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Information on SUBCLASS 2.2.1
Subclass Accession number: 6658
Subclass: 2.2.1 PSSM
Type: AR beta-beta link
DB: ArchDB-EC

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB
Number of loops: 47

Average sequence ID (%) : 9.7 +/- 15.2
Average RMSD (Å) : 0.466 +/- 0.202

Consensus geometry
d (Å): 9 delta (°): 45-90 theta (°): 90-135 rho (°): 180-225
Consensus Sequence: hpXpXX
(φψ)-conformation: bpaabb
Pattern: xx[acfgiklmtv][adegnpst]x[adegknqrst]xx[acfgilmpvwy]x
Conservation:-1.000-0.5261.3290.488-1.3490.9900.236-1.3530.184-1.000
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1a8d_*_421a8d   -4352VITYPDAQLVEEE-TT-EEEbbbxaaxxbb
1aj0_*_81aj0   -817TSLDLSHPHVEEEETTS-EEbbbxaabxbb
1am2_*_21am2   -29..ITGDALVA..EETT-EEE..bxaapxxx
1cxv_A_1781cxv   A178187AHFDDDETWTEEEETTS-EEbbbxaaxxxb
1dci_A_1831dci   A184193RYCTQDAFFQEEEETT-EEEbbbxaaxbbb
1dj2_A_1161dj2   A116124ILVSDRAHL.EEEESSSEE.bxxpaaxxx.
1dj2_A_841dj2   A8593CVIGNGVVV.EEE-TT-EE.xbbpaaxbx.
1dj3_A_1151dj3   A115123ILVSDRAHL.EEEETTSEE.bbbpaaxxb.
1dj3_A_831dj3   A8492CVVGNGAVI.EEE-TT-EE.xbbpaaxbb.
1ejx_C_11101ejx   C11101119IPIGAATEVIEE--TT-EEEbwbbaabxbb
1fi2_A_841fi2   A8796PHIHPRATEIEEE-TT--EEpbbbaabxbb
1g94_A_801g94   A8390VDTLINHM..EEEE-SEE..xxbxaabb..
1gkd_A_2021gkd   A202211AHFDDDELWSEEEETTS-EEbbbxaaxxxb
1gpp_A_721gpp   A7382FTCNATHELVEEEETT-EEEbbbxaaxxxx
1gxy_A_1661gxy   A169177IIKTCLGVY.EEEESS-EE.bbbbaaxbx.
1h3f_A_4091h3f   A409417.QVDLSRPRI.EEE-SS-EE.bbbaabpbb
1h5r_A_1051h5r   A106115ALVLGDNIFYEEEETT-EEEbbbxaabbbb
1hv5_A_1931hv5   A195204VHFDYDETWTEEEETTS-EEbbbxaaxxxb
1hy7_A_1781hy7   A178187AHFDDDEQWTEEEETTS-EEbbbxaaxxxb
1hzd_A_1961hzd   A197206RVAASSAKMGEEEETT-EEEbbbxaaxbbe
1ig3_A_1991ig3   A204213GLIPVGQPCNEEE--SS-EEbbbxaabxba
1ile_*_2401ile   -240249AAVHPEYTYAEEE-TTS-EEbbbxaaxbxx
1iwe_A_1281iwe   A128136LIISDRAHL.EEEETT-EE.bbbxaaxxx.
1iwe_A_951iwe   A96104SFIGNGVVI.EEE-TTBEE.xbbxaaxbb.
1j58_A_2731j58   A273281.HWHPNTHEW.EE-SSS-EE.bbbaabxbb
1jk3_A_1951jk3   A195204AHFDEDEFWTEEEETTS-EEbbbxaaxbxb
1jva_A_3551jva   A356365FTCNATNELVEEEETT-EEEbbbxaaxxxx
1kgq_A_2071kgq   A207215.YLGQSTRIY.EE-TT--EE.bbbaaxxbx
1ll2_A_971ll2   A99107VFMDADTLV.EEE-TTEEE.bxbpaabbx.
1lns_A_7141lns   A716725YHLEKADKLREEE-TT-EEEbbbxaaxbbx
1lxa_*_311lxa   -3138.IVGPHVEI..EE-TT-EE..bbxaaxbb.
1lxa_*_71lxa   -714.FVHPTAIV..EE-TT-EE..xbxaaxbb.
1lzj_A_2061lzj   A208216VCVDVDMEF.EEE-SSEEE.bbbxaabbx.
1mi8_A_21mi8   A29..ISGDSLIS..EETT-EEE..bxaapxxx
1mi8_A_661mi8   A6776IKATANHRFLEEE-TT-EEEbbbxaaxxbx
1mmq_*_1951mmq   -195204AHFDEDERWTEEEETTS-EEbbbxaaxxxb
1o7q_A_2201o7q   A222230FCMDVDQVF.EEE-SSEEE.bbbxaabbx.
1od2_A_20161od2   A20162023..ADVNARAG..EETT-EEE..bxaaxbbe
1od3_A_231od3   A2330..RSAFSNIQ..EETTS-EE..xxaabpbx
1omz_A_1461omz   A148156LMVDDDTLI.EEE-TTEEE.bbbxaabbb.
1pix_A_2041pix   A205214IIAHEKANMAEEEETT-EEEbbbxaaxbbb
1pix_A_4711pix   A474483SIGTAATEIAEEE-TT-EEEbbbbaaxbbb
1pzt_A_2471pzt   A249257VFSDVDLIP.EEE-TTEEE.bxbxaabbx.
1qjv_A_2951qjv   A295302.SMDNHIYG..EE-TTEEE..xbxaaxae.
1qre_A_271qre   A2734.VIDPTAYI..EE-TT-EE..bbxaaxbb.
1qre_A_331qre   A3341.YIDPQASVI.EE-TT-EEE.bbpaaxbbb
1tyf_A_1111tyf   A111120RFCLPNSRVMEEE-TT-EEEbbbxaapbbb
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1aj0_*_81aj0   *     PH22-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE M - 18
1cxv_A_1781cxv   A     ZNZINC ION H - 179
1cxv_A_1781cxv   A     CACALCIUM ION D - 181
1cxv_A_1781cxv   A     CACALCIUM ION D - 183
1cxv_A_1781cxv   A     CACALCIUM ION E - 184
1dci_A_1831dci   A     EDO1,2-ETHANEDIOL I - 183
1dci_A_1831dci   A     EDO1,2-ETHANEDIOL R - 184
1fi2_A_841fi2   A     MNMANGANESE (II) ION N - 85
1fi2_A_841fi2   A     MNMANGANESE (II) ION H - 88
1fi2_A_841fi2   A     MNMANGANESE (II) ION H - 90
1fi2_A_841fi2   A     MNMANGANESE (II) ION E - 95
1g94_A_801g94   A     DAF1,4-DEOXY-4-((5-HYDROXYMETHYL-2,3,4-TRIHYDROXYCYCLOHEX -5-ENYL)AMINO)FRUCTOSE L - 86
1g94_A_801g94   A     CACALCIUM ION N - 88
1g94_A_801g94   A     DAF1,4-DEOXY-4-((5-HYDROXYMETHYL-2,3,4-TRIHYDROXYCYCLOHEX -5-ENYL)AMINO)FRUCTOSE H - 89
1g94_A_801g94   A     GLCGLUCOSE H - 89
1gkd_A_2021gkd   A     ZNZINC ION H - 203
1gkd_A_2021gkd   A     CACALCIUM ION D - 205
1gkd_A_2021gkd   A     CACALCIUM ION D - 206
1gkd_A_2021gkd   A     CACALCIUM ION D - 207
1gkd_A_2021gkd   A     CACALCIUM ION E - 208
1gkd_A_2021gkd   A     CACALCIUM ION L - 209
1gkd_A_2021gkd   A     CACALCIUM ION W - 210
1gkd_A_2021gkd   A     CACALCIUM ION S - 211
1h5r_A_1051h5r   A     THMTHYMIDINE L - 109
1h5r_A_1051h5r   A     G1PALPHA-D-GLUCOSE-1-PHOSPHATE L - 109
1h5r_A_1051h5r   A     THMTHYMIDINE G - 110
1h5r_A_1051h5r   A     THMTHYMIDINE D - 111
1h5r_A_1051h5r   A     G1PALPHA-D-GLUCOSE-1-PHOSPHATE N - 112
1h5r_A_1051h5r   A     THMTHYMIDINE F - 114
1h5r_A_1051h5r   A     THMTHYMIDINE Y - 115
1hv5_A_1931hv5   A     CPS3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE G - 193
1hv5_A_1931hv5   A     ZNZINC ION H - 196
1hv5_A_1931hv5   A     CACALCIUM ION D - 198
1hv5_A_1931hv5   A     CACALCIUM ION D - 200
1hv5_A_1931hv5   A     CACALCIUM ION E - 201
1hy7_A_1781hy7   A     CACALCIUM ION D - 182
1hy7_A_1781hy7   A     CACALCIUM ION Q - 185
1hy7_A_1781hy7   A     CACALCIUM ION W - 186
1ig3_A_1991ig3   A     VIB3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY -ETHYL)-4-METHYL-THIAZOL-3-IUM C - 203
1j58_A_2731j58   A     MSESELENOMETHIONINE H - 273
1j58_A_2731j58   A     MNMANGANESE (II) ION H - 273
1j58_A_2731j58   A     MSESELENOMETHIONINE W - 274
1j58_A_2731j58   A     MNMANGANESE (II) ION W - 274
1j58_A_2731j58   A     MSESELENOMETHIONINE H - 275
1j58_A_2731j58   A     MNMANGANESE (II) ION H - 275
1j58_A_2731j58   A     MSESELENOMETHIONINE E - 280
1j58_A_2731j58   A     MNMANGANESE (II) ION E - 280
1j58_A_2731j58   A     MSESELENOMETHIONINE Q - 282
1j58_A_2731j58   A     MNMANGANESE (II) ION Q - 282
1j58_A_2731j58   A     MSESELENOMETHIONINE Y - 284
1jk3_A_1951jk3   A     CACALCIUM ION E - 199
1jk3_A_1951jk3   A     CACALCIUM ION F - 202
1jk3_A_1951jk3   A     CACALCIUM ION W - 203
1ll2_A_971ll2   A     UPGURIDINE-5'-DIPHOSPHATE-GLUCOSE F - 100
1ll2_A_971ll2   A     UPGURIDINE-5'-DIPHOSPHATE-GLUCOSE M - 101
1ll2_A_971ll2   A     MNMANGANESE (II) ION D - 102
1ll2_A_971ll2   A     UPGURIDINE-5'-DIPHOSPHATE-GLUCOSE D - 102
1ll2_A_971ll2   A     MNMANGANESE (II) ION A - 103
1ll2_A_971ll2   A     UPGURIDINE-5'-DIPHOSPHATE-GLUCOSE A - 103
1ll2_A_971ll2   A     MNMANGANESE (II) ION D - 104
1ll2_A_971ll2   A     UPGURIDINE-5'-DIPHOSPHATE-GLUCOSE D - 104
1ll2_A_971ll2   A     MNMANGANESE (II) ION T - 105
1ll2_A_971ll2   A     UPGURIDINE-5'-DIPHOSPHATE-GLUCOSE T - 105
1lzj_A_2061lzj   A     HGMERCURY (II) ION L - 207
1lzj_A_2061lzj   A     HGMERCURY (II) ION V - 208
1lzj_A_2061lzj   A     HGMERCURY (II) ION C - 209
1lzj_A_2061lzj   A     HGMERCURY (II) ION V - 210
1lzj_A_2061lzj   A     UDPURIDINE-5'-DIPHOSPHATE V - 210
1lzj_A_2061lzj   A     HGMERCURY (II) ION D - 211
1lzj_A_2061lzj   A     MNMANGANESE (II) ION D - 211
1lzj_A_2061lzj   A     UDPURIDINE-5'-DIPHOSPHATE D - 211
1lzj_A_2061lzj   A     MNMANGANESE (II) ION V - 212
1lzj_A_2061lzj   A     UDPURIDINE-5'-DIPHOSPHATE V - 212
1lzj_A_2061lzj   A     MNMANGANESE (II) ION D - 213
1lzj_A_2061lzj   A     UDPURIDINE-5'-DIPHOSPHATE D - 213
1lzj_A_2061lzj   A     MNMANGANESE (II) ION M - 214
1lzj_A_2061lzj   A     UDPURIDINE-5'-DIPHOSPHATE M - 214
1o7q_A_2201o7q   A     UDPURIDINE-5'-DIPHOSPHATE M - 224
1o7q_A_2201o7q   A     MNMANGANESE (II) ION D - 225
1o7q_A_2201o7q   A     GALD-GALACTOSE D - 225
1o7q_A_2201o7q   A     UDPURIDINE-5'-DIPHOSPHATE D - 225
1o7q_A_2201o7q   A     MNMANGANESE (II) ION V - 226
1o7q_A_2201o7q   A     UDPURIDINE-5'-DIPHOSPHATE V - 226
1o7q_A_2201o7q   A     MNMANGANESE (II) ION D - 227
1o7q_A_2201o7q   A     UDPURIDINE-5'-DIPHOSPHATE D - 227
1o7q_A_2201o7q   A     MNMANGANESE (II) ION Q - 228
1o7q_A_2201o7q   A     UDPURIDINE-5'-DIPHOSPHATE Q - 228
1o7q_A_2201o7q   A     GOLGLYCEROL V - 229
1od2_A_20161od2   A     MSESELENOMETHIONINE A - 2016
1od2_A_20161od2   A     MSESELENOMETHIONINE D - 2017
1od2_A_20161od2   A     MSESELENOMETHIONINE A - 2020
1od2_A_20161od2   A     MSESELENOMETHIONINE R - 2021
1od2_A_20161od2   A     MSESELENOMETHIONINE A - 2022
1od3_A_231od3   A     BGCBETA-D-GLUCOSE R - 23
1od3_A_231od3   A     CACALCIUM ION Q - 30
1omz_A_1461omz   A     UD2URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE V - 150
1omz_A_1461omz   A     MNMANGANESE (II) ION D - 151
1omz_A_1461omz   A     UD2URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE D - 151
1omz_A_1461omz   A     UD2URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE D - 152
1omz_A_1461omz   A     MNMANGANESE (II) ION D - 153
1omz_A_1461omz   A     UD2URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE D - 153
1omz_A_1461omz   A     MNMANGANESE (II) ION T - 154
1omz_A_1461omz   A     UD2URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE T - 154
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1h5r_A_1051h5r   A THMTHM BINDING SITE FOR CHAIN DD - 111
1o7q_A_2201o7q   A AC3MN BINDING SITE FOR CHAIN AD - 225
1o7q_A_2201o7q   A AC3MN BINDING SITE FOR CHAIN AD - 227
1od3_A_231od3   A AC4CA BINDING SITE FOR CHAIN AQ - 30

Clusters included in this Subclass
CLUSTER: AR.2.40
CLUSTER: AR.3.20
CLUSTER: AR.3.9
CLUSTER: AR.4.1
CLUSTER: AR.4.34
CLUSTER: AR.5.3
CLUSTER: AR.5.30