PDB: 1lya Compound: Cathepsin d Classification: LYSOSOMAL ASPARTIC PROTEASE Entry date in PDB: 1994-01-31 Resolution [Å]: 2.50 R-Factor: 0.188

CHAIN: A SWISS-PROT/TREMBL: P07339    KEYWORD: 3D-structure    Alzheimer's disease    Aspartyl protease    Glycoprotein    Hydrolase    Lysosome    Polymorphism    Signal    Zymogen    EC: 3.4.23.5 SCOP: b.50.1.2 All beta proteins    Acid proteases    Acid proteases    Pepsin-like    Cathepsin D    Human (Homo sapiens) GO:  aspartic-type endopeptidase activity    pepsin A activity    proteolysis and peptidolysis    CHAIN: B SWISS-PROT/TREMBL: P07339    KEYWORD: 3D-structure    Alzheimer's disease    Aspartyl protease    Glycoprotein    Hydrolase    Lysosome    Polymorphism    Signal    Zymogen    EC: 3.4.23.5 SCOP: b.50.1.2 All beta proteins    Acid proteases    Acid proteases    Pepsin-like    Cathepsin D    Human (Homo sapiens) GO:  aspartic-type endopeptidase activity    pepsin A activity    proteolysis and peptidolysis    CHAIN: C SWISS-PROT/TREMBL: P07339    KEYWORD: 3D-structure    Alzheimer's disease    Aspartyl protease    Glycoprotein    Hydrolase    Lysosome    Polymorphism    Signal    Zymogen    EC: 3.4.23.5 SCOP: b.50.1.2 All beta proteins    Acid proteases    Acid proteases    Pepsin-like    Cathepsin D    Human (Homo sapiens) GO:  aspartic-type endopeptidase activity    pepsin A activity    proteolysis and peptidolysis    CHAIN: D SWISS-PROT/TREMBL: P07339    KEYWORD: 3D-structure    Alzheimer's disease    Aspartyl protease    Glycoprotein    Hydrolase    Lysosome    Polymorphism    Signal    Zymogen    EC: 3.4.23.5 SCOP: b.50.1.2 All beta proteins    Acid proteases    Acid proteases    Pepsin-like    Cathepsin D    Human (Homo sapiens) GO:  aspartic-type endopeptidase activity    pepsin A activity    proteolysis and peptidolysis

Image Source: PDB

Loops in ArchDB95 clusters

1lya_B_226 - AR => SUBCLASS : 4.7.1
1lya_B_281 - AR => SUBCLASS : 4.11.1
1lya_B_281 - AR => SUBCLASS : 5.23.1
1lya_B_179 - AR => SUBCLASS : 7.15.1
1lya_B_191 - AR => SUBCLASS : 7.30.1
1lya_B_260 - AR => SUBCLASS : 10.2.1
1lya_B_254 - HA => SUBCLASS : 2.1.1
1lya_B_207 - HA => SUBCLASS : 3.1.2
1lya_A_8 - HA => SUBCLASS : 3.7.1
1lya_B_329 - HA => SUBCLASS : 4.1.1
1lya_B_207 - HA => SUBCLASS : 5.1.3
1lya_A_68 - HA => SUBCLASS : 5.3.1

Loops in ArchDB-EC clusters

1lya_A_51 - HE => SUBCLASS : 12.2.2

Loops not clustered in ArchDB

1lya_A_82 - AR
1lya_B_306 - AR
1lya_B_179 - AR
1lya_B_191 - AR
1lya_B_220 - AR
1lya_B_226 - AR
1lya_B_260 - AR
1lya_B_281 - AR
1lya_B_301 - AR
1lya_B_306 - AR
1lya_B_301 - AR
1lya_A_82 - AR
1lya_B_220 - AR
1lya_A_26 - EH
1lya_B_319 - EH
1lya_B_237 - EH
1lya_A_8 - HA
1lya_B_329 - HA
1lya_A_14 - HA
1lya_A_68 - HA
1lya_B_291 - HA
1lya_B_274 - HA
1lya_B_291 - HA
1lya_B_274 - HA
1lya_B_164 - HA
1lya_B_164 - HA
1lya_B_207 - HA
1lya_A_14 - HA
1lya_B_254 - HA
1lya_B_323 - HE
1lya_B_150 - HE
1lya_B_241 - HE

1dpj A - percentage of sequence identity: 60
1lya B - percentage of sequence identity: 100
1lya D - percentage of sequence identity: 100
1lyb B - percentage of sequence identity: 100
1lyb D - percentage of sequence identity: 100
1lyw B - percentage of sequence identity: 100
1lyw D - percentage of sequence identity: 100
1lyw F - percentage of sequence identity: 100
1lyw H - percentage of sequence identity: 100
1qdm A - percentage of sequence identity: 63
1smr A - percentage of sequence identity: 63