PDB: 3dfr Compound: Dihydrofolate reductase complex with nadph and met Classification: OXIDO-REDUCTASE Entry date in PDB: 1982-10-21 Resolution [Å]: 1.70 R-Factor: 0.152

CHAIN: - SWISS-PROT/TREMBL: P00381    KEYWORD: 3D-structure    Methotrexate resistance    NADP    One-carbon metabolism    Oxidoreductase    EC: 1.5.1.3 SCOP: c.71.1.1 Alpha and beta proteins (a/b)    Dihydrofolate reductases    Dihydrofolate reductases    Dihydrofolate reductases    Dihydrofolate reductase, prokaryotic type    Lactobacillus casei GO:  dihydrofolate reductase activity    glycine biosynthesis    nucleotide biosynthesis

Image Source: PDB

Loops in ArchDB40 clusters

3dfr_*_24 - HE => SUBCLASS : 3.16.1
3dfr_*_74 - EH => SUBCLASS : 2.1.1
3dfr_*_94 - EH => SUBCLASS : 3.27.1
3dfr_*_12 - EH => SUBCLASS : 8.7.1
3dfr_*_112 - AR => SUBCLASS : 7.11.1

Loops in ArchDB95 clusters

3dfr_*_74 - EH => SUBCLASS : 2.1.1
3dfr_*_94 - EH => SUBCLASS : 3.40.1
3dfr_*_12 - EH => SUBCLASS : 8.28.1
3dfr_*_2 - AR => SUBCLASS : 4.13.4
3dfr_*_112 - AR => SUBCLASS : 7.42.1

Loops in ArchDB-EC clusters

3dfr_*_12 - EH => SUBCLASS : 8.11.1

Loops not clustered in ArchDB

3dfr_*_126 - AR
3dfr_*_112 - AR
3dfr_*_2 - AR
3dfr_*_126 - AR
3dfr_*_38 - EH
3dfr_*_58 - HA
3dfr_*_136 - HA
3dfr_*_58 - HA
3dfr_*_136 - HA
3dfr_*_100 - HE
3dfr_*_79 - HE
3dfr_*_43 - HE

1ao8 - - percentage of sequence identity: 98
1bzf - - percentage of sequence identity: 98
1dis - - percentage of sequence identity: 98
1diu - - percentage of sequence identity: 98
1lud A - percentage of sequence identity: 98