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Information on SUBCLASS 4.31.2
Subclass Accession number: 4841
Subclass: 4.31.2 PSSM
Type: HH alpha-alpha
DB: ArchDB95

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
GO : GO:0003700 (>50 %)  
SCOP : 51331 (>50 %)  51332 (>50 %)  51333 (>50 %)  
 Number of loops: 3

Average sequence ID (%) : 18.0 +/- 23.7
Average RMSD (Å) : 0.967 +/- 0.379

Consensus geometry
d (Å): 13 delta (°): 45-90 theta (°): 135-180 rho (°): 180-225
Consensus Sequence: ppcXXDXp
(φψ)-conformation: aalpapaa
Pattern: xx[AC]x[DT][HKQ][GIL][IL][EST][FHL][FY][ER][ENS][DGN][GS]x[D]x[EHR][DEK][HK][AI]x[HTY][LW][IK]x[IM]xx[EM][CSV][AV]x[ALY]x[KR]
Conservation:-1.154-0.8981.562-0.3190.4470.038-1.3240.844-0.302-0.6432.3020.521-0.0470.0380.346-0.8983.103-0.9830.0380.2081.025-0.245-1.154-0.1321.414-0.683-0.8980.634-0.683-0.494-0.205-0.7280.207-1.068-0.898-0.2171.247
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1abr_A_1311abr   A131167LQALTHGISFFRSGGNDNEEKARTLIVIIQMVAEAARHHHHHHHHHHHHTT---HHHHHHHHHHHHHHHHHHHHaaaaaaaaaaaaagpaxaaaaaaaaaaaaaaaaaaaa
1dto_A_11dto   A945NVCQDKILTHYENDSTDLRDHIDYWKHMRLECAIYYKHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHaaaaaaaaaaaaalxaxaaaaaaaaaaaaaaaaaaaa
1r6n_A_41r6n   A945DACQDQLLELYEENSIDIHKHIMHWKCIRLESVLLHKHHHHHHHHHHHHH----HHHHHHHHHHHHHHHHHHHHaaaaaaaaaaaaalxaxaaaaaaaaaaaaaaaaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1r6n_A_41r6n   A     ALQ2-METHYL-PROPIONIC ACID Q - 12
1r6n_A_41r6n   A     434SPIRO[3-CARBOXY-4-{(4-[1,2,3]THIADIAZOL-4-YL-PHENYL)-AMINO-CARBONYL} -5-[3,4-DICHLORO-PHENYL]-TETRAHYDROFURAN-2,2'-5-METHYL-INDAN-1,3-DIONE] L - 15
1r6n_A_41r6n   A     ALQ2-METHYL-PROPIONIC ACID L - 15
1r6n_A_41r6n   A     ALQ2-METHYL-PROPIONIC ACID L - 16
1r6n_A_41r6n   A     ALQ2-METHYL-PROPIONIC ACID E - 17
1r6n_A_41r6n   A     ALQ2-METHYL-PROPIONIC ACID L - 18
1r6n_A_41r6n   A     434SPIRO[3-CARBOXY-4-{(4-[1,2,3]THIADIAZOL-4-YL-PHENYL)-AMINO-CARBONYL} -5-[3,4-DICHLORO-PHENYL]-TETRAHYDROFURAN-2,2'-5-METHYL-INDAN-1,3-DIONE] Y - 19
1r6n_A_41r6n   A     ALQ2-METHYL-PROPIONIC ACID Y - 19
1r6n_A_41r6n   A     DMSDIMETHYL SULFOXIDE Y - 19
1r6n_A_41r6n   A     434SPIRO[3-CARBOXY-4-{(4-[1,2,3]THIADIAZOL-4-YL-PHENYL)-AMINO-CARBONYL} -5-[3,4-DICHLORO-PHENYL]-TETRAHYDROFURAN-2,2'-5-METHYL-INDAN-1,3-DIONE] K - 28
1r6n_A_41r6n   A     434SPIRO[3-CARBOXY-4-{(4-[1,2,3]THIADIAZOL-4-YL-PHENYL)-AMINO-CARBONYL} -5-[3,4-DICHLORO-PHENYL]-TETRAHYDROFURAN-2,2'-5-METHYL-INDAN-1,3-DIONE] H - 29
1r6n_A_41r6n   A     434SPIRO[3-CARBOXY-4-{(4-[1,2,3]THIADIAZOL-4-YL-PHENYL)-AMINO-CARBONYL} -5-[3,4-DICHLORO-PHENYL]-TETRAHYDROFURAN-2,2'-5-METHYL-INDAN-1,3-DIONE] I - 30
1r6n_A_41r6n   A     434SPIRO[3-CARBOXY-4-{(4-[1,2,3]THIADIAZOL-4-YL-PHENYL)-AMINO-CARBONYL} -5-[3,4-DICHLORO-PHENYL]-TETRAHYDROFURAN-2,2'-5-METHYL-INDAN-1,3-DIONE] H - 32
1r6n_A_41r6n   A     ALQ2-METHYL-PROPIONIC ACID H - 32
1r6n_A_41r6n   A     434SPIRO[3-CARBOXY-4-{(4-[1,2,3]THIADIAZOL-4-YL-PHENYL)-AMINO-CARBONYL} -5-[3,4-DICHLORO-PHENYL]-TETRAHYDROFURAN-2,2'-5-METHYL-INDAN-1,3-DIONE] W - 33
1r6n_A_41r6n   A     434SPIRO[3-CARBOXY-4-{(4-[1,2,3]THIADIAZOL-4-YL-PHENYL)-AMINO-CARBONYL} -5-[3,4-DICHLORO-PHENYL]-TETRAHYDROFURAN-2,2'-5-METHYL-INDAN-1,3-DIONE] I - 36
1r6n_A_41r6n   A     ALQ2-METHYL-PROPIONIC ACID I - 36
1r6n_A_41r6n   A     434SPIRO[3-CARBOXY-4-{(4-[1,2,3]THIADIAZOL-4-YL-PHENYL)-AMINO-CARBONYL} -5-[3,4-DICHLORO-PHENYL]-TETRAHYDROFURAN-2,2'-5-METHYL-INDAN-1,3-DIONE] E - 39

Clusters included in this Subclass
CLUSTER: HH.4.293