PDB: 1aqf Compound: pyruvate kinase Classification: TRANSFERASE Entry date in PDB: 1998-09-16 Resolution [Å]: 2.70 R-Factor: 0.196

CHAIN: A SWISS-PROT/TREMBL: P11974    KEYWORD: 3D-structure    Alternative splicing    Glycolysis    Kinase    Magnesium    Multigene family    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Rabbit (Oryctolagus cuniculus) GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: B SWISS-PROT/TREMBL: P11974    KEYWORD: 3D-structure    Alternative splicing    Glycolysis    Kinase    Magnesium    Multigene family    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Rabbit (Oryctolagus cuniculus) GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: C SWISS-PROT/TREMBL: P11974    KEYWORD: 3D-structure    Alternative splicing    Glycolysis    Kinase    Magnesium    Multigene family    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Rabbit (Oryctolagus cuniculus) GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: D SWISS-PROT/TREMBL: P11974    KEYWORD: 3D-structure    Alternative splicing    Glycolysis    Kinase    Magnesium    Multigene family    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Rabbit (Oryctolagus cuniculus) GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: E SWISS-PROT/TREMBL: P11974    KEYWORD: 3D-structure    Alternative splicing    Glycolysis    Kinase    Magnesium    Multigene family    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Rabbit (Oryctolagus cuniculus) GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: F SWISS-PROT/TREMBL: P11974    KEYWORD: 3D-structure    Alternative splicing    Glycolysis    Kinase    Magnesium    Multigene family    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Rabbit (Oryctolagus cuniculus) GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: G SWISS-PROT/TREMBL: P11974    KEYWORD: 3D-structure    Alternative splicing    Glycolysis    Kinase    Magnesium    Multigene family    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Rabbit (Oryctolagus cuniculus) GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: H SWISS-PROT/TREMBL: P11974    KEYWORD: 3D-structure    Alternative splicing    Glycolysis    Kinase    Magnesium    Multigene family    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Rabbit (Oryctolagus cuniculus) SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Rabbit (Oryctolagus cuniculus) GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis

Image Source: PDB

Loops in ArchDB-EC clusters

1aqf_E_17 - HH => SUBCLASS : 3.4.2

Loops in ArchDB-KI clusters

1aqf_A_288 - EH => SUBCLASS : 0.1.2
1aqf_A_155 - EH => SUBCLASS : 2.2.1
1aqf_A_426 - EH => SUBCLASS : 3.1.1
1aqf_A_45 - EH => SUBCLASS : 7.1.1
1aqf_A_468 - EH => SUBCLASS : 8.2.1
1aqf_A_208 - EH => SUBCLASS : 11.1.1
1aqf_A_323 - EH => SUBCLASS : 14.1.1
1aqf_A_180 - HA => SUBCLASS : 2.2.4
1aqf_A_172 - HA => SUBCLASS : 4.4.1
1aqf_A_507 - HA => SUBCLASS : 10.1.1
1aqf_A_279 - HE => SUBCLASS : 2.2.1
1aqf_A_57 - HE => SUBCLASS : 3.1.1
1aqf_A_222 - HE => SUBCLASS : 3.1.1
1aqf_A_341 - HE => SUBCLASS : 3.1.1
1aqf_A_407 - HE => SUBCLASS : 3.1.1
1aqf_A_456 - HE => SUBCLASS : 3.6.1
1aqf_A_163 - HE => SUBCLASS : 5.2.1
1aqf_A_247 - HE => SUBCLASS : 7.2.1
1aqf_A_481 - HE => SUBCLASS : 7.3.1
1aqf_A_80 - HE => SUBCLASS : 7.5.1
1aqf_A_25 - HE => SUBCLASS : 13.1.1
1aqf_A_293 - HH => SUBCLASS : 2.1.1
1aqf_A_370 - HH => SUBCLASS : 2.5.1
1aqf_A_390 - HH => SUBCLASS : 3.4.1
1aqf_A_17 - HH => SUBCLASS : 3.5.1

Loops not clustered in ArchDB

1aqf_E_45 - EH
1aqf_E_468 - EH
1aqf_E_449 - EH
1aqf_E_426 - EH
1aqf_E_357 - EH
1aqf_E_323 - EH
1aqf_E_288 - EH
1aqf_E_265 - EH
1aqf_E_238 - EH
1aqf_E_108 - EH
1aqf_E_70 - EH
1aqf_E_507 - HA
1aqf_E_57 - HE
1aqf_E_481 - HE
1aqf_E_456 - HE
1aqf_E_435 - HE
1aqf_E_407 - HE
1aqf_E_341 - HE
1aqf_E_305 - HE
1aqf_E_222 - HE
1aqf_E_80 - HE
1aqf_E_25 - HE
1aqf_E_247 - HE
1aqf_E_279 - HE
1aqf_E_293 - HH
1aqf_E_362 - HH
1aqf_E_370 - HH
1aqf_E_390 - HH
1aqf_E_273 - HH

Loops not clustered in ArchDB-KI

1aqf_A_131 - AR
1aqf_A_191 - AR
1aqf_A_201 - AR
1aqf_A_108 - AR
1aqf_A_70 - EH
1aqf_A_265 - EH
1aqf_A_449 - EH
1aqf_A_238 - EH
1aqf_A_357 - EH
1aqf_A_305 - HE
1aqf_A_435 - HE
1aqf_A_273 - HH
1aqf_A_362 - HH

1a49 A - percentage of sequence identity: 100
1a49 B - percentage of sequence identity: 100
1a49 C - percentage of sequence identity: 100
1a49 D - percentage of sequence identity: 100
1a49 E - percentage of sequence identity: 100
1a49 F - percentage of sequence identity: 100
1a49 G - percentage of sequence identity: 100
1a49 H - percentage of sequence identity: 100
1a5u A - percentage of sequence identity: 100
1a5u B - percentage of sequence identity: 100
1a5u C - percentage of sequence identity: 100
1a5u D - percentage of sequence identity: 100
1a5u E - percentage of sequence identity: 100
1a5u F - percentage of sequence identity: 100
1a5u G - percentage of sequence identity: 100
1a5u H - percentage of sequence identity: 100
1aqf A - percentage of sequence identity: 100
1aqf B - percentage of sequence identity: 100
1aqf C - percentage of sequence identity: 100
1aqf D - percentage of sequence identity: 100
1aqf E - percentage of sequence identity: 100
1aqf F - percentage of sequence identity: 100
1aqf G - percentage of sequence identity: 100
1aqf H - percentage of sequence identity: 100
1f3w A - percentage of sequence identity: 99
1f3w B - percentage of sequence identity: 99
1f3w C - percentage of sequence identity: 99
1f3w D - percentage of sequence identity: 99
1f3w E - percentage of sequence identity: 99
1f3w F - percentage of sequence identity: 99
1f3w G - percentage of sequence identity: 99
1f3w H - percentage of sequence identity: 99
1f3x A - percentage of sequence identity: 99
1f3x B - percentage of sequence identity: 99
1f3x C - percentage of sequence identity: 99
1f3x D - percentage of sequence identity: 99
1f3x E - percentage of sequence identity: 99
1f3x F - percentage of sequence identity: 99
1f3x G - percentage of sequence identity: 99
1f3x H - percentage of sequence identity: 99
1liu A - percentage of sequence identity: 69
1liu B - percentage of sequence identity: 69
1liu C - percentage of sequence identity: 69
1liu D - percentage of sequence identity: 69
1liw A - percentage of sequence identity: 68
1liw B - percentage of sequence identity: 68
1liw C - percentage of sequence identity: 68
1liw D - percentage of sequence identity: 68
1lix A - percentage of sequence identity: 68
1lix B - percentage of sequence identity: 68
1lix C - percentage of sequence identity: 68
1lix D - percentage of sequence identity: 68
1liy A - percentage of sequence identity: 68
1liy B - percentage of sequence identity: 68
1liy C - percentage of sequence identity: 68
1liy D - percentage of sequence identity: 68
1pkm - - percentage of sequence identity: 96
1pkn - - percentage of sequence identity: 98
1t5a A - percentage of sequence identity: 93
1t5a B - percentage of sequence identity: 93
1t5a C - percentage of sequence identity: 93
1t5a D - percentage of sequence identity: 93
1zjh A - percentage of sequence identity: 93