ArchDB - Biological DataBase of Protein Loops

Information on SUBCLASS 2.2.2

Subclass Accession number: 63
Subclass: 2.2.2
Type: HA beta-beta hairpin
DB: ArchDB-KI

Number of loops: 6

Average sequence ID (%) : 41.0 +/- 4.4
Average RMSD (Å) : 0.50 +/- 0.12

Consensus geometry

d (Å): 3

delta (°): 45-90

theta (°): 135-180

rho (°): 0-45

Consensus Sequence:	pGXhGV
(φψ)-conformation:	bbaaeb

Pattern:	[FY]	[DKQR]	{ILV}	{GLV}	[ER]	[EKR]	[IL]	[G]	[EST]	[G]	x	[FY]	[G]	{V}	[IV]	{HY}	{EKR}	[ACGV]	{TV}	[DEN]
Conservation:	1.248	-0.695	-0.892	-1.593	-0.097	-0.141	0.157	1.650	-0.584	1.650	-0.427	1.050	1.650	-0.737	0.386	0.402	-1.017	-1.137	-0.766	-0.107

Loops included in this Subclass

Loop	PDB	Chain	Start	End	Sequence	Sec Struct	Ramachandran
1b38_A_4	1b38	A	4	23	FQKVEKIGEGTYGVVYKARN	EEEEEEEEE-SS-EEEEEEE	bbxabxaebbaaexbbxbbx
1cki_A_12	1cki	A	12	31	YRLGRKIGSGSFGDIYLGTD	EEEEEEEEE-SSSEEEEEEE	xxxbpxaebbaaebbbxbbx
1hcl_*_4	1hcl	-	4	23	FQKVEKIGEGTYGVVYKARN	EEEEEEEEE-SSSEEEEEEE	bxxabxaebxaaexbbxbbx
1koa_*_5942	1koa	-	5942	5961	YDIHEELGTGAFGVVHRVTE	EEEEEEEEEETTEEEEEEEE	bbxbpxabbbaaexbbxbbx
1kob_A_53	1kob	A	53	72	YDILEELGSGAFGVVHRCVE	EEEEEEEEEETTEEEEEEEE	bbxbxxabbbaaebbbxbbx
2csn_*_12	2csn	-	12	31	YKVGRRIGEGSFGVIFEGTN	EEEEEEEEEETTEEEEEEEE	bxxFbxabbbaaebbbxbbx

PDB ligands within a cut-off distance of 6 Å in this subclass

Loop	PDB	Chain	Ligands	Residue
1b38_A_4	1b38	A	ATPADENOSINE-5'-TRIPHOSPHATE	I - 10
1b38_A_4	1b38	A	ATPADENOSINE-5'-TRIPHOSPHATE	G - 11
1b38_A_4	1b38	A	ATPADENOSINE-5'-TRIPHOSPHATE	E - 12
1b38_A_4	1b38	A	ATPADENOSINE-5'-TRIPHOSPHATE	G - 13
1b38_A_4	1b38	A	ATPADENOSINE-5'-TRIPHOSPHATE	T - 14
1b38_A_4	1b38	A	ATPADENOSINE-5'-TRIPHOSPHATE	Y - 15
1b38_A_4	1b38	A	ATPADENOSINE-5'-TRIPHOSPHATE	G - 16
1b38_A_4	1b38	A	ATPADENOSINE-5'-TRIPHOSPHATE	V - 17
1b38_A_4	1b38	A	ATPADENOSINE-5'-TRIPHOSPHATE	V - 18
2csn_*_12	2csn	*	CKIN-(2-AMINOETHYL)-5-CHLOROISOQUINOLINE-8-SULFONAMIDE	I - 18
2csn_*_12	2csn	*	CKIN-(2-AMINOETHYL)-5-CHLOROISOQUINOLINE-8-SULFONAMIDE	G - 19
2csn_*_12	2csn	*	CKIN-(2-AMINOETHYL)-5-CHLOROISOQUINOLINE-8-SULFONAMIDE	E - 20
2csn_*_12	2csn	*	CKIN-(2-AMINOETHYL)-5-CHLOROISOQUINOLINE-8-SULFONAMIDE	I - 26

Bibliographic annotations

Loop	PDB	Chain	Annotation	Residue
1cki_A_12	1cki RefK.L.LONGENECKER,P.J.ROACH,T.D.HURLEY. THREE DIMENSIONAL STRUCTURE OF MAMMALIAN CASEIN KINASE I: MOLECULAR BASIS FOR PHOSPHATE RECOGNITION J. MOL. BIOL. v.257;618,1996	A	ATP BINDING RESIDUE	I - 18
1cki_A_12	1cki RefK.L.LONGENECKER,P.J.ROACH,T.D.HURLEY. THREE DIMENSIONAL STRUCTURE OF MAMMALIAN CASEIN KINASE I: MOLECULAR BASIS FOR PHOSPHATE RECOGNITION J. MOL. BIOL. v.257;618,1996	A	GLY-RICH-LOOP	G - 19
1cki_A_12	1cki RefK.L.LONGENECKER,P.J.ROACH,T.D.HURLEY. THREE DIMENSIONAL STRUCTURE OF MAMMALIAN CASEIN KINASE I: MOLECULAR BASIS FOR PHOSPHATE RECOGNITION J. MOL. BIOL. v.257;618,1996	A	GLY-RICH-LOOP	G - 21
1cki_A_12	1cki RefK.L.LONGENECKER,P.J.ROACH,T.D.HURLEY. THREE DIMENSIONAL STRUCTURE OF MAMMALIAN CASEIN KINASE I: MOLECULAR BASIS FOR PHOSPHATE RECOGNITION J. MOL. BIOL. v.257;618,1996	A	P-ATP BINDING RESIDUE	S - 22
1cki_A_12	1cki RefK.L.LONGENECKER,P.J.ROACH,T.D.HURLEY. THREE DIMENSIONAL STRUCTURE OF MAMMALIAN CASEIN KINASE I: MOLECULAR BASIS FOR PHOSPHATE RECOGNITION J. MOL. BIOL. v.257;618,1996	A	GLY-RICH-LOOP	G - 24
1cki_A_12	1cki RefK.L.LONGENECKER,P.J.ROACH,T.D.HURLEY. THREE DIMENSIONAL STRUCTURE OF MAMMALIAN CASEIN KINASE I: MOLECULAR BASIS FOR PHOSPHATE RECOGNITION J. MOL. BIOL. v.257;618,1996	A	P-ATP BINDING RESIDUE	G - 24
1cki_A_12	1cki RefK.L.LONGENECKER,P.J.ROACH,T.D.HURLEY. THREE DIMENSIONAL STRUCTURE OF MAMMALIAN CASEIN KINASE I: MOLECULAR BASIS FOR PHOSPHATE RECOGNITION J. MOL. BIOL. v.257;618,1996	A	ATP BINDING RESIDUE	I - 26
1kob_A_53	1kob RefB.KOBE,J.HEIERHORST,S.C.FEIL,M.W.PARKER,G.M.BENIAN,K.R.WEISS,B.E.KEMP. GIANT PROTEIN KINASES: DOMAIN INTERACTIONS AND STRUCTURAL BASIS OF AUTOREGULATION EMBO J. v.15;6810,1996	A	GLY-RICH-LOOP	G - 60
1kob_A_53	1kob RefB.KOBE,J.HEIERHORST,S.C.FEIL,M.W.PARKER,G.M.BENIAN,K.R.WEISS,B.E.KEMP. GIANT PROTEIN KINASES: DOMAIN INTERACTIONS AND STRUCTURAL BASIS OF AUTOREGULATION EMBO J. v.15;6810,1996	A	GLY-RICH-LOOP	G - 65

Clusters included in this Subclass

CLUSTER: HA.3.13