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Information on SUBCLASS 27.1.1
Subclass Accession number: 5182
Subclass: 27.1.1 PSSM
Type: HH alpha-alpha
DB: ArchDB95

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
EC : 3.4 (>50 %)  3.4.24 (>50 %)  
GO : GO:0004175 (>75 %)  GO:0004222 (>75 %)  GO:0005509 (>50 %)  GO:0008233 (>75 %)  GO:0008237 (>75 %)  GO:0008270 (>75 %)  GO:0046914 (>75 %)  
SCOP : 55485 (>75 %)  55486 (>75 %)  55528 (>75 %)  
 Number of loops: 3

Average sequence ID (%) : 58.3 +/- -5.0
Average RMSD (Å) : 0.700 +/- 0.265

Consensus geometry
d (Å): 17 delta (°): 90-135 theta (°): 0-45 rho (°): 270-315
Consensus Sequence: XLGLXHSpDPXAhMhPXYXhXpXpphpLXXD
(φψ)-conformation: aagpppbapaapaapabpbpbpaaapbpwaa
Pattern: [L][F][L][TV][A][AV][H][AE][FIL][G][H][AS][L][G][L][AEG][H][S][NS][D][P][GKT][A][ILV][M][AFY][P]x[Y][AKQ][FY]x[DE][IT][DNS][NT][FY][KRS][L][PS][ANQ][D][D][IL][DQR][G][I][Q]
Conservation:0.0601.0050.060-0.7780.060-0.8531.950-0.931-0.8861.0051.950-0.6250.0601.0050.060-1.3581.9500.060-0.4681.0051.478-1.5160.060-0.5710.532-1.0431.478-1.4631.478-1.2010.486-1.411-0.075-0.931-0.781-0.4580.399-0.9910.060-0.612-1.3581.0051.005-0.397-1.0961.0050.0600.532
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1i76_A_1911i76   A191238LFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQHHHHHHHHHHHHHTB---S-TTSTTSSS------TT----HHHHHHHHaaaaaaaaaaaaagxxxbaxaaxaaxabxbxbpaaaxbpwaaaaaaaa
1jk3_A_2121jk3   A212259LFLTAVHAIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQHHHHHHHHHHHHHT----S-TTSTTSSS-----TTT----HHHHHHHHaaaaaaaaaaaaagxbxbaxaaxaaxabxbxbxaaaxbxxaaaaaaaa
1rm8_A_2401rm8   A240287LFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQHHHHHHHHHHHHHT----S-TTSTTSSS------TT----HHHHHHHHaaaaaaaaaaaaagxxxbaxaaxaaxabpbxbxaaapbxwaaaaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1i76_A_1911i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID L - 193
1i76_A_1911i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID V - 194
1i76_A_1911i76   A     ZNZINC ION H - 197
1i76_A_1911i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID H - 197
1i76_A_1911i76   A     ZNZINC ION E - 198
1i76_A_1911i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID E - 198
1i76_A_1911i76   A     ZNZINC ION H - 201
1i76_A_1911i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID H - 201
1i76_A_1911i76   A     ZNZINC ION H - 207
1i76_A_1911i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID H - 207
1i76_A_1911i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID A - 213
1i76_A_1911i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID L - 214
1i76_A_1911i76   A     ZNZINC ION M - 215
1i76_A_1911i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID M - 215
1i76_A_1911i76   A     ZNZINC ION Y - 216
1i76_A_1911i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID Y - 216
1i76_A_1911i76   A     ZNZINC ION P - 217
1i76_A_1911i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID P - 217
1i76_A_1911i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID N - 218
1i76_A_1911i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID Y - 219
1i76_A_1911i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID A - 220
1i76_A_1911i76   A     BSI2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID R - 222
1jk3_A_2121jk3   A     BAT4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE L - 214
1jk3_A_2121jk3   A     BAT4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE T - 215
1jk3_A_2121jk3   A     ZNZINC ION H - 218
1jk3_A_2121jk3   A     BAT4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE H - 218
1jk3_A_2121jk3   A     BAT4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE A - 219
1jk3_A_2121jk3   A     ZNZINC ION H - 222
1jk3_A_2121jk3   A     BAT4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE H - 222
1jk3_A_2121jk3   A     ZNZINC ION H - 228
1jk3_A_2121jk3   A     BAT4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE H - 228
1jk3_A_2121jk3   A     BAT4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE V - 235
1jk3_A_2121jk3   A     ZNZINC ION M - 236
1jk3_A_2121jk3   A     ZNZINC ION F - 237
1jk3_A_2121jk3   A     BAT4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE F - 237
1jk3_A_2121jk3   A     ZNZINC ION P - 238
1jk3_A_2121jk3   A     BAT4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE P - 238
1jk3_A_2121jk3   A     BAT4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE T - 239
1jk3_A_2121jk3   A     BAT4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE Y - 240
1jk3_A_2121jk3   A     BAT4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE K - 241
1rm8_A_2401rm8   A     BAT4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE L - 242
1rm8_A_2401rm8   A     BAT4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE V - 243
1rm8_A_2401rm8   A     ZNZINC ION H - 246
1rm8_A_2401rm8   A     BAT4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE H - 246
1rm8_A_2401rm8   A     ZNZINC ION E - 247
1rm8_A_2401rm8   A     BAT4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE E - 247
1rm8_A_2401rm8   A     ZNZINC ION H - 250
1rm8_A_2401rm8   A     BAT4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE H - 250
1rm8_A_2401rm8   A     ZNZINC ION H - 256
1rm8_A_2401rm8   A     BAT4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE H - 256
1rm8_A_2401rm8   A     BAT4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE I - 263
1rm8_A_2401rm8   A     ZNZINC ION M - 264
1rm8_A_2401rm8   A     ZNZINC ION A - 265
1rm8_A_2401rm8   A     BAT4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE A - 265
1rm8_A_2401rm8   A     ZNZINC ION P - 266
1rm8_A_2401rm8   A     BAT4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE P - 266
1rm8_A_2401rm8   A     BAT4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE F - 267
1rm8_A_2401rm8   A     BAT4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE Y - 268
1rm8_A_2401rm8   A     BAT4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE Q - 269

Clusters included in this Subclass
CLUSTER: HH.26.1