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Information on SUBCLASS 4.1.2
Subclass Accession number: 9032
Subclass: 4.1.2 PSSM
Type: HH alpha-alpha
DB: ArchDB-EC

Image coordinates: Rasmol PDB Jmol PDB
Consensus coordinates: Rasmol PDB Jmol PDB
Number of loops: 16

Average sequence ID (%) : 13.2 +/- 17.5
Average RMSD (Å) : 0.869 +/- 0.275

Consensus geometry
d (Å): 11 delta (°): 90-135 theta (°): 135-180 rho (°): 135-180
Consensus Sequence: XpcXhXXX
(φψ)-conformation: aalabpaa
Pattern: x[afitv]x[hnqrs]x[afly][adegqrt][dknqst][egn][cdenrst]x[adegnpst]xx[adegqr][AFLMVWY][adknrst]x[ilmvy]x
Conservation:-1.7700.705-0.0480.364-1.4100.877-0.4180.0252.587-1.0460.9080.046-0.583-1.3720.2380.3370.294-0.6520.8840.035
Loops included in this Subclass
LoopPDBChainStartEndSequenceSec StructRamachandran
1brw_A_181brw   A2342WIVRGYTNGDIPDYQMSALAHHHHHHHTTSS-HHHHHHHHaaaaaaaavabxaaaaaaaa
1cgt_*_2831cgt   -288307AVRNVFRDNTSNMYALDSMIHHHHHHTS-SS-HHHHHHHHaaaaaaaavabbaaaaaaaa
1ciu_*_2841ciu   -289308KVRQVFRDNTDTMYGLDSMIHHHHHHTT-SS-HHHHHHHHaaaaaaaalabbaaaaaaaa
1d3c_A_2831d3c   A288307KVRQVFRDNTDNMYGLKAMLHHHHHHTT-SS-HHHHHHHHaaaaaaaavabbaaaaaaaa
1dqs_A_2871dqs   A298317EAELARHLGILKGVAVSRIVHHHHHHHTTSS-HHHHHHHHaaaaaaaavabxaaaaaaaa
1e2k_A_961e2k   A102121TTQHRLDQGEISAGDAAVVMHHHHHHHHTSS-HHHHHHHHaaaaaaaavabxaaaaaaaa
1h5r_A_2541h5r   A254273PEEIAFRKGFIDVEQVRKLAHHHHHHHTTSS-HHHHHHHHaaaaaaaavabbaaaaaaaa
1iw0_A_271iw0   A2746TFMSDLLKGRLGVAEFTRLQHHHHHHHHTSS-HHHHHHHHaaaaaaaavaFbaaaaaaaa
1j0h_A_3771j0h   A382401GVLRFFAKEEISARQFANQMHHHHHHTS--S-HHHHHHHHaaaaaaaalabxaaaaaaaa
1jag_A_1511jag   A151170FAKNLFENGSLSDIEWHIYQHHHHHHHTTSS-HHHHHHHHaaaaaaaavabxaaaaaaaa
1ji2_A_3741ji2   A379398SVIRFFATGEIHAERFDAELHHHHHHTS--S-HHHHHHHHaaaaaaaavabxaaaaaaaa
1oe0_A_1141oe0   A114133FVENMRRNGSLEQGMYNTLEHHHHHHHTTSS-HHHHHHHHaaaaaaaavabxaaaaaaaa
1p5z_B_1371p5z   B137156FASNLYESECMNETEWTIYQHHHHHHHTTSS-HHHHHHHHaaaaaaaavabxaaaaaaaa
1p6x_A_731p6x   A7998DTQNRKQQGNLAVDDAALITHHHHHHHHTSS-HHHHHHHHaaaaaaaagabxaaaaaaaa
1q5n_A_201q5n   A3453LAQAQAQVGVIPQSAATVIQHHHHHHHTTSS-HHHHHHHHaaaaaaaavabxaaaaaaaa
1qho_A_2841qho   A289308VIRNVFGTFTQTMYDLNNMVHHHHHHTS-SS-HHHHHHHHaaaaaaaavabbaaaaaaaa
PDB ligands within a cut-off distance of 6 Å in this subclass
LoopPDBChainLigandsResidue
1brw_A_181brw   A     MES2-(N-MORPHOLINO)-ETHANESULFONIC ACID I - 45
1brw_A_181brw   A     MES2-(N-MORPHOLINO)-ETHANESULFONIC ACID Y - 46
1brw_A_181brw   A     MES2-(N-MORPHOLINO)-ETHANESULFONIC ACID F - 47
1brw_A_181brw   A     MES2-(N-MORPHOLINO)-ETHANESULFONIC ACID R - 48
1d3c_A_2831d3c   A     GLCGLUCOSE Y - 301
1dqs_A_2871dqs   A     ZNZINC ION H - 287
1dqs_A_2871dqs   A     NADNICOTINAMIDE-ADENINE-DINUCLEOTIDE H - 287
1dqs_A_2871dqs   A     CRB[1R-(1ALPHA,3BETA,4ALPHA,5BETA)]-5-(PHOSPHONOMETHYL)-1,3,4-TRIHYDROXYCYCLOHEXANE-1-CARBOXYLIC ACID H - 287
1dqs_A_2871dqs   A     ZNZINC ION V - 291
1dqs_A_2871dqs   A     CRB[1R-(1ALPHA,3BETA,4ALPHA,5BETA)]-5-(PHOSPHONOMETHYL)-1,3,4-TRIHYDROXYCYCLOHEXANE-1-CARBOXYLIC ACID V - 291
1e2k_A_961e2k   A     TMC1-[4-HYDROXY-5-(HYDROXYMETHYL)BICYCLO[3.1.0]HEX-2-YL]-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE I - 97
1e2k_A_961e2k   A     TMC1-[4-HYDROXY-5-(HYDROXYMETHYL)BICYCLO[3.1.0]HEX-2-YL]-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE I - 100
1e2k_A_961e2k   A     TMC1-[4-HYDROXY-5-(HYDROXYMETHYL)BICYCLO[3.1.0]HEX-2-YL]-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE Y - 101
1e2k_A_961e2k   A     TMC1-[4-HYDROXY-5-(HYDROXYMETHYL)BICYCLO[3.1.0]HEX-2-YL]-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE Q - 125
1e2k_A_961e2k   A     TMC1-[4-HYDROXY-5-(HYDROXYMETHYL)BICYCLO[3.1.0]HEX-2-YL]-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE M - 128
1e2k_A_961e2k   A     TMC1-[4-HYDROXY-5-(HYDROXYMETHYL)BICYCLO[3.1.0]HEX-2-YL]-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE G - 129
1e2k_A_961e2k   A     TMC1-[4-HYDROXY-5-(HYDROXYMETHYL)BICYCLO[3.1.0]HEX-2-YL]-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE Y - 132
1h5r_A_2541h5r   A     THMTHYMIDINE E - 256
1h5r_A_2541h5r   A     THMTHYMIDINE I - 257
1h5r_A_2541h5r   A     THMTHYMIDINE R - 260
1iw0_A_271iw0   A     HEMPROTOPORPHYRIN IX CONTAINING FE M - 29
1iw0_A_271iw0   A     HEMPROTOPORPHYRIN IX CONTAINING FE L - 33
1jag_A_1511jag   A     ATPADENOSINE-5'-TRIPHOSPHATE F - 151
1jag_A_1511jag   A     ATPADENOSINE-5'-TRIPHOSPHATE A - 152
1jag_A_1511jag   A     ATPADENOSINE-5'-TRIPHOSPHATE L - 155
1oe0_A_1141oe0   A     TTPTHYMIDINE-5'-TRIPHOSPHATE F - 114
1oe0_A_1141oe0   A     TTPTHYMIDINE-5'-TRIPHOSPHATE V - 115
1oe0_A_1141oe0   A     TTPTHYMIDINE-5'-TRIPHOSPHATE M - 118
1p5z_B_1371p5z   B     AR3CYTARABINE F - 137
1p5z_B_1371p5z   B     AR3CYTARABINE A - 138
1p5z_B_1371p5z   B     AR3CYTARABINE L - 141
1p6x_A_731p6x   A     THMTHYMIDINE I - 74
1p6x_A_731p6x   A     THMTHYMIDINE I - 77
1p6x_A_731p6x   A     THMTHYMIDINE Y - 78
1p6x_A_731p6x   A     THMTHYMIDINE Q - 102
1p6x_A_731p6x   A     THMTHYMIDINE F - 105
1p6x_A_731p6x   A     THMTHYMIDINE T - 106
1p6x_A_731p6x   A     THMTHYMIDINE Y - 109
1qho_A_2841qho   A     ABDACARBOSE DERIVED HEXASACCHARIDE T - 288
1qho_A_2841qho   A     MALMALTOSE Y - 302
PDB Site Annotated loops in this subclass
LoopPDBChainSiteResidue
1e2k_A_961e2k   A AC1TMC BINDING SITE FOR CHAIN AI - 97
1e2k_A_961e2k   A AC1TMC BINDING SITE FOR CHAIN AI - 100
1e2k_A_961e2k   A AC1TMC BINDING SITE FOR CHAIN AY - 101
1e2k_A_961e2k   A AC1TMC BINDING SITE FOR CHAIN AQ - 125
1e2k_A_961e2k   A AC1TMC BINDING SITE FOR CHAIN AM - 128
1h5r_A_2541h5r   A THMTHM BINDING SITE FOR CHAIN DE - 256

Clusters included in this Subclass
CLUSTER: HH.4.79
CLUSTER: HH.5.7