PDB: 1n8y Compound: protooncoprotein Classification: TRANSFERASE Entry date in PDB: 2003-02-18 Resolution [Å]: 2.40 R-Factor: 0.224

CHAIN: C SWISS-PROT/TREMBL: P06494    KEYWORD: 3D-structure    ATP-binding    Disease mutation    Glycoprotein    Multigene family    Phosphorylation    Proto-oncogene    Receptor    Signal    Transferase    Transmembrane    Tyrosine-protein kinase    EC: 2.7.1.112 SCOP: c.10.2.5 Alpha and beta proteins (a/b)    Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)    L domain-like    L domain    Protooncoprotein Her2 extracellular domain    Rat (Rattus norvegicus) SCOP: c.10.2.5 Alpha and beta proteins (a/b)    Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)    L domain-like    L domain    Protooncoprotein Her2 extracellular domain    Rat (Rattus norvegicus) SCOP: g.3.9.1 Small proteins    Knottins (small inhibitors, toxins, lectins)    Growth factor receptor domain    Growth factor receptor domain    Protooncoprotein Her2 extracellular domain    Rat (Rattus norvegicus) SCOP: g.3.9.1 Small proteins    Knottins (small inhibitors, toxins, lectins)    Growth factor receptor domain    Growth factor receptor domain    Protooncoprotein Her2 extracellular domain    Rat (Rattus norvegicus) GO:  membrane    ATP binding    epidermal growth factor receptor activity    protein kinase activity    protein-tyrosine kinase activity    transmembrane receptor protein tyrosine kinase activity    protein amino acid phosphorylation    transmembrane receptor protein tyrosine kinase signaling pathway

Image Source: PDB

Loops in ArchDB40 clusters

1n8y_C_237 - HA => SUBCLASS : 2.1.1
1n8y_C_569 - HA => SUBCLASS : 2.3.1
1n8y_C_513 - HA => SUBCLASS : 2.3.1
1n8y_C_268 - HA => SUBCLASS : 2.3.1
1n8y_C_283 - HA => SUBCLASS : 3.1.1
1n8y_C_592 - HA => SUBCLASS : 3.1.1
1n8y_C_532 - HA => SUBCLASS : 4.5.1
1n8y_C_581 - HA => SUBCLASS : 5.10.1
1n8y_C_33 - AR => SUBCLASS : 1.3.5
1n8y_C_348 - AR => SUBCLASS : 1.3.5
1n8y_C_261 - AR => SUBCLASS : 4.3.3
1n8y_C_273 - AR => SUBCLASS : 6.7.1
1n8y_C_290 - AR => SUBCLASS : 6.7.1

Loops in ArchDB95 clusters

1n8y_C_348 - AR => SUBCLASS : 2.7.2
1n8y_C_33 - AR => SUBCLASS : 2.7.2
1n8y_C_261 - AR => SUBCLASS : 4.6.2
1n8y_C_261 - AR => SUBCLASS : 5.22.1
1n8y_C_290 - AR => SUBCLASS : 6.18.1
1n8y_C_273 - AR => SUBCLASS : 6.18.1
1n8y_C_17 - HE => SUBCLASS : 4.12.1
1n8y_C_461 - HE => SUBCLASS : 5.6.2
1n8y_C_532 - HA => SUBCLASS : 2.1.1
1n8y_C_237 - HA => SUBCLASS : 2.1.1
1n8y_C_513 - HA => SUBCLASS : 2.3.1
1n8y_C_268 - HA => SUBCLASS : 2.3.1
1n8y_C_569 - HA => SUBCLASS : 2.3.1
1n8y_C_592 - HA => SUBCLASS : 3.1.1
1n8y_C_283 - HA => SUBCLASS : 3.1.1
1n8y_C_532 - HA => SUBCLASS : 5.37.1

Loops in ArchDB-EC clusters

1n8y_C_148 - HE => SUBCLASS : 9.8.1

Loops not clustered in ArchDB

1n8y_C_574 - AR
1n8y_C_242 - AR
1n8y_C_161 - AR
1n8y_C_126 - AR
1n8y_C_90 - AR
1n8y_C_79 - AR
1n8y_C_62 - AR
1n8y_C_57 - AR
1n8y_C_38 - AR
1n8y_C_33 - AR
1n8y_C_574 - AR
1n8y_C_261 - AR
1n8y_C_273 - AR
1n8y_C_540 - AR
1n8y_C_518 - AR
1n8y_C_439 - AR
1n8y_C_420 - AR
1n8y_C_409 - AR
1n8y_C_389 - AR
1n8y_C_384 - AR
1n8y_C_348 - AR
1n8y_C_308 - AR
1n8y_C_290 - AR
1n8y_C_540 - AR
1n8y_C_518 - AR
1n8y_C_439 - AR
1n8y_C_242 - AR
1n8y_C_38 - AR
1n8y_C_57 - AR
1n8y_C_62 - AR
1n8y_C_79 - AR
1n8y_C_90 - AR
1n8y_C_126 - AR
1n8y_C_161 - AR
1n8y_C_409 - AR
1n8y_C_389 - AR
1n8y_C_308 - AR
1n8y_C_384 - AR
1n8y_C_420 - AR
1n8y_C_444 - EH
1n8y_C_353 - EH
1n8y_C_131 - EH
1n8y_C_3 - EH
1n8y_C_472 - EH
1n8y_C_298 - HA
1n8y_C_581 - HA
1n8y_C_237 - HA
1n8y_C_569 - HA
1n8y_C_251 - HA
1n8y_C_532 - HA
1n8y_C_251 - HA
1n8y_C_513 - HA
1n8y_C_298 - HA
1n8y_C_268 - HA
1n8y_C_283 - HA
1n8y_C_321 - HA
1n8y_C_321 - HA
1n8y_C_592 - HA
1n8y_C_357 - HE
1n8y_C_480 - HE

1s78 A - percentage of sequence identity: 85
1s78 B - percentage of sequence identity: 85