PDB: 1ldn Compound: L-lactate dehydrogenase complexed with nadh, oxama Classification: OXIDOREDUCTASE(CHOH(D)-NAD(A)) Entry date in PDB: 1994-01-31 Resolution [Å]: 2.50 R-Factor: 0.157

CHAIN: A SWISS-PROT/TREMBL: P00344    KEYWORD: 3D-structure    Glycolysis    NAD    Oxidoreductase    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Bacillus stearothermophilus SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Bacillus stearothermophilus GO:  cytoplasm    catalytic activity    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism    CHAIN: B SWISS-PROT/TREMBL: P00344    KEYWORD: 3D-structure    Glycolysis    NAD    Oxidoreductase    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Bacillus stearothermophilus SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Bacillus stearothermophilus GO:  cytoplasm    catalytic activity    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism    CHAIN: C SWISS-PROT/TREMBL: P00344    KEYWORD: 3D-structure    Glycolysis    NAD    Oxidoreductase    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Bacillus stearothermophilus SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Bacillus stearothermophilus GO:  cytoplasm    catalytic activity    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism    CHAIN: D SWISS-PROT/TREMBL: P00344    KEYWORD: 3D-structure    Glycolysis    NAD    Oxidoreductase    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Bacillus stearothermophilus SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Bacillus stearothermophilus GO:  cytoplasm    catalytic activity    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism    CHAIN: E SWISS-PROT/TREMBL: P00344    KEYWORD: 3D-structure    Glycolysis    NAD    Oxidoreductase    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Bacillus stearothermophilus SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Bacillus stearothermophilus GO:  cytoplasm    catalytic activity    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism    CHAIN: F SWISS-PROT/TREMBL: P00344    KEYWORD: 3D-structure    Glycolysis    NAD    Oxidoreductase    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Bacillus stearothermophilus SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Bacillus stearothermophilus GO:  cytoplasm    catalytic activity    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism    CHAIN: G SWISS-PROT/TREMBL: P00344    KEYWORD: 3D-structure    Glycolysis    NAD    Oxidoreductase    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Bacillus stearothermophilus SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Bacillus stearothermophilus GO:  cytoplasm    catalytic activity    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism    CHAIN: H SWISS-PROT/TREMBL: P00344    KEYWORD: 3D-structure    Glycolysis    NAD    Oxidoreductase    EC: 1.1.1.27 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Lactate dehydrogenase    Bacillus stearothermophilus SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Lactate dehydrogenase    Bacillus stearothermophilus GO:  cytoplasm    catalytic activity    L-lactate dehydrogenase activity    oxidoreductase activity    anaerobic glycolysis    glycolysis    tricarboxylic acid cycle intermediate metabolism

Image Source: PDB

Loops in ArchDB40 clusters

1ldn_A_283 - HA => SUBCLASS : 2.2.15
1ldn_A_198 - HA => SUBCLASS : 2.3.4
1ldn_A_158 - EH => SUBCLASS : 2.7.2
1ldn_A_132 - EH => SUBCLASS : 4.28.1
1ldn_A_297 - EH => SUBCLASS : 6.12.1
1ldn_A_77 - AR => SUBCLASS : 8.10.1

Loops in ArchDB95 clusters

1ldn_A_158 - EH => SUBCLASS : 2.7.2
1ldn_A_132 - EH => SUBCLASS : 4.17.1
1ldn_A_297 - EH => SUBCLASS : 6.8.1
1ldn_A_91 - EH => SUBCLASS : 11.3.1
1ldn_A_77 - AR => SUBCLASS : 8.26.1
1ldn_A_222 - HH => SUBCLASS : 4.45.1
1ldn_A_110 - HE => SUBCLASS : 3.1.1
1ldn_A_249 - HE => SUBCLASS : 3.17.1
1ldn_A_30 - HE => SUBCLASS : 4.2.2
1ldn_A_164 - HE => SUBCLASS : 6.1.1
1ldn_A_140 - HE => SUBCLASS : 6.2.1
1ldn_A_283 - HA => SUBCLASS : 2.2.22
1ldn_A_198 - HA => SUBCLASS : 2.3.7
1ldn_A_185 - HA => SUBCLASS : 3.5.1

Loops in ArchDB-EC clusters

1ldn_A_164 - HE => SUBCLASS : 6.2.1

Loops not clustered in ArchDB

1ldn_A_77 - AR
1ldn_A_22 - EH
1ldn_A_209 - EH
1ldn_A_47 - EH
1ldn_A_268 - HA
1ldn_A_185 - HA
1ldn_A_198 - HA
1ldn_A_268 - HA
1ldn_A_283 - HA
1ldn_A_55 - HE

1ldb - - percentage of sequence identity: 100
1ldn A - percentage of sequence identity: 100
1ldn B - percentage of sequence identity: 100
1ldn C - percentage of sequence identity: 100
1ldn D - percentage of sequence identity: 100
1ldn E - percentage of sequence identity: 100
1ldn F - percentage of sequence identity: 100
1ldn G - percentage of sequence identity: 100
1ldn H - percentage of sequence identity: 100
2ldb - - percentage of sequence identity: 100