PDB: 4mdh Compound: Cytoplasmic malate dehydrogenase Classification: OXIDOREDUCTASE(NAD(A)-CHOH(D)) Entry date in PDB: 1989-04-19 Resolution [Å]: 2.50 R-Factor: 0.167

CHAIN: A SWISS-PROT/TREMBL: P11708    KEYWORD: 3D-structure    Acetylation    NAD    Oxidoreductase    Tricarboxylic acid cycle    EC: 1.1.1.37 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Malate dehydrogenase    Pig (Sus scrofa) SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Malate dehydrogenase    Pig (Sus scrofa) GO:  L-lactate dehydrogenase activity    L-malate dehydrogenase activity    malate dehydrogenase activity    oxidoreductase activity    glycolysis    malate metabolism    tricarboxylic acid cycle intermediate metabolism    CHAIN: B SWISS-PROT/TREMBL: P11708    KEYWORD: 3D-structure    Acetylation    NAD    Oxidoreductase    Tricarboxylic acid cycle    EC: 1.1.1.37 SCOP: c.2.1.5 Alpha and beta proteins (a/b)    NAD(P)-binding Rossmann-fold domains    NAD(P)-binding Rossmann-fold domains    LDH N-terminal domain-like    Malate dehydrogenase    Pig (Sus scrofa) SCOP: d.162.1.1 Alpha and beta proteins (a+b)    LDH C-terminal domain-like    LDH C-terminal domain-like    Lactate & malate dehydrogenases, C-terminal domain    Malate dehydrogenase    Pig (Sus scrofa) GO:  L-lactate dehydrogenase activity    L-malate dehydrogenase activity    malate dehydrogenase activity    oxidoreductase activity    glycolysis    malate metabolism    tricarboxylic acid cycle intermediate metabolism

Image Source: PDB

Loops in ArchDB95 clusters

4mdh_A_35 - EH => SUBCLASS : 1.1.10
4mdh_A_295 - EH => SUBCLASS : 7.45.1
4mdh_A_177 - AR => SUBCLASS : 1.1.3
4mdh_A_177 - AR => SUBCLASS : 2.5.3
4mdh_A_191 - AR => SUBCLASS : 3.2.1
4mdh_A_208 - HH => SUBCLASS : 2.5.1
4mdh_A_208 - HH => SUBCLASS : 2.5.6
4mdh_A_46 - HE => SUBCLASS : 4.7.1
4mdh_A_46 - HE => SUBCLASS : 4.7.2
4mdh_A_105 - HE => SUBCLASS : 5.1.1
4mdh_A_156 - HE => SUBCLASS : 6.1.1
4mdh_A_132 - HE => SUBCLASS : 8.13.1
4mdh_A_14 - HE => SUBCLASS : 9.5.1
4mdh_A_198 - HA => SUBCLASS : 2.2.2
4mdh_A_198 - HA => SUBCLASS : 3.12.1
4mdh_A_181 - HA => SUBCLASS : 7.10.1

Loops not clustered in ArchDB

4mdh_A_151 - EH
4mdh_A_205 - EH
4mdh_A_4 - EH
4mdh_A_64 - EH
4mdh_A_82 - EH
4mdh_A_124 - EH
4mdh_A_266 - HA
4mdh_A_284 - HA
4mdh_A_73 - HE
4mdh_A_243 - HE
4mdh_A_215 - HH
4mdh_A_221 - HH

4mdh A - percentage of sequence identity: 100
4mdh B - percentage of sequence identity: 100
5mdh A - percentage of sequence identity: 100
5mdh B - percentage of sequence identity: 100