hmmpfam - search one or more sequences against HMM database HMMER 2.2g (August 2001) Copyright (C) 1992-2001 HHMI/Washington University School of Medicine Freely distributed under the GNU General Public License (GPL) - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /disc9/DB/pfam/Pfam Sequence file: seq7.fa - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query sequence: gi|117147|sp|P00187|CP12_RABIT Accession: [none] Description: Cytochrome P450 1A2 (CYPIA2) (P450 isozyme 4) (P450-PM4) (P450 LM4) Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- p450 Cytochrome P450 552.8 1.1e-163 1 ISK_Channel Slow voltage-gated potassium channel -32.8 3 1 Leptin Leptin -0.8 4 1 DNA_pol_viral_C DNA polymerase (viral) C-terminal dom -2.5 4.8 1 Vir_DNA_binding Viral DNA-binding protein -1.9 5.5 1 Guanylin Guanylin precursor -44.5 6.1 1 Filo_VP35 Filoviridae VP35 -1.8 7.6 1 Lipase_2 Lipase (class 2) -145.9 8.6 1 Antibiotic_NAT Aminoglycoside 3-N-acetyltransferase -167.5 9.3 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- p450 1/1 42 512 .. 1 496 [] 552.8 1.1e-163 Guanylin 1/1 47 143 .. 1 121 [] -44.5 6.1 Filo_VP35 1/1 58 77 .. 264 282 .. -1.8 7.6 Leptin 1/1 73 108 .. 111 146 .] -0.8 4 Lipase_2 1/1 82 273 .. 1 269 [] -145.9 8.6 Vir_DNA_binding 1/1 121 134 .. 1 16 [. -1.9 5.5 Antibiotic_NAT 1/1 180 321 .. 1 253 [] -167.5 9.3 DNA_pol_viral_C 1/1 297 315 .. 1 19 [. -2.5 4.8 ISK_Channel 1/1 322 454 .. 1 129 [] -32.8 3 Alignments of top-scoring domains: p450: domain 1 of 1, from 42 to 512: score 552.8, E = 1.1e-163 *->PPgPpplPliGnllqlgrapgpiphsltklrkakrYGkpvftlylGp PgP+++Pl+G+ll lg+ +p+ l++l++ + YG +vf ++lG+ gi|117147| 42 LPGPWGWPLLGHLLTLGK--NPH-VALARLSR-R-YG-DVFQIRLGS 82 rpvVvltgpeavkevLidkgeeFakgRgdfnptfpwlskgyreqgllfs. +pvVvl+g +++k++L+++g++F gR+d+ ++ ++++g+ +++fs+ gi|117147| 83 TPVVVLSGLDTIKQALVRQGDDFK-GRPDL-YSSSFITEGQ---SMTFSp 127 dnGpkWrklRrFslltlrfHFgmGa....ysKrsqkleePriqeeardLv d+Gp+W ++Rr++ +l F++ a+++ +s s+ lee ++ +ea+ L+ gi|117147| 128 DSGPVWAARRRLAQDSLKS-FSI-AsnpaSS-SSCYLEE-HVSQEAENLI 173 erlrkeqa..gspiDitellarlaplnvIcsllFGvrfdylrpeDpeflk r+++ +a g + D++ l ++ vI++++FG+rf+ +e+l gi|117147| 174 GRFQELMAavGRF-DPYSQLV-VSAARVIGAMCFGRRFPQ---GSEEMLD 218 lidkllnemfdrvspwhqlldifPfLlrylpgslfrkafkaakd.lkdyl +++ + +++ ++ + + ++d+fP+L rylp++ +++fk+++ ++ +l gi|117147| 219 VVRN-SSKFV-ETASSGSPVDFFPIL-RYLPNR-PLQRFKDFNQrFLRFL 264 dklieerretlepagdpRrlDigflDslLleakreggnpk...selsdee +k ++e++e +++ +++ D ++ + L k ++n k +++ + e gi|117147| 265 QKTVREHYEDFDR-NSIQ--D--ITGA-LF--KHSEKNSKansGLIPQEK 306 laatvldllfAGteTTsstLswaLylLakhPevqaklreEideviGrdrs ++ v d+++AG++T +++Lsw+L +L+++P q+k++eE+d v+Gr+r+ gi|117147| 307 IVNLVNDIFGAGFDTITTALSWSLMYLVTNPRRQRKIQEELDAVVGRARQ 356 ptydvDaraqmPYLdAvIkEtLRlypvvPlllpRvatkDteiPdGylIPK p+++ D r+q+PYL+A+I E++R+ ++vP+++p+ +t+Dt++ +G++IPK gi|117147| 357 PRLS-D-RPQLPYLEAFILELFRHTSFVPFTIPHSTTRDTTL-NGFHIPK 403 GtlVivnlyslhrDpkvfpnPeeFdPeRFLdengk..fkk.syaflPFGa +++++n++ +++Dp+++ +PeeF+PeRFL+++g+ +k+ s++ FG gi|117147| 404 ECCIFINQWQINHDPQLWGDPEEFRPERFLTADGAaiNKPlSEKVTLFGL 453 GpRnClGerlArmElflfLatlLqrFPelelavpp.gdipsltpkpelgl G+R+C+Ge lAr+E+flfLa lLqr+ e++ vpp+ +++ ltp+ +gl gi|117147| 454 GKRRCIGETLARWEVFLFLAILLQRL-EFS--VPPgVPVD-LTPI--YGL 497 pskpply.kvqlrpa<-* ++k+p +++vq rp+ gi|117147| 498 TMKHPRCeHVQARPR 512 Guanylin: domain 1 of 1, from 47 to 143: score -44.5, E = 6.1 *->MnafllsaLcLsavAvvLl.....vlaqltqsVtiqygg.FsvqLeS ++ l++ +L + L+++++ +la l +yg+ F++ L S gi|117147| 47 --GWPLLG-HL----LTLGknphvALARLSR----RYGDvFQIRLGS 82 ..VKKLkdLeEvqepssprlqkqalqPskPvvPalCsnpalPedLqPvCe ++V L+ L ++++ +++ +++ +P +l +++ + + q gi|117147| 83 tpVVVLSGLDTIKQALVRQGDDFKGRP------DL-YSSSFITEGQSMTF 125 speAasIlqaLrtIaqDdsTCElCvnvACTGC<-* sp++ + a r +aqD gi|117147| 126 SPDSGPVWAARRRLAQDS-------------- 143 Filo_VP35: domain 1 of 1, from 58 to 77: score -1.8, E = 7.6 *->GdsaQaALirlskrv.diFl<-* G ++ AL rls+r +d+F+ gi|117147| 58 GKNPHVALARLSRRYgDVFQ 77 Leptin: domain 1 of 1, from 73 to 108: score -0.8, E = 4 *->ggvLEAslYstEvvALsRLqgsLqDmLrqLDlsPgC<-* g+v l st vv Ls L q ++rq D g gi|117147| 73 GDVFQIRLGSTPVVVLSGLDTIKQALVRQGDDFKGR 108 Lipase_2: domain 1 of 1, from 82 to 273: score -145.9, E = 8.6 *->ndPvifvHGnSDs...ALkt.nglaatgwskllqyFleqGYtkgelY ++Pv++ G+ D+ ++AL + + + ++++ ++ F+ +G++ gi|117147| 82 STPVVVLSGL-DTikqALVRqGDDFKGRPDLYSSSFITEGQSM---- 123 aTTwgdtntltsleraeysmkCeyVkriRkfieAVlgYTGaakVDIiahS +++++++ + +r++ ++ +++f +A gi|117147| 124 TFSPDSGPVWAARRRLA-----QD--SLKSFSIA------S--------- 151 mGvpWiARKAIlGGkvnCvaDtnedLGppLtslVdTfvs....vaGaNyG +p + ++++L++ ++++ ++ +++ +++ a G gi|117147| 152 --NP------------ASS--SSCYLEEHVSQEAENLIGrfqeLM-AAVG 184 iclCalpdsvPCratCgflfpiCvNmvnGLnPGtCpaltnglcsksplps + +++ ++++ +v+G + C gi|117147| 185 RFDPYSQL----VVSA--------ARVIGAM---C--------------- 204 Pccgqt..kySkFLqDI..NaspkyEgkyvfsIwSkaDeviGPYkgrmvC +g + +S+ + D +N+s++ +++s S++D+ ++ r gi|117147| 205 --FGRRfpQGSEEMLDVvrNSSKF---VETASSGSPVDFFPI---LRYLP 246 GkptseIPgsdgkkiydllnHdqvkdlTaedQfk<-* +p ++ ++++ ++l +T+ ++ gi|117147| 247 NRPLQRFKDFNQRF-LRFL------QKTVREHYE 273 Vir_DNA_binding: domain 1 of 1, from 121 to 134: score -1.9, E = 5.5 *->anfkllPdqgTLevyk<-* +++++ Pd+g v++ gi|117147| 121 QSMTFSPDSG--PVWA 134 Antibiotic_NAT: domain 1 of 1, from 180 to 321: score -167.5, E = 9.3 *->MvHaSlsAVGpVeGGPqtvIdALrDaVGptGTllvyasWndasDPsP + AVG+ q v++A r ++G+ ++ ++ gi|117147| 180 -----MAAVGRFDPYSQLVVSAAR-VIGA------MCFGRR------ 208 YeltdwPdawqdaiReswPAFDPatSpAtrgnGvlpEfLrryPgakRSaH ++ + +++ d++R s + f ++ gi|117147| 209 --FPQGSEEMLDVVRNS------------------SKFVETA-------- 230 PDaSfvAvGpqAakLtadHplddphGpgSPLARLvalgGkVLLLGAPlDt + gSP+ + +l gi|117147| 231 -------------------------SSGSPVDFFPILR------------ 243 vTlLHhAEalAdipgKRfVtYeqPilGvdGkrVWrtfediDsndelfddY +l p Rf++ q +l k+V++ +ed+D n + gi|117147| 244 --------YLPNRPLQRFKDFNQRFLRFLQKTVREHYEDFDRNSI----- 280 srvvpegpdafegIardylAagigrrGiVGaAdsrLfdAadivdFgveWl + I ++ ++ A+s L+ iv+ + gi|117147| 281 -----------QDITGALFKHSEKNS----KANSGLIPQEKIVNLVNDIF 315 Ekrfga<-* + f + gi|117147| 316 GAGFDT 321 DNA_pol_viral_C: domain 1 of 1, from 297 to 315: score -2.5, E = 4.8 *->gskgvlpqekrvkklktvl<-* +g pqek+v+ + ++ gi|117147| 297 ANSGLIPQEKIVNLVNDIF 315 ISK_Channel: domain 1 of 1, from 322 to 454: score -32.8, E = 3 *->milpnatavlPFLt..kLwqEtaeqgGnvsgLARrsplsdDgklEAL + + + + + +t+++ + e v g AR+ +lsd +l L gi|117147| 322 ITTALSWSLMYLVTnpRRQRKIQEELDAVVGRARQPRLSDRPQLPYL 368 ..YiLmvLGFFGFFtLGimLsYiRskKLEHshDPFnvYiEsdaWqEKdkA + +iL F i s R L h P i ++Wq gi|117147| 369 eaFILELFRHTSFVPFTIPHSTTRDTTLNGFHIPKECCIFINQWQINHDP 418 yfqARvLEsfRaCYvvEnqlAvEqPdtHLPElKPsl<-* + E + +A+ +P l + gi|117147| 419 QLWGDPEEFRPERFLTADGAAINKPLSEKVTLFGLG 454 //