PDB: 1jr2 Compound: uroporphyrinogen-iii synthase Classification: LYASE Entry date in PDB: 2001-11-07 Resolution [Å]: 1.84 R-Factor: 0.203

CHAIN: A SWISS-PROT/TREMBL: P10746    KEYWORD: 3D-structure    Disease mutation    Heme biosynthesis    Lyase    Porphyrin biosynthesis    EC: 4.2.1.75 SCOP: c.113.1.1 Alpha and beta proteins (a/b)    Uroporphyrinogen III synthase (U3S, HemD)    Uroporphyrinogen III synthase (U3S, HemD)    Uroporphyrinogen III synthase (U3S, HemD)    Uroporphyrinogen III synthase (U3S, HemD)    Human (Homo sapiens) GO:  uroporphyrinogen-III synthase activity    heme biosynthesis    porphyrin biosynthesis    CHAIN: B SWISS-PROT/TREMBL: P10746    KEYWORD: 3D-structure    Disease mutation    Heme biosynthesis    Lyase    Porphyrin biosynthesis    EC: 4.2.1.75 SCOP: c.113.1.1 Alpha and beta proteins (a/b)    Uroporphyrinogen III synthase (U3S, HemD)    Uroporphyrinogen III synthase (U3S, HemD)    Uroporphyrinogen III synthase (U3S, HemD)    Uroporphyrinogen III synthase (U3S, HemD)    Human (Homo sapiens) GO:  uroporphyrinogen-III synthase activity    heme biosynthesis    porphyrin biosynthesis

Image Source: PDB

Loops in ArchDB40 clusters

1jr2_A_151 - HE => SUBCLASS : 1.1.3
1jr2_A_18 - HE => SUBCLASS : 1.1.3
1jr2_A_151 - HE => SUBCLASS : 2.1.1
1jr2_A_18 - HE => SUBCLASS : 2.2.2
1jr2_A_198 - HE => SUBCLASS : 6.25.1
1jr2_A_168 - EH => SUBCLASS : 1.1.61
1jr2_A_95 - EH => SUBCLASS : 1.2.16
1jr2_A_220 - EH => SUBCLASS : 2.1.1
1jr2_A_58 - EH => SUBCLASS : 2.1.1
1jr2_A_192 - EH => SUBCLASS : 2.1.4
1jr2_A_58 - EH => SUBCLASS : 2.1.4
1jr2_A_36 - EH => SUBCLASS : 2.6.3
1jr2_A_241 - EH => SUBCLASS : 4.11.5
1jr2_A_29 - AR => SUBCLASS : 1.1.1
1jr2_A_162 - AR => SUBCLASS : 1.1.1
1jr2_A_64 - HH => SUBCLASS : 1.3.2
1jr2_A_64 - HH => SUBCLASS : 1.3.3

Loops in ArchDB95 clusters

1jr2_A_95 - EH => SUBCLASS : 1.7.1
1jr2_A_220 - EH => SUBCLASS : 2.1.1
1jr2_A_58 - EH => SUBCLASS : 2.1.2
1jr2_A_192 - EH => SUBCLASS : 2.1.2
1jr2_A_36 - EH => SUBCLASS : 2.6.2
1jr2_A_241 - EH => SUBCLASS : 4.4.2
1jr2_A_29 - AR => SUBCLASS : 1.2.3
1jr2_A_162 - AR => SUBCLASS : 1.2.3
1jr2_A_29 - AR => SUBCLASS : 1.2.10
1jr2_A_64 - HH => SUBCLASS : 1.3.2
1jr2_A_18 - HE => SUBCLASS : 1.1.1
1jr2_A_18 - HE => SUBCLASS : 1.1.2
1jr2_A_151 - HE => SUBCLASS : 2.1.1
1jr2_A_198 - HE => SUBCLASS : 6.54.1

Loops in ArchDB-EC clusters

1jr2_A_64 - HH => SUBCLASS : 1.3.2

Loops not clustered in ArchDB

1jr2_A_162 - AR
1jr2_A_29 - AR
1jr2_A_2 - EH
1jr2_A_139 - EH
1jr2_A_88 - HE
1jr2_A_122 - HE
1jr2_A_43 - HE
1jr2_A_226 - HE
1jr2_A_176 - HE
1jr2_A_80 - HH
1jr2_A_101 - HH

1jr2 A - percentage of sequence identity: 100
1jr2 B - percentage of sequence identity: 100