PDB: 1a5u Compound: pyruvate kinase Classification: TRANSFERASE Entry date in PDB: 1999-03-02 Resolution [Å]: 2.35 R-Factor: 0.190

CHAIN: A SWISS-PROT/TREMBL: P11974    KEYWORD: 3D-structure    Alternative splicing    Glycolysis    Kinase    Magnesium    Multigene family    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Rabbit (Oryctolagus cuniculus) GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: B SWISS-PROT/TREMBL: P11974    KEYWORD: 3D-structure    Alternative splicing    Glycolysis    Kinase    Magnesium    Multigene family    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Rabbit (Oryctolagus cuniculus) GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: C SWISS-PROT/TREMBL: P11974    KEYWORD: 3D-structure    Alternative splicing    Glycolysis    Kinase    Magnesium    Multigene family    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Rabbit (Oryctolagus cuniculus) GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: D SWISS-PROT/TREMBL: P11974    KEYWORD: 3D-structure    Alternative splicing    Glycolysis    Kinase    Magnesium    Multigene family    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Rabbit (Oryctolagus cuniculus) GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: E SWISS-PROT/TREMBL: P11974    KEYWORD: 3D-structure    Alternative splicing    Glycolysis    Kinase    Magnesium    Multigene family    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Rabbit (Oryctolagus cuniculus) GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: F SWISS-PROT/TREMBL: P11974    KEYWORD: 3D-structure    Alternative splicing    Glycolysis    Kinase    Magnesium    Multigene family    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Rabbit (Oryctolagus cuniculus) GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: G SWISS-PROT/TREMBL: P11974    KEYWORD: 3D-structure    Alternative splicing    Glycolysis    Kinase    Magnesium    Multigene family    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Rabbit (Oryctolagus cuniculus) GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: H SWISS-PROT/TREMBL: P11974    KEYWORD: 3D-structure    Alternative splicing    Glycolysis    Kinase    Magnesium    Multigene family    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Rabbit (Oryctolagus cuniculus) GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis

Image Source: PDB

1a49 A - percentage of sequence identity: 100
1aqf E - percentage of sequence identity: 100
1liu A - percentage of sequence identity: 69
1lix B - percentage of sequence identity: 68