PDB: 1hs6 Compound: leukotriene a-4 hydrolase Classification: HYDROLASE Entry date in PDB: 2001-06-24 Resolution [Å]: 1.95 R-Factor: 0.185

CHAIN: A SWISS-PROT/TREMBL: P09960    KEYWORD: 3D-structure    Hydrolase    Leukotriene biosynthesis    Metal-binding    Metalloprotease    Multifunctional enzyme    Zinc    EC: 3.3.2.6 SCOP: a.118.1.7 All alpha proteins    alpha-alpha superhelix    ARM repeat    Leukotriene A4 hydrolase C-terminal domain    Leukotriene A4 hydrolase C-terminal domain    Human (Homo sapiens) SCOP: b.98.1.1 All beta proteins    Leukotriene A4 hydrolase N-terminal domain    Leukotriene A4 hydrolase N-terminal domain    Leukotriene A4 hydrolase N-terminal domain    Leukotriene A4 hydrolase N-terminal domain    Human (Homo sapiens) SCOP: d.92.1.13 Alpha and beta proteins (a+b)    Zincin-like    Metalloproteases ("zincins"), catalytic domain    Leukotriene A4 hydrolase catalytic domain    Leukotriene A4 hydrolase catalytic domain    Human (Homo sapiens) GO:  membrane alanyl aminopeptidase activity    metallopeptidase activity    zinc ion binding    proteolysis and peptidolysis

Image Source: PDB

Loops in ArchDB40 clusters

1hs6_A_400 - HE => SUBCLASS : 2.7.3
1hs6_A_209 - HA => SUBCLASS : 2.2.1
1hs6_A_16 - HA => SUBCLASS : 4.1.6
1hs6_A_417 - EH => SUBCLASS : 1.1.2
1hs6_A_306 - EH => SUBCLASS : 1.3.1
1hs6_A_86 - AR => SUBCLASS : 3.3.1
1hs6_A_86 - AR => SUBCLASS : 3.5.4
1hs6_A_186 - AR => SUBCLASS : 4.2.1
1hs6_A_49 - AR => SUBCLASS : 5.30.1
1hs6_A_257 - AR => SUBCLASS : 7.6.1
1hs6_A_564 - HH => SUBCLASS : 1.1.12
1hs6_A_581 - HH => SUBCLASS : 2.1.19
1hs6_A_436 - HH => SUBCLASS : 2.1.22
1hs6_A_532 - HH => SUBCLASS : 2.2.4
1hs6_A_381 - HH => SUBCLASS : 2.6.2
1hs6_A_550 - HH => SUBCLASS : 3.4.2

Loops in ArchDB95 clusters

1hs6_A_306 - EH => SUBCLASS : 2.1.2
1hs6_A_86 - AR => SUBCLASS : 2.3.2
1hs6_A_49 - AR => SUBCLASS : 6.8.2
1hs6_A_257 - AR => SUBCLASS : 7.26.1
1hs6_A_564 - HH => SUBCLASS : 1.2.25
1hs6_A_581 - HH => SUBCLASS : 2.1.20
1hs6_A_532 - HH => SUBCLASS : 2.2.3
1hs6_A_532 - HH => SUBCLASS : 2.2.12
1hs6_A_581 - HH => SUBCLASS : 2.3.12
1hs6_A_436 - HH => SUBCLASS : 2.3.21
1hs6_A_381 - HH => SUBCLASS : 2.6.2
1hs6_A_550 - HH => SUBCLASS : 3.3.2
1hs6_A_400 - HE => SUBCLASS : 2.12.1
1hs6_A_209 - HA => SUBCLASS : 2.2.1
1hs6_A_16 - HA => SUBCLASS : 4.1.5

Loops in ArchDB-EC clusters

1hs6_A_550 - HH => SUBCLASS : 3.4.1

Loops not clustered in ArchDB

1hs6_A_99 - AR
1hs6_A_86 - AR
1hs6_A_33 - AR
1hs6_A_33 - AR
1hs6_A_99 - AR
1hs6_A_130 - AR
1hs6_A_154 - AR
1hs6_A_167 - AR
1hs6_A_186 - AR
1hs6_A_130 - AR
1hs6_A_167 - AR
1hs6_A_154 - AR
1hs6_A_257 - AR
1hs6_A_69 - AR
1hs6_A_49 - AR
1hs6_A_69 - AR
1hs6_A_218 - EH
1hs6_A_275 - EH
1hs6_A_115 - HA
1hs6_A_73 - HA
1hs6_A_204 - HA
1hs6_A_209 - HA
1hs6_A_269 - HA
1hs6_A_59 - HA
1hs6_A_73 - HA
1hs6_A_16 - HA
1hs6_A_269 - HA
1hs6_A_204 - HA
1hs6_A_173 - HA
1hs6_A_173 - HA
1hs6_A_115 - HA
1hs6_A_59 - HA
1hs6_A_291 - HE
1hs6_A_237 - HE
1hs6_A_496 - HH
1hs6_A_444 - HH
1hs6_A_421 - HH
1hs6_A_314 - HH
1hs6_A_374 - HH
1hs6_A_335 - HH
1hs6_A_224 - HH
1hs6_A_514 - HH
1hs6_A_466 - HH

1gw6 A - percentage of sequence identity: 99
1h19 A - percentage of sequence identity: 99
1sqm A - percentage of sequence identity: 99