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Information on SUBCLASS 4.1.12
Subclass Accession number: 7877
Subclass: 4.1.12 PSSM
Type: HA beta-beta hairpin
DB: ArchDB-EC

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB
Number of loops: 4

Average sequence ID (%) : 21.9 +/- 21.5
Average RMSD (Å) : 0.500 +/- 0.271

Consensus geometry
d (Å): 3 delta (°): 45-90 theta (°): 135-180 rho (°): 270-315
Consensus Sequence: XDXpTcXp
(φψ)-conformation: bpaaalbp
Pattern: [CST][AQS][AFM][FTY][D][ANPT]x[LT][DGK]x[NQRT][FV]x[GIV][AIK][DKT]
Conservation:0.416-0.012-0.4200.4633.200-0.613-0.8790.751-0.173-1.145-0.2140.406-0.417-0.386-0.748-0.228
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1clc_*_941clc   -94109TSMFDNDTKETVYIADEEEEETTTTEEEEEEEbxbxxaaalbxbbxxb
1d7b_A_41d7b   A419SQFTDPTTGFQFTGITEEEE-TTT--EEEEEEbxbbxaaavpxbbebb
1ove_A_381ove   A3954CAAFDTKTGLRVAVKKEEEEETTTTEEEEEEEbbbbxaaavxxbbbbx
1pmn_A_771pmn   A7994CAAYDAVLDRNVAIKKEEEEETTTTEEEEEEEbxbbxaaalbxbbbbb
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1d7b_A_41d7b   A     NAGN-ACETYL-D-GLUCOSAMINE D - 8
1d7b_A_41d7b   A     NAGN-ACETYL-D-GLUCOSAMINE P - 9
1d7b_A_41d7b   A     MANALPHA-D-MANNOSE P - 9
1d7b_A_41d7b   A     NAGN-ACETYL-D-GLUCOSAMINE T - 10
1d7b_A_41d7b   A     CDCADMIUM ION F - 13
1d7b_A_41d7b   A     PCAPYROGLUTAMIC ACID I - 18
1d7b_A_41d7b   A     1PG2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL T - 19
1d7b_A_41d7b   A     CDCADMIUM ION D - 20
1ove_A_381ove   A     3581-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERIDIN-4-YL-3,4-DIHYDROQUINOLIN-2(1H)-ONE V - 38
1ove_A_381ove   A     3581-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERIDIN-4-YL-3,4-DIHYDROQUINOLIN-2(1H)-ONE C - 39
1ove_A_381ove   A     3581-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERIDIN-4-YL-3,4-DIHYDROQUINOLIN-2(1H)-ONE A - 51
1ove_A_381ove   A     3581-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERIDIN-4-YL-3,4-DIHYDROQUINOLIN-2(1H)-ONE V - 52
1ove_A_381ove   A     3581-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERIDIN-4-YL-3,4-DIHYDROQUINOLIN-2(1H)-ONE K - 53
1pmn_A_771pmn   A     984CYCLOPROPYL-{4-[5-(3,4-DICHLOROPHENYL)-2-[(1-METHYL)-PIPERIDIN]-4-YL-3-PROPYL-3H-IMIDAZOL-4-YL]-PYRIMIDIN-2-YL}AMINE V - 78
1pmn_A_771pmn   A     984CYCLOPROPYL-{4-[5-(3,4-DICHLOROPHENYL)-2-[(1-METHYL)-PIPERIDIN]-4-YL-3-PROPYL-3H-IMIDAZOL-4-YL]-PYRIMIDIN-2-YL}AMINE A - 91
1pmn_A_771pmn   A     984CYCLOPROPYL-{4-[5-(3,4-DICHLOROPHENYL)-2-[(1-METHYL)-PIPERIDIN]-4-YL-3-PROPYL-3H-IMIDAZOL-4-YL]-PYRIMIDIN-2-YL}AMINE I - 92
1pmn_A_771pmn   A     984CYCLOPROPYL-{4-[5-(3,4-DICHLOROPHENYL)-2-[(1-METHYL)-PIPERIDIN]-4-YL-3-PROPYL-3H-IMIDAZOL-4-YL]-PYRIMIDIN-2-YL}AMINE K - 93

Clusters included in this Subclass
CLUSTER: HA.4.114
CLUSTER: HA.5.85