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Information on SUBCLASS 4.2.1
Subclass Accession number: 271
Subclass: 4.2.1 PSSM
Type: HE alpha-beta
DB: ArchDB40

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB

Conserved Annotation
SCOP : 53849 (>50 %)  53850 (>50 %)  53851 (>75 %)  
 Number of loops: 39

Average sequence ID (%) : 18.8 +/- 18.9
Average RMSD (Å) : 0.431 +/- 0.147

Consensus geometry
d (Å): 9 delta (°): 90-135 theta (°): 135-180 rho (°): 135-180
Consensus Sequence: XXcphXhh
(φψ)-conformation: aalababb
Pattern: [adegknqrst]x[ACFILTV]x[adeknrst][DGKNR][adeknqrst][AFGILMVY][adegpqst][acfilmv][afgilmtv]
Conservation:-0.834-0.9371.254-0.880-0.1782.324-0.4220.259-0.3940.241-0.433
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1a99_A_2291a99   A231241NDLANGDICVAHHHHTTS-SEEaaaaavababb
1amf_*_1521amf   -157167ALVERNEAPLGHHHHTTSSSEEaaaaalababb
1atg_*_1471atg   -152162SQTASGAADLGHHHHTTSSSEEaaaaavababb
1cb6_A_11911cb6   A11971207KCLRDGAGDVAHHHHTTS-SEEaaaaavababb
1cb6_A_15271cb6   A15331543RCLAENAGDVAHHHHTTS-SEEaaaaavababb
1dc1_A_2861dc1   A294304DQLQSGSLTNSHHHHHTSS-EEaaaaavababb
1drk_*_2181drk   -222232KAVNDGKLAATHHHHHTSS-EEaaaaavababb
1elj_A_2101elj   A215225SIFLEGRAPMMHHHHTTSSSEEaaaaavababb
1gud_A_2301gud   A234244KMVEAGQMTATHHHHHTSS-EEaaaaavababb
1gv8_A_1931gv8   A199209QCLKDGKGDVAHHHHTTS-SEEaaaaavababb
1i6a_A_1291i6a   A134144AQLDSGKLDAVHHHHHTS-SEEaaaaagababb
1ii5_A_541ii5   A5969TAVAEGELDILHHHHTTS-SEEaaaaavababb
1ixc_A_1291ixc   A134144EGLLAGTIHVGHHHHHTS-SEEaaaaavababb
1jx6_A_2931jx6   A297307DAIQKGDLDITHHHHHTSS-EEaaaaavababb
1lst_*_1431lst   -148158SDLTAGRLDAAHHHHTTS-SEEaaaaavababb
1lst_*_551lst   -5767PSLKAKKIDAIHHHHTTS-SEEaaaaavababb
1m22_A_2041m22   A208218VAVAANLASVAHHHHTTSSSEEaaaaalababb
1m4j_A_111m4j   A1828ARARNGKYRLLHHHHTTT-SEEaaaaagababb
1mqi_A_731mqi   A7686GELVYGKADIAHHHHTTS-SEEaaaaavababb
1naq_A_211naq   A3040KVLAEKLAACAHHHHTTS-SEEaaaaalababb
1nh8_A_1421nh8   A142152ISVQLGVADAIHHHHTTS-SEEaaaaavababb
1nnf_A_1751nnf   A180190QAVENGEVPAAHHHHTTS-SEEaaaaavababb
1nza_A_121nza   A2131ALVEERLAACVHHHHTTS-SEEaaaaalababb
1o9p_A_1331o9p   A137147AAVGAGMIPLAHHHHTTS-SEEaaaaavababb
1oyw_A_2721oyw   A280290EKFQRDDLQIVHHHHTTS-SEEaaaaavababb
1p99_A_781p99   A8090KALNDGDIDMNHHHHTTSSSEEaaaaavababb
1pb7_A_1081pb7   A111121GELLSGQADMIHHHHHTS-SEEaaaaagababb
1pb7_A_2061pb7   A211221QAVRDNKLHAFHHHHTTS-SEEaaaaavababb
1pda_*_641pda   -6878VALLENRADIAHHHHTTS-SEEaaaaalababb
1ptm_A_931ptm   A106116DGCLNGEFAALHHHHHTS-SEEaaaaavababb
1r9l_A_461r9l   A5161TSLASGDATFTHHHHHTSS-EEaaaaavababb
1ryo_A_1871ryo   A193203KCLKDGAGDVAHHHHTTS-SEEaaaaavababb
1s14_A_10331s14   A10451055DEALAGHAKRVHHHHTTS-SEEaaaaavababb
1uiu_A_2021uiu   A207217VAFETGDIDLLHHHHTTS-SEEaaaaavababb
1uku_A_111uku   A2030TLLKERLIACAHHHHTTS-SEEaaaaavababb
1urs_A_2351urs   A240250AEFLAGKIGMYHHHHTT--SEEaaaaavababb
1us5_A_601us5   A6575NAINAGEFEMAHHHHTTS-SEEaaaaavababb
1wdn_A_1391wdn   A144154MELGTNRADAVHHHHTTS-SEEaaaaavababb
1wdn_A_531wdn   A5565PALQTKNVDLAHHHHTTSSSEEaaaaalababb
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1a99_A_2291a99   A     PUT1,4-DIAMINOBUTANE I - 230
1a99_A_2291a99   A     PUT1,4-DIAMINOBUTANE W - 244
1amf_*_1521amf   *     MOOMOLYBDATE ION V - 152
1amf_*_1521amf   *     MOOMOLYBDATE ION R - 153
1amf_*_1521amf   *     MOOMOLYBDATE ION G - 154
1amf_*_1521amf   *     MOOMOLYBDATE ION Y - 170
1atg_*_1471atg   *     WO4TUNGSTATE(VI)ION V - 147
1atg_*_1471atg   *     WO4TUNGSTATE(VI)ION G - 148
1atg_*_1471atg   *     ACTACETATE ION G - 157
1atg_*_1471atg   *     ACTACETATE ION A - 158
1atg_*_1471atg   *     ACTACETATE ION A - 159
1atg_*_1471atg   *     ACTACETATE ION D - 160
1atg_*_1471atg   *     ACTACETATE ION L - 161
1elj_A_2101elj   A     GLCGLUCOSE Y - 210
1gud_A_2301gud   A     ZNZINC ION R - 233
1gud_A_2301gud   A     ZNZINC ION E - 237
1gv8_A_1931gv8   A     GLYGLYCINE Y - 194
1gv8_A_1931gv8   A     CO3CARBONATE ION Y - 194
1gv8_A_1931gv8   A     FEFE (III) ION Y - 194
1gv8_A_1931gv8   A     CO3CARBONATE ION F - 210
1gv8_A_1931gv8   A     CO3CARBONATE ION V - 211
1gv8_A_1931gv8   A     CO3CARBONATE ION K - 212
1gv8_A_1931gv8   A     FEFE (III) ION K - 212
1ii5_A_541ii5   A     GLUGLUTAMIC ACID I - 54
1ii5_A_541ii5   A     GLUGLUTAMIC ACID P - 72
1ii5_A_541ii5   A     GLUGLUTAMIC ACID I - 73
1ii5_A_541ii5   A     GLUGLUTAMIC ACID S - 74
1ixc_A_1291ixc   A     MSESELENOMETHIONINE K - 129
1ixc_A_1291ixc   A     MSESELENOMETHIONINE E - 131
1ixc_A_1291ixc   A     MSESELENOMETHIONINE Q - 132
1ixc_A_1291ixc   A     MSESELENOMETHIONINE G - 135
1ixc_A_1291ixc   A     MSESELENOMETHIONINE T - 140
1ixc_A_1291ixc   A     MSESELENOMETHIONINE I - 141
1ixc_A_1291ixc   A     MSESELENOMETHIONINE F - 145
1jx6_A_2931jx6   A     AI23A-METHYL-5,6-DIHYDRO-FURO[2,3-D][1,3,2]DIOXABOROLE-2, 2,6,6A-TETRAOL E - 295
1jx6_A_2931jx6   A     AI23A-METHYL-5,6-DIHYDRO-FURO[2,3-D][1,3,2]DIOXABOROLE-2, 2,6,6A-TETRAOL R - 310
1naq_A_211naq   A     MBOMERCURIBENZOIC ACID T - 23
1naq_A_211naq   A     HGMERCURY (II) ION L - 27
1naq_A_211naq   A     MBOMERCURIBENZOIC ACID L - 27
1naq_A_211naq   A     HGMERCURY (II) ION E - 34
1naq_A_211naq   A     HGMERCURY (II) ION L - 36
1naq_A_211naq   A     HGMERCURY (II) ION A - 38
1naq_A_211naq   A     MBOMERCURIBENZOIC ACID A - 38
1naq_A_211naq   A     HGMERCURY (II) ION C - 39
1naq_A_211naq   A     MBOMERCURIBENZOIC ACID C - 39
1naq_A_211naq   A     HGMERCURY (II) ION A - 40
1naq_A_211naq   A     MBOMERCURIBENZOIC ACID A - 40
1naq_A_211naq   A     HGMERCURY (II) ION T - 41
1naq_A_211naq   A     MBOMERCURIBENZOIC ACID T - 41
1naq_A_211naq   A     HGMERCURY (II) ION S - 48
1naq_A_211naq   A     MBOMERCURIBENZOIC ACID S - 48
1naq_A_211naq   A     HGMERCURY (II) ION L - 49
1naq_A_211naq   A     MBOMERCURIBENZOIC ACID L - 49
1naq_A_211naq   A     HGMERCURY (II) ION Y - 50
1naq_A_211naq   A     MBOMERCURIBENZOIC ACID Y - 50
1nh8_A_1421nh8   A     AMPADENOSINE MONOPHOSPHATE V - 155
1nh8_A_1421nh8   A     AMPADENOSINE MONOPHOSPHATE V - 156
1nnf_A_1751nnf   A     FEFE (III) ION N - 175
1nnf_A_1751nnf   A     EDT{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID N - 175
1nnf_A_1751nnf   A     FEFE (III) ION N - 193
1nnf_A_1751nnf   A     EDT{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID N - 193
1nza_A_121nza   A     GOLGLYCEROL P - 35
1nza_A_121nza   A     GOLGLYCEROL G - 36
1nza_A_121nza   A     GOLGLYCEROL L - 37
1nza_A_121nza   A     GOLGLYCEROL T - 38
1o9p_A_1331o9p   A     MLAMALONIC ACID T - 150
1o9p_A_1331o9p   A     MLAMALONIC ACID Q - 151
1p99_A_781p99   A     GLYGLYCINE F - 92
1p99_A_781p99   A     METMETHIONINE F - 92
1p99_A_781p99   A     METMETHIONINE Q - 93
1p99_A_781p99   A     METMETHIONINE H - 94
1pb7_A_2061pb7   A     GLYGLYCINE W - 223
1pb7_A_2061pb7   A     GLYGLYCINE D - 224
1pda_*_641pda   *     DPM3-{2-[4-(2-CARBOXY-ETHYL)-3-CARBOXYMETHYL-5H-PYRROL-2-YLMETHYL]-4-CARBOXYMETHYL-5-METHYL-2H-PYRROL-3-YL}-PROPIONIC ACID S - 81
1ptm_A_931ptm   A     PO4PHOSPHATE ION T - 118
1r9l_A_461r9l   A     BETTRIMETHYL GLYCINE Y - 46
1r9l_A_461r9l   A     BETTRIMETHYL GLYCINE W - 65
1ryo_A_1871ryo   A     OXLOXALATE ION G - 187
1ryo_A_1871ryo   A     OXLOXALATE ION Y - 188
1ryo_A_1871ryo   A     FEFE (III) ION Y - 188
1ryo_A_1871ryo   A     OXLOXALATE ION F - 204
1ryo_A_1871ryo   A     OXLOXALATE ION V - 205
1s14_A_10331s14   A     NOVNOVOBIOCIN V - 1039
1s14_A_10331s14   A     NOVNOVOBIOCIN D - 1041
1s14_A_10331s14   A     NOVNOVOBIOCIN N - 1042
1s14_A_10331s14   A     NOVNOVOBIOCIN S - 1043
1s14_A_10331s14   A     NOVNOVOBIOCIN D - 1045
1s14_A_10331s14   A     NOVNOVOBIOCIN E - 1046
1us5_A_601us5   A     GLUGLUTAMIC ACID S - 60
1us5_A_601us5   A     GLUGLUTAMIC ACID V - 61
1us5_A_601us5   A     GLUGLUTAMIC ACID A - 77
1us5_A_601us5   A     GLUGLUTAMIC ACID Q - 78
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1amf_*_1521amf   * MO4MOLYBDATE BINDING SITE.V - 152
1amf_*_1521amf   * MO4MOLYBDATE BINDING SITE.Y - 170
1atg_*_1471atg   * MOBANION-BINDING POCKET LOCATED AT THE INTERFACE BETWEEN THE 2 DOMAINS OF THE PROTEIN. BINDS BOTH MOLYBDATE AND TUNGSTATE.V - 147
1cb6_A_11911cb6   A CLBCHLORIDE ION LOCATED NEAR CARBONATE SITE IN OPEN N LOBE, FORMING HYDROGEN BONDS WITH THR117_OG1, ARG121_NE, ALA123_N AND TYR192_OHY - 1192
1cb6_A_15271cb6   A CLACHLORIDE ION LOCATED NEAR CARBONATE SITE IN CLOSED C LOBE, FORMING HYDROGEN BONDS WITH THR461_OG1, ARG465_NE, ARG465_NH2, GLY468_N AND TYR528_OHY - 1528
1gud_A_2301gud   A ZN4ZN BINDING SITE FOR CHAIN AE - 237
1gv8_A_1931gv8   A AC1GLY BINDING SITE FOR CHAIN AY - 194
1us5_A_601us5   A AC2GLU BINDING SITE FOR CHAIN AS - 60

Clusters included in this Subclass
CLUSTER: HE.4.8
CLUSTER: HE.5.56
CLUSTER: HE.6.10
CLUSTER: HE.6.6