPGVYAGFIH GFLfaFDKGL dhso_yeast NHADVVFECS GADVCIDAAV KTTKVGGTMV QVGMGKNYTN FPIAEV.SGK adh3_emeni LGAHAVILLA VAEKPFQQAT EYVRSHGSVV AIGL...... .PANAF.... tdh_xancp EGFDVGLEMS GNPRAFNDML DCMYHGGKIA MLGIMPRGAG CDWDKIikGL tdh_ecoli EGFDVGLEMS GAPPAFRTML DTMNHGGRIA MLGIPPSDMS IDWTKVikGL fadh_amyme FGADVVIDAV GRPETWKQAF YARDLAGTVV LVGVPTPdlE MPLLDFFSRG adhp_human GGVDFALDCA GGSETMKAAL DCTTAGwtFI GVAAGSKGLT IFPEELIIGR dhso_human CKPEVTIECT GAEASIQAGI YATRSGGTLV LVGLGSEMTT VPL..LHAAI dhso_bachd YGADVVLECS GAVPAAKQGI DLLRKKGQYA QVGLFAQ... .PEIQFneKI dhso_bommo DRPDVSIDAC GYGSAQRVAL LVTKTAGLVL VVGIADKTVE LPLSQAldVV terd_psesp QGCDYALECT GLVSVMEQAI DSMAMRGQLA VVGVPP.... .KLDATAAVS fdeh_psepu RGASLVVEAA GALPAFPEGV NLTGNHGRYV ILGLWGAIGT QPISPRDLTI tdh_bacsu EGADLVCEMS GHPSAIAQGL AMAANGGRFH ILSLPEHPVT IDLTN.KVVF adh3_paspi WGVDHTFECI GNVNVMRSAL ESAHRGWGQS viGVAGAGKE ISTRPFQLVT dhso_sheep SKPEVTIECT GVETSIQAGI YATHSGGTLV LVGLGSEMTS VPL..VHAAT tdh_rhime EGFDVGLEMS GAAPAFRDMI DKMNNGGKIA ILGIAPAGFE IDWNKVIFKM adh_sulsr KGVDAVIDLN NSEKTLSVYP KALAKQGKYI MVGLFGADLH FH..APLITL adh5_yeast .GSHGVINVS VSEAAIEAST RYCRPNGTVV LVGMPAhdTR EALDFFARGL adhx_rat GGVDFSFECI GNVKVMRSAL EAAHKGWGVS vvGVAASGEE ISTRPFQLVT adh1_bacst .GVHATVVTA VSKAAFESAY KSIRRGGACV LVGLPPEEIP IPI..FDTVL fadh_psepu PEVDCAVDAV GFEavLNSLM QVTRVAGKIG IPGLYVTEDP GAVDA.AAKI adha_rhime .GLHGALVTA VSPKAMEQAY SMLRSKGTMA LVGLPPGQIC LPV..FDTVL adh2_yeast .GAHGIINVS VSEAAIEAST RYCRANGTVV LVGLPAgdTR EALDFFARGL adhx_mouse GGVDYSFECI GNVKVMRSAL EAAHKGWGVS vvGVAASGEE ISTRPFQLVT adh2_bacst .GVHAAISVA VNKKAFEQAY QSVKRGGTLV VVGLPNADLP IPI..FDTVL adh3_bacst .GVHAAVVTA VSKPAFQSAY NSIRRGGACV LVGLPPEEMP IPI..FDTVL adh1_yeast .GAHGVINVS VSEAAIEAST RYVRANGTTV LVGMPAgdTR EALDFFARGL adh2_strca GGVDFAIECI GNPDVMKAAF ESTTVggTCV IVGVAVGEQS IPFSPMQLIM adh3_syny3 WGVDHSFECI GNVEVMRSAL ECAHRGWGQS viGVAGAGQE ISTRPFQLVT dhso_rat SKPEVTIECT GAESSVQDGI YATHSGGTLV VVGMGPEMIN LPL..VHAAV xyl2_picst NVPNVVLECT GAEPCIKLGV DAIAPGGRFV QVGNAAGPVS FPITVFayGF adhh_gadmo GGVDYSFECI GNVEIMRSAL EahKGWGESV IIGVAGAGQE IATRPFQLVT adhx_uroha GGVDYSFECI GNVGVMRAAL EACHKGWGVS vvGVAAAGQE IATRPFQLVT adhx_drome .GFDYTFECI GNVNTMRSAL EATHKGWGTS viGVAGAGQE ISTRPFQLVV adhx_pea GGVDYSFECL GNVSVMRSAL ecHKGWGTSV IVGVAASGQE ISTRPFQLVT adhl_gadmo GGVDYSFECV GNIAVMRAAL EahKGWGTSV IIGVAAAGQE ISTRPFQLVT adh_macmu GGVDFSFEVI GRLDTMMASL lcHEACGTSV IVGVPPDSQN LSINPMLLLT adhb_human GGVDFSFEVI GRLDTMMASL lcHEACGTSV IVGVPPASQN LSINPMLLLT adh1_allmi GGVDYSFEVI GRIDTMTAAL acQDNYGTSV IVGVPPASEK ITFNPMMLFT adh3_ecoli WGIDHTFECI GNVNVMRAAL ESAHRGWGQS viGVAVAGQE ISTRPFQLVT adhp_rabit GGVDFAIDCA GGSEVMKATV daTVGWGSCT FVGVNLADKG LTISPIELIL dhso_mouse SKPEVTIECT GAESSVQSGI YATHSGGTLV IVGMGAEMVN LPL..VHAAI adha_human GGVDFSFEVI GRLDTMMASL lcHEACGTSV IVGVPPDSQN LSMNPMLLLT adhx_arath GGVDYSFECI GNVSVMRAAL ecHKGWGTSV IVGVAASGQE ISTRPFQLVT fah1_schpo .GVDYAFDCT GNVTVMQQEL QfhKGWGKLC VIGVAAAGKT LDFRPFLVVT ydjl_ecoli DNLGLVIECS GANIALKQAI EMLRPNGEVV RVGMGFKPLD FSINDITAWN adha_perma GGVDFSFEVI GRLDTMTSSL LSCHASCGVS vvGVPPNAQS LSVNPMSLLM adhx_orysa GGVDYSFECI GNVSVMRSAL ecHKGWGTSV IVGVAASGQE ISTRPFQLVT adh3_haein WGIDHTFECI GNVNVMRQAL ESAHRGWGQS iiGVAGAGQE ISTRPFQLVT fadh_yeast .GLDFTFDCT GNTKIMRDAL EACHKGWGQS iiGVAAAGEE ISTRPFQLVT adhx_myxgl GGLDYTFECV GNVGIMRAAL ESCHKGWGVS vlGVAGGGQE ISTRPFQLVT adha_uroha EGVDYSFEVI GRTDTMTAAL acHMDYGTSI IVGLPPSASE ITFSPGLIFT adhx_caeel GGFDYTFECI GNVHTMRQAL EAAHKGWGVS ciGVAGAGQE IATRPFQLVT adha_rat GGVDFSFEVI GRLDTMTSAL LSCHSACGVS vvGVPPSAQS LSVNPMSLLL adh_maldo RGVDRSIECT GSTEAMISAF ECVHDGWGVA VLVGVPHKDA VFKTHPVNFL adhb_uroha EGVEYSFEVI GRTDTMTAAL acHNNYGTSV IVGVPPSASQ IAFDPLLLFT adhp_ecoli .GAHAAVVTA VAKAAFNSAV DAVRAGGRVV AVGLPPESMS LDIPRL.... adhx_maize GGVDYSFECI GNVSIMRAAL esDKGWGTSV IVGVAASGQE ISTRPFQLVT adh_gadca GGVDFSLECV GNVGVMRNAL ESCLKGWGVS VLVGWTDLHD VATRPIQLIA adh1_rabit GGVDFSFEVI GRLDTVVAAL lcHGACGTSV IVGVPPDSQS LTVNPM.LLL adh7_rat NTVQYTFEVI GRLETMVDAL SSCHMNYGTS VVVGAPPSAK MLSYDPMLLF adh2_perma DGADFTFEVT GNPETVETAL acHKDHGVCV IVGSLASWIQ LNINSHLFFS 301 350 predict_h1020 GDHKINTALC PGGKERMRRL INVIESGRVD LGALVTHQYR LDDIVAAYDL adh_alceu GDHKINTALC PGGKERMRRL INVIESGRVD LGALVTHQYR LDDIVAAYDL adh_clobe AHKTIKGGLC PGGRLRAEML RDMVVYNRVD LSKLVTHVyg FDHIEEALLL adh_thebr AHKTIKGGLC PGGRLRMERL IDLVFYKRVD PSKLVTHVFr fDNIEKAFML adh1_enthi GHKHIHGGLT PGGRVRMEKL ASLISTGKLD TSKLITHRfg LEKVEDALML adh_mycpn AHKAIHGGLM LGGRLRLEKL ARLIMTKKLD PSKMITHRfg FEHIEEALFL fadh_metmr TLKMGQTHV. ...QRYLEPL LEKIEEDQID PSFVITHSLG LDEGPQAYKT dhso_bacsu ADNEIDIYGI FRYANTYPKG IEFLASGIVD TKHLVTDQYS LEQTQDAMER ybdr_ecoli SFKMGQTHV. ...HAWLGEL LPLIEKGLLK PEEIVTHYMP FEEAARGYEI dhso_yeast EMKLIGCFRY SFGDYRD..A VNLVATGKVN VKPLITHKFK FEDAAKAYDY adh3_emeni ........LK APVFTTVVRM INIK...... .GSYVGNR.. .QDGVEALDF tdh_xancp TVQGIYGRKM YETWYKMTQL V....LSGFP LQKVLTHQLS IDEFQKGFDL tdh_ecoli FIKGIYGREM FETWYKMAAL I....QSGLD LSPIITHRFS IDDFQKGFDA fadh_amyme GALKSSWYGD CLPERDFPVL IDLHLQGRLP LDKFVTERIS LDDVEKAFHT adhp_human T...INGTFF GGWkdSIPKL VTDYKNKKFN LDALVTHTLP FDKISEAFDL dhso_human REVDIKGVFR YCNTWPV..A ISMLASKSVN VKPLVTHRFP LEKALEAFET dhso_bachd IQKEISVVGS RSQKPADwpA LSLLNEKKVN AKTLVTHEYT ISEWDKAYHA dhso_bommo GSFRIMNTY. .......QPA LAAVSSGAIP LDKFITHRFP LNKTKEALDL terd_psesp PLALIQKGL. ........KL MGVIesCRVY SSTSCTRSSR L......... fdeh_psepu KNMSIAGATF PKPKHYYQAM QLAArqDRYP LADLITQRFS IDEASKALEL tdh_bacsu KGLTIQGITG RKMFSTWRQV SQLISSNMID LAPVITHQFP LEEFEKGFEL adh3_paspi GRVWKGTAFg vKGRTQLPGM VEDAMSGKIE LAPFVTHTME LDKINEAFDL dhso_sheep REVDIKGVFR YCNTWPM..A ISMLASKSVN VKPLVTHRFP LEKALEAFET tdh_rhime LN..LKGIYG REMFETWYKM IAFV.QGGLD LSPIITHRIG IDDFRDGFEA adh_sulsr SEIQFVGSL. VGNQSDFLGI MRLAEAGKVK P..MITKTMK LEEANEAIDN adh5_yeast ....IKSPIH LAGLSDVPEI FAKMEKGEIV GRYVVETS.. .......... adhx_rat GRTWKGTAFG gkSVESVPKL VSEYMSKKIK VDEFVTGNLS FDQINKAFDL adh1_bacst NGVKIIGSI. VGTRKDLQEA LQFAAEGKVK TIVEVQPLEN INDVFDRMLK fadh_psepu GSLSIRFGLG WAKSHSFhaL MQAIMWDRIN IAEVVGVQvs LDDAPRGYGE adha_rhime KRITVRGSI. VGTRQDLEEA LEFAGEGKVA A......HFS WDKIENINAI adh2_yeast VKSPIKVV.. ..GLSSLPEI YEKMEKGQIA GRYVVDTS.. .......... adhx_mouse GRTWKGTAFG gkSVESVPKL VSEYMSKKIK VDEFVTGNLS FDQINQAFDL adh2_bacst NGVSVKGSI. VGTRKDMQEA LDFAARGKVR P...IVETAE LEEINEVFER adh3_bacst NGIKIIGSI. VGTRKDLQEA LQFAAEGKVK TIIEVQPLEK INEV...... adh1_yeast VKSPIKVV.. ..GLSTLPEI YEKMEKGQIV GRYVVDTS.. .......... adh2_strca G.RKIKATFF GGWkkSVPKL VSDYMAKKFD LDALVSHTLP LDKINDAFDL adh3_syny3 GRKWMGTAFg vKGRSQLPGM VEQSMRGEIQ LAPFVTHTME LKDINQAFDL dhso_rat REVDIKGVFR YCNTWPM..A VSMLASKTLN VKPLVTHRFP LEKAVEAFET xyl2_picst NDYKTAVGI. .....FDTNY QNGRENAPID FEQLITHRYK FKDAIEAYDL adhh_gadmo GRVWKATAFG gkSVESVPKL VEDYMNKKLK VDEFVTHTLP FDSINEGFDL adhx_uroha GRTWKGTAFG gkSVESVPKL VDEYMSKKMK VDEFVTHTLP FEQINEAFEL adhx_drome GRVWKGSAFG grSVSDVPKL VEDYLKKDLL VDEFITHELP LSQINEAFDL adhx_pea GRVWKGTAFG gkSRSQVPWL VEKYLKKEIK VDEYITHNLT LLEINKAFDL adhl_gadmo GRTWKGTAFG gkSVESVPKL VEEYMNKKVK VDEFVTHTLP FEKIHEGFDL adh_macmu GRtkGAVYGG FKSKEDIPKL VADFMAKKFS LDALITHVLP FEKINEGFDL adhb_human GRtkGAVYGG FKSKEGIPKL VADFMAKKFS LDALITHVLP FEKINEGFDL adh1_allmi GRTWKGSVFG gkSKESVPKL VADYMEKKIN LDGLITHTLP FDKINEGFEL adh3_ecoli GRVWKGSAFg vKGRSQLPGM VEDAMKGDID LEPFVTHTMS LDEINDAFDL adhp_rabit GRTLKGTNFG GWDAETVPKL VSDYKNGKFD LDALVTHTLP FDKINEALNL dhso_mouse REVDIKGVFR YCNTWPM..A ISMLASKTLN VKPLVTHRFP LEKAVEAFET adha_human GRTWKGAILG gkSKECVPKL VADFMAKKFS LDALITHVLP FEKINEGFDL adhx_arath GRVWKGTAFG gkSRTQVPWL VEKYMNKEIK VDEYITHNLT LGEINKAFDL fah1_schpo GRQVLGSAFg vKGRSELPNF VDEYMQGHFK VDEYITNEEP LKNINKAFDH ydjl_ecoli KSIIGHMAY. ..DSTSWRNA IRLLASGAIK VKPMITHRIG LSQWREGFDA adha_perma GRskGAIFGG FKSKDSVPKL VTDFMAKKFP LEPLITHVLP FEKINEAFDL adhx_orysa GRVWKGTAFG gkSRSQVPWL VEKYLNKEIK VDEYVTHSMN LTDINKAFDL adh3_haein GRVWKGSAFg vKGRSELPQM VEDSMKGDIQ LEPFVTHTMP LDKINEAFEL fadh_yeast GRVWKGSAFG gkGRSEMGGL IKDYQKGALK VEEFITHRRP FKEINQAFED adhx_myxgl GRTWKGAAFG gkSVESVPKL VDDYMAGKIM VDEFVSHSLP FDSINEAFDL adha_uroha GRTWKGSVFG gkSKDSVPRL VSDFMQKKFS LDPLITHTMP FDKINEGFEL adhx_caeel GRTWKGTAFG gkSVESVPRL VDDYMNKKLL IDEFITHRWN IDDINTAFDV adha_rat GRtkGAIFGG FKSKDAVPKL VADFMAKKFP LEPLITHVLP FEKINEAFDL adh_maldo NERTLKGTFF GNYKTRTdsV VEKYMNKELE LEKFITHKVP FSEINKAFEY adhb_uroha GRTWKGSVFG gkSKDAVPRL VSDFMGKKFI LDPLITHTMP FEKINEGFEL adhp_ecoli .......... .......... ...VLDGIEV VGSLVGTRQD LTEA....FQ adhx_maize GRVWKGTAFG gkSRTQVPWL VDKYMKKEIK VDEYITHNMN LADINDAFHL adh_gadca GRtkGSMFGG FKGKDGVPKM VKAYLDKKVK LDEFITHRMP LESVNDAIDL adh1_rabit SGRTWKGAIF GgsKDSVPKL VADFMAKKFS LDPLITNVLP FEKINEGFDL adh7_rat TGRTWKGCVF GGWKSRDdkL VTEFLEKKFD LGQLITHTLP FHNISEGFEL adh2_perma GRTLKGSVLG gkTKEEIPKL VSDYTAKKFN LDPLITHTLT LDKVNEAIQL 351 366 predict_h1020 FANQRDGVLK IAIKPH adh_alceu FANQRDGVLK IAIKPH adh_clobe MKDKPKDLIK AVV... adh_thebr MKDKPKDLIK PVV... adh1_enthi MKNKPADLIK PVVRIH adh_mycpn MKDKPKDLIK SVV... fadh_metmr FRDKEDGCIK VVLKP. dhso_bacsu ALQFKNECLK VMVYPN ybdr_ecoli FEKREEECRK VILVP. dhso_yeast NIAHGGEVVK TII... adh3_emeni FAR...GLIK APFK.. tdh_xancp MEEGKAGKVV LSWN.. tdh_ecoli MRSGQSGKV. ...... fadh_amyme M......... ...... adhp_human M.NQGKSVRT ILIFGR dhso_human F..KKGLGLK IMLK.. dhso_bachd IKS..GEAIK VLLTP. dhso_bommo AKS..GAAMK ILIH.. terd_psesp .......... ...... fdeh_psepu VKA..GALIK PVIDST tdh_bacsu MRSGQCGKV. ...... adh3_paspi MHDGK..... ...... dhso_sheep ..SKKGLGLK VMIK.. tdh_rhime MRSGNSGKVV M..... adh_sulsr LENFKAVGRQ VLI... adh5_yeast .......... ...... adhx_rat MhnSIRTVLK L..... adh1_bacst GQINGRVVLK V..... fadh_psepu FDA..GVPKK FVIDPH adha_rhime FERMEEGKID GRI... adh2_yeast .......... ...... adhx_mouse MhdSIRTVLK M..... adh2_bacst MEKGknGRIV LKLKED adh3_bacst ....FDRMLK GQINGR adh1_yeast .......... ...... adh2_strca MNAGK..... ...... adh3_syny3 MHDGK..... ...... dhso_rat ..AKKGLGLK VMIK.. xyl2_picst VRAGKGAV.. ...... adhh_gadmo MHAGK..... ...... adhx_uroha MHAGK..... ...... adhx_drome MHK....... ...... adhx_pea LHEGQ..... ...... adhl_gadmo MGAGK..... ...... adh_macmu LRSGK..... ...... adhb_human LHSGK..... ...... adh1_allmi LRTGK..... ...... adh3_ecoli MHEGK..... ...... adhp_rabit LDQGK..... ...... dhso_mouse ..AKKGVGLK VMIK.. adha_human LHSGK..... ...... adhx_arath LHE....... ...... fah1_schpo MHEGK..... ...... ydjl_ecoli M......VDK TAIK.. adha_perma LRAGK..... ...... adhx_orysa LHE....... ...... adh3_haein MHEGK..... ...... fadh_yeast LHN....... ...... adhx_myxgl MHAGK..... ...... adha_uroha LRAGK..... ...... adhx_caeel LHK....... ...... adha_rat LRAGK..... ...... adh_maldo MLK....... ...... adhb_uroha LRSGK..... ...... adhp_ecoli FAAEGKVVPK VALRP. adhx_maize LHE....... ...... adh_gadca MKHGK..... ...... adh1_rabit LRSGK..... ...... adh7_rat LYSGQ..... ...... adh2_perma MKNGQ..... ...... ________________________________________________________________________________ Result of COILS prediction (Andrei Lupas): ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ A Lupas: Methods in Enzymology, 1996, 266, 513-525. version 2.2: Rob B. Russell & Andrei N. Lupas, 1999 ________________________________________________________________________________ no coiled-coil above probability 0.5 ________________________________________________________________________________ PHD: Profile fed neural network systems from HeiDelberg ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Prediction of: secondary structure, by PHDsec solvent accessibility, by PHDacc and helical transmembrane regions, by PHDhtm Author: Burkhard Rost EMBL, 69012 Heidelberg, Germany Internet: Rost@EMBL-Heidelberg.DE All rights reserved. The network systems are described in: PHDsec: B Rost & C Sander: JMB, 1993, 232, 584-599. B Rost & C Sander: Proteins, 1994, 19, 55-72. PHDacc: B Rost & C Sander: Proteins, 1994, 20, 216-226. PHDhtm: B Rost et al.: Prot. Science, 1995, 4, 521-533. The resulting network (PHD) prediction is: ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ ________________________________________________________________________________ PHD: Profile fed neural network systems from HeiDelberg ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Prediction of: secondary structure, by PHDsec solvent accessibility, by PHDacc and helical transmembrane regions, by PHDhtm Author: Burkhard Rost EMBL, 69012 Heidelberg, Germany Internet: Rost@EMBL-Heidelberg.DE All rights reserved. The network systems are described in: PHDsec: B Rost & C Sander: JMB, 1993, 232, 584-599. B Rost & C Sander: Proteins, 1994, 19, 55-72. PHDacc: B Rost & C Sander: Proteins, 1994, 20, 216-226. PHDhtm: B Rost et al.: Prot. Science, 1995, 4, 521-533. Some statistics ~~~~~~~~~~~~~~~ Percentage of amino acids: +--------------+--------+--------+--------+--------+--------+ | AA: | G | A | L | V | I | | % of AA: | 11.7 | 11.2 | 8.2 | 7.7 | 7.7 | +--------------+--------+--------+--------+--------+--------+ | AA: | T | D | R | P | E | | % of AA: | 6.6 | 6.6 | 4.9 | 4.4 | 4.1 | +--------------+--------+--------+--------+--------+--------+ | AA: | S | K | N | Q | M | | % of AA: | 3.8 | 3.8 | 3.6 | 3.3 | 2.7 | +--------------+--------+--------+--------+--------+--------+ | AA: | Y | F | C | H | W | | % of AA: | 2.5 | 2.5 | 2.5 | 2.2 | 0.3 | +--------------+--------+--------+--------+--------+--------+ Percentage of secondary structure predicted: +--------------+--------+--------+--------+ | SecStr: | H | E | L | | % Predicted: | 22.1 | 26.8 | 51.1 | +--------------+--------+--------+--------+ According to the following classes: all-alpha: %H>45 and %E< 5; all-beta : %H<5 and %E>45 alpha-beta : %H>30 and %E>20; mixed: rest, this means that the predicted class is: mixed class PHD output for your protein ~~~~~~~~~~~~~~~~~~~~~~~~~~~ Wed May 22 09:32:45 2002 Jury on: 10 different architectures (version 5.94_317 ). Note: differently trained architectures, i.e., different versions can result in different predictions. About the protein ~~~~~~~~~~~~~~~~~ HEADER /home/phd/server/work/predict_h10291.fas COMPND SOURCE AUTHOR SEQLENGTH 366 NCHAIN 1 chain(s) in predict_h10291 data set NALIGN 63 (=number of aligned sequences in HSSP file) Abbreviations: PHDsec ~~~~~~~~~~~~~~~~~~~~~ sequence: AA : amino acid sequence secondary structure: HEL: H=helix, E=extended (sheet), blank=other (loop) PHD: Profile network prediction HeiDelberg Rel: Reliability index of prediction (0-9) detail: prH: 'probability' for assigning helix prE: 'probability' for assigning strand prL: 'probability' for assigning loop note: the 'probabilites' are scaled to the interval 0-9, e.g., prH=5 means, that the first output node is 0.5-0.6 subset: SUB: a subset of the prediction, for all residues with an expected average accuracy > 82% (tables in header) note: for this subset the following symbols are used: L: is loop (for which above " " is used) ".": means that no prediction is made for this residue, as the reliability is: Rel < 5 Abbreviations: PHDacc ~~~~~~~~~~~~~~~~~~~~~ SS : secondary structure HEL: H=helix, E=extended (sheet), blank=other (loop) solvent accessibility: 3st: relative solvent accessibility (acc) in 3 states: b = 0-9%, i = 9-36%, e = 36-100%. PHD: Profile network prediction HeiDelberg Rel: Reliability index of prediction (0-9) O_3: observed relative acc. in 3 states: B, I, E note: for convenience a blank is used intermediate (i). P_3: predicted relative accessibility in 3 states 10st:relative accessibility in 10 states: = n corresponds to a relative acc. of n*n % subset: SUB: a subset of the prediction, for all residues with an expected average correlation > 0.69 (tables in header) note: for this subset the following symbols are used: "I": is intermediate (for which above " " is used) ".": means that no prediction is made for this residue, as the reliability is: Rel < 4 Abbreviations: PHDhtm ~~~~~~~~~~~~~~~~~~~~~ secondary structure: HL: T=helical transmembrane region, blank=other (loop) PHD: Profile network prediction HeiDelberg PHDF:filtered prediction, i.e., too long transmembrane segments are split, too short ones are deleted Rel: Reliability index of prediction (0-9) detail: prH: 'probability' for assigning helical transmembrane region prL: 'probability' for assigning loop note: the 'probabilites' are scaled to the interval 0-9, e.g., prH=5 means, that the first output node is 0.5-0.6 subset: SUB: a subset of the prediction, for all residues with an expected average accuracy > 82% (tables in header) note: for this subset the following symbols are used: L: is loop (for which above " " is used) ".": means that no prediction is made for this residue, as the reliability is: Rel < 5 protein: predict length 366 ....,....1....,....2....,....3....,....4....,....5....,....6 AA |MTAMMKAAVFVEPGRIELADKPIPDIGPNDALVRITTTTICGTDVHILKGEYPVAKGLTV| PHD sec | HHHHHHHHH EEEEE EEEEEEEEE EE EEE| Rel sec |924578524324788187662459999984799999622114221112689789995476| detail: prH sec |046678656542100000000000000000000000000012333311000000000000| prE sec |000001232321001588774320000006789999754431111344110110002687| prL sec |952210000135888411125679999882100000245445544333788889997212| subset: SUB sec |L..HHHH.....LLL.EEEE..LLLLLLL.EEEEEEE...........LLLLLLLLL.EE| accessibility 3st: P_3 acc |beeebebbbbeeeeebebeebebbeeeeeebbbebbbbbbbbbbbbbbebeeeeebbbbb| 10st: PHD acc |077606000077777060660700777776000600000000000000707677700000| Rel acc |011071856201111104103000112001829170627571402021111000113476| subset: SUB acc |....b.bbb........b............b.b.b.b.bbb.b..............bbb| ....,....7....,....8....,....9....,....10...,....11...,....12 AA |GHEPVGIIEKLGSAVTGYREGQRVIAGAICPNFNSYAAQDGVASQDGSYLMASGQCGCHG| PHD sec |E EEEEEE E EEEE | Rel sec |146427986542342121389727651466566665454688689876225589999667| detail: prH sec |111110000112321100000000000000011122222110000111100000000111| prE sec |421237887653113454300157774211210000001000100001332200000000| prL sec |457541001124554434588731224677777776666788788886556788998777| subset: SUB sec |..L..EEEEE.........LLL.EEE..LLLLLLLL.L.LLLLLLLLL..LLLLLLLLLL| accessibility 3st: P_3 acc |bbebbbbbbbbbeebeebeebbebbbebbbeeeebeebeeeeeeeeeebbeeeeeeeeee| 10st: PHD acc |006000000000770670660060006000767706607777777777006777777666| Rel acc |720434190163305102101017540100100101011201100001010011121001| subset: SUB acc |b..b.b.b..b...b........bbb..................................| ....,....13...,....14...,....15...,....16...,....17...,....18 AA |YKATAGWRFGNMIDGTQAEYVLVPDAQANLTPIPDGLTDEQVLMCPDIMSTGFKGAENAN| PHD sec | EEEEEE EEEEEEE EEEEEE HHHHHH | Rel sec |776887134542145512478772111321236899754422465112333213432222| detail: prH sec |000001000000001111100011333233331000122221000001122345545411| prE sec |111111456665421245678874321222211000000124676443222222121233| prL sec |787887432223566643211113344544456899876543212445555432223355| subset: SUB sec |LLLLLL...E....LL...EEEE.........LLLLLL.....EE...............| accessibility 3st: P_3 acc |bebebebbbbbbbebbbbebbbbbebebbbbebeeebeeeebbbbbbbbbbbbebbeebe| 10st: PHD acc |060707000000070000600000706000060687077770000000000006006607| Rel acc |211111012010001033034341010112414012010006556211312410520152| subset: SUB acc |....................b.b.......b.b........bbbb......b..b...b.| ....,....19...,....20...,....21...,....22...,....23...,....24 AA |IRIGHTVAVFAQGPIGLCATAGARLCGATTIIAIDGNDHRLEIARKMGADVVLNFRNCDV| PHD sec | EEEEE HHHHHHHHHHHHH EEEEE HHHHHHHHH EEEE H| Rel sec |139974899717468899999999858845998328947899997249815414679947| detail: prH sec |010000000000278899989988861000000000068899998530011000110038| prE sec |430016898741000000000000000027898531000000000000146642100000| prL sec |459983100158621100000000128862001358831100001469832246789961| subset: SUB sec |..LLL.EEEE.L.HHHHHHHHHHHHHLL.EEEE..LL.HHHHHHH..LL.E...LLLL.H| accessibility 3st: P_3 acc |beebbebbbbbbbbbbbbbbbbbebbbbbbbbbbbbeeeebeebeebbbbebbeeeeeeb| 10st: PHD acc |077006000000000000000006000000000000677606607700006006697970| Rel acc |211100789564425676952591203420999610012102081214500440102021| subset: SUB acc |......bbbbbbb.bbbbbb.bb....b..bbbb.........b...bb..bb.......| ....,....25...,....26...,....27...,....28...,....29...,....30 AA |VDEVMKLTGGRGVDASIEALGTQATFEQSLRVLKPGGTLSSLGVYSSDLTIPLSAFAAGL| PHD sec |HHHHHHHH EEEEE HHHHHHHHHHHH EEEEE EEEE| Rel sec |999877881878826888347638999999999438918999727777643145221243| detail: prH sec |898888884110000000000258999999999631000000000011100001322321| prE sec |000111000000147888631000000000000000048999731100023421123455| prL sec |000000004888851101368731000000000368951000158787765566543222| subset: SUB sec |HHHHHHHH.LLLL.EEEE..LL.HHHHHHHHHH..LL.EEEEE.LLLLL....L......| accessibility 3st: P_3 acc |beebbeebeeebbebbbebbbeeebbebbbebbeeebebbbbbbbbeeeebbbeebbbbb| 10st: PHD acc |076007607770060006000667006000700779060000000077770006600000| Rel acc |210831110221202681413100461264131130003678650000012011031111| subset: SUB acc |...b...........bb.b.....bb..bb.........bbbbb................| ....,....31...,....32...,....33...,....34...,....35...,....36 AA |GDHKINTALCPGGKERMRRLINVIESGRVDLGALVTHQYRLDDIVAAYDLFANQRDGVLK| PHD sec |EEEEEEEEE HHHHHHHHHHH EEEEE HHHHHHHHHHHH EE| Rel sec |212342231678632269999999863756544211113716689999999924997268| detail: prH sec |000000000000134578999999873100001111001037789999999953000000| prE sec |545565554110000000000000000021236544443110000000000000001478| prL sec |343333334788765320000000126877762344455742110000000046998520| subset: SUB sec |.........LLLL...HHHHHHHHHH.LLLL........L.HHHHHHHHHHH..LLL.EE| accessibility 3st: P_3 acc |eeeeeebbbeeeeeeebeebbeebbeeebebeebbbbebebeebeebbebbeeeeeebbe| 10st: PHD acc |766667000677767706700760077706076000060606706700600777777006| Rel acc |010001201002012131256111121111411473202131140275034130230141| subset: SUB acc |...................bb.........b..bb........b..bb..b.......b.| ....,....37...,....38...,....39...,....40...,....41...,....42 AA |IAIKPH| PHD sec |EEEE | Rel sec |875359| detail: prH sec |000000| prE sec |886620| prL sec |112379| subset: SUB sec |EEE.LL| accessibility 3st: P_3 acc |bbbeee| 10st: PHD acc |000699| Rel acc |535215| subset: SUB acc |b.b..e| PHDhtm Helical transmembrane prediction note: PHDacc and PHDsec are reliable for water- soluble globular proteins, only. Thus, please take the predictions above with particular caution wherever transmembrane helices are predicted by PHDhtm! PHDhtm --- --- PhdTopology REFINEMENT AND TOPOLOGY PREDICTION: SYMBOLS --- AA : amino acid in one-letter code --- PHD htm : HTM's predicted by the PHD neural network --- system (T=HTM, ' '=not HTM) --- Rel htm : Reliability index of prediction (0-9, 0 is low) --- detail : Neural network output in detail --- prH htm : 'Probability' for assigning a helical trans- --- membrane region (HTM) --- prL htm : 'Probability' for assigning a non-HTM region --- note: 'Probabilites' are scaled to the interval --- 0-9, e.g., prH=5 means, that the first --- output node is 0.5-0.6 --- subset : Subset of more reliable predictions --- SUB htm : All residues for which the expected average --- accuracy is > 82% (tables in header). --- note: for this subset the following symbols are used: --- L: is loop (for which above ' ' is used) --- '.': means that no prediction is made for this, --- residue as the reliability is: Rel < 5 --- other : predictions derived based on PHDhtm --- PHDFhtm : filtered prediction, i.e., too long HTM's are --- split, too short ones are deleted --- PHDRhtm : refinement of neural network output --- PHDThtm : topology prediction based on refined model --- symbols used: --- i: intra-cytoplasmic --- T: transmembrane region --- o: extra-cytoplasmic --- --- PhdTopology REFINEMENT AND TOPOLOGY PREDICTION ....,....1....,....2....,....3....,....4....,....5....,....6 AA |MTAMMKAAVFVEPGRIELADKPIPDIGPNDALVRITTTTICGTDVHILKGEYPVAKGLTV| PHD htm | | Rel htm |999999999999999999999999999999999999999999999999999999999988| detail: prH htm |000000000000000000000000000000000000000000000000000000000000| prL htm |999999999999999999999999999999999999999999999999999999999999| PHDRhtm | | PHDThtm |oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo| subset: SUB htm |LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL| ....,....7....,....8....,....9....,....10...,....11...,....12 AA |GHEPVGIIEKLGSAVTGYREGQRVIAGAICPNFNSYAAQDGVASQDGSYLMASGQCGCHG| PHD htm | | Rel htm |899999999999999999999999999999999999999999999999999999999999| detail: prH htm |000000000000000000000000000000000000000000000000000000000000| prL htm |999999999999999999999999999999999999999999999999999999999999| PHDRhtm | | PHDThtm |oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo| subset: SUB htm |LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL| ....,....13...,....14...,....15...,....16...,....17...,....18 AA |YKATAGWRFGNMIDGTQAEYVLVPDAQANLTPIPDGLTDEQVLMCPDIMSTGFKGAENAN| PHD htm | | Rel htm |999999999999999999999999999999999999999999888765433223467777| detail: prH htm |000000000000000000000000000000000000000000000112233333211111| prL htm |999999999999999999999999999999999999999999999887766666788888| PHDRhtm | | PHDThtm |oooooooooooooooooooooooooooooooooooooooooooooooooooooooooooo| subset: SUB htm |LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL.....LLLLLL| ....,....19...,....20...,....21...,....22...,....23...,....24 AA |IRIGHTVAVFAQGPIGLCATAGARLCGATTIIAIDGNDHRLEIARKMGADVVLNFRNCDV| PHD htm | TTTTTTTTTTTTTTTTTTTTT | Rel htm |777765214567777777776665443114223678999999999999999999999999| detail: prH htm |111112357788888888888887776542333110000000000000000000000000| prL htm |888887642211111111111112223457666889999999999999999999999999| PHDRhtm | TTTTTTTTTTTTTTTTTT | PHDThtm |ooooooooTTTTTTTTTTTTTTTTTTiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiii| subset: SUB htm |LLLLLL..HHHHHHHHHHHHHHHHHH...L...LLLLLLLLLLLLLLLLLLLLLLLLLLL| ....,....25...,....26...,....27...,....28...,....29...,....30 AA |VDEVMKLTGGRGVDASIEALGTQATFEQSLRVLKPGGTLSSLGVYSSDLTIPLSAFAAGL| PHD htm | | Rel htm |999999999999999999999999999999999999888877777889999999999999| detail: prH htm |000000000000000000000000000000000000000011111000000000000000| prL htm |999999999999999999999999999999999999999988888999999999999999| PHDRhtm | | PHDThtm |iiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiii| subset: SUB htm |LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL| ....,....31...,....32...,....33...,....34...,....35...,....36 AA |GDHKINTALCPGGKERMRRLINVIESGRVDLGALVTHQYRLDDIVAAYDLFANQRDGVLK| PHD htm | | Rel htm |999999999999999999999999999999999999999999999999999999999999| detail: prH htm |000000000000000000000000000000000000000000000000000000000000| prL htm |999999999999999999999999999999999999999999999999999999999999| PHDRhtm | | PHDThtm |iiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiii| subset: SUB htm |LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL| ....,....37...,....38...,....39...,....40...,....41...,....42 AA |IAIKPH| PHD htm | | Rel htm |999999| detail: prH htm |000000| prL htm |999999| PHDRhtm | | PHDThtm |iiiiii| subset: SUB htm |LLLLLL| --- --- PhdTopology REFINEMENT AND TOPOLOGY PREDICTION END --- ________________________________________________________________________________ Result of ASP prediction(Malin Young, Kent Kirshenbaum, Stefan Highsmith) ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Kirshenbaum K, Young M and Highsmith S. Prot. Sci.(1999) 8:1806-1815. Young M, Kirshenbaum K, Dill KA and Highsmith S. Prot. Sci.(1999) 8:1752-1764. ________________________________________________________________________________ Ambivalent Sequence Predictor (ASP v1.0) mmy Parameters: Window size : 5 Min mu dPr : 9 Z-score cutoff : -1.75 Mean dPr score=12.884, Standard deviation=3.352 ....,....1....,....2....,....3....,....4....,....5....,....6 AA |MTAMMKAAVFVEPGRIELADKPIPDIGPNDALVRITTTTICGTDVHILKGEYPVAKGLTV| prH sec |046678656542100000000000000000000000000012333311000000000000| prE sec |000001232321001588774320000006789999754431111344110110002687| prL sec |952210000135888411125679999882100000245445544333788889997212| ASP sec |..........................................SSSSS.............| ....,....7....,....8....,....9....,....10...,....11...,....12 AA |GHEPVGIIEKLGSAVTGYREGQRVIAGAICPNFNSYAAQDGVASQDGSYLMASGQCGCHG| prH sec |111110000112321100000000000000011122222110000111100000000111| prE sec |421237887653113454300157774211210000001000100001332200000000| prL sec |457541001124554434588731224677777776666788788886556788998777| ASP sec |............SS..............................................| ....,....13...,....14...,....15...,....16...,....17...,....18 AA |YKATAGWRFGNMIDGTQAEYVLVPDAQANLTPIPDGLTDEQVLMCPDIMSTGFKGAENAN| prH sec |000001000000001111100011333233331000122221000001122345545411| prE sec |111111456665421245678874321222211000000124676443222222121233| prL sec |787887432223566643211113344544456899876543212445555432223355| ASP sec |........................SSSSSSS..................SSSSSSSSS..| ....,....19...,....20...,....21...,....22...,....23...,....24 AA |IRIGHTVAVFAQGPIGLCATAGARLCGATTIIAIDGNDHRLEIARKMGADVVLNFRNCDV| prH sec |010000000000278899989988861000000000068899998530011000110038| prE sec |430016898741000000000000000027898531000000000000146642100000| prL sec |459983100158621100000000128862001358831100001469832246789961| ASP sec |............................................................| ....,....25...,....26...,....27...,....28...,....29...,....30 AA |VDEVMKLTGGRGVDASIEALGTQATFEQSLRVLKPGGTLSSLGVYSSDLTIPLSAFAAGL| prH sec |898888884110000000000258999999999631000000000011100001322321| prE sec |000111000000147888631000000000000000048999731100023421123455| prL sec |000000004888851101368731000000000368951000158787765566543222| ASP sec |.......................................................SSSS.| ....,....31...,....32...,....33...,....34...,....35...,....36 AA |GDHKINTALCPGGKERMRRLINVIESGRVDLGALVTHQYRLDDIVAAYDLFANQRDGVLK| prH sec |000000000000134578999999873100001111001037789999999953000000| prE sec |545565554110000000000000000021236544443110000000000000001478| prL sec |343333334788765320000000126877762344455742110000000046998520| ASP sec |............................................................| ....,....37...,....38...,....39...,....40...,....41...,....42 AA |IAIKPH| prH sec |000000| prE sec |886620| prL sec |112379| ASP sec |......| Please note: ASP was designed to identify the location of conformational switches in amino acid sequences. It is NOT designed to predict whether a given sequence does or does not contain a switch. For best results, ASP should be used on sequences of length >150 amino acids with >10 sequence homologues in the SWISS-PROT data bank. ASP has been validated against a set of globular proteins and may not be generally applicable. Please see Young et al., Protein Science 8(9):1852-64. 1999. for details and for how best to interpret this output. We consider ASP to be experimental at this time, and would appreciate any feedback from our users. ________________________________________________________________________________ ________________________________________________________________________________ ----------------------------------------------------------------------------- - PredictProtein (PP): News 2000 - ----------------------------------------------------------------------------- - - - PP home: - New York http://cubic.bioc.columbia.edu/predictprotein/ - - - PP mirrors: - Australia Sydney http://molmod.angis.org.au/predictprotein/ Germany EMBL http://www.embl-heidelberg.de/predictprotein/ China CBI,Peking http://www.cbi.pku.edu.cn/predictprotein/ China Inst. 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