PDB: 2shp Compound: shp-2 Classification: TYROSINE PHOSPHATASE Entry date in PDB: 1999-02-16 Resolution [Å]: 2.00 R-Factor: 0.199

CHAIN: A SWISS-PROT/TREMBL: Q06124    KEYWORD: 3D-structure    Deafness    Disease mutation    Hydrolase    Phosphorylation    Protein phosphatase    Repeat    SH2 domain    EC: 3.1.3.48 SCOP: c.45.1.2 Alpha and beta proteins (a/b)    (Phosphotyrosine protein) phosphatases II    (Phosphotyrosine protein) phosphatases II    Higher-molecular-weight phosphotyrosine protein phosphatases    Tyrosine phosphatase    Human (Homo sapiens), shp-2 SCOP: d.93.1.1 Alpha and beta proteins (a+b)    SH2-like    SH2 domain    SH2 domain    Tyrosine phoshatase shp-2    Human (Homo sapiens) SCOP: d.93.1.1 Alpha and beta proteins (a+b)    SH2-like    SH2 domain    SH2 domain    Tyrosine phoshatase shp-2    Human (Homo sapiens) GO:  phosphoprotein phosphatase activity    protein tyrosine phosphatase activity    intracellular signaling cascade    protein amino acid dephosphorylation    CHAIN: B SWISS-PROT/TREMBL: Q06124    KEYWORD: 3D-structure    Deafness    Disease mutation    Hydrolase    Phosphorylation    Protein phosphatase    Repeat    SH2 domain    EC: 3.1.3.48 SCOP: c.45.1.2 Alpha and beta proteins (a/b)    (Phosphotyrosine protein) phosphatases II    (Phosphotyrosine protein) phosphatases II    Higher-molecular-weight phosphotyrosine protein phosphatases    Tyrosine phosphatase    Human (Homo sapiens), shp-2 SCOP: d.93.1.1 Alpha and beta proteins (a+b)    SH2-like    SH2 domain    SH2 domain    Tyrosine phoshatase shp-2    Human (Homo sapiens) SCOP: d.93.1.1 Alpha and beta proteins (a+b)    SH2-like    SH2 domain    SH2 domain    Tyrosine phoshatase shp-2    Human (Homo sapiens) GO:  phosphoprotein phosphatase activity    protein tyrosine phosphatase activity    intracellular signaling cascade    protein amino acid dephosphorylation

Image Source: PDB

Loops in ArchDB40 clusters

2shp_A_338 - HE => SUBCLASS : 3.1.1
2shp_A_432 - HE => SUBCLASS : 4.4.1
2shp_A_432 - HE => SUBCLASS : 4.4.2
2shp_A_119 - HE => SUBCLASS : 4.27.1
2shp_A_119 - HE => SUBCLASS : 4.35.1
2shp_A_166 - HA => SUBCLASS : 2.1.1
2shp_A_41 - HA => SUBCLASS : 2.1.1
2shp_A_360 - HA => SUBCLASS : 2.1.1
2shp_A_383 - HA => SUBCLASS : 2.2.3
2shp_A_377 - HA => SUBCLASS : 2.3.5
2shp_A_63 - HA => SUBCLASS : 4.17.1
2shp_A_63 - HA => SUBCLASS : 5.4.1
2shp_A_134 - HA => SUBCLASS : 6.5.1
2shp_A_221 - EH => SUBCLASS : 1.3.1
2shp_A_70 - EH => SUBCLASS : 2.1.1
2shp_A_327 - EH => SUBCLASS : 4.13.5
2shp_A_352 - AR => SUBCLASS : 4.23.1

Loops in ArchDB95 clusters

2shp_A_221 - EH => SUBCLASS : 1.2.1
2shp_A_70 - EH => SUBCLASS : 2.1.1
2shp_A_327 - EH => SUBCLASS : 4.10.3
2shp_A_352 - AR => SUBCLASS : 4.14.1
2shp_A_490 - HH => SUBCLASS : 7.3.1
2shp_A_338 - HE => SUBCLASS : 3.1.1
2shp_A_432 - HE => SUBCLASS : 4.9.2
2shp_A_119 - HE => SUBCLASS : 5.8.2
2shp_A_13 - HE => SUBCLASS : 5.8.2
2shp_A_432 - HE => SUBCLASS : 5.36.1
2shp_A_41 - HA => SUBCLASS : 2.1.1
2shp_A_360 - HA => SUBCLASS : 2.1.1
2shp_A_166 - HA => SUBCLASS : 2.1.1
2shp_A_383 - HA => SUBCLASS : 2.2.3
2shp_A_377 - HA => SUBCLASS : 2.3.3
2shp_A_377 - HA => SUBCLASS : 2.3.4
2shp_A_63 - HA => SUBCLASS : 2.4.2
2shp_A_63 - HA => SUBCLASS : 5.3.1
2shp_A_134 - HA => SUBCLASS : 7.1.1

Loops in ArchDB-EC clusters

2shp_A_490 - HH => SUBCLASS : 7.4.1

Loops not clustered in ArchDB

2shp_A_364 - AR
2shp_A_364 - AR
2shp_A_352 - AR
2shp_A_214 - AR
2shp_A_214 - AR
2shp_A_100 - EH
2shp_A_178 - EH
2shp_A_487 - EH
2shp_A_408 - EH
2shp_A_455 - EH
2shp_A_396 - HA
2shp_A_63 - HA
2shp_A_134 - HA
2shp_A_147 - HA
2shp_A_166 - HA
2shp_A_289 - HA
2shp_A_304 - HA
2shp_A_360 - HA
2shp_A_377 - HA
2shp_A_383 - HA
2shp_A_50 - HA
2shp_A_41 - HA
2shp_A_28 - HA
2shp_A_50 - HA
2shp_A_147 - HA
2shp_A_289 - HA
2shp_A_304 - HA
2shp_A_396 - HA
2shp_A_28 - HA
2shp_A_74 - HE
2shp_A_464 - HE
2shp_A_266 - HE
2shp_A_190 - HE
2shp_A_247 - HH
2shp_A_226 - HH

1fpr A - percentage of sequence identity: 60
1gwz - - percentage of sequence identity: 60
2shp A - percentage of sequence identity: 100
2shp B - percentage of sequence identity: 100