PDB: 2src Compound: tyrosine-protein kinase src Classification: TYROSINE-PROTEIN KINASE Entry date in PDB: 1999-07-22 Resolution [Å]: 1.50 R-Factor: 0.226

CHAIN: - SWISS-PROT/TREMBL: P12931    KEYWORD: 3D-structure    ATP-binding    Lipoprotein    Myristate    Phosphorylation    Proto-oncogene    SH2 domain    SH3 domain    Transferase    Tyrosine-protein kinase    EC: 2.7.1.112 SCOP: b.34.2.1 All beta proteins    SH3-like barrel    SH3-domain    SH3-domain    c-src protein tyrosine kinase    Human (Homo sapiens) SCOP: d.93.1.1 Alpha and beta proteins (a+b)    SH2-like    SH2 domain    SH2 domain    c-src tyrosine kinase    Human (Homo sapiens) SCOP: d.144.1.7 Alpha and beta proteins (a+b)    Protein kinase-like (PK-like)    Protein kinase-like (PK-like)    Protein kinases, catalytic subunit    c-src tyrosine kinase    Human (Homo sapiens) GO:  ATP binding    protein kinase activity    protein-tyrosine kinase activity    intracellular signaling cascade    protein amino acid phosphorylation

Image Source: PDB

Loops in ArchDB-KI clusters

2src_*_129 - AR => SUBCLASS : 3.2.1
2src_*_335 - EH => SUBCLASS : 7.2.1
2src_*_392 - HA => SUBCLASS : 2.1.2
2src_*_279 - HA => SUBCLASS : 3.3.1
2src_*_267 - HA => SUBCLASS : 3.4.1
2src_*_118 - HA => SUBCLASS : 4.1.1
2src_*_196 - HA => SUBCLASS : 4.1.1
2src_*_171 - HA => SUBCLASS : 7.1.1
2src_*_86 - HA => SUBCLASS : 18.1.1
2src_*_304 - HE => SUBCLASS : 8.1.1
2src_*_360 - HE => SUBCLASS : 11.1.1
2src_*_431 - HH => SUBCLASS : 4.2.1
2src_*_489 - HH => SUBCLASS : 9.1.3
2src_*_441 - HH => SUBCLASS : 10.1.1
2src_*_468 - HH => SUBCLASS : 11.1.1

Loops not clustered in ArchDB-KI

2src_*_243 - AR
2src_*_137 - EH
2src_*_399 - EH
2src_*_219 - EH
2src_*_290 - EH
2src_*_184 - HA
2src_*_107 - HA
2src_*_212 - HA
2src_*_325 - HA
2src_*_155 - HE
2src_*_223 - HE
2src_*_346 - HH
2src_*_414 - HH

1efn A - percentage of sequence identity: 75
1f2f A - percentage of sequence identity: 96
1fmk - - percentage of sequence identity: 100
1qcf A - percentage of sequence identity: 62
1qpc A - percentage of sequence identity: 67
1shf A - percentage of sequence identity: 76