PDB: 2irf Compound: interferon regulatory factor 2 Classification: GENE REGULATION/DNA Entry date in PDB: 1999-10-08 Resolution [Å]: 2.20 R-Factor: 0.202

CHAIN: G SWISS-PROT/TREMBL: P23906    KEYWORD: 3D-structure    DNA-binding    Interferon induction    Nuclear protein    Repressor    Transcription regulation    SCOP: a.4.5.23 All alpha proteins    DNA/RNA-binding 3-helical bundle    "Winged helix" DNA-binding domain    Interferon regulatory factor    Interferon regulatory factor-2, IRF-2    Mouse (Mus musculus) GO:  nucleus    transcription factor activity    regulation of transcription, DNA-dependent    CHAIN: H SWISS-PROT/TREMBL: P23906    KEYWORD: 3D-structure    DNA-binding    Interferon induction    Nuclear protein    Repressor    Transcription regulation    SCOP: a.4.5.23 All alpha proteins    DNA/RNA-binding 3-helical bundle    "Winged helix" DNA-binding domain    Interferon regulatory factor    Interferon regulatory factor-2, IRF-2    Mouse (Mus musculus) GO:  nucleus    transcription factor activity    regulation of transcription, DNA-dependent    CHAIN: I SWISS-PROT/TREMBL: P23906    KEYWORD: 3D-structure    DNA-binding    Interferon induction    Nuclear protein    Repressor    Transcription regulation    SCOP: a.4.5.23 All alpha proteins    DNA/RNA-binding 3-helical bundle    "Winged helix" DNA-binding domain    Interferon regulatory factor    Interferon regulatory factor-2, IRF-2    Mouse (Mus musculus) GO:  nucleus    transcription factor activity    regulation of transcription, DNA-dependent    CHAIN: J SWISS-PROT/TREMBL: P23906    KEYWORD: 3D-structure    DNA-binding    Interferon induction    Nuclear protein    Repressor    Transcription regulation    SCOP: a.4.5.23 All alpha proteins    DNA/RNA-binding 3-helical bundle    "Winged helix" DNA-binding domain    Interferon regulatory factor    Interferon regulatory factor-2, IRF-2    Mouse (Mus musculus) GO:  nucleus    transcription factor activity    regulation of transcription, DNA-dependent    CHAIN: K SWISS-PROT/TREMBL: P23906    KEYWORD: 3D-structure    DNA-binding    Interferon induction    Nuclear protein    Repressor    Transcription regulation    SCOP: a.4.5.23 All alpha proteins    DNA/RNA-binding 3-helical bundle    "Winged helix" DNA-binding domain    Interferon regulatory factor    Interferon regulatory factor-2, IRF-2    Mouse (Mus musculus) GO:  nucleus    transcription factor activity    regulation of transcription, DNA-dependent    CHAIN: L SWISS-PROT/TREMBL: P23906    KEYWORD: 3D-structure    DNA-binding    Interferon induction    Nuclear protein    Repressor    Transcription regulation    SCOP: a.4.5.23 All alpha proteins    DNA/RNA-binding 3-helical bundle    "Winged helix" DNA-binding domain    Interferon regulatory factor    Interferon regulatory factor-2, IRF-2    Mouse (Mus musculus) GO:  nucleus    transcription factor activity    regulation of transcription, DNA-dependent

Image Source: PDB

Loops in ArchDB40 clusters

2irf_G_74 - HE => SUBCLASS : 3.3.1
2irf_G_25 - HA => SUBCLASS : 4.1.1
2irf_G_25 - HA => SUBCLASS : 4.1.2

Loops in ArchDB95 clusters

2irf_G_74 - HE => SUBCLASS : 3.6.1
2irf_G_25 - HA => SUBCLASS : 4.1.1

Loops not clustered in ArchDB

2irf_G_33 - EH
2irf_G_91 - HA
2irf_G_8 - HE
2irf_G_48 - HH
2irf_G_53 - HH

1if1 A - percentage of sequence identity: 75
1if1 B - percentage of sequence identity: 75
1irf - - percentage of sequence identity: 100
1irg - - percentage of sequence identity: 100
2irf G - percentage of sequence identity: 100
2irf H - percentage of sequence identity: 100
2irf I - percentage of sequence identity: 100
2irf J - percentage of sequence identity: 100
2irf K - percentage of sequence identity: 100
2irf L - percentage of sequence identity: 100