PDB: 1fb1 Compound: gtp cyclohydrolase i Classification: HYDROLASE Entry date in PDB: 2000-12-08 Resolution [Å]: 3.10 R-Factor: 0.204

CHAIN: A SWISS-PROT/TREMBL: P30793    KEYWORD: 3D-structure    Allosteric enzyme    Alternative splicing    Disease mutation    Hydrolase    Phenylketonuria    Phosphorylation    Polymorphism    Tetrahydrobiopterin biosynthesis    EC: 3.5.4.16 SCOP: d.96.1.1 Alpha and beta proteins (a+b)    T-fold    Tetrahydrobiopterin biosynthesis enzymes-like    GTP cyclohydrolase I    GTP cyclohydrolase I    Human (Homo sapiens) GO:  GTP cyclohydrolase I activity    biosynthesis    CHAIN: B SWISS-PROT/TREMBL: P30793    KEYWORD: 3D-structure    Allosteric enzyme    Alternative splicing    Disease mutation    Hydrolase    Phenylketonuria    Phosphorylation    Polymorphism    Tetrahydrobiopterin biosynthesis    EC: 3.5.4.16 SCOP: d.96.1.1 Alpha and beta proteins (a+b)    T-fold    Tetrahydrobiopterin biosynthesis enzymes-like    GTP cyclohydrolase I    GTP cyclohydrolase I    Human (Homo sapiens) GO:  GTP cyclohydrolase I activity    biosynthesis    CHAIN: C SWISS-PROT/TREMBL: P30793    KEYWORD: 3D-structure    Allosteric enzyme    Alternative splicing    Disease mutation    Hydrolase    Phenylketonuria    Phosphorylation    Polymorphism    Tetrahydrobiopterin biosynthesis    EC: 3.5.4.16 SCOP: d.96.1.1 Alpha and beta proteins (a+b)    T-fold    Tetrahydrobiopterin biosynthesis enzymes-like    GTP cyclohydrolase I    GTP cyclohydrolase I    Human (Homo sapiens) GO:  GTP cyclohydrolase I activity    biosynthesis    CHAIN: D SWISS-PROT/TREMBL: P30793    KEYWORD: 3D-structure    Allosteric enzyme    Alternative splicing    Disease mutation    Hydrolase    Phenylketonuria    Phosphorylation    Polymorphism    Tetrahydrobiopterin biosynthesis    EC: 3.5.4.16 SCOP: d.96.1.1 Alpha and beta proteins (a+b)    T-fold    Tetrahydrobiopterin biosynthesis enzymes-like    GTP cyclohydrolase I    GTP cyclohydrolase I    Human (Homo sapiens) GO:  GTP cyclohydrolase I activity    biosynthesis    CHAIN: E SWISS-PROT/TREMBL: P30793    KEYWORD: 3D-structure    Allosteric enzyme    Alternative splicing    Disease mutation    Hydrolase    Phenylketonuria    Phosphorylation    Polymorphism    Tetrahydrobiopterin biosynthesis    EC: 3.5.4.16 SCOP: d.96.1.1 Alpha and beta proteins (a+b)    T-fold    Tetrahydrobiopterin biosynthesis enzymes-like    GTP cyclohydrolase I    GTP cyclohydrolase I    Human (Homo sapiens) GO:  GTP cyclohydrolase I activity    biosynthesis

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1is8 A - percentage of sequence identity: 96