PDB: 1ex4 Compound: integrase Classification: VIRUS/VIRAL PROTEIN Entry date in PDB: 2000-06-07 Resolution [Å]: 2.80 R-Factor: 0.258

CHAIN: A SWISS-PROT/TREMBL: P04585    KEYWORD: 3D-structure    AIDS    Aspartyl protease    Endonuclease    Hydrolase    Metal-binding    Nuclease    Polyprotein    RNA-directed DNA polymerase    Transferase    Zinc    Zinc-finger    EC: 2.7.7.49 SCOP: b.34.7.1 All beta proteins    SH3-like barrel    DNA-binding domain of retroviral integrase    DNA-binding domain of retroviral integrase    DNA-binding domain of retroviral integrase    Human immunodeficiency virus type 1 SCOP: c.55.3.2 Alpha and beta proteins (a/b)    Ribonuclease H-like motif    Ribonuclease H-like    Retroviral integrase, catalytic domain    Retroviral integrase, catalytic domain    Human immunodeficiency virus type 1 GO:  aspartic-type endopeptidase activity    DNA binding    integrase activity    nucleic acid binding    ribonuclease H activity    RNA binding    RNA-directed DNA polymerase activity    zinc ion binding    DNA integration    DNA recombination    proteolysis and peptidolysis    RNA-dependent DNA replication    CHAIN: B SWISS-PROT/TREMBL: P04585    KEYWORD: 3D-structure    AIDS    Aspartyl protease    Endonuclease    Hydrolase    Metal-binding    Nuclease    Polyprotein    RNA-directed DNA polymerase    Transferase    Zinc    Zinc-finger    EC: 2.7.7.49 SCOP: b.34.7.1 All beta proteins    SH3-like barrel    DNA-binding domain of retroviral integrase    DNA-binding domain of retroviral integrase    DNA-binding domain of retroviral integrase    Human immunodeficiency virus type 1 SCOP: c.55.3.2 Alpha and beta proteins (a/b)    Ribonuclease H-like motif    Ribonuclease H-like    Retroviral integrase, catalytic domain    Retroviral integrase, catalytic domain    Human immunodeficiency virus type 1 GO:  aspartic-type endopeptidase activity    DNA binding    integrase activity    nucleic acid binding    ribonuclease H activity    RNA binding    RNA-directed DNA polymerase activity    zinc ion binding    DNA integration    DNA recombination    proteolysis and peptidolysis    RNA-dependent DNA replication

Image Source: PDB

Loops in ArchDB-EC clusters

1ex4_A_119 - HH => SUBCLASS : 1.1.2

Loops not clustered in ArchDB

1ex4_A_257 - AR
1ex4_A_84 - EH
1ex4_A_136 - EH
1ex4_A_112 - EH
1ex4_A_60 - HA
1ex4_A_248 - HA
1ex4_A_236 - HA
1ex4_A_224 - HA
1ex4_A_71 - HA
1ex4_A_96 - HE
1ex4_A_211 - HE
1ex4_A_124 - HE
1ex4_A_196 - HH
1ex4_A_149 - HH
1ex4_A_173 - HH

1b92 A - percentage of sequence identity: 94
1b9d A - percentage of sequence identity: 95
1b9f A - percentage of sequence identity: 93
1bhl - - percentage of sequence identity: 93
1bi4 A - percentage of sequence identity: 94
1bi4 B - percentage of sequence identity: 93
1bi4 C - percentage of sequence identity: 94
1bis A - percentage of sequence identity: 94
1bis B - percentage of sequence identity: 94
1biu A - percentage of sequence identity: 94
1biu B - percentage of sequence identity: 94
1biu C - percentage of sequence identity: 94
1biz A - percentage of sequence identity: 95
1biz B - percentage of sequence identity: 95
1bl3 A - percentage of sequence identity: 94
1bl3 B - percentage of sequence identity: 94
1bl3 C - percentage of sequence identity: 94
1c6v X - percentage of sequence identity: 62
1ex4 A - percentage of sequence identity: 100
1ex4 B - percentage of sequence identity: 100
1exq A - percentage of sequence identity: 100
1exq B - percentage of sequence identity: 100
1hyv A - percentage of sequence identity: 95
1hyz A - percentage of sequence identity: 95
1ihv A - percentage of sequence identity: 94
1ihv B - percentage of sequence identity: 94
1ihw A - percentage of sequence identity: 94
1ihw B - percentage of sequence identity: 94
1itg - - percentage of sequence identity: 95
1k6y A - percentage of sequence identity: 95
1k6y B - percentage of sequence identity: 95
1k6y C - percentage of sequence identity: 95
1k6y D - percentage of sequence identity: 95
1qmc A - percentage of sequence identity: 98
1qmc B - percentage of sequence identity: 98
1qs4 A - percentage of sequence identity: 94
1qs4 B - percentage of sequence identity: 94
1qs4 C - percentage of sequence identity: 94
2b4j A - percentage of sequence identity: 95
2b4j B - percentage of sequence identity: 95
2itg - - percentage of sequence identity: 94