ArchDB - Biological DataBase of Protein Loops

Information on SUBCLASS 8.4.1

Subclass Accession number: 2525
Subclass: 8.4.1

Type: HH alpha-alpha
DB: ArchDB40

Image coordinates:

Consensus coordinates:

Conserved Annotation
EC : 2.5 (>75 %)  2.5.1 (>75 %)  2.5.1.18 (>75 %)  2.7.3 (>75 %)  2.7.3.2 (>75 %)  3.2 (>75 %)  3.2.1 (>75 %)  3.2.1.8
GO : GO:0004111 (>75 %)  GO:0004364 (>75 %)  GO:0004553 (>75 %)  GO:0016301 (>75 %)  GO:0016765 (>75 %)  GO:0016775 (>75 %)  GO:0016798 (>75 %)
SCOP : 47615 (>75 %)  47616 (>75 %)  47617 (>75 %)  48033 (>75 %)  48034 (>75 %)  48035 (>75 %)  51350 (>75 %)  51445 (>75 %)  51487 (>75 %)

Number of loops: 6

Average sequence ID (%) : 29.3 +/- 21.6
Average RMSD (Å) : 0.417 +/- 0.075

Consensus geometry

d (Å): 17

delta (°): 90-135

theta (°): 90-135

rho (°): 180-225

Consensus Sequence:	XhpPXhLcXhPX
(φψ)-conformation:	aabaaaaaabaa

Pattern:	[fhlwy]	[APV]	[D]	[FILY]	[hlmy]	[ACLW]	[lvy]	x	[ACIL]	[l]	[dety]	[itvy]	[lpvy]	x	x	[FHLM]	[ADEKT]	[PS]	[degks]	[CL]	[IL]	[DKS]	[ADNS]	[cf]	[P]	x	[IL]	[kv]	[ACDT]	[FLY]	x	[AKT]	[KR]	[FILV]	[AEQS]
Conservation:	-0.677	-0.091	2.683	0.316	-0.520	-0.640	-0.515	-0.535	-0.404	0.140	-1.067	-0.733	-0.989	-0.862	-0.881	-0.329	-0.554	1.477	-0.916	0.612	1.024	0.365	-0.315	0.083	3.297	-0.680	1.021	-0.631	-0.508	0.220	-0.582	-0.252	1.412	0.206	-0.178

Loops included in this Subclass

Loop	PDB	Chain	Start	End	Sequence	Sec Struct	Ramachandran
1dug_A_149	1dug	A	149	183	HPDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIE	HHHHHHHHHHHHHHHH-TTTTTT-HHHHHHHHHHH	aaaaaaaaaaaaaaaabaaaaaabaaaaaaaaaaa
1glq_A_150	1glq	A	150	184	FADYNLLDLLLIHQVLAPGCLDNFPLLSAYVARLS	HHHHHHHHHHHHHHHHSTTTTTT-HHHHHHHHHHH	aaaaaaaaaaaaaaaabaaaaaabaaaaaaaaaaa
1iyh_A_148	1iyh	A	148	182	WADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQ	HHHHHHHHHHHHHHHH-TTTTTT-HHHHHHHHHHH	aaaaaaaaaaaaaaaabaaaaaabaaaaaaaaaaa
1k3y_A_155	1k3y	A	155	189	RADIHLVELLYYVEELDSSLISSFPLLKALKTRIS	HHHHHHHHHHHHHHHH-TTTTTT-HHHHHHHHHHH	aaaaaaaaaaaaaaaabaaaaaabaaaaaaaaaaa
2gsq_*_151	2gsq	-	151	185	LADLHCYVALEVPLKHTPELLKDCPKIVALRKRVA	HHHHHHHHHHHHHHHH-TTTTTT-HHHHHHHHHHH	aaaaaaaaaaaaaaaabaaaaaabaaaaaaaaaaa
2gst_A_154	2gst	A	154	188	YVDFLAYDILDQYHIFEPKCLDAFPNLKDFLARFE	HHHHHHHHHHHHHHHHSTTTTTT-HHHHHHHHHHH	aaaaaaaaaaaaaaaabaaaaaabaaaaaaaaaaa

PDB ligands within a cut-off distance of 6 Å in this subclass

Loop	PDB	Chain	Ligands	Residue
1k3y_A_155	1k3y	A	GOLGLYCEROL	R - 155
1k3y_A_155	1k3y	A	GOLGLYCEROL	H - 159
2gst_A_154	2gst	A	GPS(9S,10S)-9-(S-GLUTATHIONYL)-10-HYDROXY-9,10-DIHYDROPHENANTHRENE	Q - 165

Clusters included in this Subclass