PDB: 1fyh Compound: interferon-gamma Classification: IMMUNE SYSTEM Entry date in PDB: 2000-10-11 Resolution [Å]: 2.04 R-Factor: 0.194

CHAIN: A SWISS-PROT/TREMBL: P01579    KEYWORD: 3D-structure    Antiviral    Cytokine    Glycoprotein    Growth regulation    Pharmaceutical    Polymorphism    Signal    SCOP: a.26.1.3 All alpha proteins    4-helical cytokines    4-helical cytokines    Interferons/interleukin-10 (IL-10)    Interferon-gamma    Human (Homo sapiens) SCOP: a.26.1.3 All alpha proteins    4-helical cytokines    4-helical cytokines    Interferons/interleukin-10 (IL-10)    Interferon-gamma    Human (Homo sapiens) GO:  extracellular region    interferon-gamma receptor binding    immune response    CHAIN: B SWISS-PROT/TREMBL: P15260    KEYWORD: 3D-structure    Disease mutation    Glycoprotein    Immunoglobulin domain    Phosphorylation    Receptor    Signal    Transmembrane    SCOP: b.1.2.1 All beta proteins    Immunoglobulin-like beta-sandwich    Fibronectin type III    Fibronectin type III    Interferon-gamma receptor alpha chain    Human (Homo sapiens) SCOP: b.1.2.1 All beta proteins    Immunoglobulin-like beta-sandwich    Fibronectin type III    Fibronectin type III    Interferon-gamma receptor alpha chain    Human (Homo sapiens) GO:  membrane    cytokine binding    hematopoietin/interferon-class (D200-domain) cytokine receptor activity    CHAIN: D SWISS-PROT/TREMBL: P01579    KEYWORD: 3D-structure    Antiviral    Cytokine    Glycoprotein    Growth regulation    Pharmaceutical    Polymorphism    Signal    SCOP: a.26.1.3 All alpha proteins    4-helical cytokines    4-helical cytokines    Interferons/interleukin-10 (IL-10)    Interferon-gamma    Human (Homo sapiens) SCOP: a.26.1.3 All alpha proteins    4-helical cytokines    4-helical cytokines    Interferons/interleukin-10 (IL-10)    Interferon-gamma    Human (Homo sapiens) GO:  extracellular region    interferon-gamma receptor binding    immune response    CHAIN: E SWISS-PROT/TREMBL: P15260    KEYWORD: 3D-structure    Disease mutation    Glycoprotein    Immunoglobulin domain    Phosphorylation    Receptor    Signal    Transmembrane    SCOP: b.1.2.1 All beta proteins    Immunoglobulin-like beta-sandwich    Fibronectin type III    Fibronectin type III    Interferon-gamma receptor alpha chain    Human (Homo sapiens) SCOP: b.1.2.1 All beta proteins    Immunoglobulin-like beta-sandwich    Fibronectin type III    Fibronectin type III    Interferon-gamma receptor alpha chain    Human (Homo sapiens) GO:  membrane    cytokine binding    hematopoietin/interferon-class (D200-domain) cytokine receptor activity

Image Source: PDB

Loops in ArchDB40 clusters

1fyh_B_114 - HA => SUBCLASS : 2.2.3
1fyh_B_152 - HA => SUBCLASS : 2.3.1
1fyh_B_16 - HA => SUBCLASS : 4.5.1
1fyh_B_97 - EH => SUBCLASS : 5.17.2

Loops in ArchDB95 clusters

1fyh_B_97 - EH => SUBCLASS : 5.54.1
1fyh_B_28 - AR => SUBCLASS : 5.12.1
1fyh_A_30 - HH => SUBCLASS : 3.5.2
1fyh_A_267 - HH => SUBCLASS : 3.7.1
1fyh_A_67 - HH => SUBCLASS : 3.7.1
1fyh_A_103 - HH => SUBCLASS : 5.1.2
1fyh_A_286 - HH => SUBCLASS : 5.19.1
1fyh_A_86 - HH => SUBCLASS : 5.19.1
1fyh_B_114 - HA => SUBCLASS : 2.2.3
1fyh_B_152 - HA => SUBCLASS : 2.3.1
1fyh_B_16 - HA => SUBCLASS : 3.2.1

Loops not clustered in ArchDB

1fyh_B_182 - AR
1fyh_B_57 - AR
1fyh_B_67 - AR
1fyh_B_92 - AR
1fyh_B_123 - AR
1fyh_B_164 - AR
1fyh_B_195 - HA
1fyh_B_41 - HA
1fyh_B_81 - HA
1fyh_B_104 - HE
1fyh_A_3 - HH
1fyh_A_39 - HH
1fyh_A_202 - HH
1fyh_A_230 - HH
1fyh_A_239 - HH

1d9c A - percentage of sequence identity: 60
1fg9 C - percentage of sequence identity: 100
1fg9 D - percentage of sequence identity: 100
1fg9 E - percentage of sequence identity: 100
1fyh B - percentage of sequence identity: 100
1fyh E - percentage of sequence identity: 100
1jrh I - percentage of sequence identity: 99