PDB: 1e4e Compound: molecule Classification: LIGASE Entry date in PDB: 2001-06-28 Resolution [Å]: 2.50 R-Factor: 0.183

CHAIN: A SWISS-PROT/TREMBL: P25051    KEYWORD: 3D-structure    Antibiotic resistance    Cell wall    Ligase    Membrane    Peptidoglycan synthesis    Plasmid    EC: 6.3.2.- SCOP: c.30.1.2 Alpha and beta proteins (a/b)    PreATP-grasp domain    PreATP-grasp domain    D-Alanine ligase N-terminal domain    D-alanine:D-lactate ligase VanA, N-domain    Enterococcus faecium SCOP: d.142.1.1 Alpha and beta proteins (a+b)    ATP-grasp    Glutathione synthetase ATP-binding domain-like    ATP-binding domain of peptide synthetases    D-alanine:D-lactate ligase VanA, C-domain    Enterococcus faecium GO:  cell wall    cytoplasm    catalytic activity    D-alanine-D-alanine ligase activity    peptidoglycan biosynthesis    CHAIN: B SWISS-PROT/TREMBL: P25051    KEYWORD: 3D-structure    Antibiotic resistance    Cell wall    Ligase    Membrane    Peptidoglycan synthesis    Plasmid    EC: 6.3.2.- SCOP: c.30.1.2 Alpha and beta proteins (a/b)    PreATP-grasp domain    PreATP-grasp domain    D-Alanine ligase N-terminal domain    D-alanine:D-lactate ligase VanA, N-domain    Enterococcus faecium SCOP: d.142.1.1 Alpha and beta proteins (a+b)    ATP-grasp    Glutathione synthetase ATP-binding domain-like    ATP-binding domain of peptide synthetases    D-alanine:D-lactate ligase VanA, C-domain    Enterococcus faecium GO:  cell wall    cytoplasm    catalytic activity    D-alanine-D-alanine ligase activity    peptidoglycan biosynthesis

Image Source: PDB

Loops in ArchDB40 clusters

1e4e_A_36 - HA => SUBCLASS : 3.1.1
1e4e_A_286 - HA => SUBCLASS : 3.1.1
1e4e_A_286 - HA => SUBCLASS : 4.2.3
1e4e_A_182 - EH => SUBCLASS : 2.1.27
1e4e_A_124 - HH => SUBCLASS : 1.1.2
1e4e_A_124 - HH => SUBCLASS : 1.2.2
1e4e_A_317 - HH => SUBCLASS : 3.1.1

Loops in ArchDB95 clusters

1e4e_A_182 - EH => SUBCLASS : 2.1.19
1e4e_A_182 - EH => SUBCLASS : 2.1.22
1e4e_A_85 - AR => SUBCLASS : 1.2.1
1e4e_A_85 - AR => SUBCLASS : 1.2.6
1e4e_A_124 - HH => SUBCLASS : 1.1.1
1e4e_A_317 - HH => SUBCLASS : 3.1.1
1e4e_A_190 - HE => SUBCLASS : 2.3.3
1e4e_A_17 - HE => SUBCLASS : 5.13.4
1e4e_A_133 - HE => SUBCLASS : 6.14.1
1e4e_A_36 - HA => SUBCLASS : 3.1.1
1e4e_A_286 - HA => SUBCLASS : 5.4.1
1e4e_A_286 - HA => SUBCLASS : 5.4.3

Loops in ArchDB-EC clusters

1e4e_A_317 - HH => SUBCLASS : 3.1.1

Loops not clustered in ArchDB

1e4e_A_227 - AR
1e4e_A_227 - AR
1e4e_A_204 - AR
1e4e_A_150 - AR
1e4e_A_85 - AR
1e4e_A_204 - AR
1e4e_A_150 - AR
1e4e_A_4 - EH
1e4e_A_93 - EH
1e4e_A_256 - EH
1e4e_A_301 - EH
1e4e_A_77 - HA
1e4e_A_232 - HA
1e4e_A_213 - HA
1e4e_A_168 - HA
1e4e_A_77 - HA
1e4e_A_65 - HA
1e4e_A_49 - HA
1e4e_A_65 - HA
1e4e_A_168 - HA
1e4e_A_49 - HA
1e4e_A_213 - HA
1e4e_A_232 - HA
1e4e_A_36 - HA
1e4e_A_286 - HA
1e4e_A_266 - HE
1e4e_A_107 - HH

1e4e A - percentage of sequence identity: 99
1e4e B - percentage of sequence identity: 99