PDB: 1r49 Compound: DNA topoisomerase i Classification: ISOMERASE/DNA Entry date in PDB: 2003-12-16 Resolution [Å]: 3.13 R-Factor: 0.280

CHAIN: A SWISS-PROT/TREMBL: P11387    KEYWORD: 3D-structure    Chromosomal translocation    DNA-binding    Isomerase    Polymorphism    Proto-oncogene    Topoisomerase    EC: 5.99.1.2 SCOP: a.2.8.1 All alpha proteins    Long alpha-hairpin    Eukaryotic DNA topoisomerase I, dispensable insert domain    Eukaryotic DNA topoisomerase I, dispensable insert domain    Eukaryotic DNA topoisomerase I, dispensable insert domain    Human (Homo sapiens) SCOP: d.163.1.2 Alpha and beta proteins (a+b)    DNA breaking-rejoining enzymes    DNA breaking-rejoining enzymes    Eukaryotic DNA topoisomerase I, catalytic core    Eukaryotic DNA topoisomerase I, catalytic core    Human (Homo sapiens) SCOP: d.163.1.2 Alpha and beta proteins (a+b)    DNA breaking-rejoining enzymes    DNA breaking-rejoining enzymes    Eukaryotic DNA topoisomerase I, catalytic core    Eukaryotic DNA topoisomerase I, catalytic core    Human (Homo sapiens) SCOP: e.15.1.1 Multi-domain proteins (alpha and beta)    Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment    Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment    Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment    Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment    Human (Homo sapiens) GO:  DNA binding    DNA topoisomerase type I activity    DNA topological change    DNA unwinding

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1a31 A - percentage of sequence identity: 99
1k4t A - percentage of sequence identity: 99