PDB: 1pv8 Compound: delta-aminolevulinic acid dehydratase Classification: LYASE Entry date in PDB: 2003-09-09 Resolution [Å]: 2.20 R-Factor: 0.199

CHAIN: A SWISS-PROT/TREMBL: P13716    KEYWORD: 3D-structure    Disease mutation    Heme biosynthesis    Lyase    Polymorphism    Porphyrin biosynthesis    Zinc    EC: 4.2.1.24 SCOP: c.1.10.3 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Aldolase    5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)    5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)    Human (Homo sapiens) GO:  porphobilinogen synthase activity    heme biosynthesis    CHAIN: B SWISS-PROT/TREMBL: P13716    KEYWORD: 3D-structure    Disease mutation    Heme biosynthesis    Lyase    Polymorphism    Porphyrin biosynthesis    Zinc    EC: 4.2.1.24 SCOP: c.1.10.3 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Aldolase    5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)    5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)    Human (Homo sapiens) GO:  porphobilinogen synthase activity    heme biosynthesis

Image Source: PDB

Loops in ArchDB95 clusters

1pv8_A_314 - EH => SUBCLASS : 0.1.24
1pv8_A_198 - EH => SUBCLASS : 3.1.17
1pv8_A_31 - AR => SUBCLASS : 7.28.1
1pv8_A_279 - HH => SUBCLASS : 4.1.1
1pv8_A_44 - HA => SUBCLASS : 7.1.1

Loops in ArchDB-EC clusters

1pv8_A_279 - HH => SUBCLASS : 4.1.1

Loops not clustered in ArchDB

1pv8_A_192 - AR
1pv8_A_31 - AR
1pv8_A_192 - AR
1pv8_A_54 - EH
1pv8_A_273 - EH
1pv8_A_249 - EH
1pv8_A_75 - EH
1pv8_A_116 - EH
1pv8_A_164 - EH
1pv8_A_44 - HA
1pv8_A_296 - HE
1pv8_A_258 - HE
1pv8_A_231 - HE
1pv8_A_174 - HE
1pv8_A_100 - HE
1pv8_A_58 - HE
1pv8_A_14 - HE
1pv8_A_141 - HE
1pv8_A_206 - HH

1e51 A - percentage of sequence identity: 99
1e51 B - percentage of sequence identity: 99
1pv8 A - percentage of sequence identity: 100
1pv8 B - percentage of sequence identity: 100