ArchDB - Biological DataBase of Protein Loops

Information on SUBCLASS 11.2.1

Subclass Accession number: 151
Subclass: 11.2.1
Type: HE alpha-beta
DB: ArchDB-KI

Number of loops: 3

Average sequence ID (%) : 92.4 +/- 0.3
Average RMSD (Å) : 0.24 +/- 0.03

Consensus geometry

d (Å): 23

delta (°): 45-90

theta (°): 90-135

rho (°): 135-180

Consensus Sequence:	WEpPXQNTApLDQFp
(φψ)-conformation:	aabppbzabbaaabb

Pattern:	[K]	[E]	[F]	[L]	[A]	[K]	[A]	[K]	[E]	[D]	[F]	[L]	[K]	[K]	[W]	[E]	[NT]	[P]	x	[Q]	[N]	[T]	[A]	[HQ]	[L]	[D]	[Q]	[F]	[DE]	[R]	[I]	[K]	[T]	[L]	[G]
Conservation:	0.015	0.015	0.707	-0.678	-0.678	0.015	-0.678	0.015	0.015	0.707	0.707	-0.678	0.015	0.015	4.169	0.015	-1.543	1.400	-1.716	0.015	0.707	0.015	-0.678	-1.197	-0.678	0.707	0.015	0.707	-0.851	0.015	-0.678	0.015	0.015	-0.678	0.707

Loops included in this Subclass

Loop	PDB	Chain	Start	End	Sequence	Sec Struct	Ramachandran
1apm_E_11	1apm	E	16	50	KEFLAKAKEDFLKKWETPSQNTAQLDQFDRIKTLG	HHHHHHHHHHHHHHHHS-------GGGEEEEEEEE	aaaaaaaaaaaaaaaabxxblabbaaabbxabxab
1cdk_A_10	1cdk	A	16	50	KEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLG	HHHHHHHHHHHHHHHHS-------GGGEEEEEEEE	aaaaaaaaaaaaaaaabxxb*abbaaabxxabxae
1ydr_E_16	1ydr	E	16	50	KEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLG	HHHHHHHHHHHHHHHHS-------GGGEEEEEEEE	aaaaaaaaaaaaaaaabxxb*abbaaabbxabxab

PDB ligands within a cut-off distance of 6 Å in this subclass

Loop	PDB	Chain	Ligands	Residue
1apm_E_11	1apm	E	PHOPHEOPHYTIN A	E - 11
1apm_E_11	1apm	E	OCTN-OCTANE	S - 14
1apm_E_11	1apm	E	OCTN-OCTANE	V - 15
1apm_E_11	1apm	E	OCTN-OCTANE	F - 18
1apm_E_11	1apm	E	OCTN-OCTANE	L - 19
1ydr_E_16	1ydr	E	IQP1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE	L - 49
1ydr_E_16	1ydr	E	IQP1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE	G - 50

Bibliographic annotations

Loop	PDB	Chain	Annotation	Residue
1apm_E_11	1apm RefD.R.KNIGHTON,S.M.BELL,J.ZHENG,L.F.TEN EYCK,N.-H.XUONG,S.S.TAYLOR,J.M.SOWADSKI. 2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT* ACTA CRYSTALLOGR D BIOL CRYSTALLOG v.49;357,1993	E	ADENINE BINDING RESIDUE	L - 49
1apm_E_11	1apm RefD.R.KNIGHTON,S.M.BELL,J.ZHENG,L.F.TEN EYCK,N.-H.XUONG,S.S.TAYLOR,J.M.SOWADSKI. 2.0 ANGSTROM REFINED CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE COMPLEXED WITH A PEPTIDE INHIBITOR AND DETERGENT* ACTA CRYSTALLOGR D BIOL CRYSTALLOG v.49;357,1993	E	GLY-RICH-LOOP	G - 50
1cdk_A_10	1cdk RefD.BOSSEMEYER,R.A.ENGH,V.KINZEL,H.PONSTINGL,R.HUBER. PHOSPHOTRANSFERASE AND SUBSTRATE BINDING MECHANISM OF THE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT FROM PORCINE HEART AS DEDUCED FROM THE 2.0 ANGSTROMS STRUCTURE OF THE COMPLEX WITH MN==2+== ADENYLYL IMIDODIPHOSPHATE AND INHIBITOR PEPTIDE PKI(5-24) EMBO J. v.12;849,1993	A	ADENINE BINDING RESIDUE	L - 49
1cdk_A_10	1cdk RefD.BOSSEMEYER,R.A.ENGH,V.KINZEL,H.PONSTINGL,R.HUBER. PHOSPHOTRANSFERASE AND SUBSTRATE BINDING MECHANISM OF THE CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT FROM PORCINE HEART AS DEDUCED FROM THE 2.0 ANGSTROMS STRUCTURE OF THE COMPLEX WITH MN==2+== ADENYLYL IMIDODIPHOSPHATE AND INHIBITOR PEPTIDE PKI(5-24) EMBO J. v.12;849,1993	A	GLY-RICH-LOOP	G - 50

Clusters included in this Subclass