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Information on SUBCLASS 3.21.1
Subclass Accession number: 7312
Subclass: 3.21.1 PSSM
Type: EH beta-alpha
DB: ArchDB-EC

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB
Number of loops: 6

Average sequence ID (%) : 40.0 +/- 25.2
Average RMSD (Å) : 0.200 +/- 0.063

Consensus geometry
d (Å): 11 delta (°): 0-45 theta (°): 135-180 rho (°): 135-180
Consensus Sequence: hhhGGXp
(φψ)-conformation: bbaewaa
Pattern: [ILV][FMVW][IV][AIV][G][G][AGST][AEQRS][ILV][FY][EKNT][AEQ]
Conservation:-0.065-0.7860.318-0.4501.6361.636-0.856-0.990-0.0521.274-0.848-0.816
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1aoe_A_1061aoe   A109120VFIIGGAEIYNEEEE---HHHHHHbbxaewaaaaaa
1dyr_*_1161dyr   -120131IFVIGGAQLYKAEEE---HHHHHHbbbaewaaaaaa
1kmv_A_1091kmv   A112123VWIVGGSSVYKEEEE---HHHHHHbbxaewaaaaaa
1ra9_*_911ra9   -91102IMVIGGGRVYEQEEE---HHHHHHbbxaewaaaaaa
3dfr_*_943dfr   -94105LVIAGGAQIFTAEEE---HHHHHHxbxaewaaaaaa
8dfr_*_1098dfr   -112123VWIVGGTAVYKAEEE---HHHHHHbbxaewaaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1aoe_A_1061aoe   A     GW37-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE I - 111
1aoe_A_1061aoe   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE I - 112
1aoe_A_1061aoe   A     GW37-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE I - 112
1aoe_A_1061aoe   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE G - 113
1aoe_A_1061aoe   A     GW37-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE G - 113
1aoe_A_1061aoe   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE G - 114
1aoe_A_1061aoe   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE A - 115
1aoe_A_1061aoe   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE E - 116
1aoe_A_1061aoe   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE I - 117
1aoe_A_1061aoe   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Y - 118
1aoe_A_1061aoe   A     GW37-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE Y - 118
1aoe_A_1061aoe   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE E - 120
1aoe_A_1061aoe   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE L - 121
1dyr_*_1161dyr   *     TOPTRIMETHOPRIM V - 122
1dyr_*_1161dyr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE I - 123
1dyr_*_1161dyr   *     TOPTRIMETHOPRIM I - 123
1dyr_*_1161dyr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE G - 124
1dyr_*_1161dyr   *     TOPTRIMETHOPRIM G - 124
1dyr_*_1161dyr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE G - 125
1dyr_*_1161dyr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE A - 126
1dyr_*_1161dyr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Q - 127
1dyr_*_1161dyr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE L - 128
1dyr_*_1161dyr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Y - 129
1dyr_*_1161dyr   *     TOPTRIMETHOPRIM Y - 129
1dyr_*_1161dyr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE A - 131
1kmv_A_1091kmv   A     LII(Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE I - 114
1kmv_A_1091kmv   A     LII(Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE V - 115
1kmv_A_1091kmv   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE V - 115
1kmv_A_1091kmv   A     DMSDIMETHYL SULFOXIDE V - 115
1kmv_A_1091kmv   A     LII(Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE G - 116
1kmv_A_1091kmv   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE G - 116
1kmv_A_1091kmv   A     DMSDIMETHYL SULFOXIDE G - 116
1kmv_A_1091kmv   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE G - 117
1kmv_A_1091kmv   A     DMSDIMETHYL SULFOXIDE G - 117
1kmv_A_1091kmv   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE S - 118
1kmv_A_1091kmv   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE S - 119
1kmv_A_1091kmv   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE V - 120
1kmv_A_1091kmv   A     LII(Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE Y - 121
1kmv_A_1091kmv   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Y - 121
1kmv_A_1091kmv   A     DMSDIMETHYL SULFOXIDE Y - 121
1kmv_A_1091kmv   A     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE E - 123
1ra9_*_911ra9   *     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE G - 95
1ra9_*_911ra9   *     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE G - 96
1ra9_*_911ra9   *     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE G - 97
1ra9_*_911ra9   *     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE R - 98
1ra9_*_911ra9   *     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE V - 99
1ra9_*_911ra9   *     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Y - 100
1ra9_*_911ra9   *     NAPNADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Q - 102
3dfr_*_943dfr   *     MTXMETHOTREXATE I - 96
3dfr_*_943dfr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE A - 97
3dfr_*_943dfr   *     MTXMETHOTREXATE A - 97
3dfr_*_943dfr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE G - 98
3dfr_*_943dfr   *     MTXMETHOTREXATE G - 98
3dfr_*_943dfr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE G - 99
3dfr_*_943dfr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE A - 100
3dfr_*_943dfr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Q - 101
3dfr_*_943dfr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE I - 102
3dfr_*_943dfr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE F - 103
3dfr_*_943dfr   *     MTXMETHOTREXATE F - 103
3dfr_*_943dfr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE A - 105
8dfr_*_1098dfr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE T - 118
8dfr_*_1098dfr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE A - 119
8dfr_*_1098dfr   *     NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE A - 123

Clusters included in this Subclass
CLUSTER: EH.2.76