ArchDB - Biological DataBase of Protein Loops

Information on SUBCLASS 10.3.1

Subclass Accession number: 8746
Subclass: 10.3.1

Type: HE alpha-beta
DB: ArchDB-EC

Image coordinates:

Consensus coordinates:

Number of loops: 5

Average sequence ID (%) : 64.5 +/- 17.4
Average RMSD (Å) : 0.340 +/- 0.114

Consensus geometry

d (Å): 17

delta (°): 90-135

theta (°): 90-135

rho (°): 225-270

Consensus Sequence:	XSIPXKXRPLXcRh
(φψ)-conformation:	aappaaabwpplbp

Pattern:	[KR]	[KR]	[T]	[W]	[ef]	[S]	[IL]	[P]	[ael]	[KQ]	x	[R]	[P]	[L]	[KP]	[DG]	[R]	[il]	[N]	[ILV]	[IV]	[IL]
Conservation:	-0.111	-0.103	0.472	2.910	-1.135	0.066	-0.318	1.285	-1.399	-0.278	-1.417	0.472	1.285	0.066	-0.543	-0.526	0.472	-1.203	0.879	-0.443	-0.122	-0.309

Loops included in this Subclass

Loop	PDB	Chain	Start	End	Sequence	Sec Struct	Ramachandran
1aoe_A_56	1aoe	A	56	77	RKTWESIPQKFRPLPDRLNIIL	HHHHHHS-GGG-S-TTSEEEEE	aaaaaaxpaaabwxxvbxxbbb
1df7_A_44	1df7	A	44	65	RRTWDSLPAKVRPLPGRRNVVL	HHHHHHS-GGGSS-TTSEEEEE	aaaaaaxxaaabwxxvbxxbbx
1dyr_*_59	1dyr	-	59	80	RKTWESIPLQFRPLKGRINVVI	HHHHHHS-TTT-S-TTSEEEEE	aaaaaaxpaaabwxxvbxbbbx
1kmv_A_54	1kmv	A	54	75	KKTWFSIPEKNRPLKGRINLVL	HHHHHHS-GGG-S-TTSEEEEE	aaaaaaxwaaabwpxvbxbbbx
8dfr_*_54	8dfr	-	54	75	KKTWFSIPEKNRPLKDRINIVL	HHHHHHS-GGG-S-TTEEEEEE	aaaaaaxpaaabwxpvbxxbbb

PDB ligands within a cut-off distance of 6 Å in this subclass

Loop	PDB	Chain	Ligands	Residue
1aoe_A_56	1aoe	A	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	R - 56
1aoe_A_56	1aoe	A	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	K - 57
1aoe_A_56	1aoe	A	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	T - 58
1aoe_A_56	1aoe	A	GW37-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE	T - 58
1aoe_A_56	1aoe	A	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	W - 59
1aoe_A_56	1aoe	A	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	S - 61
1aoe_A_56	1aoe	A	GW37-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE	S - 61
1aoe_A_56	1aoe	A	GW37-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE	I - 62
1aoe_A_56	1aoe	A	GW37-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE	L - 69
1aoe_A_56	1aoe	A	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	L - 77
1df7_A_44	1df7	A	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	R - 44
1df7_A_44	1df7	A	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	R - 45
1df7_A_44	1df7	A	GOLGLYCEROL	R - 45
1df7_A_44	1df7	A	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	T - 46
1df7_A_44	1df7	A	MTXMETHOTREXATE	T - 46
1df7_A_44	1df7	A	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	W - 47
1df7_A_44	1df7	A	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	S - 49
1df7_A_44	1df7	A	MTXMETHOTREXATE	S - 49
1df7_A_44	1df7	A	MTXMETHOTREXATE	L - 50
1df7_A_44	1df7	A	MTXMETHOTREXATE	P - 51
1df7_A_44	1df7	A	MTXMETHOTREXATE	K - 53
1df7_A_44	1df7	A	MTXMETHOTREXATE	V - 54
1df7_A_44	1df7	A	MTXMETHOTREXATE	L - 57
1df7_A_44	1df7	A	MTXMETHOTREXATE	P - 58
1df7_A_44	1df7	A	MTXMETHOTREXATE	R - 60
1df7_A_44	1df7	A	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	L - 65
1dyr_*_59	1dyr	*	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	R - 59
1dyr_*_59	1dyr	*	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	K - 60
1dyr_*_59	1dyr	*	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	T - 61
1dyr_*_59	1dyr	*	TOPTRIMETHOPRIM	T - 61
1dyr_*_59	1dyr	*	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	W - 62
1dyr_*_59	1dyr	*	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	S - 64
1dyr_*_59	1dyr	*	TOPTRIMETHOPRIM	S - 64
1dyr_*_59	1dyr	*	TOPTRIMETHOPRIM	I - 65
1dyr_*_59	1dyr	*	TOPTRIMETHOPRIM	P - 66
1dyr_*_59	1dyr	*	TOPTRIMETHOPRIM	F - 69
1dyr_*_59	1dyr	*	TOPTRIMETHOPRIM	L - 72
1dyr_*_59	1dyr	*	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	I - 80
1kmv_A_54	1kmv	A	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	K - 54
1kmv_A_54	1kmv	A	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	K - 55
1kmv_A_54	1kmv	A	LII(Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE	T - 56
1kmv_A_54	1kmv	A	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	T - 56
1kmv_A_54	1kmv	A	DMSDIMETHYL SULFOXIDE	T - 56
1kmv_A_54	1kmv	A	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	W - 57
1kmv_A_54	1kmv	A	LII(Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE	S - 59
1kmv_A_54	1kmv	A	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	S - 59
1kmv_A_54	1kmv	A	LII(Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE	I - 60
1kmv_A_54	1kmv	A	LII(Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE	P - 61
1kmv_A_54	1kmv	A	LII(Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE	N - 64
1kmv_A_54	1kmv	A	SULSULFATE ANION	L - 67
1kmv_A_54	1kmv	A	LII(Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE	L - 67
1kmv_A_54	1kmv	A	SULSULFATE ANION	K - 68
1kmv_A_54	1kmv	A	SULSULFATE ANION	G - 69
1kmv_A_54	1kmv	A	SULSULFATE ANION	R - 70
1kmv_A_54	1kmv	A	NDPNADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	L - 75
8dfr_*_54	8dfr	*	CACALCIUM ION	K - 54

Clusters included in this Subclass

CLUSTER: HE.10.7