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Information on SUBCLASS 2.2.12
Subclass Accession number: 2218
Subclass: 2.2.12 PSSM
Type: HH alpha-alpha
DB: ArchDB40

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
GO : GO:0004857 (>75 %)  GO:0004866 (>75 %)  GO:0016788 (>50 %)  GO:0016798 (>75 %)  GO:0030414 (>75 %)  
SCOP : 48207 (>75 %)  48207 (>75 %)  48208 (>75 %)  48239 (>75 %)  48251 (>75 %)  
 Number of loops: 4

Average sequence ID (%) : 16.7 +/- 18.6
Average RMSD (Å) : 0.525 +/- 0.263

Consensus geometry
d (Å): 9 delta (°): 90-135 theta (°): 135-180 rho (°): 135-180
Consensus Sequence: XXcpXp
(φψ)-conformation: aalpaa
Pattern: [AGL][FGLT]x[LM][WY]xx[FT][GKN][DKS]xx[LY][AILV][KMT]x[AGL][EKL][NQRT][FLMT]
Conservation:-0.756-1.149-0.8701.4122.910-0.917-0.2300.6220.4090.246-0.684-0.1481.5500.105-0.152-0.870-0.447-0.638-0.127-0.266
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1ia6_A_2101ia6   A217236ATWLYTATNDSTYITDAEQFHHHHHHHH--THHHHHHHHHaaaaaaaavxaaaaaaaaaa
1nc5_A_961nc5   A96115LFPLYEQTKDERYVKAAKRLHHHHHHHH--HHHHHHHHHHaaaaaaaavxaaaaaaaaaa
1qaz_A_801qaz   A97116LGNLYVATGKPVYATCLLNMHHHHHHHH--THHHHHHHHHaaaaaaaavxwaaaaaaaaa
1v54_C_161v54   C3049GLTMWFHFNSMTLLMIGLTTHHHHHHHHS--HHHHHHHHHaaaaaaaalbaaaaaaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1ia6_A_2101ia6   A     CACALCIUM ION G - 210
1ia6_A_2101ia6   A     CACALCIUM ION D - 211
1ia6_A_2101ia6   A     CACALCIUM ION D - 212
1v54_C_161v54   C     PGV(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY) PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE W - 16
1v54_C_161v54   C     CHDCHOLIC ACID L - 18
1v54_C_161v54   C     PGV(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY) PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE G - 20
1v54_C_161v54   C     PGV(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY) PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE A - 21
1v54_C_161v54   C     PGV(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY) PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE S - 23
1v54_C_161v54   C     PGV(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY) PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE A - 24
1v54_C_161v54   C     PGV(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY) PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE M - 27
1v54_C_161v54   C     PGV(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY) PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE T - 28
1v54_C_161v54   C     PEK(1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8, 11,14-TETRAENOATE L - 31
1v54_C_161v54   C     PGV(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY) PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE L - 31
1v54_C_161v54   C     PEK(1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8, 11,14-TETRAENOATE W - 34
1v54_C_161v54   C     PEK(1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8, 11,14-TETRAENOATE F - 35
1v54_C_161v54   C     CDLCARDIOLIPIN T - 48
1v54_C_161v54   C     CDLCARDIOLIPIN N - 50
1v54_C_161v54   C     PGV(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY) PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE N - 50
1v54_C_161v54   C     CDLCARDIOLIPIN M - 51
1v54_C_161v54   C     PGV(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY) PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE M - 51
1v54_C_161v54   C     CDLCARDIOLIPIN L - 52
1v54_C_161v54   C     PGV(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY) PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE T - 53
1v54_C_161v54   C     CDLCARDIOLIPIN M - 54
1v54_C_161v54   C     PGV(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY) PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE M - 54
1v54_C_161v54   C     CDLCARDIOLIPIN Y - 55
1v54_C_161v54   C     CDLCARDIOLIPIN Q - 56
1v54_C_161v54   C     PGV(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY) PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE W - 57
1v54_C_161v54   C     CDLCARDIOLIPIN W - 58
1v54_C_161v54   C     PGV(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY) PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE W - 58
1v54_C_161v54   C     CDLCARDIOLIPIN R - 59
1v54_C_161v54   C     PGV(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY) PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE R - 59
1v54_C_161v54   C     CDLCARDIOLIPIN D - 60
1v54_C_161v54   C     PGV(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY) PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE D - 60
1v54_C_161v54   C     PGV(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY) PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE V - 61
1v54_C_161v54   C     CDLCARDIOLIPIN I - 62
1v54_C_161v54   C     PGV(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY) PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE I - 62
1v54_C_161v54   C     CDLCARDIOLIPIN R - 63
1v54_C_161v54   C     PGV(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY) PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE E - 64
1v54_C_161v54   C     PGV(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY) PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE S - 65

Clusters included in this Subclass
CLUSTER: HH.2.162