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Information on SUBCLASS 2.2.5
Subclass Accession number: 4566
Subclass: 2.2.5 PSSM
Type: HH alpha-alpha
DB: ArchDB95

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB
Number of loops: 22

Average sequence ID (%) : 13.8 +/- 14.9
Average RMSD (Å) : 0.545 +/- 0.179

Consensus geometry
d (Å): 5 delta (°): 90-135 theta (°): 135-180 rho (°): 135-180
Consensus Sequence: pXXpXX
(φψ)-conformation: aalpaa
Pattern: xxxxxx[acfilmt]xx[acnstv][adegknqs][adeknqt][aeknqs][DEGKNQRT][adknt]xx[agiklt][afiklmv]xx[acflvy]xx[afgikv]x[adegknrst]xx[adegkqt][adegknqr]x
Conservation:-0.374-0.391-0.184-0.8890.180-1.4130.278-0.094-0.0652.175-0.4692.4250.9752.1021.007-1.863-0.178-0.6421.167-0.095-0.1521.193-1.381-0.436-0.481-0.894-0.515-0.489-0.232-0.3270.141-0.081
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1afr_A_1851afr   A201232ISHGNTARQAKEHGDIKLAQICGTIAADEKRHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHHaaaaaaaaaaaaavbaaaaaaaaaaaaaaaaa
1bgf_*_501bgf   -6293IQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKHHHHHHHHHHHHHT-HHHHHHHHHHHHHHHHHaaaaaaaaaaaaalxaaaaaaaaaaaaaaaaa
1f4n_A_31f4n   A1748SQALTILEKANELDADEIADIAESIHDHADEIHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHHaaaaaaaaaaaaavxaaaaaaaaaaaaaaaaa
1fpo_A_1111fpo   A126157DTRHQLMVEQLDNETWDAAADTCRKLRFLDKLHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHHaaaaaaaaaaaaavxaaaaaaaaaaaaaaaaa
1h6g_A_3981h6g   A398429NVPLLVLIEAAKNGNEKEVKEYAQVFREHANKHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHHaaaaaaaaaaaaalbaaaaaaaaaaaaaaaaa
1j30_A_81j30   A2556RRYLYFAKRADEEGYPEIAGLLRSIAEGETAHHHHHHHHHHHHHHT-HHHHHHHHHHHHHHHHHaaaaaaaaaaaaavbaaaaaaaaaaaaaaaaa
1j5w_A_2061j5w   A214245DEYEKEFYRLVEKNLYLPAYDYILKCSHTFNLHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHHaaaaaaaaaaaaavxaaaaaaaaaaaaaaaaa
1ji5_A_891ji5   A105136VELKKGMEIAQNSDDEMTSDLLLGIYTELEKHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHHaaaaaaaaaaaaalbaaaaaaaaaaaaaaaaa
1jig_A_911jig   A107138QELKEGMEVAGEAGDATSADMLLAIHTTLEQHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHHaaaaaaaaaaaaavbaaaaaaaaaaaaaaaaa
1k75_A_3971k75   A402433ALASTIETLAAAERLTAHKNAVTLRVNALKEQHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHHaaaaaaaaaaaaalbaaaaaaaaaaaaaaaaa
1kkc_A_441kkc   A5384NAALEAQKKAAEATDVPKLVSVQQAIKFNGGGHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHHaaaaaaaaaaaaalxaaaaaaaaaaaaaaaaa
1moj_A_1151moj   A131162EATREHTELAENLGDHATAHMLREGLIELEDDHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHHaaaaaaaaaaaaavxaaaaaaaaaaaaaaaaa
1n1q_A_931n1q   A109140GELKVARDVADEADDEATADMLDAIEAGLEKHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHHaaaaaaaaaaaaalbaaaaaaaaaaaaaaaaa
1nf4_A_881nf4   A104135EAYSQFLKVCKEQGDIVTARLFERIIEEEQAHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHHaaaaaaaaaaaaalbaaaaaaaaaaaaaaaaa
1nnq_A_61nnq   A2455MRYLIFAEKAEQEGFPNIAKLFRAIAYAEFVHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHHaaaaaaaaaaaaavbaaaaaaaaaaaaaaaaa
1o9r_A_1031o9r   A119150NMIRKAIDDSDEAGDPTTADIFTAASRDLDKSHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHHaaaaaaaaaaaaavbaaaaaaaaaaaaaaaaa
1pie_A_2741pie   A287318NNRTKIAQKAFVAGNLTKFGELLNASHASLKDHHHHHHHHHHHHHT-HHHHHHHHHHHHHHHHHaaaaaaaaaaaaavxaaaaaaaaaaaaaaaaa
1qgh_A_951qgh   A111142DEYKQGIELTDKEGDDVTNDMLIAFKASIDKHHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHHaaaaaaaaaaaaavxaaaaaaaaaaaaaaaaa
1umn_A_1111umn   A127158ALFQKGFDVSDEEGDSVTNDIFNVAKASIEKHHHHHHHHHHHHHHT-HHHHHHHHHHHHHHHHHaaaaaaaaaaaaavxaaaaaaaaaaaaaaaaa
1us7_B_1841us7   B188219NYLVIWCIDLEVEEKCALMEQVAHQTIVMQFIHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHHaaaaaaaaaaaaavxaaaaaaaaaaaaaaaaa
2a0b_*_6772a0b   -692723PGYVSVLESNLTAQDKKGIVEEGHKIKGAAGSHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHHaaaaaaaaaaaaalxaaaaaaaaaaaaaaaaa
2e2a_A_32e2a   A2152RSKLLEALKAAENGDFAKADSLVVEAGSCIAEHHHHHHHHHHHHTT-HHHHHHHHHHHHHHHHHaaaaaaaaaaaaavxaaaaaaaaaaaaaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1afr_A_1851afr   A     FE2FE (II) ION E - 196
1afr_A_1851afr   A     FE2FE (II) ION T - 199
1afr_A_1851afr   A     FE2FE (II) ION H - 203
1afr_A_1851afr   A     FE2FE (II) ION I - 225
1afr_A_1851afr   A     FE2FE (II) ION D - 228
1afr_A_1851afr   A     FE2FE (II) ION E - 229
1afr_A_1851afr   A     FE2FE (II) ION H - 232
1f4n_A_31f4n   A     MPD2-METHYL-2,4-PENTANEDIOL K - 6
1f4n_A_31f4n   A     MPD2-METHYL-2,4-PENTANEDIOL L - 9
1f4n_A_31f4n   A     MPD2-METHYL-2,4-PENTANEDIOL N - 10
1f4n_A_31f4n   A     MPD2-METHYL-2,4-PENTANEDIOL R - 13
1f4n_A_31f4n   A     CACALCIUM ION N - 27
1f4n_A_31f4n   A     CACALCIUM ION D - 30
1f4n_A_31f4n   A     CACALCIUM ION A - 31
1f4n_A_31f4n   A     CACALCIUM ION D - 32
1f4n_A_31f4n   A     MPD2-METHYL-2,4-PENTANEDIOL Y - 49
1f4n_A_31f4n   A     CACALCIUM ION L - 53
1f4n_A_31f4n   A     MPD2-METHYL-2,4-PENTANEDIOL L - 53
1f4n_A_31f4n   A     CACALCIUM ION A - 54
1h6g_A_3981h6g   A     MSESELENOMETHIONINE L - 401
1h6g_A_3981h6g   A     MSESELENOMETHIONINE L - 404
1h6g_A_3981h6g   A     MSESELENOMETHIONINE I - 405
1h6g_A_3981h6g   A     CACALCIUM ION I - 405
1h6g_A_3981h6g   A     MSESELENOMETHIONINE A - 408
1j30_A_81j30   A     O2OXYGEN MOLECULE G - 19
1j30_A_81j30   A     FEFE (III) ION E - 20
1j30_A_81j30   A     ZNZINC ION E - 20
1j30_A_81j30   A     O2OXYGEN MOLECULE E - 20
1j30_A_81j30   A     FEFE (III) ION A - 23
1j30_A_81j30   A     ZNZINC ION A - 23
1j30_A_81j30   A     O2OXYGEN MOLECULE A - 23
1j30_A_81j30   A     ZNZINC ION Y - 27
1j30_A_81j30   A     O2OXYGEN MOLECULE Y - 27
1j30_A_81j30   A     ZNZINC ION I - 49
1j30_A_81j30   A     FEFE (III) ION G - 52
1j30_A_81j30   A     FEFE (III) ION E - 53
1j30_A_81j30   A     ZNZINC ION E - 53
1j30_A_81j30   A     O2OXYGEN MOLECULE E - 53
1j30_A_81j30   A     FEFE (III) ION H - 56
1j30_A_81j30   A     ZNZINC ION H - 56
1j30_A_81j30   A     O2OXYGEN MOLECULE H - 56
1j5w_A_2061j5w   A     MSESELENOMETHIONINE F - 213
1j5w_A_2061j5w   A     MSESELENOMETHIONINE Y - 216
1j5w_A_2061j5w   A     MSESELENOMETHIONINE E - 217
1j5w_A_2061j5w   A     MSESELENOMETHIONINE F - 220
1j5w_A_2061j5w   A     MSESELENOMETHIONINE Y - 221
1j5w_A_2061j5w   A     MSESELENOMETHIONINE V - 224
1j5w_A_2061j5w   A     MSESELENOMETHIONINE D - 234
1j5w_A_2061j5w   A     MSESELENOMETHIONINE Y - 235
1j5w_A_2061j5w   A     MSESELENOMETHIONINE I - 236
1j5w_A_2061j5w   A     MSESELENOMETHIONINE L - 237
1j5w_A_2061j5w   A     MSESELENOMETHIONINE K - 238
1j5w_A_2061j5w   A     MSESELENOMETHIONINE C - 239
1k75_A_3971k75   A     MSESELENOMETHIONINE T - 406
1k75_A_3971k75   A     MSESELENOMETHIONINE L - 410
1kkc_A_441kkc   A     MNMANGANESE (II) ION H - 44
1kkc_A_441kkc   A     MNMANGANESE (II) ION Y - 48
1kkc_A_441kkc   A     MNMANGANESE (II) ION H - 88
1kkc_A_441kkc   A     MNMANGANESE (II) ION W - 92
1moj_A_1151moj   A     FEFE (III) ION H - 150
1moj_A_1151moj   A     FEFE (III) ION E - 154
1moj_A_1151moj   A     MGMAGNESIUM ION H - 164
1moj_A_1151moj   A     MGMAGNESIUM ION E - 167
1moj_A_1151moj   A     MGMAGNESIUM ION H - 168
1nf4_A_881nf4   A     FE2FE (II) ION E - 99
1nf4_A_881nf4   A     FE2FE (II) ION T - 102
1nf4_A_881nf4   A     FE2FE (II) ION Y - 106
1nf4_A_881nf4   A     FE2FE (II) ION I - 128
1nf4_A_881nf4   A     FE2FE (II) ION E - 131
1nf4_A_881nf4   A     FE2FE (II) ION E - 132
1nf4_A_881nf4   A     FE2FE (II) ION H - 135
1nf4_A_881nf4   A     FE2FE (II) ION L - 136
1nf4_A_881nf4   A     FE2FE (II) ION Y - 139
1nnq_A_61nnq   A     ZNZINC ION E - 19
1nnq_A_61nnq   A     ZNZINC ION A - 22
1nnq_A_61nnq   A     ZNZINC ION Y - 26
1nnq_A_61nnq   A     ZNZINC ION I - 48
1nnq_A_61nnq   A     ZNZINC ION A - 51
1nnq_A_61nnq   A     ZNZINC ION E - 52
1nnq_A_61nnq   A     ZNZINC ION H - 55
1o9r_A_1031o9r   A     TMNTRIS(HYDROXYMETHYL)AMINOMETHANE D - 138
1o9r_A_1031o9r   A     TMNTRIS(HYDROXYMETHYL)AMINOMETHANE T - 141
1o9r_A_1031o9r   A     TMNTRIS(HYDROXYMETHYL)AMINOMETHANE A - 142
1o9r_A_1031o9r   A     TMNTRIS(HYDROXYMETHYL)AMINOMETHANE R - 145
1o9r_A_1031o9r   A     FEFE (III) ION K - 149
1o9r_A_1031o9r   A     FEFE (III) ION W - 152
1qgh_A_951qgh   A     FEFE (III) ION K - 141
1qgh_A_951qgh   A     FEFE (III) ION W - 144
1umn_A_1111umn   A     EPE4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID E - 112
1umn_A_1111umn   A     EPE4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID E - 165
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1o9r_A_1031o9r   A AC7TMN BINDING SITE FOR CHAIN ED - 138
2a0b_*_6772a0b   * PHBPHOSPHORYLATION SITE.H - 715

Clusters included in this Subclass
CLUSTER: HH.1.84
CLUSTER: HH.2.112
CLUSTER: HH.2.195
CLUSTER: HH.2.68
CLUSTER: HH.3.207
CLUSTER: HH.3.67
CLUSTER: HH.3.97
CLUSTER: HH.4.88