PDB: 1a4i Compound: methylenetetrahydrofolate dehydrogenase methenylte Classification: OXIDOREDUCTASE Entry date in PDB: 1999-02-09 Resolution [Å]: 1.50 R-Factor: 0.199

CHAIN: A SWISS-PROT/TREMBL: P11586    KEYWORD: 3D-structure    Amino-acid biosynthesis    ATP-binding    Disease mutation    Histidine biosynthesis    Hydrolase    Ligase    Methionine biosynthesis    Multifunctional enzyme    NADP    One-carbon metabolism    Oxidoreductase    Polymorphism    Purine biosynthesis    EC: 1.5.1.5 SCOP: c.2.1.7 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    Aminoacid dehydrogenase-like, C-terminal domain    Methylenetetrahydrofolate dehydrogenase/cyclohydrolase    Human (Homo sapiens) SCOP: c.58.1.2 Alpha and beta proteins (a/b)    Aminoacid dehydrogenase-like, N-terminal domain    Aminoacid dehydrogenase-like, N-terminal domain    Tetrahydrofolate dehydrogenase/cyclohydrolase    Tetrahydrofolate dehydrogenase/cyclohydrolase    Human (Homo sapiens) GO:  ATP binding    catalytic activity    formate-tetrahydrofolate ligase activity    folic acid and derivative biosynthesis    CHAIN: B SWISS-PROT/TREMBL: P11586    KEYWORD: 3D-structure    Amino-acid biosynthesis    ATP-binding    Disease mutation    Histidine biosynthesis    Hydrolase    Ligase    Methionine biosynthesis    Multifunctional enzyme    NADP    One-carbon metabolism    Oxidoreductase    Polymorphism    Purine biosynthesis    EC: 1.5.1.5 SCOP: c.2.1.7 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    Aminoacid dehydrogenase-like, C-terminal domain    Methylenetetrahydrofolate dehydrogenase/cyclohydrolase    Human (Homo sapiens) SCOP: c.58.1.2 Alpha and beta proteins (a/b)    Aminoacid dehydrogenase-like, N-terminal domain    Aminoacid dehydrogenase-like, N-terminal domain    Tetrahydrofolate dehydrogenase/cyclohydrolase    Tetrahydrofolate dehydrogenase/cyclohydrolase    Human (Homo sapiens) GO:  ATP binding    catalytic activity    formate-tetrahydrofolate ligase activity    folic acid and derivative biosynthesis

Image Source: PDB

Loops in ArchDB40 clusters

1a4i_A_5 - EH => SUBCLASS : 2.2.3
1a4i_A_37 - EH => SUBCLASS : 3.2.2
1a4i_A_66 - EH => SUBCLASS : 5.1.2

Loops in ArchDB95 clusters

1a4i_A_5 - EH => SUBCLASS : 2.2.2
1a4i_A_37 - EH => SUBCLASS : 3.5.3
1a4i_A_66 - EH => SUBCLASS : 4.2.2
1a4i_A_178 - HE => SUBCLASS : 1.1.1
1a4i_A_47 - HE => SUBCLASS : 1.1.1
1a4i_A_202 - HE => SUBCLASS : 2.2.5
1a4i_A_258 - HE => SUBCLASS : 2.3.3
1a4i_A_258 - HE => SUBCLASS : 2.3.16
1a4i_A_78 - HE => SUBCLASS : 5.34.1

Loops in ArchDB-EC clusters

1a4i_A_78 - HE => SUBCLASS : 5.5.2

Loops not clustered in ArchDB

1a4i_A_96 - EH
1a4i_A_167 - EH
1a4i_A_191 - EH
1a4i_A_232 - EH
1a4i_A_267 - EH
1a4i_A_211 - HA
1a4i_A_211 - HA
1a4i_A_147 - HE
1a4i_A_9 - HE
1a4i_A_111 - HH
1a4i_A_129 - HH

1a4i A - percentage of sequence identity: 100
1a4i B - percentage of sequence identity: 100
1dia A - percentage of sequence identity: 100
1dia B - percentage of sequence identity: 100
1dib A - percentage of sequence identity: 100
1dib B - percentage of sequence identity: 100
1dig A - percentage of sequence identity: 100
1dig B - percentage of sequence identity: 100