ArchDB - Biological DataBase of Protein Loops

Information on SUBCLASS 12.2.2

Subclass Accession number: 7675
Subclass: 12.2.2

Type: EH beta-alpha
DB: ArchDB-EC

Image coordinates:

Consensus coordinates:

Conserved Annotation
EC : 1.7 (>50 %)  1.7.99 (>50 %)  1.7.99.4
GO : GO:0008940 (>50 %)  GO:0016661 (>50 %)  GO:0030151 (>75 %)  GO:0046914 (>75 %)
SCOP : 53705 (>75 %)  53706 (>75 %)  53707 (>75 %)

Number of loops: 3

Average sequence ID (%) : 25.3 +/- 17.4
Average RMSD (Å) : 0.733 +/- 0.058

Consensus geometry

d (Å): 13

delta (°): 45-90

theta (°): 45-90

rho (°): 90-135

Consensus Sequence:	hXpXhhDPhhphXXph
(φψ)-conformation:	bbppabpppeapbpaa

Pattern:	[FR]	[IY]	[HRS]	[LP]	x	[ES]	[AK]	[AF]	[MV]	[D]	[P]	[AP]	[GW]	[EQT]	[AC]	[KMR]	[APS]	[DT]	[CVW]	x	[IT]	[ALY]	[AKV]	[AER]	[FI]	[A]	[KNR]	[AKR]	[AFL]
Conservation:	-0.501	-0.044	-0.481	-0.682	-0.785	0.269	-0.049	-0.431	0.419	2.636	3.320	0.498	0.553	-0.329	0.452	-0.329	-0.481	0.332	-0.557	-1.241	-0.224	-0.937	-0.937	-0.709	0.182	1.268	0.051	-0.405	-0.861

Loops included in this Subclass

Loop	PDB	Chain	Start	End	Sequence	Sec Struct	Ramachandran
1g8k_A_546	1g8k	A	546	574	RIRLSEKFMDPPGTAMADCLIAARIANAL	EEEEE---S--STT-B-HHHHHHHHHHHH	xxbbxxxNbxwxeaxbpaaaaaaaaaaaa
1q16_A_805	1q16	A	805	833	FIHPLSAAVDPAWEAKSDWEIYKAIAKKF	EEEEE--SS--STT-B-HHHHHHHHHHHH	bbbbbbxabppxeaxbxaaaaaaaaaaaa
2nap_A_477	2nap	A	477	505	RYSLTEKAVDPPGQCRPTVNTLVEFARRA	EEEEE---S---TT-B-HHHHHHHHHHHH	xbbxbxxabxxxeaxbxaaaaaaaaaaaa

PDB ligands within a cut-off distance of 6 Å in this subclass

Loop	PDB	Chain	Ligands	Residue
1g8k_A_546	1g8k	A	EDO1,2-ETHANEDIOL	R - 546
1g8k_A_546	1g8k	A	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	D - 563
2nap_A_477	2nap	A	MGD2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE	T - 494

Clusters included in this Subclass