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Information on SUBCLASS 5.2.1
Subclass Accession number: 352
Subclass: 5.2.1 PSSM
Type: HE alpha-beta
DB: ArchDB40

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
SCOP : 53382 (>75 %)  53383 (>75 %)  
 Number of loops: 26

Average sequence ID (%) : 21.6 +/- 20.8
Average RMSD (Å) : 0.665 +/- 0.254

Consensus geometry
d (Å): 11 delta (°): 45-90 theta (°): 135-180 rho (°): 180-225
Consensus Sequence: XXhpXGpXh
(φψ)-conformation: aabppgpbb
Pattern: [afgilvy]x[aeknqrst]x[acfilmtv][dehknpqrt]x[dgn][DEQST]x[ailvy][fgilpvy]
Conservation:0.302-1.092-0.519-0.933-0.0890.033-0.5412.0231.358-1.1940.917-0.265
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1a8h_*_3171a8h   -324335LLREIPYGQDTPHHHHS-TTS-EEaaaabxxgbxbx
1az9_*_51az9   -1526LVEQMQPGSAALHHHTS-SSEEEEaaaaxxxvbbbb
1bw0_A_1121bw0   A121132ITAICDAGDYALHHHH--TT-EEEaaaabbpgxbbx
1c7n_A_981c7n   A106117VREFTKPGDGVIHHHH--TT-EEEaaaabbpgxxbx
1cl1_A_861cl1   A94105ILAFIEQGDHVLHHHH--TT-EEEaaaaxbpvxbbb
1cs1_A_761cs1   A8495TTVFLKPGDLLVHHHH--TT-EEEaaaabbpgxbbb
1d2f_A_961d2f   A104115IRQWSETGEGVVHHHSS-TT-EEEaaaabbpgxbbx
1g60_A_1991g60   A206217IRASSNPNDLVLHHHH--TT-EEEaaaabbpvxbbb
1gc0_A_891gc0   A97108LWTLLRPGDEVLHHHH--TT-EEEaaaabbpgxbbx
1im8_A_491im8   A4960AERFVTADSNVYHHHH--TT-EEEaaaaxxplbbbb
1in4_A_901in4   A96107ILTSLERGDVLFHHHH--TT-EEEaaaaxbpvxbbx
1iug_A_601iug   A6879VKNLFAPGERVLHHHH--TT-EEEaaaabxpvxxbb
1jf9_A_941jf9   A106117GNSNVRAGDNIIHHHH--TT-EEEaaaabbpvxbbb
1jx6_A_1801jx6   A191202FGKFFPKHTYYSHHHHS-TT-EEEaaaabxpvxxbb
1kl1_A_941kl1   A102113YFTVLEHGDTVLHHHH--TT-EEEaaaabbpvxxbb
1m6s_A_581m6s   A6677IMAHTQRGDEVIHHHH--TT-EEEaaaabbpvxbbx
1m7y_A_1191m7y   A128139IFCLADPGEAVLHHHH--TT-EEEaaaabxpvxbbx
1mgt_A_911mgt   A100111LTKNVKRGSVITHHHHS-TT--EEaaaaxxpvbbbx
1nw6_A_2291nw6   A236247VRALSHPGSTVLHHHHS-TT-EEEaaaabxpvxxbb
1o4s_A_971o4s   A106117FMALLDPGDEVIHHHH--TT-EEEaaaaxxpvxbbx
1qmg_A_2021qmg   A212223VFSHMKPNSILGHHHHS-TT-EEEaaaaxxxvxbxb
1qnt_A_941qnt   A102113LLKVVKFGEVISHHHH--TT--EEaaaaxxxvbbbx
1ri5_A_441ri5   A5869IRLYTKRGDSVLHHHH--TT-EEEaaaabbpvxxbb
1ufk_A_1051ufk   A114125LARHLRPGDKVLHHHH--TT-EEEaaaaxbpvxxbb
1vjo_A_881vjo   A90101IANAVEPGDVVLHHHH--TT-EEEaaaabbpvxxbb
1zym_A_2081zym   A208219VTSQVKNDDYLIHHHH--TT-EEEaaaabbpvxxbb
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1bw0_A_1121bw0   A     LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE) G - 112
1bw0_A_1121bw0   A     LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE) G - 113
1bw0_A_1121bw0   A     LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE) S - 114
1bw0_A_1121bw0   A     LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE) H - 115
1bw0_A_1121bw0   A     LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE) I - 117
1c7n_A_981c7n   A     PLPPYRIDOXAL-5'-PHOSPHATE V - 98
1c7n_A_981c7n   A     PLPPYRIDOXAL-5'-PHOSPHATE V - 99
1c7n_A_981c7n   A     PLPPYRIDOXAL-5'-PHOSPHATE P - 100
1cl1_A_861cl1   A     LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE) G - 86
1cl1_A_861cl1   A     LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE) A - 87
1cl1_A_861cl1   A     LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE) A - 88
1cl1_A_861cl1   A     LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE) A - 89
1cl1_A_861cl1   A     LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE) V - 90
1cs1_A_761cs1   A     LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE) G - 76
1cs1_A_761cs1   A     LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE) M - 77
1cs1_A_761cs1   A     LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE) S - 78
1cs1_A_761cs1   A     LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE) I - 80
1d2f_A_961d2f   A     PLPPYRIDOXAL-5'-PHOSPHATE V - 96
1d2f_A_961d2f   A     PLPPYRIDOXAL-5'-PHOSPHATE I - 97
1d2f_A_961d2f   A     PLPPYRIDOXAL-5'-PHOSPHATE Y - 98
1g60_A_1991g60   A     SAMS-ADENOSYLMETHIONINE I - 202
1g60_A_1991g60   A     SAMS-ADENOSYLMETHIONINE D - 218
1gc0_A_891gc0   A     LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE) G - 89
1gc0_A_891gc0   A     LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE) M - 90
1gc0_A_891gc0   A     LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE) G - 91
1im8_A_491im8   A     MSESELENOMETHIONINE A - 49
1im8_A_491im8   A     MSESELENOMETHIONINE E - 50
1im8_A_491im8   A     MSESELENOMETHIONINE R - 51
1im8_A_491im8   A     MSESELENOMETHIONINE F - 52
1im8_A_491im8   A     MSESELENOMETHIONINE V - 53
1im8_A_491im8   A     MSESELENOMETHIONINE S - 57
1im8_A_491im8   A     MSESELENOMETHIONINE N - 58
1im8_A_491im8   A     MSESELENOMETHIONINE V - 59
1im8_A_491im8   A     MSESELENOMETHIONINE Y - 60
1im8_A_491im8   A     MSESELENOMETHIONINE D - 61
1im8_A_491im8   A     SAIS-ADENOSYL-L-HOMOSELENOCYSTEINE D - 61
1im8_A_491im8   A     SAIS-ADENOSYL-L-HOMOSELENOCYSTEINE L - 62
1in4_A_901in4   A     ADPADENOSINE-5'-DIPHOSPHATE F - 107
1in4_A_901in4   A     ADPADENOSINE-5'-DIPHOSPHATE D - 109
1iug_A_601iug   A     LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE) G - 60
1iug_A_601iug   A     LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE) T - 61
1iug_A_601iug   A     PO4PHOSPHATE ION T - 61
1iug_A_601iug   A     LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE) L - 62
1iug_A_601iug   A     LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE) M - 64
1jf9_A_941jf9   A     PLPPYRIDOXAL-5'-PHOSPHATE T - 94
1jf9_A_941jf9   A     PLPPYRIDOXAL-5'-PHOSPHATE T - 95
1jf9_A_941jf9   A     PLPPYRIDOXAL-5'-PHOSPHATE E - 96
1jf9_A_941jf9   A     PLPPYRIDOXAL-5'-PHOSPHATE I - 98
1jx6_A_1801jx6   A     AI23A-METHYL-5,6-DIHYDRO-FURO[2,3-D][1,3,2]DIOXABOROLE-2, 2,6,6A-TETRAOL H - 180
1kl1_A_941kl1   A     PLPPYRIDOXAL-5'-PHOSPHATE G - 94
1kl1_A_941kl1   A     PLPPYRIDOXAL-5'-PHOSPHATE A - 95
1kl1_A_941kl1   A     PLPPYRIDOXAL-5'-PHOSPHATE Q - 96
1kl1_A_941kl1   A     PLPPYRIDOXAL-5'-PHOSPHATE N - 98
1m6s_A_581m6s   A     LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE) G - 58
1m6s_A_581m6s   A     LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE) T - 59
1m6s_A_581m6s   A     LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE) M - 60
1m6s_A_581m6s   A     LLP2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE) N - 62
1m7y_A_1191m7y   A     PPG4-(2-AMINO-ETHOXY)-2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-BUT-3-ENOIC ACID G - 119
1m7y_A_1191m7y   A     PPG4-(2-AMINO-ETHOXY)-2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-BUT-3-ENOIC ACID A - 120
1m7y_A_1191m7y   A     PPG4-(2-AMINO-ETHOXY)-2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-BUT-3-ENOIC ACID T - 121
1m7y_A_1191m7y   A     MPD2-METHYL-2,4-PENTANEDIOL T - 121
1m7y_A_1191m7y   A     PPG4-(2-AMINO-ETHOXY)-2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-BUT-3-ENOIC ACID S - 122
1m7y_A_1191m7y   A     PPG4-(2-AMINO-ETHOXY)-2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-BUT-3-ENOIC ACID N - 124
1o4s_A_971o4s   A     PLPPYRIDOXAL-5'-PHOSPHATE G - 97
1o4s_A_971o4s   A     PLPPYRIDOXAL-5'-PHOSPHATE A - 98
1o4s_A_971o4s   A     PLPPYRIDOXAL-5'-PHOSPHATE K - 99
1o4s_A_971o4s   A     PLPPYRIDOXAL-5'-PHOSPHATE Q - 100
1o4s_A_971o4s   A     PLPPYRIDOXAL-5'-PHOSPHATE L - 102
1qmg_A_2021qmg   A     DMV2,3-DIHYDROXY-VALERIANIC ACID D - 202
1qmg_A_2021qmg   A     APX2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHORIBOSE D - 202
1qmg_A_2021qmg   A     MNMANGANESE (II) ION D - 202
1qmg_A_2021qmg   A     APX2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHORIBOSE A - 204
1qmg_A_2021qmg   A     APX2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHORIBOSE Q - 205
1qmg_A_2021qmg   A     APX2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHORIBOSE N - 208
1vjo_A_881vjo   A     MSESELENOMETHIONINE A - 88
1vjo_A_881vjo   A     MSESELENOMETHIONINE T - 89
1vjo_A_881vjo   A     MSESELENOMETHIONINE I - 90
1vjo_A_881vjo   A     MSESELENOMETHIONINE A - 91
1vjo_A_881vjo   A     MSESELENOMETHIONINE N - 92
1vjo_A_881vjo   A     MSESELENOMETHIONINE A - 93

Clusters included in this Subclass
CLUSTER: HE.5.6
CLUSTER: HE.6.1