PDB: 1lix Compound: pyruvate kinase, isozymes rL Classification: TRANSFERASE Entry date in PDB: 2002-09-11 Resolution [Å]: 2.87 R-Factor: 0.245

CHAIN: A SWISS-PROT/TREMBL: P30613    KEYWORD: 3D-structure    Alternative splicing    Disease mutation    Glycolysis    Kinase    Magnesium    Multigene family    Phosphorylation    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Human (Homo sapiens) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Human (Homo sapiens) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Human (Homo sapiens) SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Human (Homo sapiens) GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: B SWISS-PROT/TREMBL: P30613    KEYWORD: 3D-structure    Alternative splicing    Disease mutation    Glycolysis    Kinase    Magnesium    Multigene family    Phosphorylation    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Human (Homo sapiens) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Human (Homo sapiens) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Human (Homo sapiens) SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Human (Homo sapiens) GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: C SWISS-PROT/TREMBL: P30613    KEYWORD: 3D-structure    Alternative splicing    Disease mutation    Glycolysis    Kinase    Magnesium    Multigene family    Phosphorylation    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Human (Homo sapiens) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Human (Homo sapiens) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Human (Homo sapiens) SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Human (Homo sapiens) GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis    CHAIN: D SWISS-PROT/TREMBL: P30613    KEYWORD: 3D-structure    Alternative splicing    Disease mutation    Glycolysis    Kinase    Magnesium    Multigene family    Phosphorylation    Transferase    EC: 2.7.1.40 SCOP: b.58.1.1 All beta proteins    PK beta-barrel domain-like    PK beta-barrel domain-like    Pyruvate kinase beta-barrel domain    Pyruvate kinase (PK)    Human (Homo sapiens) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Human (Homo sapiens) SCOP: c.1.12.1 Alpha and beta proteins (a/b)    TIM beta/alpha-barrel    Phosphoenolpyruvate/pyruvate domain    Pyruvate kinase    Pyruvate kinase, N-terminal domain    Human (Homo sapiens) SCOP: c.49.1.1 Alpha and beta proteins (a/b)    Pyruvate kinase C-terminal domain-like    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Pyruvate kinase, C-terminal domain    Human (Homo sapiens) GO:  pyruvate kinase activity    transferase activity, transferring phosphorus-containing groups    glycolysis

Image Source: PDB

Loops in ArchDB-EC clusters

1lix_B_414 - HH => SUBCLASS : 2.1.9

Loops not clustered in ArchDB

1lix_B_152 - AR
1lix_B_224 - AR
1lix_B_89 - EH
1lix_B_512 - EH
1lix_B_492 - EH
1lix_B_470 - EH
1lix_B_401 - EH
1lix_B_367 - EH
1lix_B_332 - EH
1lix_B_309 - EH
1lix_B_282 - EH
1lix_B_252 - EH
1lix_B_114 - EH
1lix_B_218 - HA
1lix_B_551 - HA
1lix_B_291 - HE
1lix_B_69 - HE
1lix_B_101 - HE
1lix_B_124 - HE
1lix_B_317 - HE
1lix_B_525 - HE
1lix_B_502 - HE
1lix_B_479 - HE
1lix_B_451 - HE
1lix_B_266 - HE
1lix_B_349 - HE
1lix_B_385 - HE
1lix_B_434 - HH
1lix_B_406 - HH
1lix_B_376 - HH
1lix_B_337 - HH
1lix_B_61 - HH

1a49 A - percentage of sequence identity: 68
1a49 B - percentage of sequence identity: 68
1a49 C - percentage of sequence identity: 68
1a49 D - percentage of sequence identity: 68
1a49 E - percentage of sequence identity: 68
1a49 F - percentage of sequence identity: 68
1a49 G - percentage of sequence identity: 68
1a49 H - percentage of sequence identity: 68
1a5u A - percentage of sequence identity: 68
1a5u B - percentage of sequence identity: 68
1a5u C - percentage of sequence identity: 68
1a5u D - percentage of sequence identity: 68
1a5u E - percentage of sequence identity: 68
1a5u F - percentage of sequence identity: 68
1a5u G - percentage of sequence identity: 68
1a5u H - percentage of sequence identity: 68
1aqf A - percentage of sequence identity: 68
1aqf B - percentage of sequence identity: 68
1aqf C - percentage of sequence identity: 68
1aqf D - percentage of sequence identity: 68
1aqf E - percentage of sequence identity: 68
1aqf F - percentage of sequence identity: 68
1aqf G - percentage of sequence identity: 68
1aqf H - percentage of sequence identity: 68
1f3w A - percentage of sequence identity: 69
1f3w B - percentage of sequence identity: 69
1f3w C - percentage of sequence identity: 69
1f3w D - percentage of sequence identity: 69
1f3w E - percentage of sequence identity: 69
1f3w F - percentage of sequence identity: 69
1f3w G - percentage of sequence identity: 69
1f3w H - percentage of sequence identity: 69
1f3x A - percentage of sequence identity: 69
1f3x B - percentage of sequence identity: 69
1f3x C - percentage of sequence identity: 69
1f3x D - percentage of sequence identity: 69
1f3x E - percentage of sequence identity: 69
1f3x F - percentage of sequence identity: 69
1f3x G - percentage of sequence identity: 69
1f3x H - percentage of sequence identity: 69
1liu A - percentage of sequence identity: 99
1liu B - percentage of sequence identity: 99
1liu C - percentage of sequence identity: 99
1liu D - percentage of sequence identity: 99
1liw A - percentage of sequence identity: 99
1liw B - percentage of sequence identity: 99
1liw C - percentage of sequence identity: 99
1liw D - percentage of sequence identity: 99
1lix A - percentage of sequence identity: 100
1lix B - percentage of sequence identity: 100
1lix C - percentage of sequence identity: 100
1lix D - percentage of sequence identity: 100
1liy A - percentage of sequence identity: 99
1liy B - percentage of sequence identity: 99
1liy C - percentage of sequence identity: 99
1liy D - percentage of sequence identity: 99
1pkm - - percentage of sequence identity: 69
1pkn - - percentage of sequence identity: 68
1t5a A - percentage of sequence identity: 71
1t5a B - percentage of sequence identity: 71
1t5a C - percentage of sequence identity: 71
1t5a D - percentage of sequence identity: 71
1zjh A - percentage of sequence identity: 71