PDB: 3grs Compound: Glutathione reductase , oxidized form (e) Classification: OXIDOREDUCTASE (FLAVOENZYME) Entry date in PDB: 1988-04-16 Resolution [Å]: 1.54 R-Factor: 0.186

CHAIN: - SWISS-PROT/TREMBL: P00390    KEYWORD: 3D-structure    Acetylation    Alternative initiation    FAD    Flavoprotein    Mitochondrion    NADP    Oxidoreductase    Polymorphism    Redox-active center    Transit peptide    EC: 1.8.1.7 SCOP: c.3.1.5 Alpha and beta proteins (a/b)    FAD/NAD(P)-binding domain    FAD/NAD(P)-binding domain    FAD/NAD-linked reductases, N-terminal and central domains    Glutathione reductase    Human (Homo sapiens) SCOP: c.3.1.5 Alpha and beta proteins (a/b)    FAD/NAD(P)-binding domain    FAD/NAD(P)-binding domain    FAD/NAD-linked reductases, N-terminal and central domains    Glutathione reductase    Human (Homo sapiens) SCOP: c.3.1.5 Alpha and beta proteins (a/b)    FAD/NAD(P)-binding domain    FAD/NAD(P)-binding domain    FAD/NAD-linked reductases, N-terminal and central domains    Glutathione reductase    Human (Homo sapiens) SCOP: d.87.1.1 Alpha and beta proteins (a+b)    CO dehydrogenase flavoprotein C-domain-like    FAD/NAD-linked reductases, dimerisation (C-terminal) domain    FAD/NAD-linked reductases, dimerisation (C-terminal) domain    Glutathione reductase    Human (Homo sapiens) GO:  cytoplasm    disulfide oxidoreductase activity    FAD binding    glutathione-disulfide reductase activity    oxidoreductase activity    electron transport    glutathione metabolism

Image Source: PDB

Loops in ArchDB40 clusters

3grs_*_139 - HA => SUBCLASS : 2.1.1
3grs_*_260 - HA => SUBCLASS : 6.13.1
3grs_*_23 - EH => SUBCLASS : 3.2.1
3grs_*_189 - EH => SUBCLASS : 3.2.1
3grs_*_429 - EH => SUBCLASS : 3.20.1
3grs_*_212 - EH => SUBCLASS : 10.3.1
3grs_*_19 - AR => SUBCLASS : 1.1.3
3grs_*_284 - AR => SUBCLASS : 3.11.1
3grs_*_152 - AR => SUBCLASS : 3.11.2
3grs_*_440 - HH => SUBCLASS : 3.2.1

Loops in ArchDB95 clusters

3grs_*_23 - EH => SUBCLASS : 3.5.1
3grs_*_189 - EH => SUBCLASS : 3.5.1
3grs_*_429 - EH => SUBCLASS : 3.11.1
3grs_*_46 - EH => SUBCLASS : 5.67.1
3grs_*_212 - EH => SUBCLASS : 10.2.1
3grs_*_19 - AR => SUBCLASS : 1.2.1
3grs_*_19 - AR => SUBCLASS : 1.2.6
3grs_*_284 - AR => SUBCLASS : 3.15.1
3grs_*_152 - AR => SUBCLASS : 3.15.2
3grs_*_440 - HH => SUBCLASS : 3.1.3
3grs_*_96 - HE => SUBCLASS : 1.1.1
3grs_*_228 - HE => SUBCLASS : 1.1.1
3grs_*_197 - HE => SUBCLASS : 1.1.1
3grs_*_197 - HE => SUBCLASS : 2.1.1
3grs_*_30 - HE => SUBCLASS : 2.1.1
3grs_*_96 - HE => SUBCLASS : 2.5.1
3grs_*_197 - HE => SUBCLASS : 2.5.5
3grs_*_384 - HE => SUBCLASS : 4.10.2
3grs_*_177 - HE => SUBCLASS : 6.10.1
3grs_*_139 - HA => SUBCLASS : 2.1.1
3grs_*_417 - HA => SUBCLASS : 4.7.3
3grs_*_260 - HA => SUBCLASS : 5.3.1

Loops in ArchDB-EC clusters

3grs_*_63 - HH => SUBCLASS : 10.9.1

Loops not clustered in ArchDB

3grs_*_19 - AR
3grs_*_275 - AR
3grs_*_124 - AR
3grs_*_145 - AR
3grs_*_145 - AR
3grs_*_124 - AR
3grs_*_152 - AR
3grs_*_275 - AR
3grs_*_284 - AR
3grs_*_291 - AR
3grs_*_291 - AR
3grs_*_158 - EH
3grs_*_326 - EH
3grs_*_377 - EH
3grs_*_369 - HA
3grs_*_396 - HA
3grs_*_369 - HA
3grs_*_260 - HA
3grs_*_249 - HA
3grs_*_244 - HA
3grs_*_131 - HA
3grs_*_139 - HA
3grs_*_131 - HA
3grs_*_244 - HA
3grs_*_249 - HA
3grs_*_396 - HA
3grs_*_417 - HA
3grs_*_339 - HE
3grs_*_56 - HH

1alg - - percentage of sequence identity: 100
1bwc A - percentage of sequence identity: 100
1dnc - - percentage of sequence identity: 100
1gra - - percentage of sequence identity: 100
1grb - - percentage of sequence identity: 100
1gre - - percentage of sequence identity: 100
1grf - - percentage of sequence identity: 100
1grg - - percentage of sequence identity: 100
1grt - - percentage of sequence identity: 99
1gsn - - percentage of sequence identity: 100
1k4q A - percentage of sequence identity: 100
1xan - - percentage of sequence identity: 100
2grt - - percentage of sequence identity: 99
3grt - - percentage of sequence identity: 99
4gr1 - - percentage of sequence identity: 100
4grt - - percentage of sequence identity: 99
5grt - - percentage of sequence identity: 99