PDB: 2cbl Compound: proto-oncogene cbl Classification: COMPLEX (PROTO-ONCOGENE/PEPTIDE) Entry date in PDB: 1999-05-18 Resolution [Å]: 2.10 R-Factor: 0.173

CHAIN: A SWISS-PROT/TREMBL: P22681    KEYWORD: 3D-structure    Calcium-binding    Ligase    Phosphorylation    Proto-oncogene    SH2 domain    Ubl conjugation pathway    Zinc-finger    EC: 6.3.2.- SCOP: a.39.1.7 All alpha proteins    EF Hand-like    EF-hand    EF-hand modules in multidomain proteins    Cbl    Human (Homo sapiens) SCOP: a.48.1.1 All alpha proteins    N-cbl like    N-terminal domain of cbl (N-cbl)    N-terminal domain of cbl (N-cbl)    N-terminal domain of cbl (N-cbl)    Human (Homo sapiens) SCOP: d.93.1.1 Alpha and beta proteins (a+b)    SH2-like    SH2 domain    SH2 domain    Cbl    Human (Homo sapiens) GO:  nucleus    ubiquitin ligase complex    calcium ion binding    signal transducer activity    ubiquitin-protein ligase activity    zinc ion binding    cell surface receptor linked signal transduction    protein ubiquitination

Image Source: PDB

Loops in ArchDB40 clusters

2cbl_A_218 - HE => SUBCLASS : 6.3.1
2cbl_A_303 - HA => SUBCLASS : 3.1.1
2cbl_A_314 - EH => SUBCLASS : 5.22.2
2cbl_A_314 - EH => SUBCLASS : 5.41.1

Loops in ArchDB95 clusters

2cbl_A_314 - EH => SUBCLASS : 6.20.1
2cbl_A_218 - HE => SUBCLASS : 6.3.1
2cbl_A_303 - HA => SUBCLASS : 3.1.1

Loops in ArchDB-EC clusters

2cbl_A_106 - HH => SUBCLASS : 1.1.2

Loops not clustered in ArchDB

2cbl_A_199 - EH
2cbl_A_235 - EH
2cbl_A_290 - HA
2cbl_A_290 - HA
2cbl_A_303 - HA
2cbl_A_184 - HE
2cbl_A_324 - HE
2cbl_A_274 - HE
2cbl_A_53 - HH
2cbl_A_254 - HH
2cbl_A_238 - HH
2cbl_A_202 - HH
2cbl_A_146 - HH
2cbl_A_84 - HH
2cbl_A_113 - HH

1b47 A - percentage of sequence identity: 100
1b47 B - percentage of sequence identity: 100
1b47 C - percentage of sequence identity: 100
1fbv A - percentage of sequence identity: 100
1yvh A - percentage of sequence identity: 100