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Information on SUBCLASS 10.5.1
Subclass Accession number: 6001
Subclass: 10.5.1 PSSM
Type: HE alpha-beta
DB: ArchDB95

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
EC : 1.5 (>75 %)  1.5.1 (>75 %)  1.5.1.33.1 (>75 %)  3.1.1 (>75 %)  3.1.1.4
GO : GO:0004146 (>75 %)  GO:0005509 (>50 %)  GO:0016298 (>50 %)  GO:0016645 (>75 %)  GO:0016646 (>75 %)  GO:0016788 (>50 %)  GO:0016789 (>50 %)  
SCOP : 48618 (>75 %)  48619 (>75 %)  48623 (>75 %)  53596 (>75 %)  53597 (>75 %)  53598 (>75 %)  
 Number of loops: 4

Average sequence ID (%) : 65.2 +/- 11.5
Average RMSD (Å) : 0.350 +/- 0.129

Consensus geometry
d (Å): 17 delta (°): 90-135 theta (°): 90-135 rho (°): 225-270
Consensus Sequence: XShPXKXRPLXcRX
(φψ)-conformation: aappaaabwpplbp
Pattern: [KR][KR][T][W]x[S][IL][P][AEQ][K]x[R][P][L][KP][DG][R]x[N][ILV][IV][L]
Conservation:-0.199-0.1900.4132.903-1.269-0.002-0.4041.243-1.0040.413-1.5730.4131.243-0.002-0.545-0.6230.413-1.3330.828-0.525-0.201-0.002
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1aoe_A_561aoe   A5677RKTWESIPQKFRPLPDRLNIILHHHHHHS-GGG-S-TTSEEEEEaaaaaaxpaaabwxxvbxxbbb
1df7_A_441df7   A4465RRTWDSLPAKVRPLPGRRNVVLHHHHHHS-GGGSS-TTSEEEEEaaaaaaxxaaabwxxvbxxbbx
1kmv_A_541kmv   A5475KKTWFSIPEKNRPLKGRINLVLHHHHHHS-GGG-S-TTSEEEEEaaaaaaxwaaabwpxvbxbbbx
8dfr_*_548dfr   -5475KKTWFSIPEKNRPLKDRINIVLHHHHHHS-GGG-S-TTEEEEEEaaaaaaxpaaabwxpvbxxbbb
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1aoe_A_561aoe   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE R - 56
1aoe_A_561aoe   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE K - 57
1aoe_A_561aoe   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE T - 58
1aoe_A_561aoe   A     GW37-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE T - 58
1aoe_A_561aoe   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE W - 59
1aoe_A_561aoe   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE S - 61
1aoe_A_561aoe   A     GW37-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE S - 61
1aoe_A_561aoe   A     GW37-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE I - 62
1aoe_A_561aoe   A     GW37-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE L - 69
1aoe_A_561aoe   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE L - 77
1df7_A_441df7   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE R - 44
1df7_A_441df7   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE R - 45
1df7_A_441df7   A     GOLGLYCEROL R - 45
1df7_A_441df7   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE T - 46
1df7_A_441df7   A     MTXMETHOTREXATE T - 46
1df7_A_441df7   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE W - 47
1df7_A_441df7   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE S - 49
1df7_A_441df7   A     MTXMETHOTREXATE S - 49
1df7_A_441df7   A     MTXMETHOTREXATE L - 50
1df7_A_441df7   A     MTXMETHOTREXATE P - 51
1df7_A_441df7   A     MTXMETHOTREXATE K - 53
1df7_A_441df7   A     MTXMETHOTREXATE V - 54
1df7_A_441df7   A     MTXMETHOTREXATE L - 57
1df7_A_441df7   A     MTXMETHOTREXATE P - 58
1df7_A_441df7   A     MTXMETHOTREXATE R - 60
1df7_A_441df7   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE L - 65
1kmv_A_541kmv   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE K - 54
1kmv_A_541kmv   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE K - 55
1kmv_A_541kmv   A     LII(Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE T - 56
1kmv_A_541kmv   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE T - 56
1kmv_A_541kmv   A     DMSDIMETHYL SULFOXIDE T - 56
1kmv_A_541kmv   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE W - 57
1kmv_A_541kmv   A     LII(Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE S - 59
1kmv_A_541kmv   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE S - 59
1kmv_A_541kmv   A     LII(Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE I - 60
1kmv_A_541kmv   A     LII(Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE P - 61
1kmv_A_541kmv   A     LII(Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE N - 64
1kmv_A_541kmv   A     SULSULFATE ANION L - 67
1kmv_A_541kmv   A     LII(Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE L - 67
1kmv_A_541kmv   A     SULSULFATE ANION K - 68
1kmv_A_541kmv   A     SULSULFATE ANION G - 69
1kmv_A_541kmv   A     SULSULFATE ANION R - 70
1kmv_A_541kmv   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE L - 75
8dfr_*_548dfr   *     CACALCIUM ION K - 54

Clusters included in this Subclass
CLUSTER: HE.10.20