hmmpfam - search one or more sequences against HMM database HMMER 2.2g (August 2001) Copyright (C) 1992-2001 HHMI/Washington University School of Medicine Freely distributed under the GNU General Public License (GPL) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /disc9/DB/pfam/Pfam Sequence file: seq4.fa - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query sequence: gi|27545328|ref|NP_079026.2| Accession: [none] Description: leucine-rich repeat-containing 2 [Homo sapiens] Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- LRR Leucine Rich Repeat 93.9 1.6e-25 7 Recep_L_domain Receptor L domain -66.2 4.5 1 spectrin Spectrin repeat 0.8 4.6 1 Ribosomal_L10 Ribosomal protein L10 -48.0 5.4 1 3H 3H domain -54.7 6.1 1 FKBP FKBP-type peptidyl-prolyl cis-trans i -0.9 6.7 1 Ribosomal_S21 Ribosomal protein S21 -30.2 8.6 1 DUF41 Domain of unknown function DUF41 -81.3 8.8 1 Ribosomal_S3_N Ribosomal protein S3, N-terminal doma -1.0 9 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- FKBP 1/1 1 13 [. 98 111 .] -0.9 6.7 Ribosomal_S3_N 1/1 1 5 [. 1 5 [. -1.0 9 Ribosomal_S21 1/1 3 44 .. 1 54 [] -30.2 8.6 3H 1/1 35 133 .. 1 106 [] -54.7 6.1 DUF41 1/1 137 264 .. 1 247 [] -81.3 8.8 LRR 1/7 145 167 .. 1 25 [] 15.3 0.073 LRR 2/7 168 190 .. 1 25 [] 22.0 0.00071 LRR 3/7 191 214 .. 1 25 [] 16.6 0.03 Ribosomal_L10 1/1 211 307 .. 1 106 [] -48.0 5.4 LRR 4/7 215 237 .. 1 25 [] 3.3 9.9 Recep_L_domain 1/1 231 327 .. 1 132 [] -66.2 4.5 LRR 5/7 238 260 .. 1 25 [] 24.9 9.3e-05 LRR 6/7 261 283 .. 1 25 [] 8.4 2.7 LRR 7/7 284 306 .. 1 25 [] 3.5 9.6 spectrin 1/1 324 355 .. 62 91 .. 0.8 4.6 Alignments of top-scoring domains: FKBP: domain 1 of 1, from 1 to 13: score -0.9, E = 6.7 *->ppPnaTLvFeVELl<-* ++ ++++vF++ ++ gi|2754532 1 MG-HKVVVFDISVI 13 Ribosomal_S3_N: domain 1 of 1, from 1 to 5: score -1.0, E = 9 *->MGQKv<-* MG+Kv gi|2754532 1 MGHKV 5 Ribosomal_S21: domain 1 of 1, from 3 to 44: score -30.2, E = 8.6 *->pqIvVrENEpiesALRRFKRaveKaGiltEvRkRefYEkPtekRKrK ++vV F +v +a+ t v+k+ + k+ ++R K gi|2754532 3 HKVVV------------FDISVIRALWETRVKKHKAWQKKEVERLEK 37 kaaAkKr<-* +a k + gi|2754532 38 SALEKIK 44 3H: domain 1 of 1, from 35 to 133: score -54.7, E = 6.1 *->ialkHdverigeeleIIvrRhGgr...IvDvkyelPgfkeplkRnin ++k ++e i+ee + +r+++I y gf + +R ++ gi|2754532 35 -LEKSALEKIKEEWNFVAE---CRrkgIPQAVYCKNGFIDTSVRLLD 77 VsdmeEverFvkeLeenPkr.krsLerLYtLSgGGvHSHtIsAPDeetie + + r + + +r+krs + +LSg H+ + PD+ + gi|2754532 78 KIERNTLTRQSSLPK---DRgKRSSAFVFELSGE----HWTELPDSLKEQ 120 kierELkeeGiLl<-* +rE + L+ gi|2754532 121 THLREWYISNTLI 133 DUF41: domain 1 of 1, from 137 to 264: score -81.3, E = 8.8 *->lteeQLlstFsNvkhliGslevqnTnfkslsFLanLesIecgirkrn +t +QL+++++ + + ++ + l+ nL+++ g gi|2754532 137 PTYIQLFQAMRILDLPKNQISHLPAEIGCLK---NLKELNVG----- 175 kdrvrkildnihdnpfswidnqnmlelgllnlTnmtrlgLpilsnldlnk +++ ++i +p elg+ + n+ rl+ gi|2754532 176 FNYLKSI------PP----------ELGDCE--NLERLD----------- 196 LnlpnlknisnpnstgekiivnfenlhpdFClTteEllnfflnsnvsien C +El+ gi|2754532 197 ------------------------------CSGNLELM------------ 204 leakyCepksrifflikktdngivyklCnfkslsssvnLdngCtiIfGdL e ++ l n k+++ ++ gi|2754532 205 ------ELPF---------------ELSNLKQVT--------------FV 219 vIgpgdEe....yVskLknveviFGsLiIqNTnLtnidFLenLkyIasLe I+++++ + + V ++ n++ L I nLt + + I +Le gi|2754532 220 DISANKFSsvpiCVLRMSNLQW----LDISSNNLTDLP-----QDIDRLE 260 dsvs<-* + +s gi|2754532 261 ELQS 264 LRR: domain 1 of 7, from 145 to 167: score 15.3, E = 0.073 *->nLeeLdLsnNnLsGslPpesfgnLp<-* + LdL N++s +lP+e +g L+ gi|2754532 145 AMRILDLPKNQIS-HLPAE-IGCLK 167 LRR: domain 2 of 7, from 168 to 190: score 22.0, E = 0.00071 *->nLeeLdLsnNnLsGslPpesfgnLp<-* nL+eL++ +N L+ s+Ppe +g++ gi|2754532 168 NLKELNVGFNYLK-SIPPE-LGDCE 190 LRR: domain 3 of 7, from 191 to 214: score 16.6, E = 0.03 *->nLeeLdLsnN.nLsGslPpesfgnLp<-* nLe+Ld s+N L +lP e ++nL+ gi|2754532 191 NLERLDCSGNlELM-ELPFE-LSNLK 214 Ribosomal_L10: domain 1 of 1, from 211 to 307: score -48.0, E = 5.4 *->skaewKaeeVaeLselfkeyksvlI....vdydGvpvaQLqeiRk.. s+ ++ +++V+ + +f++ + ++++ ++ +++++ L+++ ++ gi|2754532 211 SNLKQ-VTFVDISANKFSSVPICVLrmsnLQWLDISSNNLTDLPQdi 256 .kLRgkavvlKvgKNTLirRAlkgageetpndelekledylkGptaiift ++L + + l +KN L+ ++ + l kl ++++ gi|2754532 257 dRLEELQSFL-LYKNKLTYLPYSMLN-------LKKLT-------LLVVS 291 kedpfelakvledfkk<-* ++++el+ +l d+ + gi|2754532 292 GDHLVELPTALCDSST 307 LRR: domain 4 of 7, from 215 to 237: score 3.3, E = 9.9 *->nLeeLdLsnNnLsGslPpesfgnLp<-* + ++ d+s N++s s+P +++ ++ gi|2754532 215 QVTFVDISANKFS-SVPICVLR-MS 237 Recep_L_domain: domain 1 of 1, from 231 to 327: score -66.2, E = 4.5 *->nctvveGnleistlipldpederllsFptlrEITgyLliiawnglet +c+ +++nl+ ++i + l +p+ + ++ +l++ gi|2754532 231 ICVLRMSNLQW-LDISSN----NLTDLPQDID--------RLEELQS 264 llslFpNLrvIRGrkLfegrekYALviyenydknsGLqeLgLrsLreIln +l L+ + k + y++ + L+ L L + + gi|2754532 265 FL-------------LYKN--KLTYLPYSMLN----LKKLTL----LVVS 291 GgVrIekNpkLCYvdT.IdWkdilfstpsqnvvldn<-* G+ ++e LC +T+ ++ +++ ++++ +d gi|2754532 292 GDHLVELPTALCDSSTpLKFVSLMDNPIDNAQCEDG 327 LRR: domain 5 of 7, from 238 to 260: score 24.9, E = 9.3e-05 *->nLeeLdLsnNnLsGslPpesfgnLp<-* nL++Ld+s+NnL+ +lP++ + L gi|2754532 238 NLQWLDISSNNLT-DLPQD-IDRLE 260 LRR: domain 6 of 7, from 261 to 283: score 8.4, E = 2.7 *->nLeeLdLsnNnLsGslPpesfgnLp<-* L++ L N+L+ lP s nL+ gi|2754532 261 ELQSFLLYKNKLT-YLPY-SMLNLK 283 LRR: domain 7 of 7, from 284 to 306: score 3.5, E = 9.6 *->nLeeLdLsnNnLsGslPpesfgnLp<-* +L+ L +s+ +L +lP ++++ + gi|2754532 284 KLTLLVVSGDHLV-ELPT-ALCDSS 306 spectrin: domain 1 of 1, from 324 to 355: score 0.8, E = 4.6 *->nelaqkLieegea..hpdseeikerleeLner<-* +e +++++e+ ++++h+d+e k+ +e+L er gi|2754532 324 CEDGNEIMESERDrqHFDKEVMKAYIEDLKER 355 //