PDB: 1rj8 Compound: ectodysplasin-a isoform eda-a2 Classification: HORMONE/GROWTH FACTOR Entry date in PDB: 2003-12-09 Resolution [Å]: 2.23 R-Factor: 0.204

CHAIN: A SWISS-PROT/TREMBL: Q92838    KEYWORD: Alternative splicing    Anhidrotic ectodermal dysplasia    Collagen    Developmental protein    Differentiation    Disease mutation    Glycoprotein    Signal-anchor    Transmembrane    SCOP: b.22.1.1 All beta proteins    TNF-like    TNF-like    TNF-like    Ectodysplasin A, Eda-a1    Human (Homo sapiens) GO:  cytoplasm    membrane    tumor necrosis factor receptor binding    immune response    phosphate transport    CHAIN: B SWISS-PROT/TREMBL: Q92838    KEYWORD: Alternative splicing    Anhidrotic ectodermal dysplasia    Collagen    Developmental protein    Differentiation    Disease mutation    Glycoprotein    Signal-anchor    Transmembrane    SCOP: b.22.1.1 All beta proteins    TNF-like    TNF-like    TNF-like    Ectodysplasin A, Eda-a1    Human (Homo sapiens) GO:  cytoplasm    membrane    tumor necrosis factor receptor binding    immune response    phosphate transport    CHAIN: D SWISS-PROT/TREMBL: Q92838    KEYWORD: Alternative splicing    Anhidrotic ectodermal dysplasia    Collagen    Developmental protein    Differentiation    Disease mutation    Glycoprotein    Signal-anchor    Transmembrane    SCOP: b.22.1.1 All beta proteins    TNF-like    TNF-like    TNF-like    Ectodysplasin A, Eda-a1    Human (Homo sapiens) GO:  cytoplasm    membrane    tumor necrosis factor receptor binding    immune response    phosphate transport    CHAIN: E SWISS-PROT/TREMBL: Q92838    KEYWORD: Alternative splicing    Anhidrotic ectodermal dysplasia    Collagen    Developmental protein    Differentiation    Disease mutation    Glycoprotein    Signal-anchor    Transmembrane    SCOP: b.22.1.1 All beta proteins    TNF-like    TNF-like    TNF-like    Ectodysplasin A, Eda-a1    Human (Homo sapiens) GO:  cytoplasm    membrane    tumor necrosis factor receptor binding    immune response    phosphate transport    CHAIN: F SWISS-PROT/TREMBL: Q92838    KEYWORD: Alternative splicing    Anhidrotic ectodermal dysplasia    Collagen    Developmental protein    Differentiation    Disease mutation    Glycoprotein    Signal-anchor    Transmembrane    SCOP: b.22.1.1 All beta proteins    TNF-like    TNF-like    TNF-like    Ectodysplasin A, Eda-a1    Human (Homo sapiens) GO:  cytoplasm    membrane    tumor necrosis factor receptor binding    immune response    phosphate transport    CHAIN: G SWISS-PROT/TREMBL: Q92838    KEYWORD: Alternative splicing    Anhidrotic ectodermal dysplasia    Collagen    Developmental protein    Differentiation    Disease mutation    Glycoprotein    Signal-anchor    Transmembrane    SCOP: b.22.1.1 All beta proteins    TNF-like    TNF-like    TNF-like    Ectodysplasin A, Eda-a1    Human (Homo sapiens) GO:  cytoplasm    membrane    tumor necrosis factor receptor binding    immune response    phosphate transport

Image Source: PDB

Loops in ArchDB40 clusters

1rj8_A_318 - HA => SUBCLASS : 2.4.1
1rj8_A_284 - HA => SUBCLASS : 4.1.2
1rj8_A_284 - HA => SUBCLASS : 6.1.1
1rj8_A_293 - AR => SUBCLASS : 3.2.13
1rj8_A_275 - AR => SUBCLASS : 3.4.7
1rj8_A_370 - AR => SUBCLASS : 5.29.1

Loops in ArchDB95 clusters

1rj8_A_293 - AR => SUBCLASS : 3.1.20
1rj8_A_342 - AR => SUBCLASS : 3.5.6
1rj8_A_370 - AR => SUBCLASS : 5.34.1
1rj8_A_318 - HA => SUBCLASS : 2.1.2
1rj8_A_284 - HA => SUBCLASS : 4.1.1

Loops not clustered in ArchDB

1rj8_A_249 - AR
1rj8_A_259 - AR
1rj8_A_299 - AR
1rj8_A_327 - AR
1rj8_A_359 - AR

1rj7 A - percentage of sequence identity: 96
1rj7 B - percentage of sequence identity: 96
1rj7 D - percentage of sequence identity: 96
1rj7 E - percentage of sequence identity: 96
1rj7 F - percentage of sequence identity: 96
1rj7 G - percentage of sequence identity: 96
1rj7 H - percentage of sequence identity: 96
1rj7 I - percentage of sequence identity: 96
1rj7 J - percentage of sequence identity: 96
1rj7 K - percentage of sequence identity: 96
1rj7 L - percentage of sequence identity: 96
1rj7 M - percentage of sequence identity: 96
1rj8 A - percentage of sequence identity: 100
1rj8 B - percentage of sequence identity: 100
1rj8 D - percentage of sequence identity: 100
1rj8 E - percentage of sequence identity: 100
1rj8 F - percentage of sequence identity: 100
1rj8 G - percentage of sequence identity: 100