PDB: 1hyh Compound: l-2-hydroxyisocaproate dehydrogenase Classification: OXIDOREDUCTASE (CHOH(D)-NAD+(A)) Entry date in PDB: 1995-10-15 Resolution [Å]: 2.20 R-Factor: 0.210

CHAIN: A SWISS-PROT/TREMBL: P14295    KEYWORD: 3D-structure    NADP    Oxidoreductase    EC: 1.1.1.- SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    L-2-hydroxyisocapronate dehydrogenase, L-HICDH    Lactobacillus confusus SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    L-2-hydroxyisocapronate dehydrogenase, L-HICDH    Lactobacillus confusus GO:  cytoplasm    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism    CHAIN: B SWISS-PROT/TREMBL: P14295    KEYWORD: 3D-structure    NADP    Oxidoreductase    EC: 1.1.1.- SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    L-2-hydroxyisocapronate dehydrogenase, L-HICDH    Lactobacillus confusus SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    L-2-hydroxyisocapronate dehydrogenase, L-HICDH    Lactobacillus confusus GO:  cytoplasm    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism    CHAIN: C SWISS-PROT/TREMBL: P14295    KEYWORD: 3D-structure    NADP    Oxidoreductase    EC: 1.1.1.- SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    L-2-hydroxyisocapronate dehydrogenase, L-HICDH    Lactobacillus confusus SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    L-2-hydroxyisocapronate dehydrogenase, L-HICDH    Lactobacillus confusus GO:  cytoplasm    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism    CHAIN: D SWISS-PROT/TREMBL: P14295    KEYWORD: 3D-structure    NADP    Oxidoreductase    EC: 1.1.1.- SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    L-2-hydroxyisocapronate dehydrogenase, L-HICDH    Lactobacillus confusus SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    L-2-hydroxyisocapronate dehydrogenase, L-HICDH    Lactobacillus confusus GO:  cytoplasm    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism

Image Source: PDB

Loops in ArchDB40 clusters

1hyh_A_210 - HA => SUBCLASS : 2.1.1
1hyh_A_269 - HA => SUBCLASS : 6.1.5
1hyh_A_48 - EH => SUBCLASS : 2.1.2
1hyh_A_294 - EH => SUBCLASS : 2.2.15
1hyh_A_163 - EH => SUBCLASS : 2.7.2
1hyh_A_23 - EH => SUBCLASS : 3.23.1
1hyh_A_137 - EH => SUBCLASS : 4.28.1
1hyh_A_203 - AR => SUBCLASS : 5.2.1

Loops in ArchDB95 clusters

1hyh_A_48 - EH => SUBCLASS : 2.1.3
1hyh_A_163 - EH => SUBCLASS : 2.7.2
1hyh_A_294 - EH => SUBCLASS : 3.7.6
1hyh_A_23 - EH => SUBCLASS : 3.37.1
1hyh_A_137 - EH => SUBCLASS : 4.17.1
1hyh_A_203 - AR => SUBCLASS : 3.2.1
1hyh_A_115 - HE => SUBCLASS : 3.1.1
1hyh_A_250 - HE => SUBCLASS : 3.17.1
1hyh_A_31 - HE => SUBCLASS : 4.2.2
1hyh_A_56 - HE => SUBCLASS : 4.3.12
1hyh_A_145 - HE => SUBCLASS : 6.2.1
1hyh_A_210 - HA => SUBCLASS : 2.1.1
1hyh_A_269 - HA => SUBCLASS : 4.1.4
1hyh_A_269 - HA => SUBCLASS : 6.2.3

Loops in ArchDB-EC clusters

1hyh_A_145 - HE => SUBCLASS : 6.1.2

Loops not clustered in ArchDB

1hyh_A_78 - AR
1hyh_A_203 - AR
1hyh_A_78 - AR
1hyh_A_92 - EH
1hyh_A_214 - EH
1hyh_A_269 - HA
1hyh_A_210 - HA
1hyh_A_194 - HA
1hyh_A_283 - HA
1hyh_A_194 - HA
1hyh_A_283 - HA
1hyh_A_169 - HE
1hyh_A_227 - HH

1hyh A - percentage of sequence identity: 100
1hyh B - percentage of sequence identity: 100
1hyh C - percentage of sequence identity: 100
1hyh D - percentage of sequence identity: 100